Effects of serotonin transporter promoter and BDNF Val66Met genotype on personality traits in a population representative sample of adolescents

Psychiatric Genetics

Volumn 21, Issue 5, 2011, Pages 261-264

  Hiio, Kelli ^a   Merenäkk, Liis ^a   Nordquist, Niklas ^d   Parik, Jüri ^b   Oreland, Lars ^d   Veidebaum, Toomas ^c   Harro, Jaanus ^a  

^a UNIVERSITY OF TARTU   (Estonia)

^b UNIVERSITY OF TARTU   (Estonia)

^c NATIONAL INSTITUTE FOR HEALTH DEVELOPMENT   (Estonia)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

5 HTTLPR; BDNF Val66Met; five factor model; gene gene interaction; personality

Indexed keywords

5 HTTLPR PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; PEPTIDES AND PROTEINS; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ADOLESCENCE; ARTICLE; BEHAVIOR; ESTONIA; FEMALE; GENE INTERACTION; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PERSONALITY; PERSONALITY TEST; PRIORITY JOURNAL; PROMOTER REGION;

ADOLESCENT; ALLELES; AMINO ACID SUBSTITUTION; BRAIN-DERIVED NEUROTROPHIC FACTOR; FEMALE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MALE; PERSONALITY; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 80052460607     PISSN: 09558829     EISSN: 14735873     Source Type: Journal    
DOI: 10.1097/YPG.0b013e32834371e8     Document Type: Article

References (34)

1. Akkermann K, Hiio K, Villa I, Harro J (2011). Food restriction leads to binge eating dependent upon the effect of the brain-derived neurotrophic factor Val66Met polymorphism. Psychiatry Res 185:39-43.
2. Bouchard TJ, Loehlin JC (2001). Genes, evolution, and personality. Behav Genet 31:243-273. (Pubitemid 33026085)
3. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H, et al. (2003). Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301:386-389. (Pubitemid 36877077)
4. Costa PT, McCrae RR (1992). Revised NEO personality inventory [NEO-PI-R] and the NEO five-factor inventory [NEO-FFI] professional manual. Florida, Odessa: Psychological Assessment Resources.
5. Cuttler C, Graf P (2007). Personality predicts prospective memory task performance: an adult lifespan study. Scand J Psychol 48:215-231.
6. Dougherty LR, Klein DN, Congdon E, Canli T, Hayden EP (2010). Interaction between 5-HTTLPR and BDNF Val66Met polymorphisms on HPA axis reactivity in preschoolers. Biol Psychol 83:93-100.
7. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. (2003). The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257-269. (Pubitemid 36144114)
8. Friedman HS, Tucker JS, Tomlinson-Keasey C, Schwartz JE, Wingard DL, Criqui MH (1993). Does childhood personality predict longevity. J Pers Soc Psychol 65:176-185.
9. Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, et al. (2003). Brain-derived neurotrophic factor val(66)met polymorphism affects human memory-related hippocampal activity and predicts memory performance. J Neurosci 23:6690-6694. (Pubitemid 36951196)
10. Harro M, Eensoo D, Kiive E, Merenäkk L, Alep J, Oreland L, et al. (2001). Platelet monoamine oxidase in healthy 9-and 15-years old children: the effect of gender, smoking and puberty. Prog Neuropsychopharmacol Biol Psychiatry 25:1497-1511. (Pubitemid 33042693)
11. Harro J, Merenäkk L, Nordquist N, Konstabel K, Comasco E, Oreland L (2009). Personality and the serotonin transporter gene: associations in a longitudinal population-based study. Biol Psychol 81:9-13.
12. Hünnerkopf R, Strobel A, Gutknecht L, Brocke B, Lesch KP (2007). Interaction between BDNF Val66Met and dopamine transporter gene variation influences anxiety-related traits. Neuropsychopharmacology 32:2552-2560. (Pubitemid 350126836)
13. Itoh K, Hashimoto K, Kumakiri C, Shimizu E, Iyo M (2004). Association between brain-derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy subjects. Am J Med Genet B Neuropsychiatr Genet 124B:61-63. (Pubitemid 38031595)
14. Jang KL, Livesley WJ, Vernon PA (1996). Heritability of the big five personality dimensions and their facets: a twin study. J Pers 64:577-591. (Pubitemid 126443604)
15. Kallasmaa T, Allik J, Realo A, McCrae RR (2000). The Estonian version of the NEO-PI-R: an examination of universal and culture-specific aspects of the five-factor model. Eur J Pers 14:265-278.
16. Kaufman J, Yang BZ, Douglas-Palumberi H, Grasso D, Lipschitz D, Houshyar S, et al. (2006). Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry 59:673-680.
17. Khan AA, Jacobson KC, Gardner CO, Prescott CA, Kendler KS (2005). Personality and comorbidity of common psychiatric disorders. Br J Psychiatry 186:190-196. (Pubitemid 40343811)
18. Kim JM, Stewart R, Kim SW, Yang SJ, Shin IS, Kim YH, et al. (2007). Interactions between life stressors and susceptibility genes (5-HTTLPR and BDNF) on depression in Korean elders. Biol Psychiatry 62:423-428. (Pubitemid 47284032)
19. Lesch K-P, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527-1531. (Pubitemid 26403928)
20. Mäestu J, Allik J, Merenäkk L, Eensoo D, Parik J, Veidebaum T, et al. (2008). Associations between an alpha 2a adrenergic receptor gene polymorphism and adolescent personality. Am J Med Genet B Neuropsychiatr Genet 147B:418-423. (Pubitemid 351830797)
21. Martinowich K, Lu B (2008). Interaction between BDNF and serotonin: role in mood disorders. Neuropsychopharmacology 33:73-83. (Pubitemid 350191318)
22. Mõttus R, Pullmann H, Allik J (2006). Toward more readable Big Five personality inventories. Eur J Psychol Assess 22:149-157. (Pubitemid 43944300)
23. Osher Y, Hamer D, Benjamin J (2000). Association and linkage of anxiety-related traits with a functional polymorphism of the serotonin transporter gene regulatory region in Israeli sibling pairs. Molecular Psychiatry 5:216-219. (Pubitemid 30229440)
24. Paaver M, Nordquist N, Parik J, Harro M, Oreland L, Harro J (2007). Platelet MAO activity and the 5-HTT gene promoter polymorphism are associated with impulsivity and cognitive style in visual information processing. Psychophar-macology (Berl) 194:545-554. (Pubitemid 47492997)
25. Pezawas L, Verchinski BA, Mattay VS, Callicott JH, Kolachana BS, Straub RE, et al. (2004). The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology. J Neurosci 24:10099-10102. (Pubitemid 39492034)
26. Pezawas L, Meyer-Lindenberg A, Goldman AL, Verchninski BA, Chen G, Kolachana BS, et al. (2008). Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression. Mol Psychiatry 13:709-716. (Pubitemid 351861533)
27. Ren-Patterson RF, Cochran LW, Holmes A, Sherrill S, Huang SJ, Tolliver T, et al. (2005). Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiencies and increases stress abnormalities of serotonin transporter knockout mice. J Neurosci Res 79:756-771. (Pubitemid 40476500)
28. Riemann R, Angleitner A, Strelau J (1997). Genetic and environmental influences on personality: a study of twins reared together using the self-and peer report NEO-FFI scales. J Pers 65:449-475.
29. Sen S, Nesse RM, Stoltenberg SF, Li S, Gleiberman L, Chakravarti A, et al. (2003). A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsycho- pharmacology 28:397-401.
30. Sjöberg RL, Nilsson KW, Nordquist N, Ohrvik J, Leppert J, Lindstrom L, et al. (2006). Development of depression: sex and the interaction between environment and a promoter polymorphism of the serotonin transporter gene. Int J Neuropsychopharmacol 9: 443-449. (Pubitemid 43979704)
31. Tochigi M, Otowa T, Suga M, Rogers M, Minato T, Yamasue H, et al. (2006). No evidence for an association between the BDNF Val66Met polymorphism and schizophrenia or personality traits. Schizophr Res 87:45-47. (Pubitemid 44428136)
32. Tsai S-J, Hong CJ, Younger WYY, Tai-Jui Chen A (2004). Association study of a brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and personality trait and intelligence in healthy young females. Neuropsychobiology 49:13-16. (Pubitemid 38134862)
33. Uher R, McGuffin P (2010). The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol Psychiatry 15:18-22.
34. Willis-Owen SAG, Fullerton J, Surtees PG, Wainwright NWJ, Miller S, Flint J (2005). The val66met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism. Biol Psychiatry 58:738-742. (Pubitemid 41547242)