A physical model reveals the mechanochemistry responsible for Dynein's processive motion

Biophysical Journal

Volumn 101, Issue 1, 2011, Pages 144-150

  Tsygankov, Denis ^a   Serohijos, Adrian W R ^b   Dokholyan, Nikolay V ^a   Elston, Timothy C ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DYNEIN ADENOSINE TRIPHOSPHATASE;

ARTICLE; BIOLOGICAL MODEL; BIOMECHANICS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; METABOLISM; MICROTUBULE; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; STATISTICS; TIME; ULTRASTRUCTURE;

BIOMECHANICS; COMPUTER SIMULATION; DYNEINS; MICROTUBULES; MODELS, BIOLOGICAL; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; STOCHASTIC PROCESSES; TIME FACTORS;

EID: 80052511038     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.05.043     Document Type: Article

References (29)

1. R.B. Vallee, and J.C. Williams L.E. Barnhart Dynein: an ancient motor protein involved in multiple modes of transport J. Neurobiol. 58 2004 189 200 (Pubitemid 38173717)
2. M.P. Koonce, and M. Samsó Of rings and levers: the dynein motor comes of age Trends Cell Biol. 14 2004 612 619 (Pubitemid 39440610)
3. R.D. Vale The molecular motor toolbox for intracellular transport Cell 112 2003 467 480 (Pubitemid 36263080)
4. R.H. Wade On and around microtubules: an overview Mol. Biotechnol. 43 2009 177 191
5. E.L. Holzbaur, and R.B. Vallee DYNEINS: molecular structure and cellular function Annu. Rev. Cell Biol. 10 1994 339 372 (Pubitemid 24372823)
6. N. Mizuno, and A. Narita M. Kikkawa Three-dimensional structure of cytoplasmic dynein bound to microtubules Proc. Natl. Acad. Sci. USA 104 2007 20832 20837
7. A.P. Carter, and J.E. Garbarino I.R. Gibbons Structure and functional role of dynein's microtubule-binding domain Science 322 2008 1691 1695
8. H. Ueno, and T. Yasunaga K. Hirose Dynein pulls microtubules without rotating its stalk Proc. Natl. Acad. Sci. USA 105 2008 19702 19707
9. T. Mogami, and T. Kon K. Sutoh Kinetic characterization of tail swing steps in the ATPase cycle of Dictyostelium cytoplasmic dynein J. Biol. Chem. 282 2007 21639 21644 (Pubitemid 47195745)
10. K. Imamula, and T. Kon K. Sutoh The coordination of cyclic microtubule association/dissociation and tail swing of cytoplasmic dynein Proc. Natl. Acad. Sci. USA 104 2007 16134 16139 (Pubitemid 350099374)
11. D. Tsygankov, and A.W. Serohijos T.C. Elston Kinetic models for the coordinated stepping of cytoplasmic dynein J. Chem. Phys. 130 2009 025101
12. H. Higuchi, and S.A. Endow Directionality and processivity of molecular motors Curr. Opin. Cell Biol. 14 2002 50 57 (Pubitemid 34131656)
13. + molecular motor J. Struct. Biol. 156 2006 182 189 (Pubitemid 44486063)
14. S.A. Burgess, and M.L. Walker K. Oiwa Dynein structure and power stroke Nature 421 2003 715 718 (Pubitemid 36227616)
15. A.W. Serohijos, and D. Tsygankov N.V. Dokholyan Multiscale approaches for studying energy transduction in dynein Phys. Chem. Chem. Phys. 11 2009 4840 4850
16. + Ring and linker swing mechanism in the dynein motor Cell 136 2009 485 495
17. A.P. Carter, and C. Cho R.D. Vale Crystal structure of the dynein motor domain Science 331 2011 1159 1165
18. S.L. Reck-Peterson, and A. Yildiz R.D. Vale Single-molecule analysis of dynein processivity and stepping behavior Cell 126 2006 335 348 (Pubitemid 44092968)
19. S. Toba, and T.M. Watanabe H. Higuchi Overlapping hand-over-hand mechanism of single molecular motility of cytoplasmic dynein Proc. Natl. Acad. Sci. USA 103 2006 5741 5745
20. C. Shingyoji, and H. Higuchi T. Yanagida Dynein arms are oscillating force generators Nature 393 1998 711 714 (Pubitemid 28289664)
21. A. Gennerich, and A.P. Carter R.D. Vale Force-induced bidirectional stepping of cytoplasmic dynein Cell 131 2007 952 965 (Pubitemid 350138087)
22. S.L. Bullock, and A. Nicol D. Zicha Guidance of bidirectional motor complexes by mRNA cargoes through control of dynein number and activity Curr. Biol. 16 2006 1447 1452 (Pubitemid 44066772)
23. J.L. Ross, and K. Wallace E.L. Holzbaur Processive bidirectional motion of dynein-dynactin complexes in vitro Nat. Cell Biol. 8 2006 562 570 (Pubitemid 43827348)
24. N.J. Carter, and R.A. Cross Mechanics of the kinesin step Nature 435 2005 308 312 (Pubitemid 40745535)
25. S.J. Iyadurai, and M.G. Li T.S. Hays Evidence for cooperative interactions between the two motor domains of cytoplasmic dynein Curr. Biol. 9 1999 771 774 (Pubitemid 29350859)
26. K.M. Ori-McKenney, and J. Xu R.B. Vallee A cytoplasmic dynein tail mutation impairs motor processivity Nat. Cell Biol. 12 2010 1228 1234
27. N. Numata, and T. Shima K. Sutoh C-sequence of the Dictyostelium cytoplasmic dynein participates in processivity modulation FEBS Lett. 585 2011 1185 1190
28. T. Oda, N. Hirokawa, and M. Kikkawa Three-dimensional structures of the flagellar dynein-microtubule complex by cryoelectron microscopy J. Cell Biol. 177 2007 243 252 (Pubitemid 46658636)
29. A. Mogilner, H. Wang, T. Elston, and G. Oster Molecular motors: theory C.P. Fall, E.S. Marland, J.M. Wagner, J.J. Tyson, Computational Cell Biology 2002 Springer New York 321 355