Possible nitric oxide mechanism in the protective effect of hesperidin againstischemic reperfusion cerebral injury in rats

Indian Journal of Experimental Biology

Volumn 49, Issue 8, 2011, Pages 609-618

  Gaur, Vaibhav ^a   Aggarwal, Aditi ^a   Kumar, Anil ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Bilateral common carotid artery occlusion; Hesperidin; Ischemia; Oxidative stress; Respiratory enzyme activity; Stroke

Indexed keywords

ARGININE; HESPERIDIN; N(G) NITROARGININE METHYL ESTER; NEUROPROTECTIVE AGENT; NITRIC OXIDE;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; BRAIN; BRAIN ISCHEMIA; DRUG EFFECT; ENZYMOLOGY; MALE; METABOLISM; MOTOR ACTIVITY; OXIDATIVE STRESS; RAT; REPERFUSION INJURY; WISTAR RAT;

ANIMALS; ARGININE; BEHAVIOR, ANIMAL; BRAIN; BRAIN ISCHEMIA; HESPERIDIN; MALE; MOTOR ACTIVITY; NEUROPROTECTIVE AGENTS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OXIDATIVE STRESS; RATS; RATS, WISTAR; REPERFUSION INJURY;

RATTUS;

EID: 80052575564     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Madl C & Holzer M, Brain function after resuscitation from cardiac arrest, Curr Opin Crit Care, 10 (2004) 213.
2. Moro MA, Cardenas A, Hurtado O, Leza JC & Lizasoain I, Role of nitric oxide after brain ischaemia, Cell Calcium, 36 (2004) 265.
3. del Zoppo GJ, Stroke and neurovascular protection, N Engl J Med, 354 (2006) 553.
4. Bok SH, Lee SH, Park YB, Bae KH, Son KH, Jeong TS & Choi MS, Plasma and hepatic cholesterol and hepatic activities of 3-hydroxy-3-methyl-glutaryl-CoA reductase and acyl CoA: cholesterol transferase are lower in rats fed citrus peel extract or a mixture of citrus bioflavonoids, J Nutr, 129 (1999) 1182.
5. Kondo T, Reaume AG, Huang TT, Carlson E, Murakami K, Chen SF, Hoffman EK, Scott RW, Epstein CJ & Chan PH, Reduction of CuZn-superoxide dismutase activity exacerbates neuronal cell injury and edema formation after transient focal cerebral ischemia, J Neurosci, 17 (1997) 4180.
6. McCord JM, Oxygen-derived free radicals in postischemic tissue injury, N Engl J Med, 312 (1985) 159.
7. Choi MS, Do KM, Park YS, Jeon SM, Jeong TS, Lee YK, Lee MK & Bok SH, Effect of naringin supplementation on cholesterol metabolism and antioxidant status in rats fed high cholesterol with different levels of vitamin E, Ann Nutr Metab, 45 (2001) 193.
8. Knowles RG & Moncada S, Nitric oxide synthases in mammals, Biochem J, 298 (Pt 2) (1994) 249.
9. Olivenza R, Moro MA, Lizasoain I, Lorenzo P, Fernandez AP, Rodrigo J, Bosca L & Leza JC, Chronic stress induces the expression of inducible nitric oxide synthase in rat brain cortex, J Neurochem, 74 (2000) 785.
10. Bolanos JP & Almeida A, Roles of nitric oxide in brain hypoxia-ischemia, Biochim Biophys Acta, 1411 (1999) 415.
11. Murphy S, Simmons ML, Agullo L, Garcia A, Feinstein DL, Galea E, Reis DJ, Minc-Golomb D & Schwartz JP, Synthesis of nitric oxide in CNS glial cells, Trends Neurosci, 16 (1993) 323.
12. Kohno K, Ohta S, Kohno K, Kumon Y, Mitani A, Sakaki S & Kataoka K, Nitric oxide synthase inhibitor reduces delayed neuronal death in gerbil hippocampal CA1 neurons after transient global ischemia without reduction of brain temperature or extracellular glutamate concentration, Brain Res, 738 (1996) 275.
13. Gaur V & Kumar A, Behavioral, biochemical and cellular correlates in the protective effect of sertraline against transient global ischemia induced behavioral despair: Possible involvement of nitric oxide-cyclic guanosine monophosphate study pathway, Brain Res Bull, 82 (2010) 57.
14. Xia Y & Zweier JL, Substrate control of free radical generation from xanthine oxidase in the postischemic heart, J Biol Chem, 270 (1995) 18797.
15. Maxwell SR, Prospects for the use of antioxidant therapies, Drugs, 49 (1995) 345.
16. Seif-El-Nasr M & El-Fattah AA, Lipid peroxide, phospholipids, glutathione levels and superoxide dismutase activity in rat brain after ischaemia: Effect of Ginkgo biloba extract, Pharmacol Res, 32 (1995) 273.
17. Shaheen AA, Abd-el-Fattah AA & Seif-el-Nasr M, Influence of verapamil on the efficacy of vitamin E in preventing the ischemia-reperfusion-induced biochemical dearrangement in cerebral cortex of rat, Arzneimittel-Forschung, 46 (1996) 670.
18. Gaur V & Kumar A, Possible involvement of L-arginine-nitric oxide signaling pathway in protective effect of hesperidin against ischemic reperfusion cerebral injury induced memory dysfunction, Pharmacol Rep, 62 (2010) 635.
19. Garg A, Garg S, Zaneveld LJ & Singla AK, Chemistry and pharmacology of the Citrus bioflavonoid hesperidin, Phytother Res, 15 (2001) 655.
20. Emim JA, Oliveira AB & Lapa AJ, Pharmacological evaluation of the anti-inflammatory activity of a citrus bioflavonoid, hesperidin, and the isoflavonoids, duartin and claussequinone, in rats and mice, J Pharm Pharmacol, 46 (1994) 118.
21. van Acker SA, van den Berg DJ, Tromp MN, Griffioen DH, van Bennekom WP, van der Vijgh WJ & Bast A, Structural aspects of antioxidant activity of flavonoids, Free Radic Biol Med, 20 (1996) 331.
22. Jingtao J, Sato S & Yamanaka N, Changes in cerebral blood flow and blood brain barrier in the gerbil hippocampal CA1 region following repeated brief cerebral ischemia, Med Electron Microsc, 32 (1999) 175.
23. Kumar A, Garg R, Gaur V & Kumar P, Nitric oxide mechanism in protective effect of imipramine and venlafaxine against acute immobilization stress-induced behavioral and biochemical alteration in mice, Neurosci Lett, 467 (2009) 72.
24. Kumar A, Garg R, Gaur V & Kumar P, Venlafaxine involves nitric oxide modulatory mechanism in experimental model of chronic behavior despair in mice, Brain Res, 1311 (2010) 73.
25. Kumar A, Garg R, Gaur V & Kumar P, Possible role of NO modulators in protective effect of trazodone and citalopram (antidepressants) in acute immobilization stess in mice, Indian J Exp Biol, 48 (2010) 1131.
26. Feeney DM, Boyeson MG, Linn RT, Murray HM & Dail WG, Responses to cortical injury: I. Methodology and local effects of contusions in the rat, Brain Res, 211 (1981) 67.
27. Gaur V, Aggarwal A & Kumar A, Protective effect of naringin against ischemic reperfusion cerebral injury: possible neurobehavioral, biochemical and cellular alterations in rat brain, Eur J Pharmacol, 616 (2009) 147.
28. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL & Bartkowski H, Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination, Stroke, 17 (1986) 472.
29. Hunter AJ, Hatcher J, Virley D, Nelson P, Irving E, Hadingham SJ & Parsons AA, Functional assessments in mice and rats after focal stroke, Neuropharmacology, 39 (2000) 806.
30. Wills ED, Mechanisms of lipid peroxide formation in animal tissues, Biochem J, 99 (1966) 667.
31. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS & Tannenbaum SR, Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids, Anal Biochem, 126 (1982) 131.
32. Luck H, Catalase, methods of enzymatic analysis, in Methods of enzymatic analysis, edited by Bergmeyer HU (Academic Press, New York) 1971, 885.
33. Kono Y, Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase, Arch Biochem Biophys, 186 (1978) 189.
34. Ellman GL, Tissue sulfhydryl groups, Arch Biochem Biophys, 82 (1959) 70.
35. Zahler WL & Cleland WW, A specific and sensitive assay for disulfides, J Biol Chem, 243 (1968) 716.
36. Habig WH, Pabst MJ & Jakoby WB, Glutathione Stransferases. The first enzymatic step in mercapturic acid formation, J Biol Chem, 249 (1974) 7130.
37. Gornall AG, Bardawill CJ & David MM, Determination of serum proteins by means of the biuret reaction, J Biol Chem, 177 (1949) 751.
38. Berman SB & Hastings TG, Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria: implications for Parkinson's disease, J Neurochem, 73 (1999) 1127.
39. King TE & Howard RL, Preparation and properties of soluble NADH dehydrogenase from cardiac muscle, Method Enzymol, 10 (1967) 275.
40. King TE, Preparation of succinate dehydrogenase and reconstitution of succinate oxidase, Method Enzymol, 10 (1967) 322.
41. Sottocasa GL, Kuylenstierna B, Ernster L & Bergstrand A, An electron-transport system associated with the outer membrane of liver mitochondria. A biochemical and morphological study, J Cell Biol, 32 (1967) 415.
42. Mosmann T, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J Immunol Methods, 65 (1983) 55.
43. Jeyaseelan K, Lim KY & Armugam A, Neuroprotectants in stroke therapy, Expert Opin Pharmacother, 9 (2008) 887.
44. Haller C & Hizoh I, The cytotoxicity of iodinated radiocontrast agents on renal cells in vitro, Invest Radiol, 39 (2004) 149.
45. Park HJ, Kim MJ, Ha E & Chung JH, Apoptotic effect of hesperidin through caspase3 activation in human colon cancer cells, SNU-C4, Phytomedicine, 15 (2008) 147.
46. Winawer S, Fletcher R, Rex D, Bond J, Burt R, Ferrucci J, Ganiats T, Levin T, Woolf S, Johnson D, Kirk L, Litin S & Simmang C, Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence, Gastroenterology, 124 (2003) 544.
47. Heffner JE & Repine JE, Pulmonary strategies of antioxidant defense, Am Rev Respir Dis, 140 (1989) 531.
48. Alonso de Lecinana M, Gutierrez M, Roda JM, Carceller F & Diez-Tejedor E, Effect of combined therapy with thrombolysis and citicoline in a rat model of embolic stroke, J Neurological Sci, 247 (2006) 121.
49. Mukherjee PK, Ahamed KF, Kumar V, Mukherjee K & Houghton PJ, Protective effect of biflavones from Araucaria bidwillii Hook in rat cerebral ischemia/reperfusion induced oxidative stress, Behav Brain Res, 178 (2007) 221.
50. Gaur V & Kumar A, Neuroprotective potentials of candesartan, atorvastatin and their combination against stroke induced motor dysfunction, Inflammopharmacol, DOI 10.1007/s10787-010-0068-y (2010).
51. Gupta YK, Briyal S, Sharma U, Jagannathan NR & Gulati A, Effect of endothelin antagonist (TAK-044) on cerebral ischemic volume, oxidative stress markers and neurobehavioral parameters in the middle cerebral artery occlusion model of stroke in rats, Life Sci, 77 (2005) 15.
52. Gaur V & Kumar A, Protective effect of desipramine, venlafaxine and trazodone against experimental animal model of transient global ischemia: possible involvement of NOcGMP pathway, Brain Res, 1353 (2010) 204.
53. Bromont C, Marie C & Bralet J, Increased lipid peroxidation in vulnerable brain regions after transient forebrain ischemia in rats, Stroke, 20 (1989) 918.
54. McCord JM & Fridovich I, Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein), J Biol Chem, 244 (1969) 6049.
55. Abidi P, Afaq F, Arif JM, Lohani M & Rahman Q, Chrysotilemediated imbalance in the glutathione redox system in the development of pulmonary injury, Toxicol Lett, 106 (1999) 31.
56. Sekhon B, Sekhon C, Khan M, Patel SJ, Singh I & Singh AK, N-Acetyl cysteine protects against injury in a rat model of focal cerebral ischemia, Brain Res, 971 (2003) 1.
57. Dawson VL, Dawson TM, London ED, Bredt DS & Snyder SH, Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures, Proc Natl Acad Sci U S A, 88 (1991) 6368.
58. Zhang ZG, Chopp M, Bailey F & Malinski T, Nitric oxide changes in the rat brain after transient middle cerebral artery occlusion, J Neurol Sci, 128 (1995) 22.
59. Allen KL, Almeida A, Bates TE & Clark JB, Changes of respiratory chain activity in mitochondrial and synaptosomal fractions isolated from the gerbil brain after graded ischaemia, J Neurochem, 64 (1995) 2222.
60. Almeida A, Allen KL, Bates TE & Clark JB, Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain, J Neurochem, 65 (1995) 1698.
61. Brorson JR, Schumacker PT & Zhang H, Nitric oxide acutely inhibits neuronal energy production. The Committees on Neurobiology and Cell Physiology, J Neurosci, 19 (1999) 147.
62. Aggarwal A, Gaur V & Kumar A, Nitric oxide mechanism in the protective effect of naringin against post-stroke depression (PSD) in mice, Life Sci, 86 (2010) 928.
63. Almeida A, Almeida J, Bolanos JP & Moncada S, Different responses of astrocytes and neurons to nitric oxide: the role of glycolytically generated ATP in astrocyte protection, Proc Natl Acad Sci U S A, 98 (2001) 15294.