Products containing bitter orange or synephrine: Suspected cardiovascular adverse reactions;Produits contenant de l'orange amère ou de la synéphrine: Effets indésirables cardiovasculaires soupçonnés

CMAJ. Canadian Medical Association Journal

Volumn 171, Issue 8, 2004, Pages

  Jordan, Scott ^a   Murty, Mano ^a   Pilon, Karen ^a  

^a HEALTH CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; CAFFEINE; EPHEDRINE; NATURAL PRODUCT; PHENYLEPHRINE;

CANADA; CARDIOTOXICITY; CARDIOVASCULAR DISEASE; CARDIOVASCULAR EFFECT; CEREBROVASCULAR DISEASE; COLLAPSE; DIET SUPPLEMENTATION; DOSE RESPONSE; DRUG EFFICACY; DRUG FATALITY; DRUG INDICATION; DRUG INFORMATION; DRUG SAFETY; DRUG STRUCTURE; DRUG UTILIZATION; EPHEDRA; HEART ARREST; HEART INFARCTION; HEART VENTRICLE ARRHYTHMIA; HEART VENTRICLE FIBRILLATION; HUMAN; METABOLIC RATE; NONHUMAN; NOTE; PATIENT EDUCATION; SOUR ORANGE; TACHYCARDIA; THERMOGENESIS; WEIGHT REDUCTION;

EID: 19544373123     PISSN: 08203946     EISSN: 14882329     Source Type: Journal    
DOI: None     Document Type: Note

References (9)

1. Blumenthal M, senior editor. Herbal mediane - expanded Commision E monographs. 1st ed. Austin (TX): American Botanical Council; 2000. p. 287-9.
2. Health Canada reminds Canadians of the dangers of Ephedra/ephedrine products. Ottawa: Health Canada; 2003 June 9. Available: www.hc-sc.gc.ca/ english/protection/warnings/2003/2003_43.htm (accessed 2004 July 5).
3. FDA announces rule prohibiting sale of dietary supplements containing ephedrine alkaloids effective April 12 [FDA statement]. Rockville (MD): US Food and Drug Adminstration; 2004 Apr 12. Available: www.fda.gov/bbs/topics/NEWS/2004 /NEW01050.html (accessed 2004 June 28).
4. Health Canada warm Canadians not to use "Thermonex." Ottawa: Health Canada; 2004 May 28. Available: www.hc-sc.gc.ca/english /protection/warnings/2004/2004_30.htm (accessed 2004 July 5).
5. Calapai G, Firenzuoli F, Saitta A, Squadrito F, Arlotta MR, Canstantino G, Inferrera G. Antiobesity and cardiovascular toxic effects of Citrus aurantium extracts in the rat: a preliminary report. Fitoterapia 1999;70:586-92.
6. Nykamp DL, Fackih MN, Compton AL. Possible association of acute lateral-wall myocardial infarction and bitter orange supplement. Ann Pharmacother 2004;38(5):812-6.
7. Bucci L, Shugarman AE, Feliciano J, Wright J. Acute metabolic responses to synephrine-caffeine compared to ephedrine-caffeine. Presented at the Conference on the Science and Policy of Performance-Enhancing Products. NIH Office of Dietary Supplements; Bethesda, Md; Jan. 8-9, 2002. Available: http://ods.od.nih.gov/news/conferences/BucciPEPCRN_Ephedra_Presentation_Jan02. pdf (accessed 2004 June 27).
8. Bitter orange. Natural Medicines Comprehensive Database. Available: www.NaturalDatabase.com (accessed 2004 June 27). Jellin JM, Gregory PJ, Batz F, Hitchens K, et al. Pharmacist's letter/prescriber's letter. Natural Medicines Comprehensive Database. 6th ed. Stockton (CA): Therapeutic Research Faculty; 2004. p. 146-8.
9. Bitter orange. Natural Medicines Comprehensive Database. Available: www.NaturalDatabase.com (accessed 2004 June 27). Jellin JM, Gregory PJ, Batz F, Hitchens K, et al. Pharmacist's letter/prescriber's letter. Natural Medicines Comprehensive Database. 6th ed. Stockton (CA): Therapeutic Research Faculty; 2004. p. 146-8.