Two gene fragments that direct podocyte-specific expression in transgenic mice

Journal of the American Society of Nephrology

Volumn 13, Issue 6, 2002, Pages 1561-1567

  Moeller, Marcus J ^a   Sanden, Silja K ^a   Soofi, Abdulsalam ^a   Wiggins, Roger C ^a   Holzman, Lawrence B ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; NEPHRIN; MEMBRANE PROTEIN; PODOCIN; PROTEIN; SIGNAL PEPTIDE;

ADOLESCENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; MOUSE; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS; PENETRANCE; PODOCYTE; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSGENIC MOUSE; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; CELL STRAIN COS1; CYTOLOGY; EPITHELIUM CELL; GENETICS; GLOMERULUS; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PRENATAL DEVELOPMENT; TRANSGENE;

ANIMALS; COS CELLS; EMBRYONIC AND FETAL DEVELOPMENT; EPITHELIAL CELLS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KIDNEY GLOMERULUS; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED ICR; MICE, TRANSGENIC; ORGAN SPECIFICITY; PROMOTER REGIONS (GENETICS); PROTEINS; TRANSGENES;

EID: 0036014939     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000015614.68893.0B     Document Type: Article

References (12)

1. Positionally cloned gene for a novel glomerular protein - Nephrin - Is mutated in congenital nephrotic syndrome
2. Nephrin localizes to the slit pore of the glomerular epithelial cell
3. NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistent nephrotic syndrome
4. Evaluation of a new tool for exploring podocyte biology: Mouse Nphs1 5′ flanking region drives lacZ expression in podocytes
5. The dopamine beta-hydroxylase promoter directs expression of Escherichia coli lacZ to sympathetic and other neurons in adult transgenic mice
6. Manipulating the mouse embryo
7. Dual Leucine Zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but Not ERK2
8. Podocyte phenotypes as defined by expression and distribution of GLEPP1 in the developing glomerulus and in nephrotic glomeruli from MCD, CNF, and FSGS
9. Identification and characterization of a glomerular-specific promoter from the human nephrin gene
10. The murine nephrin gene is specifically expressed in kidney, brain and pancreas: Inactivation of the gene leads to massive proteinuria and neonatal death
11. Podocin, a stomatin-like protein linked to steroid-resistant nephrotic syndrome, is a raft-associated component of the glomerular slit diaphragm that interacts with CD 2AP and nephrin
12. Interaction with podocin facilitates nephrin signaling