The T-1237C polymorphism of the toll-like receptor-9 gene is associated with chronic kidney disease in a Han Chinese population

Tohoku Journal of Experimental Medicine

Volumn 225, Issue 2, 2011, Pages 109-116

  Lu, Kuo Cheng ^a   Yang, Hsin Yi ^b   Lin, Yuh Feng ^c,d   Kao, Sen Yeong ^b   Lai, Ching Huang ^b   Chu, Chi Ming ^b   Wu, Chia Chao ^d   Su, Sui Lung ^b  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Chronic kidney disease; Single nucleotide polymorphism; Toll like receptor 2; Toll like receptor 4; Tolllike receptor 9

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; LIPOPOLYSACCHARIDE; MESSENGER RNA;

AGED; ALBUMINURIA; ARTICLE; CASE CONTROL STUDY; CHINESE; CHRONIC KIDNEY DISEASE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE; GENE FUNCTION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; GLOMERULUS FILTRATION RATE; HAPLOTYPE; HEMATURIA; HUMAN; KIDNEY INJURY; MAJOR CLINICAL STUDY; MALE; PROMOTER REGION; PROTEINURIA; REAL TIME POLYMERASE CHAIN REACTION; RECEPTOR GENE; RISK FACTOR; RNA CONFORMATION; SINGLE NUCLEOTIDE POLYMORPHISM; TOLL LIKE RECEPTOR 2 GENE; TOLL LIKE RECEPTOR 4 GENE; TOLL LIKE RECEPTOR 9 GENE;

AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHINA; ETHNIC GROUPS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; KIDNEY FAILURE, CHRONIC; LINKAGE DISEQUILIBRIUM; MALE; POLYMORPHISM, SINGLE NUCLEOTIDE; TOLL-LIKE RECEPTOR 9;

EID: 80052607652     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.225.109     Document Type: Article

References (42)

1. Akira, S., Takeda, K. & Kaisho, T. (2001) Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol., 2, 675-680.
2. Anders, H.J., Vielhauer, V., Eis, V., Linde, Y., Kretzler, M., Perez de Lema, G., Strutz, F., Bauer, S., Rutz, M., Wagner, H., Gröne, H.J. & Schlöndorff, D. (2004) Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice. FASEB J., 18, 534-536.
3. Anders, H.J. & Schlondorff, D. (2007) Toll-like receptors: emerging concepts in kidney disease. Curr. Opin. Nephrol. Hypertens., 16, 177-183.
4. Barrett, J.C., Fry, B., Maller, J. & Daly, M.J. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioin-formatics, 21, 263-265.
5. Barton, G.M. & Kagan, J.C. (2009) A cell biological view of Tolllike receptor function: regulation through compartmentaliza-tion. Nat. Rev. Immunol., 9, 535-542.
6. Batsford, S., Duermueller, U., Seemayer, C., Mueller, C., Hopfer, H. & Mihatsch, M. (2011) Protein level expression of Tolllike receptors 2, 4 and 9 in renal disease. Nephrol. Dial. Transplant, 26, 1413-1416.
7. Beutler, B. & Rehli, M. (2002) Evolution of the TIR, tolls and TLRs: functional inferences from computational biology. Curr. Top Microbiol. Immunol., 270, 1-21.
8. Cheng, P.L., Eng, H.L., Chou, M.H., You, H.L. & Lin, T.M. (2007) Genetic polymorphisms of viral infection-associated Toll-like receptors in Chinese population. Transl. Res., 150, 311-318.
9. Drexler, S.K. & Foxwell, B.M. (2010) The role of toll-like receptors in chronic infammation. Int. J. Biochem. Cell Biol., 42, 506-518.
10. Gauderman, W.J. (2002) Sample size requirements for association studies of gene-gene interaction. Am. J. Epidemiol., 155, 478-484.
11. Gluba, A., Banach, M., Hannam, S., Mikhailidis, D.P., Sakowicz, A. & Rysz, J. (2010) The role of Toll-like receptors in renal diseases. Nat. Rev. Nephrol., 6, 224-235.
12. Gollapudi, P., Yoon, J.W., Gollapudi, S., Pahl, M.V. & Vaziri, N.D. (2010) Leukocyte toll-like receptor expression in end-stage kidney disease. Am. J.Nephrol., 31, 247-254.
13. Hajjar, A.M., Ernst, R.K., Tsai, J.H., Wilson, C.B. & Miller, S.I. (2002) Human Toll-like receptor 4 recognizes host-specific LPS modifcations. Nat. Immunol., 3, 354-359.
14. Hamann, L., Hamprecht, A., Gomma, A. & Schumann, R.R. (2004) Rapid and inexpensive real-time PCR for genotyping functional polymorphisms within the Toll-like receptor -2, -4, and -9 genes. J. Immunol. Methods, 285, 281-291.
15. Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K. & Akira, S. (2000) A Toll-like receptor recognizes bacterial DNA. Nature, 408, 740-745.
16. Holla, L.I., Vokurka, J., Hrdlickova, B., Augustin, P. & Fassmann, A. (2010) Association of Toll-like receptor 9 haplotypes with chronic periodontitis in Czech population. J. Clin. Peri-odontol., 37, 152-159.
17. Hwang, S.J., Tsai, J.C. & Chen, H.C. (2010) Epidemiology, impact and preventive care of chronic kidney disease in Taiwan. Nephrology (Carlton), 15, 3-9.
18. Kazimierczak, K., Kopec, W. & Klinger, M. (2007) Toll-like receptors (TLR) in the pathogenesis of kidney diseases. Pol. Merkur. Lekarski, 23, 382-385.
19. Kubarenko, A.V., Ranjan, S., Rautanen, A., Mills, T.C., Wong, S., Vannberg, F., Neumaier, M., Bekeredjian-Ding, I., Hill, A.V., Ahmad-Nejad, P. & Weber, A.N. (2010) A naturally occurring variant in human TLR9, P99L, is associated with loss of CpG oligonucleotide responsiveness. J. Bio. Chem., 285, 36486-36494.
20. Lazarus, R., Klimecki, W.T., Raby, B.A., Vercelli, D., Palmer, L.J., Kwiatkowski, D.J., Silverman, E.K., Martinez, F. & Weiss, S.T. (2003) Single-nucleotide polymorphisms in the Toll-like receptor 9 gene (TLR9): frequencies, pairwise linkage disequilibrium, and haplotypes in three U.S. ethnic groups and exploratory case-control disease association studies. Genomics, 81, 85-91.
21. Levey, A., Greene T., Kusek, J. & Beck, G.J. (2000) A simplifed equation to predict glomerular fltration rate from serum creat-inine. J. Am. Soc. Nephrol., 11, 155.
22. Levey, A.S., Eckardt, K.U., Tsukamoto, Y., Levin, A., Coresh, J., Rossert, J., De Zeeuw, D., Hostetter, T.H., Lameire, N. & Eknoyan, G. (2005) Defnition and classifcation of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int., 267, 2089-2100.
23. Lien, E. & Ingalls, R.R. (2002) Toll-like receptors. Crit. Care Med., 30, S1-11.
24. Lorenz, E., Mira, J.P., Cornish, K.L., Arbour, N.C. & Schwartz, D.A. (2000) A novel polymorphism in the toll-like receptor 2 gene and its potential association with staphylococcal infection. Infect. Immun., 68, 6398-6401.
25. Luttropp, K., Lindholm, B., Carrero, J.J., Glorieux, G., Schepers, E., Vanholder, R., Schalling, M., Stenvinkel, P. & Nordfors, L. (2009) Genetics/Genomics in chronic kidney disease- towards personalized medicine? Semin. Dial., 22, 417-422.
26. McClellan, W.M. & Flanders, W.D. (2003) Risk factors for progressive chronic kidney disease. J. Am. Soc. Nephrol., 14, S65-70.
27. Misch, E.A. & Hawn, T.R. (2008) Toll-like receptor polymorphisms and susceptibility to human disease. Clin. Sci. (Lond.), 114, 347-360.
28. Noguchi, E., Nishimura, F., Fukai, H., Kim, J., Ichikawa, K., Shibasaki, M. & Arinami, T. (2004) An association study of asthma and total serum immunoglobin E levels for Toll-like receptor polymorphisms in a Japanese population. Clin. Exp. Allergy, 34, 177-183.
29. Papadimitraki, E.D., Tzardi, M., Bertsias, G., Sotsiou, E. & Boumpas, D.T. (2009) Glomerular expression of toll-like receptor-9 in lupus nephritis but not in normal kidneys: implications for the amplification of the inflammatory response. Lupus, 18, 831-835.
30. Papadopoulos, A.I., Ferwerda, B., Antoniadou, A., Sakka, V., Galani, L., Kavatha, D., Panagopoulos, P., Poulakou, G., Kanellakopoulou, K., van der Meer, J.W., Giamarellos-Bourboulis, E.J. & Netea, M.G. (2010) Association of toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms with increased infection risk in patients with advanced HIV-1 infection. Clin. Infect. Dis., 51, 242-247.
31. Purcell, S., Daly, M.J. & Sham, P.C. (2007) WHAP: haplotype-based association analysis. Bioinformatics, 23, 255-256.
32. Robson, M.G. (2009) Toll-like receptors and renal disease. Nephron. Exp. Nephrol., 113, e1-e7.
33. Satko, S.G., Sedor, J.R., Iyengar, S.K. & Freedman, B.I. (2007) Familial clustering of chronic kidney disease. Semin. Dial., 20, 229-236.
34. Schwartz, D.A. & Cook, D.N. (2005) Polymorphisms of the Tolllike receptors and human disease. Clin. Infect. Dis., 41, S403-407.
35. Shastry, B.S. (2009) SNPs: impact on gene function and pheno-type. Methods Mol. Biol., 578, 3-22.
36. Smith, K.D. (2008) Toll-like receptors in kidney disease. Curr. Opin. Nephrol. Hypertens., 18, 189-196.
37. Soriano-Sarabia, N., Vallejo, A., Ramírez-Lorca, R., Rodríguez Mdel, M., Salinas, A., Pulido, I., Sáez, M.E. & Leal, M. (2008) Influence of the Toll-like receptor 9 1635A/G polymorphism on the CD4 count, HIV viral load, and clinical progression. J. Acquir. Immune Defc. Syndr., 49, 128-135.
38. Suzuki, H., Suzuki, Y., Narita, I., Aizawa, M., Kihara, M., Yamanaka, T., Kanou, T., Tsukaguchi, H., Novak, J., Horikoshi, S. & Tomino, Y. (2008) Toll-like receptor 9 affects severity of IgA nephropathy. J. Am. Soc. Nephrol., 19, 2384-2395.
39. Torok, H.P., Glas, J., Endres, I., Tonenchi, L., Teshome, M.Y., Wetzke, M., Klein, W., Lohse, P., Ochsenkühn, T., Folwaczny, M., Göke, B., Folwaczny, C., Müller-Myhsok, B. & Brand, S. (2009) Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease. Am. J. Gastroenterol., 104, 1723-1733.
40. Wen, C.P., Cheng, T.Y., Tsai, M.K., Chang, Y.C., Chan, H.T., Tsai, S.P., Chiang, P.H., Hsu, C.C., Sung, P.K., Hsu, Y.H. & Wen, S.F. (2008) All-cause mortality attributable to chronic kidney disease: a prospective cohort study based on 462 293 adults in Taiwan. Lancet, 371, 2173-2182.
41. Werts, C., Tapping, R.I., Mathison, J.C., Chuang, T.H., Kravchenko, V., Saint Girons, I., Haake, D.A., Godowski, P.J., Hayashi, F., Ozinsky, A., Underhill, D.M., Kirschning, C.J., Wagner, H., Aderem, A., Tobias, P.S. & Ulevitch, R.J. (2001) Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat. Immunol., 2, 346-352.
42. Xu, C.J., Zhang, W.H., Pan, H.F., Li, X.P., Xu, J.H. & Ye, D.Q. (2009) Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese. Mol. Biol. Rep., 36, 2245-2248.