Lubricin: A novel potential biotherapeutic approaches for the treatment of osteoarthritis

Molecular Biology Reports

Volumn 38, Issue 5, 2011, Pages 2879-2885

  Bao, Jia Peng ^a   Chen, Wei Ping ^a   Wu, Li Dong ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2 INHIBITOR; GLYCOPROTEIN; HYALURONIC ACID; LUBRICIN; NONSTEROID ANTIINFLAMMATORY AGENT; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; ARTICULAR CARTILAGE; BIOLOGICAL THERAPY; CARTILAGE DEGENERATION; DRUG BINDING; DRUG EFFICACY; DRUG POTENTIATION; DRUG STRUCTURE; GENE; GENE EXPRESSION; INFRAPAOTELLAR FAT PAD; JOINT FUNCTION; KNEE LIGAMENT; KNEE MENISCUS; LUBRICATION; LUBRICIN GENE; NONHUMAN; OSTEOARTHRITIS; PRG4 GENE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SYNOVIAL FLUID; SYNOVIUM; TENDON; TISSUE DISTRIBUTION;

ANIMALS; CARTILAGE, ARTICULAR; CHONDROCYTES; DISEASE PROGRESSION; GLYCOPROTEINS; HUMANS; JOINTS; LUBRICATION; OSTEOARTHRITIS; SYNOVIAL MEMBRANE;

ANIMALIA;

EID: 80052506675     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-9949-9     Document Type: Article

References (67)

1. Buckwalter JA, Mankin HJ (1998) Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation. Instr Course Lect 47:487-504
2. Swann DA, Slayter HS, Silver FH (1981) The molecular structure of lubricating glycoprotein-I, the boundary lubricant for articular cartilage. J Biol Chem 256:5921-5925 (Pubitemid 11043462)
3. Rhee DK, Marcelino J, Baker M et al (2005) The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth. J Clin Invest 115:622-631 (Pubitemid 40322236)
4. Schumacher BL, Block JA, Schmid TM, Aydelotte MB, Kuettner KE (1994) A novel proteoglycan synthesized and secreted by chondrocytes of the superficial zone of articular cartilage. Arch Biochem Biophys 311:144-152 (Pubitemid 24190113)
5. Jay GD, Harris DA, Cha CJ (2001) Boundary lubrication by lubricin is mediated by O-linked beta(1-3)Gal-GalNAc oligosaccharides. Glycoconj J 18:807-815 (Pubitemid 36071942)
6. Justen HP, Grunewald E, Totzke G et al (2000) Differential gene expression in synovium of rheumatoid arthritis and osteoarthritis. Mol Cell Biol Res Commun 3:165-172 (Pubitemid 30430017)
7. Flannery CR, Zollner R, Corcoran C et al (2009) Prevention of cartilage degeneration in a rat model of osteoarthritis by intraarticular treatment with recombinant lubricin. Arthritis Rheum 60:840-847
8. Ikegawa S, Sano M, Koshizuka Y, Nakamura Y (2000) Isolation, characterization and mapping of the mouse and human PRG4 (proteoglycan 4) genes. Cytogenet Cell Genet 90:291-297 (Pubitemid 32008781)
9. Jay GD, Cha CJ (1999) The effect of phospholipase digestion upon the boundary lubricating ability of synovial fluid. J Rheumatol 26:2454-2457 (Pubitemid 29528990)
10. Flannery CR, Hughes CE, Schumacher BL et al (1999) Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective, and lubricating properties in cartilage metabolism. Biochem Biophys Res Commun 254:535-541 (Pubitemid 29290501)
11. Liu YJ, Lu SH, Xu B et al (2004) Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages. Blood 103:4449-4456 (Pubitemid 38745970)
12. Jay GD (1992) Characterization of a bovine synovial fluid lubricating factor. I. Chemical, surface activity and lubricating properties. Connect Tissue Res 28:71-88
13. Zappone B, Ruths M, Greene GW, Jay GD, Israelachvili JN (2007) Adsorption, lubrication, and wear of lubricin on model surfaces: polymer brush-like behavior of a glycoprotein. Biophys J 92:1693-1708 (Pubitemid 46393480)
14. Jay GD, Tantravahi U, Britt DE, Barrach HJ, Cha CJ (2001) Homology of lubricin and superficial zone protein (SZP): products of megakaryocyte stimulating factor (MSF) gene expression by human synovial fibroblasts and articular chondrocytes localized to chromosome 1q25. J Orthop Res 19:677-687 (Pubitemid 32700985)
15. Deng G, Curriden SA, Hu G, Czekay RP, Loskutoff DJ (2001) Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin. J Cell Physiol 189:23-33
16. Schvartz I, Seger D, Shaltiel S (1999) Vitronectin. Int J Biochem Cell Biol 31:539-544 (Pubitemid 29219400)
17. Seiffert D, Smith JW (1997) The cell adhesion domain in plasma vitronectin is cryptic. J Biol Chem 272:13705-13710 (Pubitemid 27224805)
18. Hrkal Z, Kuzelova K, Muller-Eberhard U, Stern R (1996) Hyaluronan- binding properties of human serum hemopexin. FEBS Lett 383:72-74 (Pubitemid 26092637)
19. Nugent-Derfus GE, Chan AH, Schumacher BL, Sah RL (2007) PRG4 exchange between the articular cartilage surface and synovial fluid. J Orthop Res 25:1269-1276 (Pubitemid 47523356)
20. Jones AR, Gleghorn JP, Hughes CE et al (2007) Binding and localization of recombinant lubricin to articular cartilage surfaces. J Orthop Res 25:283-292 (Pubitemid 46455899)
21. Swann DA, Silver FH, Slayter HS, Stafford W, Shore E (1985) The molecular structure and lubricating activity of lubricin isolated from bovine and human synovial fluids. Biochem J 225:195-201 (Pubitemid 15151970)
22. Jay GD, Haberstroh K, Cha CJ (1998) Comparison of the boundary-lubricating ability of bovine synovial fluid, lubricin, and Healon. J Biomed Mater Res 40:414-418 (Pubitemid 28182885)
23. Su JL, Schumacher BL, Lindley KM et al (2001) Detection of superficial zone protein in human and animal body fluids by cross-species monoclonal antibodies specific to superficial zone protein. Hybridoma 20:149-157 (Pubitemid 32881309)
24. Schumacher BL, Hughes CE, Kuettner KE, Caterson B, Aydelotte MB (1999) Immunodetection and partial cDNA sequence of the proteoglycan, superficial zone protein, synthesized by cells lining synovial joints. J Orthop Res 17:110-120 (Pubitemid 29096013)
25. Schumacher BL, Schmidt TA, Voegtline MS, Chen AC, Sah RL (2005) Proteoglycan 4 (PRG4) synthesis and immunolocalization in bovine meniscus. J Orthop Res 23:562-568 (Pubitemid 40631327)
26. Rees SG, Davies JR, Tudor D et al (2002) Immunolocalisation and expression of proteoglycan 4 (cartilage superficial zone proteoglycan) in tendon. Matrix Biol 21:593-602 (Pubitemid 35435299)
27. Lee SY, Nakagawa T, Reddi AH (2008) Induction of chondrogenesis and expression of superficial zone protein (SZP)/lubricin by mesenchymal progenitors in the infrapatellar fat pad of the knee joint treated with TGF-beta1 and BMP-7. Biochem Biophys Res Commun 376:148-153
28. Sun Y, Berger EJ, Zhao C, An KN, Amadio PC, Jay G (2006) Mapping lubricin in canine musculoskeletal tissues. Connect Tissue Res 47:215-221 (Pubitemid 44467653)
29. Jay GD, Elsaid KA, Zack J et al (2004) Lubricating ability of aspirated synovial fluid from emergency department patients with knee joint synovitis. J Rheumatol 31:557-564 (Pubitemid 38337619)
30. Kumar P, Oka M, Toguchida J et al (2001) Role of uppermost superficial surface layer of articular cartilage in the lubrication mechanism of joints. J Anat 199:241-250 (Pubitemid 32825621)
31. Neu CP, Khalafi A, Komvopoulos K, Schmid TM, Reddi AH (2007) Mechanotransduction of bovine articular cartilage superficial zone protein by transforming growth factor beta signaling. Arthritis Rheum 56:3706-3714 (Pubitemid 350100705)
32. Marcelino J, Carpten JD, SuwairiWMet al (1999) CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathycoxa vara-pericarditis syndrome. Nat Genet 23:319-322 (Pubitemid 29526430)
33. Bahabri SA, Suwairi WM, Laxer RM, Polinkovsky A, Dalaan AA, Warman ML (1998) The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1. Arthritis Rheum 41:730-735 (Pubitemid 28214993)
34. Schmidt TA, Schumacher BL, Klein TJ, Voegtline MS, Sah RL (2004) Synthesis of proteoglycan 4 by chondrocyte subpopulations in cartilage explants, monolayer cultures, and resurfaced cartilage cultures. Arthritis Rheum 50:2849-2857 (Pubitemid 39209522)
35. Schmidt TA, Gastelum NS, Han EH, Nugent-Derfus GE, Schumacher BL, Sah RL (2008) Differential regulation of proteoglycan 4 metabolism in cartilage by IL-1alpha, IGF-I, and TGF-beta1. Osteoarthr Cartil 16:90-97
36. Khalafi A, Schmid TM, Neu C, Reddi AH (2007) Increased accumulation of superficial zone protein (SZP) in articular cartilage in response to bone morphogenetic protein-7 and growth factors. J Orthop Res 25:293-303 (Pubitemid 46455900)
37. Darling EM, Athanasiou KA (2005) Growth factor impact on articular cartilage subpopulations. Cell Tissue Res 322:463-473 (Pubitemid 41682356)
38. Niikura T, Reddi AH (2007) Differential regulation of lubricin/ superficial zone protein by transforming growth factor beta/bone morphogenetic protein superfamily members in articular chondrocytes and synoviocytes. Arthritis Rheum 56:2312-2321 (Pubitemid 47173579)
39. Jones AR, Flannery CR (2007) Bioregulation of lubricin expression by growth factors and cytokines. Eur Cell Mater 13:40-45 discussion 45 (Pubitemid 46890453)
40. Elsaid KA, Fleming BC, Oksendahl HL et al (2008) Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury. Arthritis Rheum 58:1707-1715 (Pubitemid 351847524)
41. Buschmann MD, Kim YJ, Wong M, Frank E, Hunziker EB, Grodzinsky AJ (1999) Stimulation of aggrecan synthesis in cartilage explants by cyclic loading is localized to regions of high interstitial fluid flow. Arch Biochem Biophys 366:1-7 (Pubitemid 29394221)
42. Wong M, Siegrist M, Goodwin K (2003) Cyclic tensile strain and cyclic hydrostatic pressure differentially regulate expression of hypertrophic markers in primary chondrocytes. Bone 33:685-693 (Pubitemid 37222395)
43. Grad S, Lee CR, Gorna K, Gogolewski S, Wimmer MA, Alini M (2005) Surface motion upregulates superficial zone protein and hyaluronan production in chondrocyte-seeded three-dimensional scaffolds. Tissue Eng 11:249-256 (Pubitemid 40515192)
44. Nugent-Derfus GE, Takara T, O'Neill JK et al (2007) Continuous passive motion applied to whole joints stimulates chondrocyte biosynthesis of PRG4. Osteoarthr Cartil 15:566-574 (Pubitemid 46667714)
45. Li Z, Yao S, Alini M, Grad S (2007) Different response of articular chondrocyte subpopulations to surface motion. Osteoarthr Cartil 15:1034-1041 (Pubitemid 47387033)
46. Grad S, Lee CR, Wimmer MA, Alini M (2006) Chondrocyte gene expression under applied surface motion. Biorheology 43:259-269 (Pubitemid 44221908)
47. Nugent GE, Schmidt TA, Schumacher BL et al (2006) Static and dynamic compression regulate cartilage metabolism of PRoteo- Glycan 4 (PRG4). Biorheology 43:191-200 (Pubitemid 44221902)
48. Nugent GE, Aneloski NM, Schmidt TA, Schumacher BL, Voegtline MS, Sah RL (2006) Dynamic shear stimulation of bovine cartilage biosynthesis of proteoglycan 4. Arthritis Rheum 54:1888-1896 (Pubitemid 43877938)
49. Das RH, Jahr H, Verhaar JA, van der Linden JC, Van Osch GJ, Weinans H (2008) In vitro expansion affects the response of chondrocytes to mechanical stimulation. Osteoarthr Cartil 16:385-391 (Pubitemid 351309187)
50. Schaefer DB, Wendt D, Moretti M et al (2004) Lubricin reduces cartilage-cartilage integration. Biorheology 41:503-508 (Pubitemid 39277106)
51. DuRaine G, Neu CP, Chan SM, Komvopoulos K, June RK, Reddi AH (2009) Regulation of the friction coefficient of articular cartilage by TGF-beta1 and IL-1beta. J Orthop Res 27:249-256
52. Young AA, McLennan S, Smith MM et al (2006) Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis. Arthritis Res Ther 8:R41
53. Jay GD, Torres JR, Warman ML, Laderer MC, Breuer KS (2007) The role of lubricin in the mechanical behavior of synovial fluid. Proc Natl Acad Sci USA 104:6194-6199 (Pubitemid 47186071)
54. Englert C, McGowan KB, Klein TJ, Giurea A, Schumacher BL, Sah RL (2005) Inhibition of integrative cartilage repair by proteoglycan 4 in synovial fluid. Arthritis Rheum 52:1091-1099 (Pubitemid 40530116)
55. Elsaid KA, Jay GD, Warman ML, Rhee DK, Chichester CO (2005) Association of articular cartilage degradation and loss of boundary-lubricating ability of synovial fluid following injury and inflammatory arthritis. Arthritis Rheum 52:1746-1755 (Pubitemid 40852883)
56. Jay GD, Torres JR, Rhee DK et al (2007) Association between friction and wear in diarthrodial joints lacking lubricin. Arthritis Rheum 56:3662-3669 (Pubitemid 350100700)
57. Elsaid KA, Jay GD, Chichester CO (2007) Reduced expression and proteolytic susceptibility of lubricin/superficial zone protein may explain early elevation in the coefficient of friction in the joints of rats with antigen-induced arthritis. Arthritis Rheum 56:108-116 (Pubitemid 46106183)
58. Zhang D, Johnson LJ, Hsu HP, Spector M (2007) Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilage. J Orthop Res 25:873-883 (Pubitemid 47046434)
59. Skotnicki JS, DiGrandi MJ, Levin JI (2003) Design strategies for the identification of MMP-13 and Tace inhibitors. Curr Opin Drug Discov Dev 6:742-759 (Pubitemid 37287943)
60. Teeple E, Elsaid KA, Fleming BC et al (2008) Coefficients of friction, lubricin, and cartilage damage in the anterior cruciate ligament-deficient guinea pig knee. J Orthop Res 26:231-237 (Pubitemid 351220142)
61. Klein TJ, Schumacher BL, Schmidt TA et al (2003) Tissue engineering of stratified articular cartilage from chondrocyte subpopulations. Osteoarthr Cartil 11:595-602 (Pubitemid 36926535)
62. Creamer P, Hochberg MC (1997) Osteoarthritis. Lancet 350: 503-508
63. Frizziero L, Govoni E, Bacchini P (1998) Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: clinical and morphological study. Clin Exp Rheumatol 16:441-449 (Pubitemid 28370856)
64. Adams ME, Atkinson MH, Lussier AJ et al (1995) The role of viscosupplementation with hylan G-F 20 (Synvisc) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan G-F 20 alone, hylan G-F 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone. Osteoarthr Cartil 3:213-225 (Pubitemid 26046657)
65. Balazs EA, Denlinger JL (1993) Viscosupplementation: a new concept in the treatment of osteoarthritis. J Rheumatol 39:3-9 (Pubitemid 23284286)
66. Rydell N, Balazs EA (1971) Effect of intra-articular injection of hyaluronic acid on the clinical symptoms of osteoarthritis and on granulation tissue formation. Clin Orthop Relat Res 80:25-32
67. Schmidt TA, Gastelum NS, Nguyen QT, Schumacher BL, Sah RL (2007) Boundary lubrication of articular cartilage: role of synovial fluid constituents. Arthritis Rheum 56:882-891 (Pubitemid 46399436)