The safety and tolerability evaluation of DepoFoam bupivacaine (bupivacaine extended-release liposome injection) administered by incision wound infiltration in rabbits and dogs

Expert Opinion on Investigational Drugs

Volumn 20, Issue 10, 2011, Pages 1327-1341

  Richard, Brigitte M ^a   Ott, Laura R ^b   Haan, Dean ^b   Brubaker, Abram N ^b   Cole, Phaedra I ^b   Nelson, Keith G ^b   Ross, Paul E ^b   Rebelatto, Marlon C ^b   Newton, Paul E ^b  

^a Pacira Pharmaceuticals Inc   (United States)

^b MPI RESEARCH   (United States)

Author keywords

Bupivacaine; Hernia repair; Liposomes; Pharmacokinetics; Sustained release; Wound infiltration

Indexed keywords

BUPIVACAINE; LIPOSOME; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLEEDING; CONTROLLED STUDY; DISEASE SEVERITY; DOG; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG MEGADOSE; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GRANULOMATOUS INFLAMMATION; INGUINAL HERNIA; MALE; MAXIMUM PLASMA CONCENTRATION; NECROSIS; NONHUMAN; ORCHITIS; POSTOPERATIVE ANALGESIA; RABBIT; SPECIES COMPARISON; TESTIS DISEASE; TIME TO MAXIMUM PLASMA CONCENTRATION; WOUND HEALING;

ANESTHETICS, LOCAL; ANIMALS; BUPIVACAINE; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DOGS; DRUG EVALUATION, PRECLINICAL; FEMALE; HERNIA, INGUINAL; INJECTIONS; LIPOSOMES; MALE; PAIN, POSTOPERATIVE; RABBITS; RANDOM ALLOCATION; WOUND HEALING;

EID: 80052757458     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.2011.611499     Document Type: Article

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