1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine (KS119): A Cytotoxic Prodrug with Two Stable Conformations Differing in Biological and Physical Properties

Chemical Biology and Drug Design

Volumn 78, Issue 4, 2011, Pages 513-526

  Penketh, Philip G ^a   Baumann, Raymond P ^a   Shyam, Krishnamurthy ^a   Williamson, Hugh S ^b   Ishiguro, Kimiko ^a   Zhu, Rui ^a   Eriksson, Emma S E ^c   Eriksson, Leif A ^c   Sartorelli, Alan C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BP EXPLORATION   (United Kingdom)

^c NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

Atropisomers; Chemotherapy; Conformers; Cytotoxicity; Hypoxia; KS119; Prodrug; Targeting

Indexed keywords

1,2 BIS(METHYLSULFONYL) 1 (2 CHLOROETHYL) 2 [[1 (4 NITROPHENYL)ETHOXY]CARBONYL]HYDRAZINE; ANTINEOPLASTIC AGENT; KS119; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AQUEOUS SOLUTION; ARTICLE; BREAST CARCINOMA; CARCINOMA CELL; CHIRALITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; ISOMERISM; MOUSE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THERMOSTABILITY;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; HYDRAZINES; ISOMERISM; MAMMARY NEOPLASMS, ANIMAL; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PRODRUGS;

MURINAE;

EID: 80052635996     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2011.01193.x     Document Type: Article

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