메뉴 건너뛰기




Volumn 27, Issue 10, 2006, Pages 1346-1352

Antidiabetic effect of a novel non-thiazolidinedione PPAR γ/α agonist on ob/ob mice

Author keywords

Diabetes; Insulin sensitizing; Peroxisome proliferator activated receptors; Thiazolidinediones

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; ROSIGLITAZONE; T 33; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

EID: 33748972676     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2006.00427.x     Document Type: Article
Times cited : (17)

References (26)
  • 2
    • 0026021161 scopus 로고
    • Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
    • DeFronzo RA, Ferrannnini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-94.
    • (1991) Diabetes Care , vol.14 , pp. 173-194
    • DeFronzo, R.A.1    Ferrannnini, E.2
  • 3
    • 0030602866 scopus 로고    scopus 로고
    • The peroxisome proliferator activated receptors (PPARs) and then effects on lipid metabolism and adipocyte differentiation
    • Schoonjans K, Staels B, Auwerx J. The peroxisome proliferator activated receptors (PPARs) and then effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1996; 1302: 93-109.
    • (1996) Biochim Biophys Acta , vol.1302 , pp. 93-109
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 5
    • 0029791412 scopus 로고    scopus 로고
    • PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
    • Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, Heyman RA, Briggs M, Deeb S, et al. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 1996; 15: 5336-48.
    • (1996) EMBO J , vol.15 , pp. 5336-5348
    • Schoonjans, K.1    Peinado-Onsurbe, J.2    Lefebvre, A.M.3    Heyman, R.A.4    Briggs, M.5    Deeb, S.6
  • 6
    • 0034064359 scopus 로고    scopus 로고
    • Distribution of peroxisome proliferators-activated receptors (PPARs) in human skeletal muscle and adipose tissue: Relation to insulin action
    • Loviscach M, Rehman N, Carter L, Mudaliar S, Mohadeen P, Ciaraldi TP, et al. Distribution of peroxisome proliferators-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action. Diabetologia 2000; 43: 304-11.
    • (2000) Diabetologia , vol.43 , pp. 304-311
    • Loviscach, M.1    Rehman, N.2    Carter, L.3    Mudaliar, S.4    Mohadeen, P.5    Ciaraldi, T.P.6
  • 7
    • 0036183630 scopus 로고    scopus 로고
    • The mechanisms of action of PPARs
    • Berger J, Moller DE. The mechanisms of action of PPARs. Annu Rev Med 2002; 53: 409-35.
    • (2002) Annu Rev Med , vol.53 , pp. 409-435
    • Berger, J.1    Moller, D.E.2
  • 8
    • 0034595980 scopus 로고    scopus 로고
    • Peroxisome proliferators-activated receptor alpha activators improve insulin sensitivity and reduce adiposity
    • Guerre-Millo M, Gervois P, Raspe E, Madsen L, Poulain P, Derudas B, et al. Peroxisome proliferators-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 2000; 275: 16638-42.
    • (2000) J Biol Chem , vol.275 , pp. 16638-16642
    • Guerre-Millo, M.1    Gervois, P.2    Raspe, E.3    Madsen, L.4    Poulain, P.5    Derudas, B.6
  • 9
    • 0037238924 scopus 로고    scopus 로고
    • Recent advances in peroxisome proliferator-activated receptor science
    • Shearer BG, Hoekstra WJ. Recent advances in peroxisome proliferator-activated receptor science. Curr Med Chem 2003; 10: 267-80.
    • (2003) Curr Med Chem , vol.10 , pp. 267-280
    • Shearer, B.G.1    Hoekstra, W.J.2
  • 10
    • 0028884048 scopus 로고
    • Repeat treatment of obese mice with BRL 49653, a new and potent insulin sensitizer, enhances insulin action in white adipocyte
    • Young PW, Cawthorne MA, Coyle PJ, Holder JC, Holman GD, Kozka IJ, et al. Repeat treatment of obese mice with BRL 49653, a new and potent insulin sensitizer, enhances insulin action in white adipocyte. Diabetes 1995; 44: 1087-92.
    • (1995) Diabetes , vol.44 , pp. 1087-1092
    • Young, P.W.1    Cawthorne, M.A.2    Coyle, P.J.3    Holder, J.C.4    Holman, G.D.5    Kozka, I.J.6
  • 11
    • 0042093782 scopus 로고    scopus 로고
    • Activation of protein kinase C-zeta by insulin and phosphatidylinositol- 3,4,5(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: Amelioration by rosiglitazone and exercise
    • Beeson M, Sajan MP, Dazon M, Grebenev D, Gomez-Daspet J, Miura A, et al. Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4, 5(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: Amelioration by rosiglitazone and exercise. Diabetes 2003; 52: 1926-34.
    • (2003) Diabetes , vol.52 , pp. 1926-1934
    • Beeson, M.1    Sajan, M.P.2    Dazon, M.3    Grebenev, D.4    Gomez-Daspet, J.5    Miura, A.6
  • 12
    • 0037883037 scopus 로고    scopus 로고
    • Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients
    • Miyazaki Y, He H, Mandarino LJ, DeFronzo RA. Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients. Diabetes 2003; 52: 1943-50.
    • (2003) Diabetes , vol.52 , pp. 1943-1950
    • Miyazaki, Y.1    He, H.2    Mandarino, L.J.3    DeFronzo, R.A.4
  • 13
    • 7844240131 scopus 로고    scopus 로고
    • Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARgamma agonist) action
    • Zierath JR, Ryder JW, Doebber T, Woods J, Wu M, Ventre J, et al. Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARgamma agonist) action. Endocrinology 1998; 139: 5034-41.
    • (1998) Endocrinology , vol.139 , pp. 5034-5041
    • Zierath, J.R.1    Ryder, J.W.2    Doebber, T.3    Woods, J.4    Wu, M.5    Ventre, J.6
  • 14
    • 0035962077 scopus 로고    scopus 로고
    • Relation of gemfibrozil treatment and lipid levels with major coronary events. VA-HIT: A randomized controlled trial
    • Robins S, Collins D, Wittes J, Papademetriou V, Deedwania P, Schaefer E, et al. Relation of gemfibrozil treatment and lipid levels with major coronary events. VA-HIT: a randomized controlled trial. J Am Med Assoc 2001; 285: 1585-91.
    • (2001) J Am Med Assoc , vol.285 , pp. 1585-1591
    • Robins, S.1    Collins, D.2    Wittes, J.3    Papademetriou, V.4    Deedwania, P.5    Schaefer, E.6
  • 15
    • 0035941990 scopus 로고    scopus 로고
    • Effect of fenofibrate on progression of coronary artery disease in type 2 diabetes: The Diabetes Atherosclerosis Intervention Study, a randomised study
    • Diabetes Atherosclerosis Intervention Study Investigators. Effect of fenofibrate on progression of coronary artery disease in type 2 diabetes: The Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet 2001; 357: 905-10.
    • (2001) Lancet , vol.357 , pp. 905-910
  • 16
    • 0141517104 scopus 로고    scopus 로고
    • Synthesis and insulin-sensitizing activity of a novel kind of benzopyran derivative
    • Tang L, Yu J, Leng Y, Feng Y, Yang Y, Ji R. Synthesis and insulin-sensitizing activity of a novel kind of benzopyran derivative. Bioorg Med Chem Lett 2003; 13: 3437-40.
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 3437-3440
    • Tang, L.1    Yu, J.2    Leng, Y.3    Feng, Y.4    Yang, Y.5    Ji, R.6
  • 18
    • 3042638625 scopus 로고    scopus 로고
    • Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice
    • Haluzik M, Colombo C, Gavrilova O, Chua S, Wolf N, Chen M, et al. Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 2004; 145: 3258-64.
    • (2004) Endocrinology , vol.145 , pp. 3258-3264
    • Haluzik, M.1    Colombo, C.2    Gavrilova, O.3    Chua, S.4    Wolf, N.5    Chen, M.6
  • 19
    • 0036847135 scopus 로고    scopus 로고
    • AZ242, a novel PPARα/γ agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats
    • Ljung B, Bamberg K, Dahllof B, Kjellstedt A, Oakes ND, Ostling J, et al. AZ242, a novel PPARα/γ agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats. J Lipid Res 2002;43:1855-63.
    • (2002) J Lipid Res , vol.43 , pp. 1855-1863
    • Ljung, B.1    Bamberg, K.2    Dahllof, B.3    Kjellstedt, A.4    Oakes, N.D.5    Ostling, J.6
  • 21
    • 4744344777 scopus 로고    scopus 로고
    • Fatty acid-induced insulin resistance in l6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B
    • Sinha S, Perdomo G, Brown NF, O'Doherty RM. Fatty acid-induced insulin resistance in l6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. J Biol Chem 2004; 279: 41294-301.
    • (2004) J Biol Chem , vol.279 , pp. 41294-41301
    • Sinha, S.1    Perdomo, G.2    Brown, N.F.3    O'Doherty, R.M.4
  • 22
    • 0037406445 scopus 로고    scopus 로고
    • Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin
    • Wiegman CH, Bandsma RH, Ouwens M, van der Sluijs FH, Havinga R, Boer T, et al. Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin. Diabetes 2003; 52: 1081-9.
    • (2003) Diabetes , vol.52 , pp. 1081-1089
    • Wiegman, C.H.1    Bandsma, R.H.2    Ouwens, M.3    Van Der Sluijs, F.H.4    Havinga, R.5    Boer, T.6
  • 24
    • 0019762341 scopus 로고
    • The effect of insulin on the disposal of intravenvous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization
    • DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenvous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 1981; 30: 1000-7.
    • (1981) Diabetes , vol.30 , pp. 1000-1007
    • DeFronzo, R.A.1    Jacot, E.2    Jequier, E.3    Maeder, E.4    Wahren, J.5    Felber, J.P.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.