Circulating kisspeptin levels exhibit sexual dimorphism in adults, are increased in obese prepubertal girls and do not suffer modifications in girls with idiopathic central precocious puberty

Peptides

Volumn 32, Issue 9, 2011, Pages 1781-1786

  Pita, Jimena ^a   Barrios, Vicente ^a,b   Gavela Pérez, Teresa ^a   Martos Moreno, Gabriel Á ^a,b   Muñoz Calvo, María T ^a,b   Pozo, Jesús ^a,b   Rovira, Adela ^a   Argente, Jesús ^a,b   Soriano Guillén, Leandro ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b Instituto de Salud Carlos III   (Spain)

Author keywords

Central precocious puberty; Kisspeptin; Leptin; Obesity

Indexed keywords

KISSPEPTIN; LEPTIN;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; CENTRAL PRECOCIOUS PUBERTY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HORMONE BLOOD LEVEL; HUMAN; MALE; NUTRITIONAL STATUS; OBESITY; PRECOCIOUS PUBERTY; PREPUBERTY; PRIORITY JOURNAL; SEX DIFFERENCE; SEXUAL DEVELOPMENT;

ADOLESCENT; ADULT; BIOLOGICAL MARKERS; BODY MASS INDEX; CASE-CONTROL STUDIES; CHILD; CROSS-SECTIONAL STUDIES; FEMALE; HUMANS; KISSPEPTINS; LEPTIN; MALE; OBESITY; PUBERTY; PUBERTY, PRECOCIOUS; REGRESSION ANALYSIS; YOUNG ADULT;

EID: 80052756887     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.07.016     Document Type: Article

References (42)

1. J. Argente, V. Barrios, J.A. Chowen, M.K. Sinha, and R.V. Considine Leptin plasma levels in healthy Spanish children and adolescents, children with obesity, and adolescents with anorexia nervosa and bulimia nervosa J Pediatr 131 1997 833 838 (Pubitemid 28027606)
2. K. Backholer, J.T. Smith, A. Rao, A. Pereira, J. Iqbal, and S. Ogawa Kisspeptin cells in the ewe brain respond to leptin and communicate with neuropeptide Y and proopiomelanocortin cells Endocrinology 151 2010 2233 2243
3. A.H. Bentsen, L. Ansel, V. Simonneaux, M. Tena-Sempere, A. Juul, and J.D. Mikkelsen Maturation of kisspeptinergic neurons coincides with puberty onset in male rats Peptides 31 2010 275 283
4. R.E. Brown, S.A. Imran, E. Ur, and M. Wilkinson KiSS-1 mRNA in adipose tissue is regulated by sex hormones and food intake Mol Cell Endocrinol 281 2008 64 72 (Pubitemid 50008883)
5. A. Carrascosa Lezcano, A. Ferrandez Longas, D. Yeste Fernandez, J. Garcia-Dihinx Villanova, A. Romo Montejo, and A. Copil Copil Spanish cross-sectional growth study 2008. Part I. Weight and height values in newborns of 26-42 weeks of gestational age An Pediatr (Barc) 68 2008 544 551 (Pubitemid 351896031)
6. J.M. Castellano, V.M. Navarro, R. Fernandez-Fernandez, R. Nogueiras, S. Tovar, and J. Roa Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition Endocrinology 146 2005 3917 3925 (Pubitemid 41175762)
7. A.E. Curtis, K.G. Murphy, O.B. Chaudhri, R. Ramachandran, A.M. Young, and J. Waxman Kisspeptin is released from human prostate cancer cell lines but plasma kisspeptin is not elevated in patients with prostate cancer Oncol Rep 23 2010 1729 1734
8. Y.M. Chan, J.P. Butler, N.E. Pinnell, F.P. Pralong, W.F. Crowley Jr., and C. Ren Kisspeptin resets the hypothalamic GnRH clock in men J Clin Endocrinol Metab 96 2011 E908 E915
9. N. de Roux, E. Genin, J.C. Carel, F. Matsuda, J.L. Chaussain, and E. Milgrom Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54 Proc Natl Acad Sci USA 100 2003 10972 10976 (Pubitemid 37140137)
10. L. de Vries, B. Shtaif, M. Phillip, and G. Gat-Yablonski Kisspeptin serum levels in girls with central precocious puberty Clin Endocrinol (Oxf) 71 2009 524 528
11. W.S. Dhillo, O.B. Chaudhri, M. Patterson, E.L. Thompson, K.G. Murphy, and M.K. Badman Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males J Clin Endocrinol Metab 90 2005 6609 6615 (Pubitemid 41759323)
12. W.S. Dhillo, O.B. Chaudhri, E.L. Thompson, K.G. Murphy, M. Patterson, and R. Ramachandran Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women J Clin Endocrinol Metab 92 2007 3958 3966 (Pubitemid 47607647)
13. W.S. Dhillo, P. Savage, K.G. Murphy, O.B. Chaudhri, M. Patterson, and G.M. Nijher Plasma kisspeptin is raised in patients with gestational trophoblastic neoplasia and falls during treatment Am J Physiol Endocrinol Metab 291 2006 E878 E884
14. J. Donato Jr., R.M. Cravo, R. Frazão, L. Gautron, M.M. Scott, and J. Lachey Leptin's effect on puberty in mice is relayed by the ventral premammillary nucleus and does not require signaling in Kiss1 neurons J Clin Invest 121 2011 355 368
15. J.T. George, J.D. Veldhuis, A.K. Roseweir, C.L. Newton, E. Faccenda, and R.P. Millar Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men J Clin Endocrinol Metab 2011 Epub ahead of print
16. S. Hameed, C.N. Jayasena, and W.S. Dhillo Kisspeptin and fertility J Endocrinol 208 2011 97 105
17. G.J. Hausman, and C.R. Barb Adipose tissue and the reproductive axis: biological aspects Endocr Dev 19 2010 31 44
18. Y. Horikoshi, H. Matsumoto, Y. Takatsu, T. Ohtaki, C. Kitada, and S. Usuki Dramatic elevation of plasma metastin concentrations in human pregnancy: metastin as a novel placenta-derived hormone in humans J Clin Endocrinol Metab 88 2003 914 919 (Pubitemid 36207842)
19. C.N. Jayasena, G.M. Nijher, O.B. Chaudhri, K.G. Murphy, A. Ranger, and A. Lim Subcutaneous injection of kisspeptin-54 acutely stimulates gonadotropin secretion in women with hypothalamic amenorrhea, but chronic administration causes tachyphylaxis J Clin Endocrinol Metab 94 2009 4315 4323
20. F. Katagiri, K. Nagai, A. Kida, K. Tomita, S. Oishi, and M. Takeyama Clinical significance of plasma metastin level in pancreatic cancer patients Oncol Rep 21 2009 815 819
21. F. Katagiri, K. Tomita, S. Oishi, M. Takeyama, and N. Fujii Establishment and clinical application of enzyme immunoassays for determination of luteinizing hormone releasing hormone and metastin J Pept Sci 13 2007 422 429 (Pubitemid 46902009)
22. A.S. Kauffman Gonadal and nongonadal regulation of sex differences in hypothalamic Kiss1 neurones J Neuroendocrinol 22 2010 682 691
23. M. Kotani, M. Detheux, A. Vandenbogaerde, D. Communi, J.M. Vanderwinden, and E. Le Poul The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54 J Biol Chem 276 2001 34631 34636
24. J.H. Lee, M.E. Miele, D.J. Hicks, K.K. Phillips, J.M. Trent, and B.E. Weissman KiSS-1, a novel human malignant melanoma metastasis-suppressor gene J Natl Cancer Inst 88 1996 1731 1737 (Pubitemid 26405010)
25. J.D. Mikkelsen, A.H. Bentsen, L. Ansel, V. Simonneaux, and A. Juul Comparison of the effects of peripherally administered kisspeptins Regul Pept 152 2009 95 100
26. A.I. Muir, L. Chamberlain, N.A. Elshourbagy, D. Michalovich, D.J. Moore, and A. Calamari AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1 J Biol Chem 276 2001 28969 28975
27. V.M. Navarro, and M. Tena-Sempere Kisspeptins and the neuroendocrine control of reproduction Front Biosci (Schol Ed) 1 2011 267 275
28. A.E. Oakley, D.K. Clifton, and R.A. Steiner Kisspeptin signaling in the brain Endocr Rev 30 2009 713 743
29. M.R. Palmert, S. Radovick, and P.A. Boepple Leptin levels in children with central precocious puberty J Clin Endocrinol Metab 83 1998 2260 2265 (Pubitemid 28503011)
30. D. Panidis, D. Rousso, G. Koliakos, A. Kourtis, I. Katsikis, and D. Farmakiotis Plasma metastin levels are negatively correlated with insulin resistance and free androgens in women with polycystic ovary syndrome Fertil Steril 85 2006 1778 1783 (Pubitemid 43816405)
31. R. Pineda, E. Aguilar, L. Pinilla, and M. Tena-Sempere Physiological roles of the kisspeptin/GPR54 system in the neuroendocrine control of reproduction Prog Brain Res 181 2010 55 77
32. J. Pita, S. Rado-Peralta, T. Gavela-Pérez, I. Aragón, V. Barrios, and A. Rovira Plasma kisspeptin levels are elevated in cord blood and present sexual dimorphism in the adult population: Relation with leptin, gonadotropins and anthropometrical data Peptides 32 2011 983 988
33. J. Pita, A. Rovira, and L. Soriano-Guillen Kisspeptin serum levels in girls with central precocious puberty: a long way to go Clin Endocrinol (Oxf) 72 2009 716
34. R. Ramachandran, M. Patterson, K.G. Murphy, W.S. Dhillo, S. Patel, and A. Kazarian Preanalytical factors affecting RIA measurement of plasma kisspeptin Clin Chem 54 2008 615 617 (Pubitemid 351348173)
35. S.B. Seminara, S. Messager, E.E. Chatzidaki, R.R. Thresher, J.S.J. Acierno, and J.K. Shagoury The GPR54 gene as a regulator of puberty N Engl J Med 349 2003 1614 1627 (Pubitemid 37303886)
36. L.G. Silveira, S.D. Noel, A.P. Silveira-Neto, A.P. Abreu, V.N. Brito, and M.G. Santos Mutations of the KISS1 gene in disorders of puberty J Clin Endocrinol Metab 95 2010 2276 2280
37. J.T. Smith, B.V. Acohido, D.K. Clifton, and R.A. Steiner KiSS-1 neurones are direct targets for leptin in the ob/ob mouse J Neuroendocrinol 18 2006 298 303 (Pubitemid 43323951)
38. L. Soriano-Guillén, R. Corripio, J.I. Labarta, R. Cañete, L. Castro-Feijóo, and R. Espino Central precocious puberty in children living in Spain: incidence, prevalence, and influence of adoption and immigration J Clin Endocrinol Metab 95 2010 4305 4313
39. M.G. Teles, S.D. Bianco, V.N. Brito, E.B. Trarbach, W. Kuohung, and S. Xu A GPR54-activating mutation in a patient with central precocious puberty N Engl J Med 358 2008 709 715 (Pubitemid 351240750)
40. M. Torricelli, L. Galleri, C. Voltolini, G. Biliotti, P. Florio, and M. De Bonis Changes of placental Kiss-1 mRNA expression and maternal/cord kisspeptin levels at preterm delivery Reprod Sci 15 2008 779 784
41. A. Verrotti, F. Basciani, D. Trotta, M. De Simone, G. Morgese, and F. Chiarelli Serum leptin levels in girls with precocious puberty Diabetes Nutr Metab 16 2003 125 129 (Pubitemid 36758014)
42. F. Wahab, R. Bano, S. Jabeen, S. Irfan, and M. Shahab Effect of peripheral kisspeptin administration on adiponectin, leptin, and resistin secretion under fed and fasting conditions in the adult male rhesus monkey (Macaca mulatta) Horm Metab Res 42 2010 570 574