Insight into thyroid-stimulating autoantibody interaction with the thyrotropin receptor N-terminus based on mutagenesis and re-evaluation of ambiguity in this region of the receptor crystal structure

Thyroid

Volumn 21, Issue 9, 2011, Pages 1013-1020

  Hamidi, Sepehr ^a,b   Chen, Chun Rong ^a,b   McLachlan, Sandra M ^a,b   Rapoport, Basil ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; DISULFIDE; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; THYROID STIMULATING IMMUNOGLOBULIN; THYROTROPIN RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL MEMBRANE; CELL TYPE; CONTROLLED STUDY; CRYSTAL STRUCTURE; FEMALE; FLOW CYTOMETRY; GENE DELETION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; BINDING SITES, ANTIBODY; CHO CELLS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY; EPITOPE MAPPING; EPITOPES; FLOW CYTOMETRY; IMMUNOGLOBULINS, THYROID-STIMULATING; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECEPTORS, THYROTROPIN; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 80052450356     PISSN: 10507256     EISSN: 15579077     Source Type: Journal    
DOI: 10.1089/thy.2011.0147     Document Type: Article

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