Metabolism of P450 Probe Substrates by Cynomolgus Monkey CYP2C76

Basic and Clinical Pharmacology and Toxicology

Volumn 109, Issue 4, 2011, Pages 315-318

  Uno, Yasuhiro ^a   Matsuno, Kiyomi ^a   Murayama, Norie ^b   Nakamura, Chika ^a   Yamazaki, Hiroshi ^b  

^a SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BUFURALOL; COUMARIN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2A23; CYTOCHROME P450 2A24; CYTOCHROME P450 2B6; CYTOCHROME P450 2C76; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; CYTOCHROME P450 4A11; CYTOCHROME P450 4F11; CYTOCHROME P450 4F2; CYTOCHROME P450 4F3V2; ETHOXYRESORUFIN; MIDAZOLAM; TESTOSTERONE; UNCLASSIFIED DRUG;

ARTICLE; CYNOMOLGUS MONKEY; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME METABOLISM; ENZYME SUBSTRATE; EXPERIMENTAL MONKEY; HUMAN; HYDROXYLATION; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MACACA FASCICULARIS; MICROSOMES, LIVER; RECOMBINANT PROTEINS; SPECIES SPECIFICITY;

MACACA FASCICULARIS;

EID: 80052659779     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2011.00740.x     Document Type: Article

References (19)

1. Nelson DR, Zeldin DC, Hoffman SM, Maltais LJ, Wain HM, Nebert DW. Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants. Pharmacogenetics 2004;14:1-18.
2. Uno Y, Iwasaki K, Yamazaki H, Nelson DR. Macaque cytochromes P450: nomenclature, transcript, gene, genomic structure, and function. Drug Metab Rev. 2011;In press.
3. Uno Y, Fujino H, Kito G, Kamataki T, Nagata R. CYP2C76, a novel cytochrome P450 in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone. Mol Pharmacol 2006;70:477-86.
4. Uno Y, Fujino H, Iwasaki K, Utoh M. Macaque CYP2C76 encodes cytochrome P450 enzyme not orthologous to any human isozymes. Curr Drug Metab 2010;11:142-52.
5. Uno Y, Hosaka S, Matsuno K, Nakamura C, Kito G, Kamataki T et al. Characterization of cynomolgus monkey cytochrome P450 (CYP) cDNAs: Is CYP2C76 the only monkey-specific CYP gene responsible for species differences in drug metabolism? Arch Biochem Biophys 2007;466:98-105.
6. Uno Y, Matsuno K, Nakamura C, Utoh M, Yamazaki H. Identification and characterization of CYP2B6 cDNA in cynomolgus macaques (Macaca fascicularis). J Vet Med Sci 2009;71:1653-6.
7. Uno Y, Uehara S, Kohara S, Murayama N, Yamazaki H. Cynomolgus monkey CYP2D44 newly identified in liver, metabolizes bufuralol and dextromethorphan. Drug Metab Dispos 2010;38:1486-92.
8. Sharer JE, Shipley LA, Vandenbranden MR, Binkley SN, Wrighton SA. Comparisons of phase I and phase II in vitro hepatic enzyme activities of human, dog, rhesus monkey, and cynomolgus monkey. Drug Metab Dispos 1995;23:1231-41.
9. Weaver RJ, Dickins M, Burke MD. A comparison of basal and induced hepatic microsomal cytochrome P450 monooxygenase activities in the cynomolgus monkey (Macaca fascicularis) and man. Xenobiotica 1999;29:467-82.
10. Mankowski DC, Laddison KJ, Christopherson PA, Ekins S, Tweedie DJ, Lawton MP. Molecular cloning, expression, and characterization of CYP2D17 from cynomolgus monkey liver. Arch Biochem Biophys 1999;372:189-96.
11. Uno Y, Uehara S, Murayama N, Yamazaki H. CYP1D1, pseudogenized in human, is expressed and encodes a functional drug-metabolizing enzyme in cynomolgus monkey. Biochem Pharmacol 2011;81:442-50.
12. Bogaards JJ, Bertrand M, Jackson P, Oudshoorn MJ, Weaver RJ, van Bladeren PJ et al. Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica 2000;30:1131-52.
13. Sakuma T, Hieda M, Igarashi T, Ohgiya S, Nagata R, Nemoto N et al. Molecular cloning and functional analysis of cynomolgus monkey CYP1A2. Biochem Pharmacol 1998;56:131-9.
14. Sadrieh N, Snyderwine EG. Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4, 5-f]quinoline (IQ) but not 2-amino-3, 8-dimethylimidazo[4, 5-f]quinoxaline (MeIQx). Carcinogenesis 1995;16:1549-55.
15. Bullock P, Pearce R, Draper A, Podval J, Bracken W, Veltman J et al. Induction of liver microsomal cytochrome P450 in cynomolgus monkeys. Drug Metab Dispos 1995;23:736-48.
16. Locuson CW, Ethell BT, Voice M, Lee D, Feenstra KL. Evaluation of Escherichia coli membrane preparations of canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with coexpressed canine cytochrome P450 reductase. Drug Metab Dispos 2009;37:457-61.
17. Narimatsu S, Torigoe F, Tsuneto Y, Saito K, Hanioka N, Masuda K et al. Cloning of a cDNA encoding a novel marmoset CYP2C enzyme, expression in yeast cells and characterization of its enzymatic functions. Biochem Pharmacol 2006;72:1738-48.
18. Iwasaki K, Murayama N, Koizumi R, Uno Y, Yamazaki H. Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans. Drug Metab Pharmacokinet 2010;25:388-91.
19. Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S et al. Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli. Protein Expr Purif 2002;24:329-37.