A complex double deletion in LMNA underlies progressive cardiac conduction disease, atrial arrhythmias, and sudden death

Circulation: Cardiovascular Genetics

Volumn 4, Issue 3, 2011, Pages 280-287

  Marsman, Roos F ^a   Bardai, Abdennasser ^a   Postma, Alex V ^b   Res, Jan C J ^c   Koopmann, Tamara T ^a   Beekman, Leander ^a   Van Der Wal, Allard C ^b   Pinto, Yigal M ^a,b   Deprez, Ronald H Lekanne ^b   Wilde, Arthur A M ^a,b   Jordaens, Luc J ^d   Bezzina, Connie R ^a  

^a Heart Failure Research Center   (Netherlands)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

^c ERASMUS MEDICAL CENTER   (Netherlands)

^d NONE

Author keywords

Complex deletion; Gene rearrangement; LMNA conduction disease; MLPA

Indexed keywords

LAMIN A; LAMIN C;

ADULT; ARTICLE; ARTIFICIAL HEART PACEMAKER; CHROMOSOME 1P; COMPLETE HEART BLOCK; CONTROLLED STUDY; DEFIBRILLATOR; DNA REPLICATION; FEMALE; FIRST DEGREE ATRIOVENTRICULAR BLOCK; GENE DELETION; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENE REARRANGEMENT; HEART ATRIUM ARRHYTHMIA; HEART ATRIUM FIBRILLATION; HEART ATRIUM FLUTTER; HEART MUSCLE CONDUCTION DISTURBANCE; HEART SINOATRIAL BLOCK; HEART VENTRICLE BIGEMINY; HUMAN; HUMAN TISSUE; LINKAGE ANALYSIS; MALE; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SINUS ARREST; SINUS BRADYCARDIA; SINUS NODE DYSFUNCTION; SUDDEN DEATH; TACHYCARDIA;

ADULT; ARRHYTHMIAS, CARDIAC; ATRIAL FIBRILLATION; DEATH, SUDDEN, CARDIAC; DNA MUTATIONAL ANALYSIS; ELECTROCARDIOGRAPHY; FEMALE; GENE REARRANGEMENT; GENETIC LINKAGE; HEART CONDUCTION SYSTEM; HUMANS; LAMIN TYPE A; MALE; MIDDLE AGED; MUTATION; MYOCARDIUM; NETHERLANDS; PEDIGREE; SEQUENCE DELETION; YOUNG ADULT;

EID: 80052747455     PISSN: 1942325X     EISSN: 19423268     Source Type: Journal    
DOI: 10.1161/CIRCGENETICS.110.959221     Document Type: Article

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