Primary prevention of sudden death in patients with lamin A/C gene mutations [18]

New England Journal of Medicine

Volumn 354, Issue 2, 2006, Pages 209-210

  Meune, Christophe ^a   Van Berlo, Jop H ^b   Anselme, Frédéric ^c   Bonne, Gisèle ^d   Pinto, Yigal M ^e   Duboc, Denis ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^c HÔPITAL CHARLES NICOLLE   (France)

^d INSERM   (France)

^e ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

LAMIN A; LAMIN C;

ADULT; ARTIFICIAL HEART PACEMAKER; CLINICAL ARTICLE; CONTROLLED STUDY; DEFIBRILLATOR; FEMALE; GENE MUTATION; GENETICS; HEART ATRIUM FIBRILLATION; HEART DISEASE; HEART EJECTION FRACTION; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE CONDUCTION DISTURBANCE; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE TACHYCARDIA; HUMAN; INCIDENCE; LETTER; MALE; NERVE BLOCK; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SUDDEN DEATH;

ADULT; DEATH, SUDDEN, CARDIAC; DEFIBRILLATORS, IMPLANTABLE; FEMALE; HUMANS; LAMIN TYPE A; MALE; MIDDLE AGED; MUTATION; PROSPECTIVE STUDIES; STROKE VOLUME; TACHYCARDIA;

EID: 30444446953     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc052632     Document Type: Letter

References (5)

1. Ben Yaou R, Muchir A, Arimura T, et al. Genetics of laminopathies. Novartis Found Symp 2005;264:81-90.
2. Bonne G, Di Barletta MR, Varnous S, et al. Mutations in the gene encoding lamin A/C cause autosomal dominant Emery-Dreifuss muscular dystrophy. Nat Genet 1999;21:285-8.
3. Taylor MR, Fain PR, Sinagra G, et al. Natural history of dilated cardiomyopathy due to lamin A/C gene mutations. J Am Coll Cardiol 2003;41:771-80. [Erratum, J Am Coll Cardiol 2003;42:590.]
4. van Berlo JH, de Voogt WG, van der Kooi AJ, et al. Metaanalysis of clinical characteristics of 299 carriers of LMNA gene mutations: do lamin A/C mutations portend a high risk of sudden death? J Mol Med 2005;83:79-83.
5. Bécane HM, Bonne G, Varnous S, et al. High incidence of sudden death with conduction system and myocardial disease due to lamins A and C gene mutation. Pacing Clin Electrophysiol 2000;23:1661-6.