Mathematical modeling and analysis of a magnetic nanoparticle-enhanced mixing in a microfluidic system using time-dependent magnetic field

IEEE Transactions on Nanotechnology

Volumn 10, Issue 5, 2011, Pages 953-961

  Munir, Ahsan ^a   Wang, Jianlong ^a   Zhu, Zanzan ^a   Susan Zhou, H ^a  

^a Worcester Polytechnic Institute   (United States)

Author keywords

Lab on a chip; magnetic nanoparticles (MNPs); magnetism; mathematical modeling; microfluidics; mixing

Indexed keywords

APPLIED MAGNETIC FIELDS; CONVECTIVE FLOW VELOCITY; DESIGN PARAMETERS; FINITE-ELEMENT TECHNIQUES; INLET VELOCITY; LAB-ON-A-CHIP; LAB-ON-A-CHIP DEVICES; MAGNETIC ACTUATION; MAGNETIC FORCE; MAGNETIC NANOPARTICLES; MAGNETIC NANOPARTICLES (MNPS); MATHEMATICAL MODELING; MICRO FLUIDIC SYSTEM; MIXING EFFICIENCY; MIXING PERFORMANCE; MIXING PROCESS; MULTIPHYSICS MODEL; NANOPARTICLE SIZES; ON CHIPS; PASSIVE MIXING; POINT OF CARE; TIME-DEPENDENT; TIME-DEPENDENT MAGNETIC FIELD;

COMPUTER SIMULATION; FLOW OF FLUIDS; FLOW VELOCITY; FLUIDIC DEVICES; FLUIDS; INLET FLOW; MICROFLUIDICS; MIXING; NANOMAGNETICS; NANOPARTICLES; SWITCHING FREQUENCY;

MAGNETIC FIELD EFFECTS;

EID: 80052628402     PISSN: 1536125X     EISSN: None     Source Type: Journal    
DOI: 10.1109/TNANO.2010.2089802     Document Type: Article

References (41)

1. M. A. Burns, B. N. Johnson, S. N. Brahmasandra, K. Handique, J. R. Webster, M. Krishnan, T. S. Sammarco, P. M. Man, D. Jones, D. Heldsinger, C. H. Mastrangelo, and D. T. Burke, "An integrated nanoliter DNA analysis device," Science, vol. 282, pp. 484-487, Oct. 1998. (Pubitemid 28483677)
2. F. Vinet, P. Chaton, and Y. Fouillet, "Microarrays and microfluidic devices: Miniaturized systems for biological analysis," Microelectron. Eng., vol. 61-62, pp. 41-47, Jul. 2002. (Pubitemid 34613346)
3. L. Cao, S. Mantell, and D. Polla, "Design and simulation of an implantable medical drug delivery system using microelectromechanical systems technology," Sens. Actuators A, Phys., vol. 94, pp. 117-125, Oct. 2001. (Pubitemid 32997670)
4. T.Vo-Dinh, G. Griffin,D.L. Stokes, andA.Wintenberg, "Multi- functional biochip for medical diagnostics and pathogen detection," Sens. Actuators B, Chem., vol. 90, pp. 104-111, Apr. 2003.
5. T. Vo-Dinh and B. Cullum, "Biosensors and biochips: Advances in biological and medical diagnostics," Fresenius J. Anal. Chem., vol. 366, pp. 540-551, Mar./Apr. 2000.
6. R. Ehrnstrom, "Miniaturization and integration: Challenges and breakthroughs in microfluidics," Lab on a Chip, vol. 2, pp. 26N-30N, 2002.
7. Q. A. Pankhurst, J. Connolly, S. K. Jones, and J. Dobson, "Applications of magnetic nanoparticles in biomedicine," J. Phys. D, Appl. Phys., vol. 36, pp. R167-R181, Jul. 2003.
8. M. A. M. Gijs, "Magnetic bead handling on-chip: New opportunities for analytical applications," Microfluid. Nanofluid., vol. 1, pp. 22-40, Nov. 2004. (Pubitemid 41166499)
9. C. C. Berry and A. S. G. Curtis, "Functionalisation of magnetic nanopar-ticles for applications in biomedicine," J. Phys. D, Appl. Phys., vol. 36, pp. R198-R206, Jul. 2003.
10. N. Pamme, "Magnetism and microfluidics," Lab on a Chip, vol. 6, pp. 24-38, 2006.
11. C. H. Ahn, M. G. Allen, W. Trimmer, Y. N. Jun, and S. Erramilli, "A fully integrated micromachined magnetic particle separator," J. Micro-electromech. Syst., vol. 5, pp. 151-158, Sep. 1996. (Pubitemid 126607083)
12. M. Q. Bu, T. B. Christensen, and K. Smistrup, "Characterization of a microfluidic magnetic bead separator for high-throughput applications," Sens. Actuators A, Phys., vol. 145, pp. 430-436, Jul./Aug. 2008.
13. J.-W. Choi, K. W. Oh, A. Han, N. Okulan, C. A. Wijayawardhana, C. Lannes, S. Bhansali, K. T. Schlueter, W. R. Heineman, H. B. Hal-sall, J. H. Nevin, H. T. Henderson, and C. H. Ahn, "Development and characterization of microfluidic devices and systems for magnetic bead-based biochemical detection," Biomed. Microdevices, vol. 3, pp. 191-200, 2001. (Pubitemid 32899145)
14. K. H. Han and A. B. Frazier, "Continuous magnetophoretic separation of blood cellsin microdevice format," J. Appl. Phys., vol. 96, pp. 5797-5802, Nov. 2004.
15. J. W. Choi, C. H. Ahn, S. Bhansali, H. T. Henderson, "A new magnetic bead-based, filterless bio-separator with planar electromagnet surfaces for integrated bio-detection systems," Sens. Actuators B, vol. 68, pp. 34-39, 2000.
16. J. W. Choi, T. M. Liakopoulos, and C. H. Ahn, "An on-chip magnetic bead separator using spiral electromagnets with semi-encapsulated permalloy," Biosens. Bioelectron., vol. 16, pp. 409-416, Aug. 2001. (Pubitemid 32728163)
17. A. Rida, V. Fernandez, and M. A. M. Gijs, "Long-range transport of magnetic microbeads using simple planar coils placed in a uniform mag-netostatic field," Appl. Phys. Lett., vol. 83, pp. 2396-2398, Sep. 2003.
18. Munir, J. Wang, and H. S. Zhou, "Dynamics of capturing process of multiple magnetic nanoparticles in a flow through microfluidic bioseparation system," IET Nanobiotechnol., vol. 3, pp. 55-64, Sep. 2009.
19. M. A. Hayes, N. A. Polson, A. N. Phayre, and A. A. Garcia, "Flow-based microimmunoassay," Anal. Chem., vol. 73, pp. 5896-5902, Dec. 2001. (Pubitemid 34042205)
20. Y. K. Hahn, Z. Jin, J. H. Kang, E. Oh, M. K. Han, H. S. Kim, J. T. Jang, J. H. Lee, J. Cheon, S. H. Kim, H. S. Park, and J. K. Park, "Magne- tophoretic immunoassay of allergen-specific IgE in an enhanced magnetic field gradient," Anal. Chem., vol. 79, pp. 2214-2220, Mar. 2007. (Pubitemid 46453723)
21. U. Lehmann, C. Vandevyver, V. K. Parashar, and M. A. M. Gijs, "Droplet-based DNA purification in a magnetic lab-on-a-chip," Angewandte Chemie-Int. Edn., vol. 45, pp. 3062-3067, 2006. (Pubitemid 44099017)
22. N. Xia, T. P. Hunt, B. T. Mayers, E. Alsberg, G. M. Whitesides, R. M. West-ervelt, and D. E. Ingber, "Combined microfluidic-micromagnetic separation of living cells in continuous flow," Biomed. Microdevices, vol. 8, pp. 299-308, Dec. 2006. (Pubitemid 44697345)
23. A. Munir, J. L. Wang, Z. H. Li, and H. S. Zhou, "Numerical analysis of a magnetic nanoparticle-enhanced microfluidic surface-based bioassay," Microfluid. Nanofluid., vol. 8, pp. 641-652, May 2010.
24. R. Miyake, T. S. J. Lammerink, M. Elwenspoek, and J. H. J. Fluitman, "Micro mixer with fast diffusion," in Proc. 1993 IEEE Micro Electro Mechan. Sys., Fort Lauderdale, FL, 1993, pp. 248-253.
25. A. D. Stroock, S. K. W. Dertinger, A. Ajdari, I. Mezic, H. A. Stone, and G. M. Whitesides, "Chaotic mixer for microchannels," Science, vol. 295, pp. 647-651, Jan. 2002. (Pubitemid 34111816)
26. V. Srinivasan, V. K. Pamula, and R. B. Fair, "Droplet-based microfluidic lab-on-a-chip for glucose detection," Analytica Chimica Acta, vol. 507, pp. 145-150, Apr. 2004. (Pubitemid 38224100)
27. R. B. Fair, A. Khlystov, T. D. Tailor, V. Ivanov, R. D. Evans, P. B. Griffin, V. Srinivasan, V. K. Pamula, M. G. Pollack, and J. Zhou, "Chemical and biological applications of digital-microfluidic devices," IEEE Design Test Comput., vol. 24, pp. 10-24, Jan./Feb. 2007. (Pubitemid 46850871)
28. L. H. Lu, K. S. Ryu, and C. Liu, "A magnetic microstirrer and array for microfluidic mixing," J. Microelectromech. Syst., vol. 11, pp. 462-469, Oct. 2002. (Pubitemid 35242050)
29. K. S. Ryu, K. Shaikh, E. Goluch, Z. F. Fan, and C. Liu, "Micro magnetic stir-bar mixer integrated with parylene microfluidic channels," Lab on a Chip, vol. 4, pp. 608-613, 2004. (Pubitemid 39657914)
30. E. Biddiss, D. Erickson, and D. Q. Li, "Heterogeneous surface charge enhanced micromixing for electrokinetic flows," Anal. Chem., vol. 76, pp. 3208-3213, Jun. 2004. (Pubitemid 38715716)
31. N. Sasaki, T. Kitamori, and H. B. Kim, "AC electroosmotic micromixer for chemical processing in a microchannel," Lab on a Chip, vol. 6, pp. 550-554, 2006.
32. J. G. Santiago, "Electroosmotic flows in microchannels with finite inertial and pressure forces," Anal. Chem., vol. 73, pp. 2353-2365, May 2001. (Pubitemid 32880705)
33. X. C. Xuan and D. Q. Li, "Electroosmotic flow in microchannels with arbitrary geometry and arbitrary distribution of wall charge," J. Colloid Interface Sci., vol. 289, pp. 291-303, Sep. 2005.
34. R. H. Liu, J. N. Yang, M. Z. Pindera, M. Athavale, and P. Grodzinski, "Bubble-induced acoustic micromixing," Lab on a Chip, vol. 2, pp. 151-157, 2002. (Pubitemid 37254494)
35. G. G. Yaralioglu, I. O. Wygant, T. C. Marentis, and B. T. Khuri-Yakub, "Ultrasonic mixing in microfluidic channels using integrated transducers," Anal. Chem., vol. 76, pp. 3694-3698, Jul. 2004. (Pubitemid 38868832)
36. J. H. Tsai and L. W. Lin, "Active microfluidic mixer and gas bubble filter driven by thermal bubble micropump," Sens. Actuators A, Phys., vol. 97-8, pp. 665-671, Apr. 2002.
37. M.A. McClain, C.T.Culbertson,S. C.Jacobson, andJ. M. Ramsey, "Flow cytometry of Escherichia coli on nucrifluidic devices," Anal. Chem., vol. 73, pp. 5334-5338, Nov. 2001. (Pubitemid 33032256)
38. H. Suzuki, C. M. Ho, and N. Kasagi, "A chaotic mixer for magnetic bead-based micro cell sorter," J. Microelectromech. Syst., vol. 13, pp. 779-790, Oct. 2004.
39. M. Zolgharni, S. M. Azimi, M. R. Bahmanyar, and W. Balachandran, "A numerical design study of chaotic mixing of magnetic particles in a microfluidic bio-separator," Microfluid. Nanofluid., vol. 3, pp. 677-687, Dec. 2007. (Pubitemid 350055448)
40. A. L. Barnes, R. A. Wassel, F. Mondalek, K. Chen, K. J. Dormer, and R. D. Kopke, "Magnetic characterization of superparamagnetic nanoparticles pulled through model membranes," Biomagn. Res. Technol., vol. 5, pp. 1-10, 2007
41. COMSOL Multiphysics ver. 3.3, COMSOL AB., Stockholm, Sweden.