Neurotoxicological assessment after intracisternal injection of liposomal bupivacaine in rabbits

Anesthesia and Analgesia

Volumn 85, Issue 6, 1997, Pages 1331-1336

  Malinovsky, Jean Marc ^a,b   Benhamou, Dan ^c   Alafandy, Mokarram ^d   Mussini, Jean Marie ^b   Coussaert, Carine ^d   Couarraze, Guy ^e   Pinaud, Michel ^a   Legros, Franz J ^d  

^a Hôtel Dieu   (Belgium)

^b HÔTEL DIEU   (France)

^c HÔPITAL ANTOINE BÉCLÈRE   (France)

^d VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^e UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BUPIVACAINE; LIPOSOME;

ANIMAL EXPERIMENT; ARTICLE; CERVICAL SPINAL CORD; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; EPIDURAL ANESTHESIA; HISTOPATHOLOGY; INTRACISTERNAL DRUG ADMINISTRATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RABBIT; TISSUE NECROSIS;

ANESTHETICS, LOCAL; ANIMALS; BLOOD-BRAIN BARRIER; BUPIVACAINE; DRUG CARRIERS; INJECTIONS, SPINAL; LIPOSOMES; NECROSIS; RABBITS; SPINAL CORD;

EID: 0031424690     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000539-199712000-00027     Document Type: Article

References (37)

1. Gregoriadis G, Florence AT. Liposomes in drug delivery: clinical, diagnostic and ophthalmic potential. Drugs 1993;45:15-28.
2. Betageri GV, Jenkins SA, Parsons DL. Liposome drug delivery systems. Lancaster, PA: Technomic Publishing Co, 1993.
3. Gesztes A, Mezei M. Topical anesthesia of the skin by liposome-encapsulated tetracaine. Anesth Analg 1988;67:1079-81.
4. Planas ME, Gonzalez P, Rodriguez L, et al. Noninvasive percutaneous induction of topical analgesia by a new type of drug carrier, and prolongation of local pain intensitivity by anesthetic liposomes. Anesth Analg 1992;75:615-21.
5. Boogaerts JG, Lafont ND, Luo H, Legros FJ. Plasma concentrations of bupivacaine after brachial plexus administration of liposome-associated and plain solutions to rabbits. Can J Anaesth 1993;40:1201-4.
6. Mashimo T, Uchida I, Pak M, et al. Prolongation of canine epidural anesthesia by liposome encapsulation of bupivacaine. Anesth Analg 1992;74:827-34.
7. Lafont ND, Boogaerts JG, Legros FJ. Use of liposome-associated bupivacaine for the management of a chronic pain syndrome [letter]. Anesth Analg 1994;79:818.
8. Lafont ND, Legros FJ, Boogaerts JG. Use of liposome-associated bupivacaine in a cancer pain syndrome. Anaesthesia 1996;51: 578-9.
9. Boogaerts JG, Lafont ND, Carlino S, et al. Biodistribution of liposome-associated bupivacaine after extradural administration to rabbits. Br J Anaesth 1995;75:319-25.
10. Boogaerts JG, Lafont ND, Declercq AG, et al. Epidural administration of liposome-associated bupivacaine for the management of postsurgical pain: a first study. J Clin Anesth 1994;6: 315-20.
11. Boogaerts J, Lafont N, Donnay M, et al. Motor blockade and absence of local nerve toxicity induced by liposomal bupivacaine injected into the axillary plexus of rabbits. Acta Anesth Belg 1995;46:19-24.
12. Firth G, Olivier AS, McKeran RO. Studies on the intracerebral injection of bleomycin free and entrapped within liposomes in the rat. J Neurol Neurosurg Psychiatry 1984;47:585-9.
13. Hall SM, Gregson NA. The in vivo and ultrastructural effects of injection of lysophosphatidylcholine into myelinated peripheral nerve fibres of the adult mouse. J Cell Sci 1971;9:769-89.
14. Smith KJ, McDonald WI. Spontaneous and mechanically evoked activity due to central demyelinating lesion. Nature 1980;286: 154-5.
15. Gutteridge JMC. Free radicals in the disease process: a compilation of cause and consequence. Free Radical Res Commun 1993;19:141-58.
16. Lichtenberg D, Barenholz Y. Liposomes: preparation characterization and preservation. Methods Biochem Anal 1988;33: 337-459.
17. Barenholz Y, Amselem S. Quality control assays in the development and clinical use of liposome-based formulations. In: Gregoriadis G, ed. Liposome technology. Boca Raton, FL: CRC Press, 1993:527-616.
18. Lentner C. Geigy scientific tables. Vol 1. Units of measurements, body fluids, composition of the body, nutrition. West Caldwell, NJ: Ciba Geigy Corp, 1981.
19. Amselem S, Gabizon A, Barenholz Y. A large-scale method for the preparation of sterile and nonpyrogenic liposomal formulations of defined size distribution for clinical use. In: Gregoriadis G, ed. Liposome technology. Boca Raton, FL: CRC Press, 1993: 501-23.
20. Food and Drug Administration. Guidelines on the validation of the Limulus amoebocyte lysate test as an end-product endotoxin test for human and animal parenteral drugs biological products and medical devices. Washington, DC: Food and Drug Administration, 1987.
21. Stewart JCM. Colorimetric determination of phospholipids with ammonium ferrothiocyanate. Anal Biochem 1980;104:10-4.
22. Asakawa T, Matsushita S. Coloring conditions of thiobarbituric acid test for detecting lipid hydroperoxides. Lipids 1980;15: 137-40.
23. 2+ in the presence of xylenol orange: comparison with the TBA assay and an iodometric method. Lipids 1991;26:853-6.
24. New RRC. Characterization of liposomes. In: New RRC, ed. Liposomes: a practical approach. Oxford: IRL Press, 1990:116.
25. Malinovsky JM, Cozian A, Lepage JY, et al. Ketamine and midazolam neurotoxicity in the rabbit. Anesthesiology 1991;75: 91-7.
26. Yanez AM, Wallace M, Ho R, et al. Touch-evoked agitation produced by spinally administered phospholipid emulsion and liposomes in rats: structure-activity relation. Anesthesiology 1995;82:1189-98.
27. Homan R, Powball HJ. Transbilayer diffusion of phospholipids: dependence of head group structure and acyl chain length. Biochim Biophys Acta 1988;938:155-66.
28. Molen JES, Hobert SBS. Permeability change induced by peroxidation in liposomes prepared from human erythrocyte lipids. J Lipid Res 1974;15:273-84.
29. Hicks M, Gebicki JM. A quantitative relationship between permeability and the degree of peroxidation of ufasome membranes. Biochem Biophys Res Commun 1978;80:704-8.
30. Gregoriadis G, Davis C. Stability of liposomes in vivo and in vitro is promoted by their cholesterol content and the presence of blood cells. Biochem Biophys Res Commun 1979;89:1287-93.
31. 2+-ascorbate-induced lipid peroxidation in lecithin liposomes. Lipids 1982;17:511-3.
32. Blakemore WF, Eames RA, Smith KJ, McDonald WI. Remyelination in the spinal cord of the cat following intraspinal injections of lysolecithin. J Neurol Sci 1977;33:31-43.
33. Umbrain V, D'Haese J, Alafandy M, et al. Scintigraphic visualization of intrathecal liposome biodistribution. Acta Anaesthesiol Scand 1997;41:25-34.
34. Malinovsky JM, Lepage JY, Cozian A, et al. Is ketamine or its preservative responsible for neurotoxicity in the rabbit? Anesthesiology 1993;78:109-15.
35. Borbjerg FM, Svensson BA, Frigats C, Gordh T. Histopathology after repeated intrathecal injections of preservative-free ketamine in the rabbit: a light and electron microscopic examination. Anesth Analg 1994;79:105-11.
36. Svensson BA, Welin M, Gordh T, Westman J. Chronic subarachnoid midazolam (Dormicum) in the rat. Reg Anesth 1995;20: 426-34.
37. Durant PAC, Yaksh TL. Epidural injections of bupivacaine, morphine, fentanyl, lofentanil, and DADL in chronically implanted rats: a pharmacologic and pathologic study. Anesthesiology 1986;64:43-53.