Donor simvastatin treatment abolishes rat cardiac allograft ischemia/reperfusion injury and chronic rejection through microvascular protection

Circulation

Volumn 124, Issue 10, 2011, Pages 1138-1150

  Tuuminen, Raimo ^a   Syrjälä, Simo ^a   Krebs, Rainer ^a   Keränen, Mikko A I ^a   Koli, Katri ^c   Abo Ramadan, Usama ^b   Neuvonen, Pertti J ^a   Tikkanen, Jussi M ^a   Nykänen, Antti I ^a,b   Lemström, Karl B ^a,b  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

endothelium; inflammation; ischemia; microcirculation; transplantation

Indexed keywords

CYCLOSPORIN A; ENDOTHELIN 1; GERANYLGERANYL PYROPHOSPHATE; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; MESSENGER RNA; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PROTEIN KINASE; PROTOPORPHYRIN ZINC; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOSCLEROSIS; ARTICLE; BLOOD FLOW; CAPILLARY LEAK SYNDROME; CARDIAC ALLOGRAFT FIBROSIS; CARDIAC ALLOGRAFT ISCHEMIA; CARDIAC ALLOGRAFT VASCULOPATHY; CARDIAC GRAFT REJECTION; CELL INFILTRATION; CHRONIC GRAFT REJECTION; COLD ISCHEMIA; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; EPITHELIAL MESENCHYMAL TRANSITION; GAP JUNCTION; GRAFT FAILURE; GRAFT PRESERVATION; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART EDEMA; HEART MUSCLE FIBROSIS; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; ISCHEMIA; LEUKOCYTE; MALE; MICROCIRCULATION; MICROVASCULAR DYSFUNCTION; MICROVASCULAR ENDOTHELIAL CELL; MICROVASCULARIZATION; NONHUMAN; ORGAN DONOR; PERICYTE; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; VASCULAR LEAKAGE;

ANIMALS; ENDOTHELIAL CELLS; ENDOTHELIN-1; ENZYME INHIBITORS; GAP JUNCTIONS; GRAFT REJECTION; HEART TRANSPLANTATION; HEME OXYGENASE-1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MICROVESSELS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE II; NO-REFLOW PHENOMENON; POLYISOPRENYL PHOSPHATES; PRIMARY GRAFT DYSFUNCTION; RATS; RATS, INBRED WF; REPERFUSION INJURY; RHO-ASSOCIATED KINASES; SIMVASTATIN;

EID: 80052566684     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.005249     Document Type: Article

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