The transcription factor Grainyhead like 3 (GRHL3) affects endothelial cell apoptosis and migration in a NO-dependent manner

Biochemical and Biophysical Research Communications

Volumn 412, Issue 4, 2011, Pages 648-653

  Lukosz, Margarete ^a   Mlynek, Arne ^a   Czypiorski, Philip ^a   Altschmied, Joachim ^a   Haendeler, Judith ^a  

^a IUF LEIBNIZ RESEARCH INSTITUTE FOR ENVIRONMENTAL MEDICINE   (Germany)

Author keywords

Apoptosis; Endothelial cell; Grainyhead; Migration; Nitric oxide

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GRAINYHEAD LIKE 3; UNCLASSIFIED DRUG; VASCULOTROPIN;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL AGING; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

APOPTOSIS; CELL MOVEMENT; CELLS, CULTURED; DNA-BINDING PROTEINS; ENDOTHELIUM, VASCULAR; HUMANS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 80052612161     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.08.018     Document Type: Article

References (29)

1. Takeshita S., Zheng L.P., Brogi E., Kearney M., Pu L.Q., Bunting S., Ferrara N., Symes J.F., Isner J.M. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. Journal of Clinical Investigation 1994, 93:662-670.
2. Ferrara N., Carver-Moore K., Chen H., Dowd M., Lu L., O'Shea K.S., Powell-Braxton L., Hillan K.J., Moore M.W. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 1996, 380:439-442.
3. Suri C., Jones P.F., Patan S., Bartunkova S., Maisonpierre P.C., Davis S., Sato T.N., Yancopoulos G.D. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 1996, 87:1171-1180.
4. Holash J., Maisonpierre P.C., Compton D., Boland P., Alexander C.R., Zagzag D., Yancopoulos G.D., Wiegand S.J. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. Science 1999, 284:1994-1998.
5. Haendeler J., Zeiher A.M., Dimmeler S. Nitric oxide and apoptosis. Vitamins and Hormones 1999, 57:49-77.
6. Berk B.C., Abe J.I., Min W., Surapisitchat J., Yan C. Endothelial atheroprotective and anti-inflammatory mechanisms. Annals of the New York Academy of Sciences 2001, 947:93-109. discussion 109-111.
7. Dimmeler S., Haendeler J., Zeiher A.M. Regulation of endothelial cell apoptosis in atherothrombosis. Current Opinion in Lipidology 2002, 13:531-536.
8. Ting S.B., Caddy J., Hislop N., Wilanowski T., Auden A., Zhao L.L., Ellis S., Kaur P., Uchida Y., Holleran W.M., Elias P.M., Cunningham J.M., Jane S.M. A homolog of Drosophila grainy head is essential for epidermal integrity in mice. Science 2005, 308:411-413.
9. Caddy J., Wilanowski T., Darido C., Dworkin S., Ting S.B., Zhao Q., Rank G., Auden A., Srivastava S., Papenfuss T.A., Murdoch J.N., Humbert P.O., Parekh V., Boulos N., Weber T., Zuo J., Cunningham J.M., Jane S.M. Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Developmental Cell 2010, 19:138-147.
10. Hislop N.R., Caddy J., Ting S.B., Auden A., Vasudevan S., King S.L., Lindeman G.J., Visvader J.E., Cunningham J.M., Jane S.M. Grhl3 and Lmo4 play coordinate roles in epidermal migration. Developmental Biology 2008, 321:263-272.
11. Guardiola-Serrano F., Haendeler J., Lukosz M., Sturm K., Melchner H., Altschmied J. Gene trapping identifies a putative tumor suppressor and a new inducer of cell migration. Biochemical and Biophysical Research Communications 2008, 376:748-752.
12. Edgell C.J., McDonald C.C., Graham J.B. Permanent cell line expressing human factor VIII-related antigen established by hybridization. Proceedings of the National Academy of Sciences of the United States of America 1983, 80:3734-3737.
13. Haendeler J., Hoffmann J., Tischler V., Berk B.C., Zeiher A.M., Dimmeler S. Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69. Nature Cell Biology 2002, 4:743-749.
14. Haendeler J., Drose S., Buchner N., Jakob S., Altschmied J., Goy C., Spyridopoulos I., Zeiher A.M., Brandt U., Dimmeler S. Mitochondrial telomerase reverse transcriptase binds to and protects mitochondrial DNA and function from damage. Arteriosclerosis, Thrombosis, and Vascular Biology 2009, 29:929-935.
15. Schroeder P., Popp R., Wiegand B., Altschmied J., Haendeler J. Nuclear redox-signaling is essential for apoptosis inhibition in endothelial cells--important role for nuclear thioredoxin-1. Arteriosclerosis, Thrombosis, and Vascular Biology 2007, 27:2325-2331.
16. Jakob S., Schroeder P., Lukosz M., Buchner N., Spyridopoulos I., Altschmied J., Haendeler J. Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. Journal of Biological Chemistry 2008, 283:33155-33161.
17. Altschmied J., Duschl J. Set of optimized luciferase reporter gene plasmids compatible with widely used CAT vectors. BioTechniques 1997, 23:436-438.
18. Spyridopoulos I., Fichtlscherer S., Popp R., Toennes S.W., Fisslthaler B., Trepels T., Zernecke A., Liehn E.A., Weber C., Zeiher A.M., Dimmeler S., Haendeler J. Caffeine enhances endothelial repair by an AMPK-dependent mechanism. Arteriosclerosis, Thrombosis, and Vascular Biology 2008, 28:1967-1974.
19. Abramoff M.D., Magelhaes P.J., Ram S.J. Image Processing with ImageJ. Biophotonics International 2004, 11:36-42.
20. Dimmeler S., Dernbach E., Zeiher A.M. Phosphorylation of the endothelial nitric oxide synthase at Ser 1177 is required for VEGF-induced endothelial cell migration. FEBS Letters 2000, 477:258-262.
21. Shizukuda Y., Tang S., Yokota R., Ware J.A. Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity. Circulation Research 1999, 85:247-256.
22. Radisavljevic Z., Avraham H., Avraham S. Vascular endothelial growth factor up-regulates ICAM-1 expression via the phosphatidylinositol 3 OH-kinase/AKT/Nitric oxide pathway and modulates migration of brain microvascular endothelial cells. Journal of Biological Chemistry 2000, 275:20770-20774.
23. Urbich C., Reissner A., Chavakis E., Dernbach E., Haendeler J., Fleming I., Zeiher A.M., Kaszkin M., Dimmeler S. Dephosphorylation of endothelial nitric oxide synthase contributes to the anti-angiogenic effects of endostatin. FASEB Journal 2002, 16:706-708.
24. Dimmeler S., Haendeler J., Nehls M., Zeiher A.M. Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. Journal of Experimental Medicine 1997, 185:601-607.
25. Dimmeler S., Fisslthaler B., Fleming I., Hermann C., Busse R., Zeiher A.M. Activation of nitric oxide synthase in endothelial cells via Akt-dependent phosphorylation. Nature 1999, 399:601-605.
26. Fulton D., Gratton J.P., McCabe T.J., Fontana J., Fujio Y., Walsh K., Franke T.F., Papapetropoulos A., Sessa W.C. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 1999, 399:597-601.
27. Hoffmann J., Haendeler J., Aicher A., Rossig L., Vasa M., Zeiher A.M., Dimmeler S. Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: important role of nitric oxide. Circulation Research 2001, 89:709-715.
28. Barrientos S., Stojadinovic O., Golinko M.S., Brem H., Tomic-Canic M. Growth factors and cytokines in wound healing. Wound Repair and Regeneration 2008, 16:585-601.
29. Schiefelbein D., Goren I., Fisslthaler B., Schmidt H., Geisslinger G., Pfeilschifter J., Frank S. Biphasic regulation of HMG-CoA reductase expression and activity during wound healing and its functional role in the control of keratinocyte angiogenic and proliferative responses. Journal of Biological Chemistry 2008, 283:15479-15490.