Podocyte main slit diaphragm proteins, nephrin and podocin, are affected at early stages of lupus nephritis and correlate with disease histology

Lupus

Volumn 20, Issue 8, 2011, Pages 781-791

  Perysinaki, G S ^a   Moysiadis, D K ^a   Bertsias, G ^a   Giannopoulou, I ^b   Kyriacou, K ^c   Nakopoulou, L ^b   Boumpas, D T ^a   Daphnis, E ^a  

^a UNIVERSITY OF CRETE   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c CYPRUS INSTITUTE OF NEUROLOGY AND GENETICS   (Cyprus)

Author keywords

Lupus nephritis; Nephrin; Podocin; Podocytes; Proteinuria

Indexed keywords

MESSENGER RNA; NEPHRIN; PODOCIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; LUPUS ERYTHEMATOSUS NEPHRITIS; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SLIT DIAPHRAGM; WESTERN BLOTTING;

ANIMALS; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUPUS NEPHRITIS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; PODOCYTES; RNA, MESSENGER;

EID: 80052728521     PISSN: 09612033     EISSN: 14770962     Source Type: Journal    
DOI: 10.1177/0961203310397412     Document Type: Article

References (43)

1. Kawachi H, Miyauchi N, Suzuki K, Han GD, Orikasa M, Shimizu F. Role of podocyte slit diaphragm as a filtration barrier. Nephrology (Carlton) 2006; 11: 274-281. (Pubitemid 44086870)
2. Pavenstadt H, Kriz W, Kretzler M. Cell biology of the glomerular podocyte. Physiol Rev 2003; 83: 253-307. (Pubitemid 36459882)
3. Rodewald R, Karnovsky MJ. Porous substructure of the glomerular slit diaphragm in the rat and mouse. J Cell Biol 1974; 60: 423-433.
4. Smoyer WE, Mundel P. Regulation of podocyte structure during the development of nephrotic syndrome. J Mol Med 1998; 76: 172-183. (Pubitemid 28098703)
5. Barker DF, Hostikka SL, Zhou J, et al. Identification of mutations in the COL4A5 collagen gene in Alport syndrome. Science 1990; 248: 1224-1227.
6. Blanco S, Bonet J, Lopez D, Casas I, Romero R. ACE inhibitors improve nephrin expression in Zucker rats with glomerulosclerosis. Kidney Int Suppl 2005; S10-S14. (Pubitemid 40019208)
7. Durvasula RV, Shankland SJ. Podocyte injury and targeting therapy: an update. Curr Opin Nephrol Hypertens 2006; 15: 1-7.
8. Shibata S, Nagase M, Fujita T. Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling. J Am Soc Nephrol 2006; 17: 754-764.
9. Kerjaschki D. Caught flat-footed: podocyte damage and the molecular bases of focal glomerulosclerosis. J Clin Invest 2001; 108: 1583-1587. (Pubitemid 33144868)
10. Kestila M, Lenkkeri U, Mannikko M, et al. Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome. Mol Cell 1998; 1: 575-582. (Pubitemid 128374693)
11. Huber TB, Kottgen M, Schilling B, Walz G, Benzing T. Interaction with podocin facilitates nephrin signaling. J Biol Chem 2001; 276: 41543-41546.
12. Saran AM, Yuan H, Takeuchi E, McLaughlin M, Salant DJ. Complement mediates nephrin redistribution and actin dissociation in experimental membranous nephropathy. Kidney Int 2003; 64: 2072-2078. (Pubitemid 37449541)
13. Hidaka T, Suzuki Y, Yamashita M, et al. Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration. Am J Pathol 2008; 172: 603-614. (Pubitemid 351354534)
14. Weening JJ, D'Agati VD, Schwartz MM, et al. The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int 2004; 65: 521-530. (Pubitemid 38130646)
15. Salant DJ, Cybulsky AV. Experimental glomerulonephritis. Methods Enzymol 1988; 162: 421-461. (Pubitemid 19019528)
16. Moeller MJ, Sanden SK, Soofi A, Wiggins RC, Holzman LB. Two gene fragments that direct podocyte-specific expression in transgenic mice. J Am Soc Nephrol 2002; 13: 1561-1567. (Pubitemid 34579245)
17. Barletta GM, Kovari IA, Verma RK, Kerjaschki D, Holzman LB. Nephrin and Neph1 co-localize at the podocyte foot process intercellular junction and form cis hetero-oligomers. J Biol Chem 2003; 278: 19266-19271. (Pubitemid 36799318)
18. Holzman LB, St John PL, Kovari IA, Verma R, Holthofer H, Abrahamson DR. Nephrin localizes to the slit pore of the glomerular epithelial cell. Kidney Int 1999; 56: 1481-1491. (Pubitemid 29451254)
19. Horinouchi I, Nakazato H, Kawano T, et al. In situ evaluation of podocin in normal and glomerular diseases. Kidney Int 2003; 64: 2092-2099. (Pubitemid 37449543)
20. Kawachi H, Suzuki K, Miyauchi N, Hashimoto T, Otaki Y, Shimizu F. Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome. Clin Exp Nephrol 2009; 13: 275-280.
21. Nakatsue T, Koike H, Han GD, et al. Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy. Kidney Int 2005; 67: 2239-2253. (Pubitemid 41623384)
22. Luimula P, Ahola H, Wang SX, et al. Nephrin in experimental glomerular disease. Kidney Int 2000; 58: 1461-1468.
23. Clement LC, Liu G, Perez-Torres I, Kanwar YS, Avila-Casado C, Chugh SS. Early changes in gene expression that influence the course of primary glomerular disease. Kidney Int 2007; 72: 337-347. (Pubitemid 47172374)
24. Yuan H, Takeuchi E, Taylor GA, McLaughlin M, Brown D, Salant DJ. Nephrin dissociates from actin, and its expression is reduced in early experimental membranous nephropathy. J Am Soc Nephrol 2002; 13: 946-956. (Pubitemid 34274091)
25. Kraft SW, Schwartz MM, Korbet SM, Lewis EJ. Glomerular podocytopathy in patients with systemic lupus erythematosus. J Am Soc Nephrol 2005; 16: 175-179. (Pubitemid 43073170)
26. Han TS, Schwartz MM, Lewis EJ. Association of glomerular podocytopathy and nephrotic proteinuria in mesangial lupus nephritis. Lupus 2006; 15: 71-75. (Pubitemid 43345330)
27. Trivedi S, Zeier M, Reiser J. Role of podocytes in lupus nephritis. Nephrol Dial Transplant 2009; 24: 3607-3612.
28. Huh W, Kim DJ, Kim MK, et al. Expression of nephrin in acquired human glomerular disease. Nephrol Dial Transplant 2002; 17: 478-484. (Pubitemid 34211147)
29. Koop K, Eikmans M, Baelde HJ, et al. Expression of podocyteassociated molecules in acquired human kidney diseases. J Am Soc Nephrol 2003; 14: 2063-2071. (Pubitemid 36909914)
30. Meyer-Schwesinger C, Meyer TN, Munster S, et al. A new role for the neuronal ubiquitin C-terminal hydrolase-L1 (UCH-L1) in podocyte process formation and podocyte injury in human glomerulopathies. J Pathol 2009; 217: 452-464.
31. Patrakka J, Ruotsalainen V, Ketola I, et al. Expression of nephrin in pediatric kidney diseases. J Am Soc Nephrol 2001; 12: 289-296. (Pubitemid 32116370)
32. Wang SX, Rastaldi MP, Patari A, Ahola H, Heikkila E, Holthofer H. Patterns of nephrin and a new proteinuria-associated protein expression in human renal diseases. Kidney Int 2002; 61: 141-147. (Pubitemid 34075140)
33. Machida H, Ito S, Hirose T, et al. Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis. Nephrol Dial Transplant 2010; 25: 2530-2537.
34. Gagliardini E, Benigni A, Tomasoni S, Abbate M, Kalluri R, Remuzzi G. Targeted downregulation of extracellular nephrin in human IgA nephropathy. Am J Nephrol 2003; 23: 277-286. (Pubitemid 36980723)
35. van den Berg JG, van den Bergh Weerman MA, Assmann KJ, Weening JJ, Florquin S. Podocyte foot process effacement is not correlated with the level of proteinuria in human glomerulopathies. Kidney Int 2004; 66: 1901-1906. (Pubitemid 41094314)
36. Lai KN, Leung JC, Chan LY, et al. Podocyte injury induced by mesangial-derived cytokines in IgA nephropathy. Nephrol Dial Transplant 2009; 24: 62-72.
37. Mao J, Zhang Y, Du L, Dai Y, Yang C, Liang L. Expression profile of nephrin, podocin, and CD2AP in Chinese children with MCNS and IgA nephropathy. Pediatr Nephrol 2006; 21: 1666-1675. (Pubitemid 44390831)
38. Doublier S, Ruotsalainen V, Salvidio G, et al. Nephrin redistribution on podocytes is a potential mechanism for proteinuria in patients with primary acquired nephrotic syndrome. Am J Pathol 2001; 158: 1723-1731. (Pubitemid 32422937)
39. Wang G, Lai FM, Tam LS, et al. Messenger RNA expression of podocyte-associated molecules in urinary sediment of patients with lupus nephritis. J Rheumatol 2007; 34: 2358-2364. (Pubitemid 350230656)
40. Couzi L, Merville P, Deminiere C, et al. Predominance of CD8p T lymphocytes among periglomerular infiltrating cells and link to the prognosis of class III and class IV lupus nephritis. Arthritis Rheum 2007; 56: 2362-2370. (Pubitemid 47173584)
41. Mason LJ, Ravirajan CT, Rahman A, Putterman C, Isenberg DA. Is alpha-actinin a target for pathogenic anti-DNA antibodies in lupus nephritis? Arthritis Rheum 2004; 50: 866-870. (Pubitemid 38326187)
42. Takano Y, Yamauchi K, Hayakawa K, et al. Transcriptional suppression of nephrin in podocytes by macrophages: roles of inflammatory cytokines and involvement of the PI3K/Akt pathway. FEBS Lett 2007; 581: 421-426. (Pubitemid 46149613)
43. Marasa M, Kopp JB. Monoclonal antibodies for podocytopathies: rationale and clinical responses. Nat Rev Nephrol 2009; 5: 337-348.