Adipose tissue and the reproductive axis: Biological aspects

Endocrine Development

Volumn 19, Issue , 2010, Pages 31-44

  Hausman, G J ^a   Barb, C R ^a  

^a RUSSELL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2; APOLIPOPROTEIN A1; APOLIPOPROTEIN E; BONE MORPHOGENETIC PROTEIN 15; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; CONNECTIVE TISSUE GROWTH FACTOR; GONADORELIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 12P35; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; KISSPEPTIN; LEPTIN; LUTEINIZING HORMONE; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; NEUROPEPTIDE Y4 RECEPTOR; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PROOPIOMELANOCORTIN; RANTES; RESISTIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN C; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; HORMONE;

ADIPOSE TISSUE; APOPTOSIS; APPETITE; BIOLOGICAL ACTIVITY; CENTRAL NERVOUS SYSTEM; CHEMOTAXIS; CORPUS LUTEUM FUNCTION; CYTOKINE PRODUCTION; DECREASED APPETITE; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; HUMAN; HYPOPHYSIS; HYPOTHALAMUS; INSULIN SENSITIVITY; LIPID METABOLISM; LIPID STORAGE; LUTEINIZING HORMONE RELEASE; NEUROENDOCRINE SYSTEM; NONHUMAN; OVULATION; PRIORITY JOURNAL; REPRODUCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; STEROIDOGENESIS; SUBCUTANEOUS FAT; SWINE; ANIMAL; ENDOCRINE SYSTEM; PHYSIOLOGY;

ADIPOSE TISSUE; ANIMALS; ENDOCRINE SYSTEM; HORMONES; REPRODUCTION; SUS SCROFA;

EID: 77955864804     PISSN: 14217082     EISSN: 16622979     Source Type: Book Series    
DOI: 10.1159/000316895     Document Type: Review

References (78)

1. Barb CR, Hausman GJ, Houseknecht KL: Biology of leptin in the pig. Domest Anim Endocrinol 2001;21:297-317.
2. Barb CR, Barrett JB, Kraeling RR: Role of leptin in modulating the hypothalamic-pituitary axis in the pig. Domest Anim Endocrinol 2004;26:201-214.
3. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and the central neural networks. Science 1995;269:546-549.
4. Zhang Y, Proenca R, Maffel M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-432.
5. Dyer CJ, Simmons JM, Matteri RL, Keisler DH: Leptin receptor mRNA is expressed in ewe anterior pituitary and adipose tissue and is differentially expressed in hypothalamic regions of well-fed and feed-restricted ewes. Domest Anim Endocrinol 1997;14:119-128.
6. Lin J, Barb CR, Matteri RL, Kraeling RR, Chen X, Meinersmann RJ, Rampacek GB: Long form leptin receptor mRNA expression in the brain, pituitary, and other tissues in the pig. Domest Anim Endocrinol 2000;19:53-61.
7. Houseknecht KL, Portocarrero CP: Leptin and its receptors: regulators of whole-body energy homeostasis. Domest Anim Endocrinol 1998;15: 457-475.
8. Kennedy GC: The role of depot fat in the hypothalamic control of food intake in the rat. Proc Roy Soc Lond B Biol Sci 1953;140:578-592.
9. Hausman GJ, Barb CR, Dean RG: Patterns of gene expression in pig adipose tissue: transforming growth factors, interferons, interleukins and other cytokines. J Anim Sci 2007;85:2445-2456.
10. Hausman GJ, Barb CR, Dean RG: Patterns of gene expression in pig adipose tissue: insulin-like growth factor system proteins, neuropeptide Y (NPY), NPY receptors, neurotrophic factors and other secreted factors. Domest Anim Endocrinol 2008;35:24-34.
11. Hausman GJ, Poulos SP, Richardson RL, Barb CR, Andacht T, Mynatt R, Kirk H: Secreted proteins and genes in fetal and neonatal pig adipose tissue and stromal-vascular cells. J Anim Sci 2006;84: 1666-1681.
12. Hausman GJ, Richardson RL: Adrenergic innervation of fetal pig adipose tissue. Histochemical and ultrastructural studies. Acta Anat (Basel) 1987;130:291-297.
13. Czaja K, Lakomy M, Sienkiewicz W, Kaleczyc J, Pidsudko Z, Barb CR, Rampacek GB, Kraeling RR: Distribution of neurons containing leptin receptors in the hypothalamus of the pig. Biochem Biophys Res Commun 2002;298:333-337.
14. Czaja K, Kraeling RR, Barb CR: Are hypothalamic neurons transsynaptically connected to porcine adipose tissue? Biochem Biophys Res Commun 2003;311:482-485.
15. Kineman RD, Leshin LS, Crim JW, Rampacek GB, Kraeling RR: Localization of luteinizing hormone- releasing hormone in the forebrain of the pig. Biol Reprod 1988;39:665-672.
16. Leshin LS, Barb CR, Kiser TE, Rampacek GB, Kraeling RR: Growth hormone-releasing hormone and somatostatin neurons within the porcine and bovine hypothalamus. Neuroendocrinology 1994; 59:251-264.
17. Campfield LA, Smith FJ, Burn P: The OB protein (leptin) pathway - a link between adipose tissue mass and central neural networks. Horm Metab Res 1996;28:619-632. (Pubitemid 27057905)
18. Barb CR, Kraeling RR, Rampacek GB, Hausman GJ: The role of neuropeptide Y and interaction with leptin in regulating feed intake and luteinizing hormone and growth hormone secretion in the pig. Reproduction 2006;131:1127-1135.
19. Rich N, Reyes P, Reap L, Goswami R, Fraley GS: Sex differences in the effect of prepubertal GALP infusion on growth, metabolism and LH secretion. Physiol Behav 2007;92:814-823.
20. Crown A, Clifton DK, Steiner RA: Neuropeptide signaling in the integration of metabolism and reproduction. Neuroendocrinology 2007;86:175-182.
21. Barb CR, Chang W-C, Leshin LS, Rampacek GB, Kraeling RR: Opioid modulation of gonadotropin- releasing hormone release from the hypothalamic preoptic area in the pig. Domest Anim Endocrinol 1994;11:375-382.
22. Arreguin-Arevalo JA, Lents CA, Farmerie TA, Nett TM, Clay CM: KiSS-1 peptide induces release of LH by a direct effect on the hypothalamus of ovariectomized ewes. Anim Reprod Sci 2007;101:265-275.
23. Luque RM, Kinemam RD, Tena-Sempere M: Regulation of hypothalamic expression of KiSS-1 and GPR54 genes by metabolic factors: analyses using mouse models and a cell line. Endocrinology 2007;148:4601-4611.
24. Castellano JM, Navarro VM, Fernandez-Fernandez R, Castano JP, Malagon MM, Aguilar E, Dieguez C, Magni P, Pinilla L, Tena-Sempere M: Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropinreleasing hormone system of the rat. Mol Cell Endocrinol 2006;257-258:75-83.
25. Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, Terao Y, Kumano S, Takatsu Y, Masuda Y, Ishibashi Y, Watanabe T, Asada M, Yamada T, Suenaga M, Kitada C, Usuki S, Kurokawa T, Onda H, Nishimura O, Fujino M: Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature 2001;411:613-617.
26. Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, Brezillon S, Tyldesley R, Suarez-Huerta N, Vandeput F, Blanpain C, Schiffmann SN, Vassart G, Parmentier M: The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem 2001;276:34631-34636.
27. Takino T, Koshikawa N, Miyamori H, Tanaka M, Sasaki T, Okada Y, Seiki M, Sato H: Cleavage of metastasis suppressor gene product KiSS-1 protein/ metastin by matrix metalloproteinases. Oncogene 2003;22:4617-4626.
28. Smith JT, Clarke IJ: Kisspeptin expression in the brain: catalyst for the initiation of puberty. Rev Endocr Metab Disord 2007;8:1-9.
29. Lents CA, Heidorn NL, Barb CR, Ford JJ: Central and peripheral administration of kisspeptin activates gonadotropin but not somatotropin secretion in prepubertal gilts. Reproduction 2008;135: 879-887.
30. Tena-Sempere M: KiSS-1 and reproduction: focus on its role in the metabolic regulation of fertility. Neuroendocrinology 2006;83:275-281.
31. Cioffi JA, Van Blerkom J, Antczak M, Shafer A, Wittmer S, Snodgrass HR: The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod 1997;3:467-472.
32. Karlsson C, Lindell K, Svensson E, Bergh C, Lind P, Billig H, Carlsson LMS, Carlsson B: Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab 1997;82:4144-4148.
33. Spicer LJ, Francisco CC: The adipose obese gene product, leptin: evidence of a direct inhibitory role in ovarian function. Endocrinology 1997;138: 3374-3379.
34. Spicer LJ, Francisco CC: Adipose obese gene product, leptin, inhibits bovine ovarian thecal cell steroidogenesis. Biol Reprod 1998;58:207-212.
35. Ruiz-Cortes ZT, Men T, Palin MF, Downey BR, Lacroix DA, Murphy BD: Porcine leptin receptor: molecular structure and expression in the ovary. Mol Reprod Dev 2000;56:465-474.
36. Delavaud C, Bocquier F, Chilliard Y, Keisler DH, Gertler A, Kann G: Plasma leptin determination in ruminants: effect of nutritional status and body fatness on plasma leptin concentration assessed by a specific RIA in sheep. J Endocrinol 2000;165: 519-526.
37. Barb CR, Barrett JB, Kraeling RR, Rampacek GB: Serum leptin concentrations, luteinizing hormone and growth hormone secretion during feed and metabolic fuel restriction in the prepuberal gilt. Domest Anim Endocrinol 2001;20:47-63.
38. Leon HV, Hernandez-Ceron J, Keislert DH, Gutierrez CG: Plasma concentrations of leptin, insulin- like growth factor-I, and insulin in relation to changes in body condition score in heifers. J Anim Sci 2004;82:445-451.
39. Spicer LJ, Chamberlain CS, Francisco CC: Ovarian action of leptin: effects on insulin-like growth factor-I-stimulated function of granulosa and thecal cells. Endocrine 2000;12:53-59.
40. Campbell BK, Guitierrez CG, Armstrong DG, Webb R, Baird DT: Leptin: in vitro and in vivo evidence for direct effects on the ovary in monovulatory ruminants. Hum Reprod 2000;14:15-16.
41. Ruiz-Cortes ZT, Martel-Kennes Y, Gevry NY, Downey BR, Palin MF, Murphy BD: Biphasic effects of leptin in porcine granulosa cells. Biol Reprod 2003;68:789-796.
42. Gregoraszczuk EL, Wojtowicz AK, Ptak A, Nowak K: In vitro effect of leptin on steroids' secretion by FSH- and LH-treated porcine small, medium and large preovulatory follicles. Reprod Biol 2003;3: 227-239.
43. Gregoraszczuk EL, Ptak A, Wojtowicz AK, Gorska T, Nowak KW: Estrus cycle-dependent action of leptin on basal and GH or IGF-I stimulated steroid secretion by whole porcine follicles. Endocr Regul 2004;38:15-21.
44. Kadowaki T, Yamauchi T: Adiponectin and adiponectin receptors. Endocr Rev 2005;26:439-451.
45. Lord E, Ledoux S, Murphy BD, Beaudry D, Palin MF: Expression of adiponectin and its receptors in swine. J Anim Sci 2005;83:565-578.
46. Ledoux S, Campos DB, Lopes FL, Dobias-Goff M, Palin MF, Murphy BD: Adiponectin induces periovulatory changes in ovarian follicular cells. Endocrinology 2006;147:5178-5186.
47. Chabrolle C, Tosca L, Dupont J: Regulation of adiponectin and its receptors in rat ovary by human chorionic gonadotrophin treatment and potential involvement of adiponectin in granulosa cell steroidogenesis. Reproduction 2007;133: 719-731.
48. Chabrolle C, Tosca L, Crochet S, Tesseraud S, Dupont J: Expression of adiponectin and its receptors (AdipoR1 and AdipoR2) in chicken ovary: potential role in ovarian steroidogenesis. Domest Anim Endocrinol 2007;33:480-487.
49. Lagaly DV, Aad PY, Grado-Ahuir JA, Hulsey LB, Spicer LJ: Role of adiponectin in regulating ovarian theca and granulosa cell function. Mol Cell Endocrinol 2008;284:38-45.
50. Oh I, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, Eguchi H, Yamamoto M, Imaki T, Hashimoto K, Tsuchiya T, Monden T, Horiguchi K, Yamada M, Mori M: Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006;443:709-712.
51. Gonzalez R, Tiwari A, Unniappan S: Pancreaticβ cells colocalize insulin and pronesfatin immunoreactivity in rodents. Biochem Biophys Res Commun 2009;381:643-648.
52. Ramanjaneya M, Chen J, Brown JEP, Tan BK, Patel S, Lehenert H, Randrva HS: Identification of a novel adipokine nesfatin-1/NUCB2 in human and murine adipose tissue: altered levels in obesity and food deprivation. Proc Endocrine Society Annual Meeting, OR31-1, 2009.
53. Kim KS, Larsen N, Short T, Plastow G, Rothschild MF: A missense variant of the porcine melanocortin-4 receptor (MC4R) gene is associated with fatness, growth, and feed intake traits. Mamm Genome 2000;11:131-135.
54. Vaisse C, Clement K, Durand E, Hercberg S, Guy- Grand B, Froguel P: Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J Clin Invest 2000;106:253-262.
55. Lubrano-Berthelier C, Cavazos M, Le Stunff C, Haas K, Shapiro A, Zhang S, Bougneres P, Vaisse C: The human MC4R promoter: characterization and role in obesity. Diabetes 2003;52:2996-3000.
56. Meehan TP, Tabeta K, Du X, Woodward LS, Firozi K, Beutler B, Justice MJ: Point mutations in the melanocortin-4 receptor cause variable obesity in mice. Mamm Genome 2006;17:1162-1171.
57. Li F, Chen H, Lei CZ, Ren G, Wang J, Li ZJ, Wang JQ: Novel SNPs of the bovine NUCB2 gene and their association with growth traits in three native Chinese cattle breeds. Mol Biol Rep 2010;37:501-505.
58. Barb CR, Hausman GJ, Rekaya R, Lents CA, Lkhagvadorj S, Qu L, Cai W, Couture OP, Anderson LL, Dekkers JCM, Tuggle CK: Microarray gene expression profiles in hypothalamus, liver and adipose tissues and feed intake response to melanocortin-4 receptor agonist in pigs expressing melanocortin-4 receptor mutations. Physiol Genomics 2009.
59. Lkhagvadorj S, Qu L, Cai W, Couture OP, Barb CR, Hausman GJ, Nettleton D, Anderson LL, Dekkers JCM, Tuggle CK: Microarray gene expression profiles of fasting induced changes in liver and adipose tissues of pigs expressing the melanocortin-4 receptor D298N variant. Physiol Genomics 2009;38:98-111.
60. Garcia-Galiano D, Navarro VM, Sanchez-Garrido MA, Pineda R, Castellano JM, Romero M, Aguilar E, Dieguez C, Pinilla L, Tena-Sempere M: The anorexigenic neuropeptide, nesfatin-1, as putative regulator of the gonadotropic axis and puberty onset in the female rat. Proc Endocrine Society Annual Meeting, OR31-1, Washington 2009.
61. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K, Matsuki Y, Murakami M, Ichisaka T, Murakami H, Watanabe E, Takagi T, Akiyoshi M, Ohtsubo T, Kihara S, Yamashita S, Makishima M, Funahashi T, Yamanaka S, Hiramatsu R, Matsuzawa Y, Shimomura I: Visfatin: a protein secreted by visceral fat that mimics the effects of insulin. Science 2005;307:426-430. (Pubitemid 40139988)
62. Plati E, Kouskouni E, Malamitsi-Puchner A, Boutsikou M, Kaparos G, Baka S: Visfatin and leptin levels in women with polycystic ovaries undergoing ovarian stimulation. Fertil Steril 2009; doi:10.1016/j.fertnstert.2009.04.055. [Epub ahead of print].
63. Bastard JP, Maachi M, Lagathu C, Kim MJ, Caron M, Vidal H, Capeau J, Feve B: Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur Cytokine Netw 2006; 17:4-12.
64. Korzekwa A, Murakami S, Woclawek-Potocka I, Bah MM, Okuda K, Skarzynski DJ: The influence of tumor necrosis factor-(TNF) on the secretory function of bovine corpus luteum: TNF and its receptors expression during the estrous cycle. Reprod Biol 2008;8:245-262.
65. Nagyova E, Nemcova L, Prochazka R: Expression of tumor necrosis factor-induced protein-6 messenger RNA in porcine preovulatory ovarian follicles. J Reprod Dev 2009;55:231-235.
66. Gorospe WC, Hughes FM Jr, Spangelo BL: Interleukin- 6: effects on and production by rat granulosa cells in vitro. Endocrinology 1992;130: 1750-1752.
67. Gorospe WC, Spangelo BL: Interleukin-6 production by rat granulosa cells in vitro: effects of cytokines, follicle-stimulating hormone, and cyclic 3,5-adenosine monophosphate. Biol Reprod 1993;48:538-543.
68. Hughes FM Jr, Lane TA, Chen TT, Gorospe WC: Effects of cytokines on porcine granulosa cell steroidogenesis in vitro. Biol Reprod 1990;43:812-817.
69. Kalra SP, Xu B, Dube MG, Moldwaer LL, Martin D, Kalra PS: Leptin and ciliary neurotropic factor inhibit fasting-induced suppression of luteinizing hormone release in rats: role of neuropeptide Y. Neurosci Lett 1998;240:45-49.
70. Xu B, Dube MG, Kalra PS, Farmerie WG, Kaibara A, Moldawer LL, Martin D, Kalra SP: Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin. Endocrinology 1998;139: 466-473.
71. Vacher CM, Crepin D, Aubourg A, Couvreur O, Bailleux V, Nicolas V, Ferezou J, Gripois D, Gertler A, Taouis M: A putative physiological role of hypothalamic CNTF in the control of energy homeostasis. FEBS Lett 2008;582:3832-3838.
72. Sukonina V, Lookene A, Olivecrona T, Olivecrona G: Angiopoietin-like protein-4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. Proc Natl Acad Sci USA 2006;103:17450-17455.
73. Xu A, Lam MC, Chan KW, Wang Y, Zhang J, Hoo RL, Xu JY, Chen B, Chow WS, Tso AW, Lam KS: Angiopoietin-like protein-4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc Natl Acad Sci USA 2005;102:6086-6091.
74. Chen XD, Lei T, Xia T, Gan L, Yang ZQ: Increased expression of resistin and tumour necrosis factor-αin pig adipose tissue as well as effect of feeding treatment on resistin and cAMP pathway. Diabetes Obes Metab 2004;6:271-279.
75. Mitchell M, Armstrong DT, Robker RL, Norman RJ: Adipokines: implications for female fertility and obesity. Reproduction 2005;130:583-597.
76. Otsuka F, Yao Z, Lee T, Yamamoto S, Erickson GF, Shimasaki S: Bone morphogenetic protein-15. Identification of target cells and biological functions. J Biol Chem 2000;275:39523-39528.
77. Otsuka F, Yamamoto S, Erickson GF, Shimasaki S: Bone morphogenetic protein-15 inhibits folliclestimulating hormone (FSH) action by suppressing FSH receptor expression. J Biol Chem 2001; 276:11387-11392.
78. Otani H, Otsuka F, Takeda M, Mukai T, Terasaka T, Miyoshi T, Inagaki K, Suzuki J, Ogura T, Lawson MA, Makino H: Regulation of GNRH production by estrogen and bone morphogenetic proteins in GT1-7 hypothalamic cells. J Endocrinol 2009;203:87-97.