Dynamics of capturing process of multiple magnetic nanoparticles in a flow through microfluidic bioseparation system

IET Nanobiotechnology

Volumn 3, Issue 3, 2009, Pages 55-64

  Munir, A ^a   Wang, J ^a   Zhou, H S ^a  

^a Worcester Polytechnic Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGULAR POSITIONS; BIO-SEPARATION; DESIGN AND DEVELOPMENT; FINITE-ELEMENT TECHNIQUES; FLOWTHROUGH; INLET VELOCITY; MAGNETIC FIELD STRENGTHS; MAGNETIC NANOPARTICLES; MICRO FLUIDIC SYSTEM; MICROFLUIDIC CHANNEL; TRAPPING EFFICIENCIES;

COMPUTER SIMULATION; FLUIDIC DEVICES; MAGNETIC FIELDS; MAGNETIC MATERIALS; MAGNETS; MATHEMATICAL MODELS; MICROCHANNELS; MICROFLUIDICS; MICROSYSTEMS;

NANOPARTICLES;

NANOPARTICLE;

ALGORITHM; ARTICLE; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; EQUIPMENT DESIGN; FINITE ELEMENT ANALYSIS; INSTRUMENTATION; MAGNETISM; METHODOLOGY; MICROFLUIDIC ANALYSIS; NANOTECHNOLOGY; REPRODUCIBILITY;

ALGORITHMS; COMPUTER SIMULATION; EQUIPMENT DESIGN; FINITE ELEMENT ANALYSIS; MAGNETICS; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, CHEMICAL; NANOPARTICLES; NANOTECHNOLOGY; REPRODUCIBILITY OF RESULTS;

EID: 68849086656     PISSN: 17518741     EISSN: None     Source Type: Journal    
DOI: 10.1049/iet-nbt.2008.0015     Document Type: Article

References (37)

1. Ahn, C.H.: ' A fully integrated micromachined magnetic particle separator ', J. Microelectromech. Syst., 1996, 5, (3), p. 151-158 1057-7157
2. Deng, T., Prentiss, M., and Whitesides, G.M.: ' Fabrication of magnetic microfiltration systems using soft lithography ', Appl. Phys. Lett., 2002, 80, (3), p. 461-463 10.1063/1.1436282 0003-6951 (Pubitemid 34105382)
3. Pankhurst, Q.A., Connolly, J., Jones, S.K., and Dobson, J.: ' Applications of magnetic nanoparticles in biomedicine ', J. Appl. Phys., 2003, 36, p. 167-181, (R) 0021-8979
4. Berry, C.C., and Curtis, A.S.G.: ' Functionalization of magnetic nanoparticles for applications in biomedicine ', J. Phys. D: Appl. Phys., 2003, 36, p. 198-206 0022-3727
5. Manz, N.G., and Widmer, H.M.: ' Miniaturized total chemical analysis system: a novel concept for chemical sensing ', Sens. Actuators, 1990, B1, p. 244-248 0250-6874
6. Pamme, N.: ' Magnetism and microfluidics ', Lab Chip., 2006, 6, p. 24-38 10.1039/b513005k 1473-0197
7. Bu, M., Christensen, T.B., Smistrup, K., Wolff, A., and Hansen, M.F.: ' Characterization of a microfluidic magnetic bead separator for high-throughput applications ', Sens. Actuators A, 2008, 145-146, p. 430-436
8. Choi, J., Oh, K.W., and Han, A.: et al. ' Development and characterization of microfluidic devices and systems for magnetic bead-based biochemical detection ', Biomed. Microdevices, 2001, 3, p. 191-200 1387-2176 (Pubitemid 32899145)
9. Furlani, E.P.: ' Analysis of particle transport in a magnetophoretic microsystem ', J. Appl. Phys., 2006, 99, (024912), p. 1-11 0021-8979
10. Gijs, M.A.M.: ' Magnetic bead handling on-chip: new opportunities for analytical applications ', Microfluidics Nanofluidics, 2004, 1, p. 22-40
11. Frazier, A.B., and Han, K.: ' Continuous magnetophoretic separation of blood cells in microdevice format ', J. Appl. Phys., 2004, 96, (10), p. 5797-5802 0021-8979
12. Choi, J., Ahn, C.H., Bhansali, S., and Henderson, H.T.: ' A new magnetic bead-based, filterless bio-separator with planar electromagnet surfaces for integrated bio-detection systems ', Sens. Actuators B, 2000, 68, p. 34-39
13. Choi, J., Liakopoulos, T.M., and Ahn, C.H.: ' An on-chip magnetic bead separator using spiral electromagnets with semi-encapsulated permalloy ', Biosens. Bioelectron., 2001, 16, p. 409-416 10.1016/S0956-5663(01)00154-3 0956-5663 (Pubitemid 32728163)
14. Rida, V.F., and Gijs, M.A.M.: ' Long-range transport of magnetic microbeads using simple planar coils placed in a uniform magnetostatic field ', Appl. Phys. Lett., 2003, 83, (12), p. 2396-2398 10.1063/1.1613038 0003-6951
15. Hayes, M.A., Polson, N.A., Phayre, A.N., and Garcia, A.A.: ' Flow based microimmunoassay ', Anal. Chem., 2001, 73, p. 5896-5902 0003-2700
16. Hahn, Y.K., Jin, Z., and Kang, J.H.: et al. ' Magnetophoretic immunoassay of allergen-specific IgE in an enhanced magnetic field gradient ', Anal. Chem., 2007, 79, p. 2214-2220 0003-2700
17. Lehmann, U., Vandevyver, C., Parashar, V.K., and Gijs, M.A.M.: ' Droplet-based DNA purification in a magnetic lab-on-a-chip ', Angew. Chem.-Int. Ed., 2006, 45, p. 3062-3067
18. Rida, A., and Gijs, M.A.M.: ' Manipulation of self-assembled structures of magnetic beads for microfluidic mixing and assaying ', Anal. Chem., 2004, 76, p. 6239-6246 0003-2700
19. Xia, N., Hunt, T.P., and Mayers, B.T.: et al. ' Combined microfluidic-micromagnetic separation of living cells in continuous flow ', Biomed. Microdevices, 2006, 8, p. 299-308 10.1007/s10544-006-0033-0 1387-2176 (Pubitemid 44697345)
20. Smistrup, K., Peter, T.T., Hansen, O., and Hansen, M.F.: ' Microelectromagnet for magnetic manipulation in lab-on-a-chip systems ', J. Magn. Magn. Mater., 2006, 300, p. 418-426 10.1016/j.jmmm.2005.05.031 0304-8853 (Pubitemid 43375163)
21. Ramadan, Q., Samper, V., Poenar, D.P., and Yu, C.: ' On-chip micro-lectromagnets for magnetic-based bio-molecules separation ', J. Magn. Magn. Mater., 2004, 281, p. 150-172 0304-8853
22. Ramadan, Q., Samper, V., Poenar, D.P., and Yu, C.: ' An integrated microfluidic platform for magnetic microbeads separation and confinement ', Biosens. Bioelectron., 2006, 21, p. 1693-1702 10.1016/j.bios.2005.08.006 0956-5663 (Pubitemid 43254758)
23. Shih, P., Shiu, J., and Lin, P.: et al. ' On-chip sorting of bacterial cells using sugar encapsulated magnetic nanoparticles ', J. Appl. Phys., 2008, 103, (07A316), p. 1-3 0021-8979
24. Furlani, E.P., and Ng, K.C.: ' Analytical model of magnetic nanoparticle transport and capture in the microvasculature ', Phys. Rev. E, 2006, 73, (061919), p. 1-10
25. Brauer, J.R., Cook, D.L., and Bray, T.E.: ' Finite-element computation of magnetic force densities on permeable particles in magnetic separators ', IEEE Trans. Magn., 2007, 43, (8), p. 3483-3487 0018-9464
26. Furlani, E.P., Sahoo, Y., Ng, K.C., Wortman, J.C., and Monk, T.E.: ' A model for predicting magnetic particle capture in a microfluidic bioseparator ', Biomed. Microdevices, 2007, 9, p. 451-463 1387-2176
27. Warnke, K.C.: ' Finite-element modeling of the separation of magnetic microparticles in fluid ', IEEE Trans. Magn., 2003, 39, (3), p. 1771-1777 10.1109/TMAG.2003.810609 0018-9464
28. Kim, M., Kim, D., and Lee, S.: ' Dynamic characteristics of superparamagnetic iron oxide nanoparticles in a viscous fluid under an external magnetic field ', IEEE Trans. Magn., 2006, 42, (4), p. 979-982 0018-9464
29. Clime, L., Drogoff, B.L., and Veres, T.: ' Dynamics of superparamagnetic and ferromagnetic nano-objects in continuous-flow microfluidic devices ', IEEE Trans. Magn., 2007, 43, (6), p. 2929-2931 0018-9464
30. Sullivan, S.P., Akpa, B.S., and Matthews, S.M.: et al. ' Simulation of miscible diffusive mixing in microchannels ', Sens. Actuators B, 2007, 123, p. 1142-1152
31. COMSOL Multiphysics ver. 3.3, COMSOL AB., Stockholm, Sweden
32. Rosensweig, R.E.: ' Ferrohydrodynamics ', (Dover Publication Inc., New York, 1997)
33. Oldenburg, C.M., Borglin, S.E., and Moridis, G.J.: ' Numerical simulation of ferrofluid flow for subsurface environmental engineering applications ', Transp. Porous Media, 2000, 38, (3), p. 319-344
34. Coulson, J.M., and Richardson, J.F.: ' Chemical engineering vol. 2: particle technology and separation processes ', 5th (Butterworth-Heinemann, 2002)
35. Furlani, E.P.: ' Permanent magnet and electromechanical devices: materials, analysis and applications ', (Academic Press Inc., New York, 2001)
36. Smistrup, K., Bu, M., Wolff, A., Bruus, H., and Hansen, M.F.: ' Theoretical analysis of a new, efficient microfluidic magnetic bead separator based on magnetic structures on multiple length scales ', Microfluidics Nanofluidics, 2008, 4, p. 565-573
37. Kim, K.S., and Park, J.P.: ' Superparamagnetic nanoparticle-based nanobiomolecular detection in a microfluidic channel ', Curr. Appl. Phys., 2006, 6, p. 976-981