IGF-I ameliorates hippocampal neurodegeneration and protects against cognitive deficits in an animal model of temporal lobe epilepsy

Experimental Neurology

Volumn 231, Issue 2, 2011, Pages 223-235

  Miltiadous, Panagiota ^a   Stamatakis, Antonios ^a   Koutsoudaki, Paraskevi N ^a   Tiniakos, Dina G ^b   Stylianopoulou, Fotini ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Adult hippocampal neurogenesis; FluoroJade B; GFAP; Hippocampal degeneration; IGF I; Kainic acid; Learning and memory; Microglia; Morris water maze; Temporal lobe epilepsy

Indexed keywords

CD11B ANTIGEN; GLIAL FIBRILLARY ACIDIC PROTEIN; KAINIC ACID; SOMATOMEDIN C;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN REGION; CELL COUNT; CELL LEVEL; CELL LOSS; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE HILUS; DISEASE SEVERITY; DRUG EFFICACY; DRUG MECHANISM; GRANULE CELL; HIPPOCAMPAL CA3 REGION; LONG TERM MEMORY; MALE; MAZE TEST; MEMORY DISORDER; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SHORT TERM MEMORY; SPATIAL MEMORY; TEMPORAL LOBE EPILEPSY;

ANIMALS; CELL COUNT; CELL DEATH; DISEASE MODELS, ANIMAL; EPILEPSY, TEMPORAL LOBE; EXCITATORY AMINO ACID AGONISTS; HIPPOCAMPUS; INSULIN-LIKE GROWTH FACTOR I; KAINIC ACID; MALE; MAZE LEARNING; MEMORY; MICE; NERVE DEGENERATION; NEUROGENESIS; NEURONS;

EID: 80052546950     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.06.014     Document Type: Article

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