Development of a fermented goats' milk containing Lactobacillus rhamnosus: In vivo study of health benefits

Journal of the Science of Food and Agriculture

Volumn 91, Issue 13, 2011, Pages 2355-2362

  Salva, Susana ^a   Nuñez, Martha ^a   Villena, Julio ^a   Ramón, Adriana ^b   Font, Graciela ^a,c   Alvarez, Susana ^a,c  

^a CENTRO DE REFERENCIA PARA LACTOBACILOS CERELA CONICET   (Argentina)

^b UNIVERSIDAD NACIONAL DE SALTA   (Argentina)

^c UNIVERSIDAD NACIONAL DE TUCUMÁN   (Argentina)

Author keywords

Fermented goats' milk; Immunostimulation; Lactobacillus rhamnosus CRL1505; Malnutrition

Indexed keywords

ADOLESCENT; ANIMAL; ARGENTINA; ARTICLE; CHILD; DAIRY PRODUCT; DIET THERAPY; DISEASE RESISTANCE; FOOD HANDLING; FOOD PREFERENCE; GOAT; GROWTH, DEVELOPMENT AND AGING; HUMAN; IMMUNOCOMPROMISED PATIENT; IMMUNOLOGY; IMMUNOMODULATION; ISOLATION AND PURIFICATION; LACTOBACILLUS RHAMNOSUS; MALE; MALNUTRITION; METABOLISM; MICROBIAL VIABILITY; MICROBIOLOGY; MOUSE; MUCOSAL IMMUNITY; PATHOPHYSIOLOGY; SALMONELLA FOOD POISONING; STREPTOCOCCUS PNEUMONIA;

ADOLESCENT; ANIMALS; ARGENTINA; CHILD; CULTURED MILK PRODUCTS; DISEASE RESISTANCE; FOOD HANDLING; FOOD PREFERENCES; GOATS; HUMANS; IMMUNITY, MUCOSAL; IMMUNOCOMPROMISED HOST; IMMUNOMODULATION; LACTOBACILLUS RHAMNOSUS; MALE; MALNUTRITION; MICE; MICROBIAL VIABILITY; PNEUMONIA, PNEUMOCOCCAL; SALMONELLA FOOD POISONING;

CAPRA HIRCUS; LACTOBACILLUS RHAMNOSUS; MUS;

EID: 80052621333     PISSN: 00225142     EISSN: 10970010     Source Type: Journal    
DOI: 10.1002/jsfa.4467     Document Type: Article

References (35)

1. FAO/WHO, Regulatory and clinical aspects of dairy probiotics. Working group Report. [Online]. Available: [1 May 2011].
2. Alvarez S, Herrero C, Bru E and Perdigón G, Effect of Lactobacillus casei and yogurt administration on prevention of Pseudomonas aeruginosa infection in young mice. J Food Protect 64: 1768-1774 (2001).
3. Perdigon G, Agüero G, Alvarez S, Gaudiosos de Allori C and Pesce de Ruiz Holgado A, Effect of viable Lactobacillus casei feeding on the immunity of the mucosae and intestinal microflora in malnourished mice. Milchwissens 50: 251-256 (1995).
4. Taranto MP, Vera JL, Hugenholtz J, De Valdez GF and Sesma F, Lactobacillus reuteri CRL1098 produces cobalamin. J Bacteriol 185: 5643-5647 (2003).
5. Villena J, Racedo S, Agüero G, Bru E, Medina M and Alvarez S, Lactobacillus casei improves resistance to pneumococcal respiratory infection in malnourished mice. J Nutr 135: 1462-1469 (2005).
6. Rodgers S, Novel applications of live bacteria in food services: probiotics and protective cultures. Trends Food Sci Technol 19: 188-197 (2008).
7. Heller KJ, Probiotic bacteria in fermented foods: product characteristics and starter organisms. Am J Clin Nutr 73: 374-379 (2001).
8. Georgieva R, Iliev I, Haertlé T, Chobert JM, Ivanova I and Danova S, Technological properties of candidate probiotic Lactobacillus plantarum strains. Int Dairy J 19: 696-702 (2009).
9. Gomes AMP and Malcata FX, Development of a probiotic cheese manufactured from goat milk: response surface analysis via technological manipulation. J Dairy Sci 81: 1492-1507 (1998).
10. Minervini F, Bilancia MT, Siragusa S, Gobbetti M and Caponio F, Fermented goats' milk produced with selected multiple starters as a potentially functional food. Food Microbiol 26: 559-564 (2009).
11. Agüero G, Lazarte S, Salva S, Villena J and Alvarez S, Biological effects of administration of goat milk in a malnutrition model. Milchwissens 5: 266-270 (2004).
12. Racedo S, Villena J, Salva S and Alvarez S, Influence of yogurt consumption on the respiratory immune response. Food Agric Immunol 20: 231-244 (2009).
13. Salva S, Villena J and Alvarez S, Immunomodulatory activity of Lactobacillus rhamnosus strains isolated from goat milk: impact on intestinal and respiratory infections. Int J Food Microbiol 141: 82-89 (2010).
14. King N, A modification of Voges-Proskauer test for rapid colorimetric determination of acetylmethyl carbinol + diacetyl in butter cultures. Dairy Ind 8: 860-866 (1948).
15. Church FC, Swaisgood HE, Porter DH and Catignani GL, Spectrophotometric assay using o-phthaldialdehyde for determination of proteolysis in milk and isolated milk proteins. J Dairy Sci 66: 1219-1227 (1983).
16. Echalar SR, Jiménez MJM and Ramón AN, Chemical, biological and acceptability of chinchilla's meat. Arch Latinoam Nutr 48: 77-81 (1998).
17. Bradford MM, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254 (1976).
18. Perdigon G, Alvarez S and Pesce de Ruiz Holgado A, Immunoadjuvant activity of oral Lactobacillus casei: influence of dose on the secretory immune response and protective capacity in intestinal infections. J Dairy Res 58: 485-496 (1991).
19. Dayenoff P, Ochoa MA and Domínguez G. Efecto del nivel de alimentación sobre la producción lechera en cabras criollas. Rev Arg Prod Animal 15: 602-604 (1995).
20. Brazis AR, Methods for estimating colony forming units, in Methods for Assessing the Bacteriological Quality of Raw Milk from the Farm. Bull Int Dairy Fed 256:(1990).
21. Gardini F, Lanciotti R, Guerzoni ME and Torriani S. Evaluation of aroma production and survival of Streptococcus thermophilus, Lactobacillus delbrueckii subsp. bulgaricus and Lactobacillus acidophilus in fermented milks. Int Dairy J 9: 125-134 (1999).
22. Patrignani F, Lanciotti R, Mathara JM, Guerzoni ME and Holzapfel WH, Potential of functional strains, isolated from traditional Maasai milk, as starters for the production of fermented milks. Int J Food Microbiol 107: 1-11 (2006).
23. FAO/WHO, Standard of fermented milks. Codex standard 243. FAO/WHO, Rome, pp. 1-8 (2003).
24. Shah NP, Probiotic bacteria: selective enumeration and survival in dairy foods. J Dairy Sci 83: 894-907 (2000).
25. +-ATPase-defective mutants exhibits enhanced viability of Bifidobacterium breve during storage. Int J Food Microbiol 116: 358-366 (2007).
26. Gaudreau H, Champagne CP and Jelen P, The use of crude cellular extracts of Lactobacillus delbrueckii subsp. bulgaricus 11842 to stimulate growth of a probiotic Lactobacillus rhamnosus culture in milk. Enzyme Microb Technol 36: 83-90 (2005).
27. Schillinger U, Isolation and identification of lactobacilli from novel-type probiotic and mild yoghurt and their stability during refrigerated storage. Int J Food Microbiol 47: 79-87 (1999).
28. Maragkoudakis PA, Miaris Ch, Rojez P, Manalis N, Magkanari F, Kalantzopoulos G et al, Production of traditional Greek yogourt using probiotic potential as starter adjuncts. Int Dairy J 16: 52-60 (2006).
29. Savoie S, Champagne CP, Chiasson S and Audet P, Media and process parameters affecting the growth, strain ratios and specific acidifying activities of a mixed lactic starter containing aroma-producing and probiotic strains. J Appl Microbiol 103: 163-174 (2007).
30. Kongo JM, Gomes AM and Malcata FX, Manufacturing of fermented goat milk with a mixed starter culture of Bifidobacterium animalis and Lactobacillus acidophilus in a controlled bioreactor. Lett Appl Microbiol 42: 595-599 (2006).
31. Saxelin M, Grenov B, Svensson U, Fonden R, Reniero R and Mattila-Sandholm T, The technology of probiotics. Trends Food Sci Technol 10: 387-392 (1999).
32. Mattila-Sandholm T, Myllarinen P, Crittenden R, Mogensen G, Fondén R and Saarela M, Technological challenger for future probiotic foods. Int Dairy J 12: 173-182 (2002).
33. Bernardeau M, Vernoux JP and Gueguen M, Probiotic properties of two Lactobacillus strains in vitro. Milchwissens 56: 663-667 (2001).
34. Holzapfel WH, Haberer P, Snel J, Schillinger U and Huis in't Veld JHJ, Overview of gut flora and probiotics. Int J Food Microbiol 41: 85-101 (1998).
35. Olasupo NA, Shillinger U and Holzapfel WH, Studies on some technological properties of predominant lactic acid bacteria isolated from Nigerian fermented foods. Food Biotechnol 15: 157-167 (2001).