Tachykinins and the hypothalamo-pituitary-gonadal axis: An update

Peptides

Volumn 32, Issue 9, 2011, Pages 1972-1978

  Lasaga, Mercedes ^a   Debeljuk, Luciano ^b  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b SOUTHERN ILLINOIS UNIVERSITY   (United States)

Author keywords

Gonads; Hypothalamus; NKB; Pituitary; SP; Tachykinins

Indexed keywords

BETA ENDORPHIN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FOLLITROPIN; GONADORELIN; GONADOTROPIN; KISSPEPTIN; MESSENGER RNA; NEUROKININ 1 RECEPTOR; NEUROKININ 2 RECEPTOR; NEUROKININ 3 RECEPTOR; NEUROKININ 3 RECEPTOR AGONIST; NEUROKININ A; NEUROKININ B; PROLACTIN; SUBSTANCE P; TACHYKININ; TACHYKININ RECEPTOR;

FEEDBACK SYSTEM; GONAD; GONADOTROPIN RELEASE; HUMAN; HYPOPHYSIS GONAD SYSTEM; HYPOTHALAMUS; IMMUNOCYTOCHEMISTRY; NERVE CELL; NONHUMAN; OVARY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PULSATILE HORMONE RELEASE; REVIEW; SIGNAL TRANSDUCTION; SPERMATOGENESIS; UTERUS;

AGING; ANIMALS; FEMALE; GONADOTROPIN-RELEASING HORMONE; GONADOTROPINS; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MICE; OVARY; OVULATION; PITUITARY-ADRENAL SYSTEM; PRIMATES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, TACHYKININ; SIGNAL TRANSDUCTION; TACHYKININS; TESTIS;

ANIMALIA; MAMMALIA; OVIS ARIES; RATTUS;

EID: 80052726039     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.07.009     Document Type: Review

References (101)

1. Amstalden M, Spell KM, Williams GL, Goodman RL, Lehman RL. Neurokinin 3 receptor internalization in the arcuate nucleus is increased during the follicular phase of the estrous cycle in the ewe. Annu Meet Soc Neurosci 2008; [Abstract 81.2].
2. M. Amstalden, L.M. Coolen, A.M. Hemmerle, H.J. Billings, J.M. Connors, and R.L. Goodman Neurokinin 3 receptor immunoreactivity in the septal region, preoptic area and hypothalamus of the female sheep: colocalisation in neurokinin B cells of the arcuate nucleus but not in gonadotropin-releasing hormone neurons J Neuroendocrinol 22 2010 1 12
3. H.J. Billing, J.M. Connors, S.N. Altman, S.M. Hileman, I. Holaskova, and M.N. Lehman Neurokinin B acts via the neurokinin 3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep Endocrinology 2010 10.1210/en.2010-0174
4. M.C. Burke, P.A. Letts, S.J. Krajewski, and N.E. Rance Coexpression of dynorphin and neurokinin B immunoreactivity in the rat hypothalamus: morphologic evidence of interrelated function with the arcuate nucleus J Comp Neurol 498 2006 712 726 (Pubitemid 44350359)
5. J. Clarkson Herbison AE postnatal development of kisspeptin neurons in mouse hypothalamus; sexual dimorphism and projections to gonaotropin-releasing hormone neurons Endocrinology 147 2006 5125 5817
6. G. Cheng, L.M. Coolen, V. Padmanabham, R.L. Goodman, and M.N. Lehman The kisspeptin/neurokinin B/dynorphin (KNDy) cell population of the arcuate nucleus: sex differences and effects of prenatal testosterone in sheep Endocrinology 151 2010 301 311
7. P. Ciofi, J.E. Krause, G.S. Prins, and M. Mazzuca Presence of nuclear androgen receptor-like immunoreactivity in neurokinin B containing neurons of the hypothalamic arcuate nucleus of the adult male rat Neurosci Lett 182 1994 193 196 (Pubitemid 24380235)
8. P. Ciofi, O.C. Lapirot, and G. Tramu An androgen-dependent sexual dimorphism visible at puberty in the rat hypothalamus Neuroscience 146 2007 630 642 (Pubitemid 46629001)
9. P. Ciofi, D. Leroy, and G. Tramu Sexual dimorphism in the organization of the rat hypothalamic infundibular area Neuroscience 141 2006 1731 1745 (Pubitemid 44251167)
10. M.P. Corander, B.G. Challis, E.L. Thompson, Z. Jovanovicz, Y.C. Loraine Tung, and D. Rimmington The effects of neurokinin B upon gonadotrophin release in male rodents J Neuroendocrinol 22 2010 181 187
11. S.K. Dahl, M. Amstalden, L. Coolen, M. Fitzgerald, and M. Lehman Dynorphin immunoreactive fibers contact GnRH neurons in the human hypothalamus Reprod Sci 16 2009 781 787
12. X. D'Anglemont de Tassigny, L.A. Fagg, M.B. Carlton, and W.H. Colledge Kisspeptin can stimulate gonadotropin-releasing hormone (GnRH) release by a direct action at GnRH nerve terminals Endocrinology 149 2008 3926 3932
13. L. Debeljuk Tachykinins in the normal and gonadotropin-stimulated ovary of the mouse Peptides 24 2003 1445 1448 (Pubitemid 38045553)
14. L. Debeljuk Tachykinins and ovarian function in mammals Peptides 27 2006 736 742
15. L. Debeljuk, A. Arce, M. Garcia Bonacho, A. Bartke, and A.I. Esquifino Tachykinins in the pineal gland: effect of castration and ganglionectomy Peptides 19 1998 1073 1078 (Pubitemid 28383806)
16. L. Debeljuk, and M. Lasaga Modulation of the hypothalamo-pituitary- gonadal axis and the pineal gland by neurokinin A, neuropeptide K and neuropeptide gamma Peptides 20 1999 285 299 (Pubitemid 29332111)
17. L. Debeljuk, J.N. Rao, and A. Bartke Tachykinins and their possible modulatory role on testicular function: a review Int J Androl 26 2003 202 210 (Pubitemid 36877450)
18. T.L. Dellovade, and I. Merchenthaler Estrogen regulation of neurokinin B gene expression in the mouse arcuate nucleus is mediated by estrogen receptor alpha Endocrinology 145 2004 736 742 (Pubitemid 38183816)
19. D.H. Eghlidi, G.E. Haley, N.C. Noriega, S.G. Kohama, and H.F. Urbanski Influence of age and 17beta estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence of female rhesus macaques Endocrinology 151 2010 3783 3794
20. S.S.G. Ferguson Evolving concepts in G protein coupled receptor endocytosis: the role in receptor desensitization and signaling Pharmacol Rev 53 2001 1 24 (Pubitemid 32173106)
21. C. Fernandez, L. Debeljuk, E. Diaz, and B. Diaz Lopez Age differences in NKA and SP from the rat hypothalamus, pituitary, pineal and striatum of the rat. Effect of melatonin Peptides 23 2002 941 945 (Pubitemid 34655395)
22. C. Fernandez Alvarez, L. Debeljuk, E. Diaz Rodriguez, and B. Diaz Lopez Developmental pattern of tachykinins during aging in several organs: effect of exogenous melatonin Peptides 23 2002 1617 1623 (Pubitemid 35246281)
23. C.D. Foradori, M. Amstalden, R.L. Goodman, and M.N. Lehman Colocalisation of dynorphin A and neurokinin B immunoreactivity in the arcuate nucleus and median eminence of the sheep J Neuroendocrinol 18 2006 534 541 (Pubitemid 43821725)
24. C.D. Foradori, L.M. Coolen, M.E. Fitzgerald, D.C. Skinner, R.L. Goodman, and M.N. Lehman Colocalization of the progesterone receptors in parvicellular dynorphin neurons of the ovine preoptic area and hypothalamus Endocrinology 143 2002 3683 3692
25. I. Franceschini, D. Lomet, M. Cateau, G. Delsol, Y. Tillet, and A. Caraty Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor α Neurosci Lett 401 2006 225 230 (Pubitemid 43729526)
26. M. Fukami, T. Maruyama, S. Deteki, N. Satao, Y. Yoshimura, and T. Ogata Hypothalamic dysfunction in a female with isolated hypogonadotropic hypogonadism and compound heterozygous TACR3 mutations and clinical manifestation in her heterozygous mother Horm Res Paediatr 73 2010 461 477
27. P. Ghosh, S.K. Saha, S. Battacharya, S. Battacharya, S. Mukherjee, and S.S. Roy Tachykinin family genes and their receptors are differentially expressed in the hypothyroid ovary and pituitary Cell Physiol Biochem 20 2007 357 368 (Pubitemid 47340598)
28. A. Gobbetti, C. Petrelli, M. Zerani, and Substance P downregulates basal and gonadotropin-releasing hormone-induced gonadotropin in vivo secretion by pituitary gland of crested newt, Triturus carnifex J Neuroendocrinol 12 2000 1160 1166
29. R.L. Goodman, L.M. Coolen, G.M. Anderson, S.L. Hardy, M. Valent, and J.M. Connors Evidence that dynorphin plays a major role in mediating progesterone negative feedback on gonadotropin-releasing hormone neurons in sheep Endocrinology 145 2004 2959 2967 (Pubitemid 38686245)
30. R.L. Goodman, M.N. Lehman, J.T. Smith, L.M. Coolen, C.V. de Oliveira, and M.R. Jafarzadehshirazi Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin A and neurokinin B Endocrinology 148 2007 5752 5760 (Pubitemid 350146171)
31. M.L. Goubillon, R.A. Forsdike, J.E. Robinson, P. Ciofi, A. Caraty, and A.E. Herbison Identification of neurokinin B-expressing neurons as an highly estrogen-receptive, sexually dimorphic cell group in the ovine arcuate nucleus Endocrinology 141 2000 4218 4225
32. T. Guran, G. Tolhurst, A. Bereket, N. Rocha, K. Porter, and S. Turan Hypogonadotrophic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin B receptor J Clin Endocrinol Metab 94 2009 3633 3639
33. G.E. Haley, and F.W. Flynn Agonist and hypertonic saline-induced trafficking of the NK3 receptors on vasopressin neurons within the paraventricular nucleus of the hypothalamus Am J Physiol Regul Integr Comp Physiol 290 2006 R1242 R1250
34. A.E. Herbison, X. Tassingy, J. Doran, and W.H. Colledge Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons Endocrinology 151 2010 312 321
35. 2+ in the secretory and biosynthetic response of porcine gonadotropes to substance P and gonadotropin-releasing hormone Regul Pept 116 2000 43 52 (Pubitemid 37352914)
36. H.E. Howe, S.J. Somponpun, and C.D. Sladeck Role of neurokinin 3 receptors in supraoptic vasopressin and oxytocin neurons J Neurosci 24 2004 10103 10110 (Pubitemid 39492035)
37. M.S. Irwig, G.S. Fraley, J.T. Smith, B.V. Acohido, S.M. Popa, and M.J. Cunningham Kisspeptin activation of gonadotorphin releasing hormone neurons ad regulation of Kiss-1 mRNA in the male rat Neuroendocrinology 80 2004 264 272 (Pubitemid 40187012)
38. D. Jessop, H. Chowdrey, P. Larsen, S.L. Lightman, and Substance P: a multifunctional peptide in the hypothalamo-pituitary system? J Endocrinol 132 1999 331 337
39. P.S. Kalra, A. Sahu, J.J. Bonavera, and S.P. Kalra Diverse effects of tachykinins on luteinizing hormone release in male rats: mechanisim of action Endocrinology 131 1992 1195 1201
40. A.S. Kauffman Coming of age in the kisspeptin era: sex differences, development, and puberty Mol Cell Endocrinol 324 2010 51 63
41. A.S. Kauffman, M.L. Gottsch, J. Roa, A.C. Byquist, A. Crown, and D.K. Clifton Sexual differentiation of Kiss1 gene expression in the brain of the rat Endocrinology 148 2000 1774 1783
42. A.S. Kauffman, V.M. Navarro, J. Kim, D.R. Clifton, and R.A. Steiner Sex differences in the regulation of Kiss1/NKB neurons in juvenile mice: implications for timing puberty Am J Physiol Endocrinol Metab 297 2009 E212 E221
43. B. Kerdelhue, R. Williams, V. Lenoir, V. Fardin, P. Kolm, and G. Hodgen Variations in plasma levels of substance P and effects of a specific substance P antagonist on the NK1 receptor on preovulatory LH and FSH surges and progesterone secretion in the cycling Cynomolgus monkey Neuroendocrinology 71 2000 228 236 (Pubitemid 30206835)
44. B. Kerdelhue, V. Lenoir, R. Scholler, and H.J. Jones Substance P plasma concentration during the LH preovulatory surge of the menstrual cycle in the human Neuroendocrinol Lett 27 2006 359 364 (Pubitemid 44399098)
45. A.M. Khawaja, and D.F. Rogers Tachykinins: receptor to effector Int J Biochem Cell Biol 28 1996 721 738 (Pubitemid 26181860)
46. F. Kinoshita, Y. Nakai, H. Katakami, and H. Imura Suppressive effect of dynorphin (1-13) on luteinizing hormone release in conscious castrated rats Life Sci 30 1982 1915 1919 (Pubitemid 12098885)
47. J.S. Kinsey-Jones, X.F. Li, S.M. Luckman, and K.T. O'Byrne Effects of kisspeptin-10 on the electrophysiological manifestation of gonadotropin- releasing hormone pulse generator activity in the female rat Endocrinology 149 2008 1004 1008 (Pubitemid 351397949)
48. S.J. Krajewski, M.J. Anderson, L. Iles-Shih, J.K. Chen, H.F. Urbanski, and N.E. Rance Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence J Comp Neurol 489 2005 372 386 (Pubitemid 41026235)
49. S.J. Krajewski, M.C. Burke, M.J. Anderson, N.T. McMullen, and N.E. Rance Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat Neuroscience 166 2010 680 697
50. K.L. Keen, F.H. Wegner, S.R. Bloom, M.A. Ghatei, and E. Terasawa An increase in kisspeptin-54 release occurs with the pubertal increase in luteininz hormone-releasing hormone-1 release in stalk median eminence of female rhesus monkeys in vivo Endocrinology 149 2008 4151 4157
51. M.N. Lehman, L.M. Coolen, and R.L. Goodman Minireview: kisspeptin/neurokininB/dynorphin (KNDy) cells of the arcuate nucleus: a central node in the control of gonadotropin-releasing hormone secretion Endocrinology 151 2010 3479 3489
52. L. Lutz, L. Dufourny, and D.C. Skinner Effect of nutrient restriction on the somatotropes and substance P-immunoreactive cells in the pituitary of the female ovine fetus Growth Horm IGF Res 16 2006 108 118 (Pubitemid 44225966)
53. D. Marzioni, G. Fiore, A. Giordano, M. Nabissi, P. Florio, and F. Verdenelli Placental expression of substance P and vasoactive intestinal peptide: evidence for a local effect on hormone release J Clin Endocrinol Metab 90 2005 2378 2383 (Pubitemid 40586288)
54. D. Mileusnic, J.M. Lee, D.J. Magnuson, M.J. Hejna, J.E. Krause, and J.B. Lorens Neurokinin 3 receptor distribution in rat and human brain: an immunohistochemical study Neuroscience 86 1999 1269 1290 (Pubitemid 29074645)
55. V. Mitchell, V. Prevot, L. Jennes, J.P. Aubert, D. Croix, and J.C. Beuvillain Presence of mu and kappa opioid receptor mRNAs in galanin but not in GnRH neurons in the female rat Neuroreport 8 1997 3167 3172 (Pubitemid 27421752)
56. S. Mukda, B. Chetsawang, P. Govitrapong, P.T. Schmidt, A. Hay-Schmidt, and M. Moller Tachykinins and tachykinin-receptors in the rat pineal gland Eur J Neurosci 21 2005 2743 2751 (Pubitemid 40835117)
57. S. Mukda, M. Moller, M. Ebadi, and P. Govitrapong The modulatory effect of substance P on the rat pineal norepinephrine release and melatonin secretion Neurosci Lett 461 2009 258 261
58. V.M. Navarro, M.L. Gottsch, C. Chavkin, H. Okamura, D.K. Clifton, and R.A. Steiner Regulation of GnRH secretion by Kiss1/Dynorphin/Neurokinin B neurons in the arcuate nucleus of the mouse J Neurosci 29 2009 11859 11866
59. Navarro VM, Castellano JM, McConkey SM, Pineda R, Ruiz-Pino F, Pinnilla L, et al. Interaction between kisspeptin and neurokinnin B in the control of GnRH secretion in the female rar. Am J Physiol Endocrinol Metab 2011;300:E202.210.
60. A.E. Oakley, D.K. Clifton, and R.A. Steiner Kisspeptin signaling in the brain Endocr Rev 30 2009 713 743
61. S. Okhura, K. Takase, S. Matsuyama, K. Mogi, T. Ichimaru, and Y. Wakabayashi Gonadotropin-releasing hormone pulse generator activity in close proximity to the arcuate kisspeptin neurons in the goat J Neuroendicrinol 21 2009 813 821
62. H.H. Ortega, J.A. Lorente, G.A. Mira, C. Baravalle, and N.R. Salvetti Constant light exposure causes dissociation in gonadotropin secretion and inhibits partially neuroendocrine differentiation of Leydig cells in adult rats Reprod Domest Anim 39 2004 417 423 (Pubitemid 40020270)
63. H.H. Ortega, N.R. Salvetti, C. Baravalle, J.A. Lorente, and G.A. Mira Oestradiol induced inhibition of neuroendocrine marker expression in Leydig cells of adult rats Reprod Domest Anim 41 2006 204 209 (Pubitemid 43725650)
64. E. Patak, F. Pinto, M. Story, C.O. Pintado, A. Fleming, and N.M. Page Functional and molecular characterization of tachykinins and tachykinin receptors in the mouse uterus Biol Reprod 72 2005 1125 1133 (Pubitemid 40547976)
65. J.N. Pennefather, A. Lecci, E. Cadenas MLPatak, F.M. Pinto, and Maggi Tachykinins and tachykinin receptors a growing family Life Sci 74 2004 1445 1463 (Pubitemid 38077208)
66. J. Pieleka-Fortuna, Z. Chu, and S.M. Moenter Kisspeptin acts directly and indirectly to increase gonadotropin-releasing hormone neuron activity and its effects are modulated by estradiol Endocrinology 149 2008 1979 1986 (Pubitemid 351468349)
67. J. Pieleka-Fortuna, and S.M. Moenter Kisspeptin increases y-aminobutyric acidergic and glutamatergic transmission directly to gonadotropin-releasing hormone neurons in a estradiol-dependent manner Endocrinology 149 2010 291 300
68. D. Pillon, A. Caraty, C. Fabre-Nys, and G. Bruneau Short-term effect of oestradiol on neurokinin B mRNA expression in the infundibular nucleus of ewes J Neuroendocrinol 15 2003 749 753 (Pubitemid 36874371)
69. C.O. Pintado, F.M. Pinto, J.N. Pennefather, A. Hidalgo, A. Baamonde, and T. Sanchez A role for tachykinins in female mouse and rat reproductive function Biol Reprod 69 2003 940 946 (Pubitemid 37064623)
70. F.M. Pinto, C.O. Pintado, J.N. Pennefather, E. Patak, and L. Candenas Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus Reprod Biol Endocrinol 7 2009 1 11
71. S.M. Popa, D.K. Clifton, and R.A. Steiner The role of kisspeptins and GPR54 in the neuroendocrine regulation of reproduction Annu Rev Physiol 70 2008 213 238 (Pubitemid 351738178)
72. B. Przybylska-Gornowicz, B. Lewczuk, and M. Moller Immonohistochemical localization of substance P in the pineal gland of the domestic pig Folia Histochem Cytobiol 38 2000 85 90 (Pubitemid 30197810)
73. S. Ramaswamy, K.A. Guerriero, R.B. Gibbs, and T.M. Plant Structural interactions between kisspeptin and GnRH neurons in the mediobasal hypothalamus of the male rhesus monkey (Macca mulatta) as revealed by double immunoflourescence and confocal microscopy Endocrinology 149 2008 4378 4395
74. S. Ramaswamy, S.B. Seminara, B. Ali, P. Ciofi, N.A. Amin, and T.M. Plant Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus Endocrinology 151 2010 4494 4503
75. N.E. Rance, and T.R. Bruce Neurokinin B gene expression is increased in the arcuate nucleus of ovariectomized rats Neuroendocronilogy 60 1994 337 345 (Pubitemid 24284817)
76. N.E. Rance Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback Peptides 30 2009 111 122
77. N.E. Rance, S.J. Krajweski, M.A. Smith, M. Cholanian, and P.A. Dacks Neurokinin B and the hypothalamic regulation of reproduction Brain Res 2010 116 128
78. C.G. Ravina, M. Seda, F.M. Pinto, A. Orea, M. Fernandez-Sanchez, and C.O. Pintado A role for tachykinins in the regulation of human sperm motility Hum Reprod 22 2007 1617 1625 (Pubitemid 47055151)
79. A.M. Rometo, S.J. Krajewski, M.L. Voytko, and N.E. Rance Hypertrophy and increased kisspeptin gene expression in the hypothalamus infundibular nucleus of postmenopausal women and ovariectomized monkeys J Clin Endocrinol Metab 92 2007 2744 2750 (Pubitemid 47037385)
80. A.M. Rometo, and N.E. Rance Changes in prodynorphin gene expression and neuronal morphology in the hypothalamus of postmenopausal women J Neuroendocrinol 20 2008 1376 1381
81. T. Sandoval-Guzmán, and N.E. Rance Central injection of senktide, an NK3 receptor agonist, or neuropeptide Y inhibits LH secretion and induces different patterns of Fos expression in the rat hypothalamus Brain Res 1026 2004 307 312 (Pubitemid 39361561)
82. T. Sandoval-Guzmán, S.T. Stalcup, S.J. Krajewski, M.L. Voytko, and N.E. Rance Effects of ovariectomy on the neuroendocrine axes regulating reproduction and energy balance in young cynomolgus macaques J Neuroindocrinol 16 2004 146 153 (Pubitemid 38256461)
83. M.I. Sanella, and S.L. Petersen Dual label in situ hybridization studies provide evidence that luteinizing hormone-releasing hormone neurons do not synthesize messenger ribonucleic acid for mu, kappa, or delta opiate receptors Endocrinology 138 1997 1667 1672 (Pubitemid 27137120)
84. R. Schulz, A. Wilhmen, K.M. Pirke, M.L. Gramsch, and A. Herz Beta-endorphin and dynorphin control serum luteinizing hormone level in immature female rats Nature 294 1981 757 759 (Pubitemid 12174447)
85. R.K. Semple, and A.K. Topaloglu The recent genetics of hypogonadotrophic hypogonadism - novel insights and new questions Clin Endocrinol 72 2010 427 435
86. D.C. Skinner Rethinking the stalk effect: a new hypothesis explaining suprasellar tumor-induced hyperprolactinemia Med Hypotheses 72 2004 309 310
87. D.C. Skinner, A. Lee Lang, L. Pahl, and Q. Wang Substance P-immunoreactive cells in the ovine pars tuberalis Neuroendocrinology 89 2009 3 8
88. J.T. Smith, H.M. Dungan, E.A. Stoll, M.L. Gottsch, R.E. Braun, and S.M. Eacker Differential regulation of kisspeptin mRNA expression by sex steroids in the brain of the male mouse Endocrinology 146 2005 2976 2984 (Pubitemid 41002804)
89. J.T. Smith, M.J. Cunningham, E.F. Rissman, D.K. Clifton, and R.A. Steiner Regulation of Kiss1 gene expression in the brain of the female mouse Endocrinology 146 2005 3686 3692 (Pubitemid 41175732)
90. J.T. Smith, C.M. Clay, A. Caraty, and I.J. Clarke Kisspeptin messenger ribonucleic acid expression in the hypothalamus of the ewe is regulated by sex steroids and season Endocrinology 148 2007 1150 1157
91. J.T. Smith, L.M. Coolen, L.J. Kriegsfled, I.P. Sari, M.R. Jaafarzadehshirazi, and M. Maltby Variation in kisspeptin and RFamide-related peptide (RFRP) expression and terminal connections to gonadotropin-releasing hormone neurons in the brain: a novel medium of seasonal breeding in the sheep Endocrinology 149 2008 5770 5782
92. J.T. Smith, S.M. Popa, D.K. Clifton, G.E. Hoffman, and R.A. Steiner Kisspeptin neurons in the forebrain as central processors for generating the preovulatory luteinizing hormone surge J Neurosci 26 2006 6687 6694 (Pubitemid 44315230)
93. M.G. Todman, S.K. Han, and A.E. Herbison Profiling neurotransmitter receptor expression in mouse gonadotropin-releasing hormone neurons using green fluorescent protein-promoter transgenics and microarrays Neuroscience 132 2005 703 712
94. A.K. Topaloglu, F. Reimann, M. Gluclu, A.S. Yalin, L.D. Kotan, and K.M. Porter TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction Nat Genet 41 2009 354 358
95. A.K. Topaloglu, L.D. Kotan, and B. Yuksel Neuokinin B signaling in human puberty J Neuroendocrinol 22 2010 765 770
96. N. Vazquez Moreno, L. Debeljuk, E. Diaz Rodriguez, C. Fernandez Alvarez, and B. Diaz Lopez Seasonal changes of SP and NKA in frontal cortex, striatum and testes in the rat. Role of maternal pineal gland Peptides 25 2004 997 1004 (Pubitemid 38760288)
97. N. Vazquez Moreno, L. Debeljuk, E. Diaz Rodriguez, C. Fernandez Alvarez, and B. Diaz Lopez Influence of maternal pineal gland on the developmental pattern of neurokinin A and substance P in male rat offspring: relationship to the season of the year Neurosci Lett 368 2004 243 248 (Pubitemid 39214961)
98. Y. Wakabayashi, T. Nakada, K. Murata, S. Ohkura, K. Mogi, and V.M. Navarro Neurokinin B an dynorphin B in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat J Neurosci 30 2010 3124 3132
99. J. Young, J. Boulingand, B. Francou, M.L. Raffin, S. Gaillez, and M. Jeanpierre TAC3, TACR3 defects cause hypothalamic congenital hypogonadotropic hypogonadism in humans J Clin Endocrinol Metab 95 2010 2287 2295
100. J. Yip, and L.A. Chahl Localization of NK1 and NK3 receptors in guinea-pig brain Regul Pept 98 2001 55 62 (Pubitemid 32155493)
101. M. Yuan, Z. Wen-Xia, C. Jun-Ping, and Z. Yong-Xiang Age-related changes in the oestrous cycle and reproductive hormones in senescence-accelerated mouse Reprod Fertil Dev 17 2009 507 512 (Pubitemid 40903452)