-
1
-
-
9144247189
-
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
-
DOI 10.1038/nature03121
-
J. Soutschek A. Akinc B. Bramlage K. Charisse R. Constien M. Donoghue S. Elbashir A. Geick P. Hadwiger J. Harborth M. John, et al. 2004 Nature 432 173 178 15538359 10.1038/nature03121 1:CAS:528:DC%2BD2cXpsF2gt7k%3D (Pubitemid 39545841)
-
(2004)
Nature
, vol.432
, Issue.7014
, pp. 173-178
-
-
Soutschek, J.1
Akinc, A.2
Bramlage, B.3
Charisse, K.4
Constien, R.5
Donoghue, M.6
Elbashir, S.7
Gelck, A.8
Hadwiger, P.9
Harborth, J.10
John, M.11
Kesavan, V.12
Lavine, G.13
Pandey, R.K.14
Racie, T.15
Rajeev, K.S.16
Rohl, I.17
Toudjarska, I.18
Wang, G.19
Wuschko, S.20
Bumcrot, D.21
Kotellansky, V.22
Limmer, S.23
Manoharan, M.24
Vornlocher, H.-P.25
more..
-
2
-
-
66349108231
-
-
19282453 10.1093/nar/gkp106 1:CAS:528:DC%2BD1MXmtlOgsbo%3D
-
J.B. Bramsen M.B. Laursen A.F. Nielsen T.B. Hansen C. Bus N. Langkjær BabuB. Ravindra T. Højland M. Abramov A. van Aerschot D. Odadzic, et al. 2009 Nucleic Acid Res. 37 2867 2881 19282453 10.1093/nar/gkp106 1:CAS:528:DC%2BD1MXmtlOgsbo%3D
-
(2009)
Nucleic Acid Res.
, vol.37
, pp. 2867-2881
-
-
Bramsen, J.B.1
Laursen, M.B.2
Nielsen, A.F.3
Hansen, T.B.4
Bus, C.5
Langkjær, N.6
Ravindra, BabuB.7
Højland, T.8
Abramov, M.9
Van Aerschot, A.10
Odadzic, D.11
-
3
-
-
42949121053
-
Comparing in vitro and in vivo activity of 2′-O-[2-(methylamino)-2- oxoethyl]- and 2′-O-methoxyethyl-modified antisense oligonucleotides
-
DOI 10.1021/jm701537z
-
T.P. Prakash A.M. Kawasaki E.V. Wancewicz L. Shen B.P. Monia B.S. Ross B. Bhat M. Manoharan 2008 J. Med. Chem. 51 2766 2776 18399648 10.1021/jm701537z 1:CAS:528:DC%2BD1cXksVOku7o%3D (Pubitemid 351620798)
-
(2008)
Journal of Medicinal Chemistry
, vol.51
, Issue.9
, pp. 2766-2776
-
-
Prakash, T.P.1
Kawasaki, A.M.2
Wancewicz, E.V.3
Shen, L.4
Monia, B.P.5
Ross, B.S.6
Bhat, B.7
Manoharan, M.8
-
4
-
-
34248523983
-
Comparison of the RNase H cleavage kinetics and blood serum stability of the north-conformationally constrained and 2′-alkoxy modified oligonucleotides
-
DOI 10.1021/bi0620205
-
D. Honcharenko J. Barman O.P. Varghese J. Chattopadhyaya 2007 Biochemistry 46 5635 5646 17411072 10.1021/bi0620205 1:CAS:528: DC%2BD2sXjvFCit70%3D (Pubitemid 46764113)
-
(2007)
Biochemistry
, vol.46
, Issue.19
, pp. 5635-5646
-
-
Honcharenko, D.1
Barman, J.2
Varghese, O.P.3
Chattopadhyaya, J.4
-
5
-
-
18844412770
-
Use of carbonyl group addition-elimination reactions for synthesis of nucleic acid conjugates
-
DOI 10.1021/bc049712v
-
T.S. Zatsepin D.A. Stetsenko M.J. Gait T.S. Oretskaya 2005 Bioconjugate Chem. 16 471 489 10.1021/bc049712v 1:CAS:528:DC%2BD2MXjvVeiurg%3D (Pubitemid 40696036)
-
(2005)
Bioconjugate Chemistry
, vol.16
, Issue.3
, pp. 471-489
-
-
Zatsepin, T.S.1
Stetsenko, D.A.2
Gait, M.J.3
Oretskaya, T.S.4
-
6
-
-
2942585676
-
Effective intracellular delivery of oligonucleotides in order to make sense of antisense
-
DOI 10.1016/j.jconrel.2004.03.016, PII S0168365904001488
-
F. Shi D. Hoekstra 2004 J. Controlled Release 97 189 209 10.1016/j.jconrel.2004.03.016 1:CAS:528:DC%2BD2cXkslKmtLY%3D (Pubitemid 38759477)
-
(2004)
Journal of Controlled Release
, vol.97
, Issue.2
, pp. 189-209
-
-
Shi, F.1
Hoekstra, D.2
-
7
-
-
0035989886
-
-
12074364 10.1089/108729002760070849 1:CAS:528:DC%2BD38Xks12htbs%3D
-
M. Manoharan 2002 Antisense Nucleic Acid Drug Dev. 12 103 128 12074364 10.1089/108729002760070849 1:CAS:528:DC%2BD38Xks12htbs%3D
-
(2002)
Antisense Nucleic Acid Drug Dev.
, vol.12
, pp. 103-128
-
-
Manoharan, M.1
-
9
-
-
0033576422
-
-
10836059 10.1021/ol991196e 1:CAS:528:DyaK1MXnsFOntbk%3D
-
J.-T. Hwang M.M. Greenberg 1999 Org. Lett. 1 2021 2024 10836059 10.1021/ol991196e 1:CAS:528:DyaK1MXnsFOntbk%3D
-
(1999)
Org. Lett.
, vol.1
, pp. 2021-2024
-
-
Hwang, J.-T.1
Greenberg, M.M.2
-
10
-
-
0035951283
-
Synthesis of 2′-modified oligodeoxynucleotides via on-column conjugation
-
DOI 10.1021/jo000917g
-
J.-T. Hwang M.M. Greenberg 2001 J. Org. Chem. 66 363 369 11429801 10.1021/jo000917g 1:CAS:528:DC%2BD3MXhtVWjsw%3D%3D (Pubitemid 32105550)
-
(2001)
Journal of Organic Chemistry
, vol.66
, Issue.2
, pp. 363-369
-
-
Hwang, J.-T.1
Greenberg, M.M.2
-
12
-
-
0036071516
-
Synthesis of peptide-oligonucleotide conjugates with single and multiple peptides attached to 2′-aldehydes through thiazolidine, oxime, and hydrazine linkages
-
DOI 10.1021/bc020016+
-
T.S. Zatsepin D.A. Stetsenko A.A. Arzumanov E.A. Romanova M.J. Gait T.S. Oretskaya 2002 Bioconjugate Chem. 13 822 830 10.1021/bc020016+ 1:CAS:528:DC%2BD38XkslehsLs%3D (Pubitemid 34801125)
-
(2002)
Bioconjugate Chemistry
, vol.13
, Issue.4
, pp. 822-830
-
-
Zatsepin, T.S.1
Stetsenko, D.A.2
Arzumanov, A.A.3
Romanova, E.A.4
Gait, M.J.5
Oretskaya, T.S.6
-
13
-
-
21744449159
-
Oligonucleotides containing 2′-O-[2-(2,3-dihydroxypropyl)amino-2- oxoethyl]uridine as suitable precursors of 2′-aldehyde oligonucleotides for chemoselective ligation
-
DOI 10.1016/j.bmc.2005.05.024, PII S0968089605004578
-
E.M. Zubin D.A. Stetsenko T.S. Zatsepin M.J. Gait T.S. Oretskaya 2005 Bioorg. Med. Chem. 13 4912 4920 15993079 10.1016/j.bmc.2005.05.024 1:CAS:528:DC%2BD2MXlvFaktbc%3D (Pubitemid 40943515)
-
(2005)
Bioorganic and Medicinal Chemistry
, vol.13
, Issue.16
, pp. 4912-4920
-
-
Zubin, E.M.1
Stetsenko, D.A.2
Zatsepin, T.S.3
Gait, M.J.4
Oretskaya, T.S.5
-
14
-
-
33745281861
-
Synthesis of 2′-hydrazine oligonucleotides and their efficient conjugation with aldehydes and 1,3-diketones
-
DOI 10.1016/j.tetlet.2006.05.152, PII S0040403906010914
-
T.S. Zatsepin M.J. Gait T.S. Oretskaya D.A. Stetsenko 2006 Tetrahedron Lett. 47 5515 5518 10.1016/j.tetlet.2006.05.152 1:CAS:528:DC%2BD28XmsVOqu7g%3D (Pubitemid 43929009)
-
(2006)
Tetrahedron Letters
, vol.47
, Issue.31
, pp. 5515-5518
-
-
Zatsepin, T.S.1
Gait, M.J.2
Oretskaya, T.S.3
Stetsenko, D.A.4
-
15
-
-
37549012482
-
-
18052191 10.1021/jo702023s 1:CAS:528:DC%2BD2sXhtlynu7jM
-
A.M. Jawalekar N. Meeuwenoord J. Cremers 2008 J. Org. Chem. 73 287 290 18052191 10.1021/jo702023s 1:CAS:528:DC%2BD2sXhtlynu7jM
-
(2008)
J. Org. Chem.
, vol.73
, pp. 287-290
-
-
Jawalekar, A.M.1
Meeuwenoord, N.2
Cremers, J.3
-
16
-
-
34249794857
-
Template-directed oligonucleotide strand ligation, covalent intramolecular DNA circularization and catenation using click chemistry
-
DOI 10.1021/ja070273v
-
R. Kumar A.H. El-Sagheer J. Tumpane P. Lincoln L.M. Wilhelmsson T. Brown 2007 J. Am. Chem. Soc. 129 6859 6864 17488075 10.1021/ja070273v 1:CAS:528:DC%2BD2sXltVajsr0%3D (Pubitemid 46847528)
-
(2007)
Journal of the American Chemical Society
, vol.129
, Issue.21
, pp. 6859-6864
-
-
Kumar, R.1
El-Sagheer, A.2
Tumpane, J.3
Lincoln, P.4
Wilhelmsson, L.M.5
Brown, T.6
-
20
-
-
0035961532
-
Structural studies of an oligodeoxynucleotide containing a trimethylene interstrand cross-link in a 5′-(CpG) motif: Model of a malondialdehyde cross-link
-
DOI 10.1021/ja003163w
-
P.A. Dooley D. Tsarouhtsis G.A. Korbel L.V. Nechev J. Shearer I.S. Zegar C.M. Harris M.P. Stone T.M. Harris 2001 J. Am. Chem. Soc. 123 1730 1739 11456774 10.1021/ja003163w 1:CAS:528:DC%2BD3MXosFSntQ%3D%3D (Pubitemid 32179423)
-
(2001)
Journal of the American Chemical Society
, vol.123
, Issue.8
, pp. 1730-1739
-
-
Dooley, P.A.1
Tsarouhtsis, D.2
Korbel, G.A.3
Nechev, L.V.4
Shearer, J.5
Zegar, I.S.6
Harris, C.M.7
Stone, M.P.8
Harris, T.M.9
-
22
-
-
0242407293
-
Control of A Double Helix DNA Assembly by Use of Cross-Linked Oligonucleotides
-
DOI 10.1021/ja036752l
-
M. Endo T. Majima 2003 J. Am. Chem. Soc. 125 13654 13655 14599191 10.1021/ja036752l 1:CAS:528:DC%2BD3sXot1Ojsrg%3D (Pubitemid 37386027)
-
(2003)
Journal of the American Chemical Society
, vol.125
, Issue.45
, pp. 13654-13655
-
-
Endo, M.1
Majima, T.2
-
23
-
-
3342920613
-
3T interstrand cross-linked DNA: Synthesis and characterization of duplexes with interstrand cross-links of variable lengths
-
DOI 10.1021/ja0498540
-
C.J. Wilds A.M. Noronha S. Robidoux P.S. Miller 2004 J. Am. Chem. Soc. 126 9257 9265 15281815 10.1021/ja0498540 1:CAS:528:DC%2BD2cXlsFemtbs%3D (Pubitemid 38989442)
-
(2004)
Journal of the American Chemical Society
, vol.126
, Issue.30
, pp. 9257-9265
-
-
Wilds, C.J.1
Noronha, A.M.2
Robidoux, S.3
Miller, P.S.4
-
24
-
-
41849094096
-
3-thymidine interstrand cross-link: A structural mimic of the cross-link formed by 1,3-bis-(2-chloroethyl)-1- nitrosourea
-
DOI 10.1021/tx700422h
-
C.J. Wilds F. Xu A.M. Noronha 2008 Chem. Res. Toxicol. 21 686 695 18257558 10.1021/tx700422h 1:CAS:528:DC%2BD1cXhslWjtrY%3D (Pubitemid 351498044)
-
(2008)
Chemical Research in Toxicology
, vol.21
, Issue.3
, pp. 686-695
-
-
Wilds, C.J.1
Xu, F.2
Noronha, A.M.3
-
25
-
-
78149468904
-
-
20730555 10.1007/s00018-010-0492-6 1:CAS:528:DC%2BC3cXhtlSjsLjE
-
A. Guainazzi O.D. Schärer 2010 Cell. Mol. Life Sci. 67 3683 3697 20730555 10.1007/s00018-010-0492-6 1:CAS:528:DC%2BC3cXhtlSjsLjE
-
(2010)
Cell. Mol. Life Sci.
, vol.67
, pp. 3683-3697
-
-
Guainazzi, A.1
Schärer, O.D.2
-
26
-
-
34248204756
-
Addressable high-information-density DNA nanostructures
-
DOI 10.1016/j.cplett.2007.04.018, PII S0009261407004526
-
J. Tumpane P. Sandin R. Kumar V.E.C. Powers E.P. Lundberg N. Gale P. Baglioni J.-M. Lehn B. Albinsson P. Lincoln L.M. Wilhelmsson T. Brown B. Nordén 2007 Chem. Phys. Lett. 440 125 129 10.1016/j.cplett.2007.04.018 1:CAS:528:DC%2BD2sXltF2qs7k%3D (Pubitemid 46711095)
-
(2007)
Chemical Physics Letters
, vol.440
, Issue.1-3
, pp. 125-129
-
-
Tumpane, J.1
Sandin, P.2
Kumar, R.3
Powers, V.E.C.4
Lundberg, E.P.5
Gale, N.6
Baglioni, P.7
Lehn, J.-M.8
Albinsson, B.9
Lincoln, P.10
Wilhelmsson, L.M.11
Brown, T.12
Norden, B.13
-
27
-
-
7944237766
-
-
15333895 1:CAS:528:DC%2BD2cXptFSjtrc%3D
-
B. Sproat 2005 Methods in Molecular Biology 288 17 31 15333895 1:CAS:528:DC%2BD2cXptFSjtrc%3D
-
(2005)
Methods in Molecular Biology
, vol.288
, pp. 17-31
-
-
Sproat, B.1
-
28
-
-
0035945004
-
Synthesis and properties of 2-azidodeoxyadenosine and its incorporation into oligodeoxynucleotides
-
DOI 10.1016/S0040-4039(01)02028-7, PII S0040403901020287
-
T. Wada A. Mochizuki S. Higashiya H. Tsuruoka S. Kawahar M. Ishikawa M. Sekine 2001 Tetrahedron Lett. 42 9215 9219 10.1016/S0040-4039(01)02028-7 1:CAS:528:DC%2BD3MXptVGmtr8%3D (Pubitemid 33152888)
-
(2001)
Tetrahedron Letters
, vol.42
, Issue.52
, pp. 9215-9219
-
-
Wada, T.1
Mochizuki, A.2
Higashiya, S.3
Tsuruoka, H.4
Kawahara, S.-I.5
Ishikawa, M.6
Sekine, M.7
-
32
-
-
33846089287
-
2-(4-Tolylsulfonyl)ethoxymethyl (TEM) - A new 2′-OH protecting group for solid-supported RNA synthesis
-
DOI 10.1039/b614210a
-
C. Zhou D. Honcharenko J. Chattapadhyaya 2007 Org. Biomol. Chem. 5 333 343 17205178 10.1039/b614210a 1:CAS:528:DC%2BD2sXhtlSgsQ%3D%3D (Pubitemid 46058483)
-
(2007)
Organic and Biomolecular Chemistry
, vol.5
, Issue.2
, pp. 333-343
-
-
Zhou, C.1
Honcharenko, D.2
Chattopadhyaya, J.3
-
34
-
-
78549256713
-
-
10.1016/j.tetlet.2010.07.101 1:CAS:528:DC%2BC3cXhtVGrtb%2FL
-
S.D. Brown D. Graham 2010 Tetrahedron Lett. 51 5032 5034 10.1016/j.tetlet.2010.07.101 1:CAS:528:DC%2BC3cXhtVGrtb%2FL
-
(2010)
Tetrahedron Lett.
, vol.51
, pp. 5032-5034
-
-
Brown, S.D.1
Graham, D.2
|