Anti-proliferative effects of the novel squamosamide derivative (FLZ) on HepG2 human hepatoma cells by regulating the cell cycle-related proteins are associated with decreased Ca2+/ROS levels

Chemico-Biological Interactions

Volumn 193, Issue 3, 2011, Pages 246-253

  Qin, Yong ^a   Pan, Xiang ^a   Tang, Tian Tian ^a   Zhou, Liang ^a   Gong, Xing Guo ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

CDK; Cell cycle; FLZ; Intracellular calcium; Oxidative stress

Indexed keywords

ACRYLAMIDE DERIVATIVE; CALCIUM ION; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN E; N [2 (4 HYDROXYPHENYL)ETHYL] 2 (2,5 DIMETHOXYPHENYL) 3 (3 METHOXY 4 HYDROXYPHENYL)ACRYLAMIDE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; RETINOBLASTOMA PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; HEPATOMA CELL; HUMAN; HUMAN CELL; OXIDATIVE STRESS; POSITIVE FEEDBACK; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ACRYLAMIDES; ANTINEOPLASTIC AGENTS; APOPTOSIS; CAFFEIC ACIDS; CALCIUM; CARCINOMA, HEPATOCELLULAR; CELL CYCLE PROTEINS; CELL PROLIFERATION; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P27; G1 PHASE; GLUTATHIONE; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; RETINOBLASTOMA PROTEIN;

EID: 80052731320     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.07.004     Document Type: Article

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