Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes

Archives of Toxicology

Volumn 85, Issue 8, 2011, Pages 929-939

  Rossato, Luciana Grazziotin ^a   Costa, Vera Marisa ^a   De Pinho, Paula Guedes ^a   Carvalho, Félix ^a   De Lourdes Bastos, Maria ^a   Remião, Fernando ^a  

^a UNIVERSITY OF PORTO   (Portugal)

Author keywords

Glutathione depletion; Organic cation transporter; Phenylephrine; Rat cardiomyocytes; Synephrine

Indexed keywords

ACETYLCYSTEINE; ALPHA ADRENERGIC RECEPTOR; GLUTATHIONE; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 4; OXEDRINE; PARA SYNEPHRINE; PHENYLEPHRINE; PRAZOSIN; TIRON; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CATION TRANSPORT; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; GAS CHROMATOGRAPHY; GLUTATHIONE METABOLISM; HEART MUSCLE CELL; ION TRAP MASS SPECTROMETRY; ISOMERIZATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; RAT;

1,2-DIHYDROXYBENZENE-3,5-DISULFONIC ACID DISODIUM SALT; ACETYLCYSTEINE; ADRENERGIC ALPHA-AGONISTS; ANIMALS; ANTIOXIDANTS; BIOLOGICAL TRANSPORT; CATECHOLAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLUTATHIONE; MALE; MYOCYTES, CARDIAC; ORGANIC CATION TRANSPORT PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; SYNEPHRINE;

EPHEDRA; RATTUS;

EID: 80052740684     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-010-0630-9     Document Type: Article

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