-
2
-
-
0026021161
-
Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease
-
DeFronzo RA, Ferrannnini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 1991; 14: 173-94.
-
(1991)
Diabetes Care
, vol.14
, pp. 173-194
-
-
DeFronzo, R.A.1
Ferrannnini, E.2
-
3
-
-
0030602866
-
The peroxisome proliferator activated receptors (PPARs) and then effects on lipid metabolism and adipocyte differentiation
-
Schoonjans K, Staels B, Auwerx J. The peroxisome proliferator activated receptors (PPARs) and then effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta 1996; 1302: 93-109.
-
(1996)
Biochim Biophys Acta
, vol.1302
, pp. 93-109
-
-
Schoonjans, K.1
Staels, B.2
Auwerx, J.3
-
5
-
-
0029791412
-
PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene
-
Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, Heyman RA, Briggs M, Deeb S, et al. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 1996; 15: 5336-48.
-
(1996)
EMBO J
, vol.15
, pp. 5336-5348
-
-
Schoonjans, K.1
Peinado-Onsurbe, J.2
Lefebvre, A.M.3
Heyman, R.A.4
Briggs, M.5
Deeb, S.6
-
6
-
-
0034064359
-
Distribution of peroxisome proliferators-activated receptors (PPARs) in human skeletal muscle and adipose tissue: Relation to insulin action
-
Loviscach M, Rehman N, Carter L, Mudaliar S, Mohadeen P, Ciaraldi TP, et al. Distribution of peroxisome proliferators-activated receptors (PPARs) in human skeletal muscle and adipose tissue: relation to insulin action. Diabetologia 2000; 43: 304-11.
-
(2000)
Diabetologia
, vol.43
, pp. 304-311
-
-
Loviscach, M.1
Rehman, N.2
Carter, L.3
Mudaliar, S.4
Mohadeen, P.5
Ciaraldi, T.P.6
-
7
-
-
0036183630
-
The mechanisms of action of PPARs
-
Berger J, Moller DE. The mechanisms of action of PPARs. Annu Rev Med 2002; 53: 409-35.
-
(2002)
Annu Rev Med
, vol.53
, pp. 409-435
-
-
Berger, J.1
Moller, D.E.2
-
8
-
-
0034595980
-
Peroxisome proliferators-activated receptor alpha activators improve insulin sensitivity and reduce adiposity
-
Guerre-Millo M, Gervois P, Raspe E, Madsen L, Poulain P, Derudas B, et al. Peroxisome proliferators-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 2000; 275: 16638-42.
-
(2000)
J Biol Chem
, vol.275
, pp. 16638-16642
-
-
Guerre-Millo, M.1
Gervois, P.2
Raspe, E.3
Madsen, L.4
Poulain, P.5
Derudas, B.6
-
9
-
-
0037238924
-
Recent advances in peroxisome proliferator-activated receptor science
-
Shearer BG, Hoekstra WJ. Recent advances in peroxisome proliferator-activated receptor science. Curr Med Chem 2003; 10: 267-80.
-
(2003)
Curr Med Chem
, vol.10
, pp. 267-280
-
-
Shearer, B.G.1
Hoekstra, W.J.2
-
10
-
-
0028884048
-
Repeat treatment of obese mice with BRL 49653, a new and potent insulin sensitizer, enhances insulin action in white adipocyte
-
Young PW, Cawthorne MA, Coyle PJ, Holder JC, Holman GD, Kozka IJ, et al. Repeat treatment of obese mice with BRL 49653, a new and potent insulin sensitizer, enhances insulin action in white adipocyte. Diabetes 1995; 44: 1087-92.
-
(1995)
Diabetes
, vol.44
, pp. 1087-1092
-
-
Young, P.W.1
Cawthorne, M.A.2
Coyle, P.J.3
Holder, J.C.4
Holman, G.D.5
Kozka, I.J.6
-
11
-
-
0042093782
-
Activation of protein kinase C-zeta by insulin and phosphatidylinositol- 3,4,5(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: Amelioration by rosiglitazone and exercise
-
Beeson M, Sajan MP, Dazon M, Grebenev D, Gomez-Daspet J, Miura A, et al. Activation of protein kinase C-zeta by insulin and phosphatidylinositol-3,4, 5(PO4)3 is defective in muscle in type 2 diabetes and impaired glucose tolerance: Amelioration by rosiglitazone and exercise. Diabetes 2003; 52: 1926-34.
-
(2003)
Diabetes
, vol.52
, pp. 1926-1934
-
-
Beeson, M.1
Sajan, M.P.2
Dazon, M.3
Grebenev, D.4
Gomez-Daspet, J.5
Miura, A.6
-
12
-
-
0037883037
-
Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients
-
Miyazaki Y, He H, Mandarino LJ, DeFronzo RA. Rosiglitazone improves downstream insulin receptor signaling in type 2 diabetic patients. Diabetes 2003; 52: 1943-50.
-
(2003)
Diabetes
, vol.52
, pp. 1943-1950
-
-
Miyazaki, Y.1
He, H.2
Mandarino, L.J.3
DeFronzo, R.A.4
-
13
-
-
7844240131
-
Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARgamma agonist) action
-
Zierath JR, Ryder JW, Doebber T, Woods J, Wu M, Ventre J, et al. Role of skeletal muscle in thiazolidinedione insulin sensitizer (PPARgamma agonist) action. Endocrinology 1998; 139: 5034-41.
-
(1998)
Endocrinology
, vol.139
, pp. 5034-5041
-
-
Zierath, J.R.1
Ryder, J.W.2
Doebber, T.3
Woods, J.4
Wu, M.5
Ventre, J.6
-
14
-
-
0035962077
-
Relation of gemfibrozil treatment and lipid levels with major coronary events. VA-HIT: A randomized controlled trial
-
Robins S, Collins D, Wittes J, Papademetriou V, Deedwania P, Schaefer E, et al. Relation of gemfibrozil treatment and lipid levels with major coronary events. VA-HIT: a randomized controlled trial. J Am Med Assoc 2001; 285: 1585-91.
-
(2001)
J Am Med Assoc
, vol.285
, pp. 1585-1591
-
-
Robins, S.1
Collins, D.2
Wittes, J.3
Papademetriou, V.4
Deedwania, P.5
Schaefer, E.6
-
15
-
-
0035941990
-
Effect of fenofibrate on progression of coronary artery disease in type 2 diabetes: The Diabetes Atherosclerosis Intervention Study, a randomised study
-
Diabetes Atherosclerosis Intervention Study Investigators. Effect of fenofibrate on progression of coronary artery disease in type 2 diabetes: The Diabetes Atherosclerosis Intervention Study, a randomised study. Lancet 2001; 357: 905-10.
-
(2001)
Lancet
, vol.357
, pp. 905-910
-
-
-
16
-
-
0141517104
-
Synthesis and insulin-sensitizing activity of a novel kind of benzopyran derivative
-
Tang L, Yu J, Leng Y, Feng Y, Yang Y, Ji R. Synthesis and insulin-sensitizing activity of a novel kind of benzopyran derivative. Bioorg Med Chem Lett 2003; 13: 3437-40.
-
(2003)
Bioorg Med Chem Lett
, vol.13
, pp. 3437-3440
-
-
Tang, L.1
Yu, J.2
Leng, Y.3
Feng, Y.4
Yang, Y.5
Ji, R.6
-
17
-
-
2342644036
-
Antidiabetic and hypolipidemic potential of DRF 2519-a dual activator of PPAR-alpha and PPAR-gamma
-
Chakrabarti R, Misra P, Vikramadithyan RK, Premkumar M, Hiriyan J, Datla SR, et al. Antidiabetic and hypolipidemic potential of DRF 2519-a dual activator of PPAR-alpha and PPAR-gamma. Eur J Pharmacol 2004; 491: 195-206.
-
(2004)
Eur J Pharmacol
, vol.491
, pp. 195-206
-
-
Chakrabarti, R.1
Misra, P.2
Vikramadithyan, R.K.3
Premkumar, M.4
Hiriyan, J.5
Datla, S.R.6
-
18
-
-
3042638625
-
Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice
-
Haluzik M, Colombo C, Gavrilova O, Chua S, Wolf N, Chen M, et al. Genetic background (C57BL/6J versus FVB/N) strongly influences the severity of diabetes and insulin resistance in ob/ob mice. Endocrinology 2004; 145: 3258-64.
-
(2004)
Endocrinology
, vol.145
, pp. 3258-3264
-
-
Haluzik, M.1
Colombo, C.2
Gavrilova, O.3
Chua, S.4
Wolf, N.5
Chen, M.6
-
19
-
-
0036847135
-
AZ242, a novel PPARα/γ agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats
-
Ljung B, Bamberg K, Dahllof B, Kjellstedt A, Oakes ND, Ostling J, et al. AZ242, a novel PPARα/γ agonist with beneficial effects on insulin resistance and carbohydrate and lipid metabolism in ob/ob mice and obese Zucker rats. J Lipid Res 2002;43:1855-63.
-
(2002)
J Lipid Res
, vol.43
, pp. 1855-1863
-
-
Ljung, B.1
Bamberg, K.2
Dahllof, B.3
Kjellstedt, A.4
Oakes, N.D.5
Ostling, J.6
-
20
-
-
21044433343
-
Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPARgamma agonists
-
Cha BS, Ciaraldi TP, Park KS, Carter L, Mudaliar SR, Henry RR. Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPARgamma agonists. Am J Physiol Endocrinol Metab 2005; 289: E151-9.
-
(2005)
Am J Physiol Endocrinol Metab
, vol.289
-
-
Cha, B.S.1
Ciaraldi, T.P.2
Park, K.S.3
Carter, L.4
Mudaliar, S.R.5
Henry, R.R.6
-
21
-
-
4744344777
-
Fatty acid-induced insulin resistance in l6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B
-
Sinha S, Perdomo G, Brown NF, O'Doherty RM. Fatty acid-induced insulin resistance in l6 myotubes is prevented by inhibition of activation and nuclear localization of nuclear factor kappa B. J Biol Chem 2004; 279: 41294-301.
-
(2004)
J Biol Chem
, vol.279
, pp. 41294-41301
-
-
Sinha, S.1
Perdomo, G.2
Brown, N.F.3
O'Doherty, R.M.4
-
22
-
-
0037406445
-
Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin
-
Wiegman CH, Bandsma RH, Ouwens M, van der Sluijs FH, Havinga R, Boer T, et al. Hepatic VLDL production in ob/ob mice is not stimulated by massive de novo lipogenesis but is less sensitive to the suppressive effects of insulin. Diabetes 2003; 52: 1081-9.
-
(2003)
Diabetes
, vol.52
, pp. 1081-1089
-
-
Wiegman, C.H.1
Bandsma, R.H.2
Ouwens, M.3
Van Der Sluijs, F.H.4
Havinga, R.5
Boer, T.6
-
23
-
-
23844470219
-
Pharmacological profile of a novel, non-TZD PPARgamma agonist
-
Chen X, Osborne MC, Rybczynski PJ, Zeck R, Yang M, Xu J, et al. Pharmacological profile of a novel, non-TZD PPARgamma agonist. Diabetes Obes Metab 2005; 7: 536-46.
-
(2005)
Diabetes Obes Metab
, vol.7
, pp. 536-546
-
-
Chen, X.1
Osborne, M.C.2
Rybczynski, P.J.3
Zeck, R.4
Yang, M.5
Xu, J.6
-
24
-
-
0019762341
-
The effect of insulin on the disposal of intravenvous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization
-
DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenvous glucose. Results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 1981; 30: 1000-7.
-
(1981)
Diabetes
, vol.30
, pp. 1000-1007
-
-
DeFronzo, R.A.1
Jacot, E.2
Jequier, E.3
Maeder, E.4
Wahren, J.5
Felber, J.P.6
|