Expression of dominant negative TGF-β receptors inhibits cartilage formation in conditional transgenic mice

Journal of Bone and Mineral Metabolism

Volumn 29, Issue 4, 2011, Pages 493-500

  Hiramatsu, Kunihiko ^a   Iwai, Takao ^a   Yoshikawa, Hideki ^a   Tsumaki, Noriyuki ^a,b  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

Bone morphogenetic protein; Chondrocytes; Col11a2; Development; Endochondral bone formation

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CRE RECOMBINASE; LUCIFERASE; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARTILAGE CELL; CELLULAR DISTRIBUTION; COLLAGEN TYPE 11A2 GENE; COLLAGEN TYPE 2A1 GENE; CONTROLLED STUDY; DOMINANT GENE; EMBRYO; ENZYME ACTIVITY; GENE; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IN VITRO STUDY; INTRACELLULAR SIGNALING; LIMB; LOXP SITE; MESENCHYME CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RECEPTOR GENE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1 GENE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2 GENE; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; CARTILAGE; CERCOPITHECUS AETHIOPS; CHONDROGENESIS; COS CELLS; GENES, DOMINANT; IMMUNOHISTOCHEMISTRY; LUCIFERASES; MICE; MICE, TRANSGENIC; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SMAD PROTEINS; TRANSGENES;

EID: 80052450127     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-010-0248-2     Document Type: Article

References (21)

1. Kronenberg HM (2006) PTHrP and skeletal development. Ann N Y Acad Sci 1068:1-13 (Pubitemid 43824131)
2. Olsen BR, Reginato AM, Wang W (2000) Bone development. Annu Rev Cell Dev Biol 16:191-220 (Pubitemid 32037505)
3. Miyazono K, Kusanagi K, Inoue H (2001) Divergence and convergence of TGF-beta/BMP signaling. J Cell Physiol 187: 265-276
4. Massague J, Seoane J, Wotton D (2005) Smad transcription factors. Genes Dev 19:2783-2810 (Pubitemid 41739965)
5. Larsson J, Goumans MJ, Sjostrand LJ, van Rooijen MA, Ward D, Leveen P, Xu X, ten Dijke P, Mummery CL, Karlsson S (2001) Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice. EMBO J 20:1663-1673 (Pubitemid 32299403)
6. Oshima M, Oshima H, Taketo MM (1996) TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev Biol 179:297-302 (Pubitemid 26363265)
7. Seo HS, Serra R (2007) Deletion of Tgfbr2 in Prx1-cre expressing mesenchyme results in defects in development of the long bones and joints. Dev Biol 310:304-316 (Pubitemid 47483680)
8. Spagnoli A, O'Rear L, Chandler RL, Granero-Molto F, Mortlock DP, Gorska AE, Weis JA, Longobardi L, Chytil A, Shimer K, Moses HL (2007) TGF-beta signaling is essential for joint morphogenesis. J Cell Biol 177:1105-1117 (Pubitemid 46955713)
9. Matsunobu T, Torigoe K, Ishikawa M, de Vega S, Kulkarni AB, Iwamoto Y, Yamada Y (2009) Critical roles of the TGF-beta type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development. Dev Biol 332:325-338
10. Baffi MO, Slattery E, Sohn P, Moses HL, Chytil A, Serra R (2004) Conditional deletion of the TGF-beta type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones. Dev Biol 276:124-142 (Pubitemid 39452851)
11. Burdette JE, Jeruss JS, Kurley SJ, Lee EJ, Woodruff TK (2005) Activin A mediates growth inhibition and cell cycle arrest through Smads in human breast cancer cells. Cancer Res 65: 7968-7975 (Pubitemid 41297276)
12. Katagiri T, Imada M, Yanai T, Suda T, Takahashi N, Kamijo R (2002) Identification of a BMP-responsive element in Id1, the gene for inhibition of myogenesis. Genes Cells 7:949-960
13. Iwai T, Murai J, Yoshikawa H, Tsumaki N (2008) Smad7 Inhibits chondrocyte differentiation at multiple steps during endochondral bone formation and down-regulates p38 MAPK pathways. J Biol Chem 283:27154-27164
14. Tsumaki N, Kimura T, Matsui Y, Nakata K, Ochi T (1996) Separable cis-regulatory elements that contribute to tissue- and site-specific alpha 2(XI) collagen gene expression in the embryonic mouse cartilage. J Cell Biol 134:1573-1582 (Pubitemid 26318028)
15. Logan M, Martin JF, Nagy A, Lobe C, Olson EN, Tabin CJ (2002) Expression of Cre recombinase in the developing mouse limb bud driven by a Prxl enhancer. Genesis 33:77-80 (Pubitemid 34651279)
16. Peters PWJ (1997) In: Neuberg HJMD, Kwasigroch TE (eds) Methods in prenatal toxicology. Thieme, Stuttgart, pp 153-154
17. Maeda S, Hayashi M, Komiya S, Imamura T, Miyazono K (2004) Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J 23:552-563 (Pubitemid 38282387)
18. Montero JA, Lorda-Diez CI, Ganan Y, Macias D, Hurle JM (2008) Activin/TGF-beta and BMP crosstalk determines digit chondrogenesis. Dev Biol 321:343-356
19. Furumatsu T, Tsuda M, Taniguchi N, Tajima Y, Asahara H (2005) Smad3 induces chondrogenesis through the activation of SOX9 via CREB-binding protein/p300 recruitment. J Biol Chem 280:8343-8350 (Pubitemid 40349737)
20. Stanton LA, Underhill TM, Beier F (2003) MAP kinases in chondrocyte differentiation. Dev Biol 263:165-175 (Pubitemid 37338601)
21. Shim JH, Greenblatt MB, Xie M, Schneider MD, Zou W, Zhai B, Gygi S, Glimcher LH (2009) TAK1 is an essential regulator of BMP signalling in cartilage. EMBO J 28:2028-2041