Prompt myocardial damage contributes to hepatic, renal, and intestinal injuries soon after a severe burn in rats

Journal of Trauma - Injury, Infection and Critical Care

Volumn 71, Issue 3, 2011, Pages 663-671

  Xiao, Rong ^a   Lei, Ze Yuan ^a   Dang, Yong Ming ^a   Huang, Yue Sheng ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Cedilanid; Enalaprilat; Ischemic hypoxic injury; Organ blood flow; Propranolol

Indexed keywords

AMINE OXIDASE (COPPER CONTAINING); BETA 2 MICROGLOBULIN; BILE ACID; ENALAPRILAT; LANATOSIDE C; PROPRANOLOL; TROPONIN I;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; BURN; CONTROLLED STUDY; ENZYME ACTIVITY; EXPERIMENTAL STUDY; HEART FUNCTION; HEART MUSCLE INJURY; HISTOPATHOLOGY; INJURY SEVERITY; INTESTINE BLOOD FLOW; INTESTINE INJURY; KIDNEY BLOOD FLOW; KIDNEY INJURY; LIVER BLOOD FLOW; LIVER INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT;

ANIMALS; BURNS; CARDIAC OUTPUT; CORONARY CIRCULATION; INTESTINES; KIDNEY; LIVER; MALE; MYOCARDIAL CONTRACTION; MYOCARDIUM; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; TIME FACTORS;

EID: 80052759829     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e31822175f6     Document Type: Article

References (38)

1. Huang YS, Yang ZC, Chen F, Crowther RS, Li A. Effects of early eschar excision en masse at one operation for prevention and treatment of organ dysfunction in severely burned patients. World J Surg. 1999;23:1272-1278. (Pubitemid 29530473)
2. Huang YS, Yang ZC, Yan BG, Hu XC, Li AN, Crowther RS. Improvement of early postburn cardiac function by use of Panax notoginseng and immediate total eschar excision in one operation. Burns. 1999;25:35-41. (Pubitemid 29092462)
3. Huang YS, Yang ZC. Measures for preventing early postburn damage improve survival rate of burn patients. Burns. 2004;30:808-812.
4. Huang YS, Yang ZC, Yan BG, et al. Pathogenesis of early cardiac myocyte damage after severe burns. J Trauma. 1999;46:428-432. (Pubitemid 29144338)
5. Huang YS, Li ZQ, Yang ZC. Roles of ischemia and hypoxia and the molecular pathogenesis of post-burn cardiac shock. Burns. 2003;29: 828-833.
6. Kaufman TM, Horton JW. Burn-induced alterations in cardiac beta-adrenergic receptors. Am J Physiol. 1992;262:H1585-H1591.
7. Horton JW, Garcia NM, White DJ, Keffer J. Postburn cardiac contractile function and biochemical markers of postburn cardiac injury. J Am Coll Surg. 1995;181:289-298.
8. 2+ transport and mechanism in the early stage after severe burns. Burns. 2002;28:431-434.
9. Zhang JP, Ying X, Liang WY, et al. Apoptosis in cardiac myocytes during the early stage after severe burn. J Trauma. 2008;65:401-408.
10. Horton JW, White DJ. Free-radical scavengers prevent intestinal ischemia-reperfusion-mediated cardiac dysfunction. J Surg Res. 1993;55: 282-289. (Pubitemid 23346862)
11. Maass DL, Hybki DP, White J, Horton JW. The time course of cardiac NF-kappa B activation and TNF-alpha secretion by cardiac myocytes after burn injury: Contribution to burn-related cardiac contractile dysfunction. Shock. 2002;17:293-299.
12. Maass DL, White J, Horton JW. Il-1 beta and Il-6 act synergistically with TNF-alpha to alter cardiac contractile function after burn trauma. Shock. 2002;18:360-366.
13. Zhang JP, Liang WY, Luo ZH, Yang ZC, Chan HC, Huang YS. Involvement of p38 map kinase in burn-induced degradation of membrane phospholipids and upregulation of cPLA(2) in cardiac myocytes. Shock. 2007;28:86-93.
14. Zhang JP, Ying X, Chen Y, Yang ZC, Huang YS. Inhibition of p38 MAP kinase improves survival of cardiac myocytes with hypoxia and burn serum challenge. Burns. 2008;34:220-227. (Pubitemid 351175692)
15. Horton JW, Tan J, White DJ, Mass DL. Burn injury decreases myocardial Na-K-ATPase activity role of PKC inhibition. Am J Physiol Regul Integr Comp Physiol. 2007;293:R1684-R1692. (Pubitemid 47535787)
16. Yang JM, Yang ZC, Cheng FM. Changes of myocardial nutrition blood flow and energy charge in rats at early stage of severe burn. Chin Crit Care Med. 1996;8:523-524.
17. Yin ZG, Huang YS, Li BX. Changes and relations between heart function and organ blood flow in rats at early stage of severe burn. Chin J Burn. 2010;26:10-13.
18. Liang WY, Tao H, Yang ZC, Yue-Sheng H. Ruthenium red attenuated cardiomyocyte and mitochondrial damage during the early stage after severe burn. Burns. 2002;28:35-38. (Pubitemid 34097683)
19. Huang YS, Hu AG. Molecular mechanism of c-jun antisense gene transfection in alleviating injury of cardiomyocytes treated with burn serum and hypoxia. World J Surg. 2004;28:951-957.
20. Huang YS, Zheng J, Fan PJ, Zhang X. Transfection of antisense p38, gene ameliorates myocardial cell injury mediated by hypoxia and burn serum. Burns. 2007;33:599-605. (Pubitemid 46887633)
21. Huang YS, Xie K, Zhang JP, Dang Y, Qiong Z. Prospective clinical and experimental studies on the cardioprotective effect of ulinastatin following severe burns. Burns. 2008;34:674-680.
22. Horton JW, Maass DL, White J, Sanders B. Hypertonic saline-dextran suppresses burn-related cytokine secretion by cardiomyocytes. Am J Physiol Heart Circul Physiol. 2001;280:H1591-H1601.
23. Horton JW, White DJ, Maass DL, Hybki DP, Haudek S, Giroir B. Antioxidant vitamin therapy alters burn trauma-mediated cardiac NF-kappa B activation and cardiomyocyte cytokine secretion. J Trauma. 2001;50:397-406.
24. Zang Q, Maass DL, White J, Horton JW. Cardiac mitochondrial damage and loss of ROS defense after burn injury: the beneficial effects of antioxidant therapy. J Appl Physiol. 2007;102:103-112. (Pubitemid 46089756)
25. Sokolow M, Chamberlain FL. Clinical evaluation of cedilanid. Ann Inter Med. 1943;18:204-213.
26. Holtz J. The cardiac renin-angiotensin system-physiological relevance and pharmacological modulation. Clin Investig. 1993;71:S25-S34. (Pubitemid 23137526)
27. Zhang BQ, Huang YS, Zhang JP, et al. Protective effects of administration of enalapril maleate on rat myocardial damage in early stage of burns. Chin J Burns. 2007;23:335-338.
28. Moore LR, Corbo M, Chien YW. Development of the rabbit model for studying the effects of propranolol on cardiac contractility: relationship of intravenous pharmacodynamics and pharmacokinetics. Methods Find Exp Clin Pharmacol. 1988;10:157-163.
29. Huang YS, Yang ZC, Liu XS, et al. Serial experimental and clinical studies on the pathogenesis of multiple organ dysfunction syndrome (MODS) in severe burns. Burns. 1998;24:706-716.
30. Murphy JT, Horton JW, Purdue GF, Hunt JL. Evaluation of troponin-I as an indicator of cardiac dysfunction after thermal injury. J Trauma. 1998;45:700-704.
31. Shima T, Tada H, Morimoto M, et al. Serum total bile acid level as a sensitive indicator of hepatic histological improvement in chronic hepatitis C patients responding to interferon treatment. J Gastroen Hepatol. 2000;15:294-299. (Pubitemid 30190744)
32. Bianchi C, Donadio C, Tramonti G, Consani C, Lorusso P, Rossi G. Reappraisal of serum beta 2-microglobulin as marker of GFR. Renal Failure 2001;23:419-429. (Pubitemid 32692277)
33. Bragg LE, Thompson JS, West WW. Intestinal diamine oxidase levels reflect ischemic-injury. J Surg Res. 1991;50:228-233.
34. Yang J, Yang Z, Chen F. Changes in cardiac renin-angiotensin system after severe burn injury in rats. Chin J Plast Surg Burns. 1999;15:102-104.
35. Li SG, Randall DC, Brown DR. Roles of cardiac output and peripheral resistance in mediating blood pressure response to stress in rats. Am J Physiol. 1998;274(4 Pt 2):R1065-1069. (Pubitemid 28217759)
36. Herndon DN, Hart DW, Wolf SE, Chinkes DL, Wolfe RR. Reversal of catabolism by beta-blockade after severe burns. N Engl J Med. 2001; 345:1223-1229. (Pubitemid 34951485)
37. Suzuki T, Morisaki H, Serita R, et al. Infusion of the beta-adrenergic blocker esmolol attenuates myocardial dysfunction in septic rats. Crit Care Med. 2005;33:2294-2301. (Pubitemid 41437484)
38. Williams FN, Herndon DN, Kulp GA, Jeschke MG. Propranolol decreases cardiac work in a dose-dependent manner in severely burned children. Surgery.2011;149:231-239.