Cell death induced by the Jak2 inhibitor, G6, correlates with cleavage of vimentin filaments

Biochemistry

Volumn 50, Issue 36, 2011, Pages 7774-7786

  Majumder, Anurima ^a   Kirabo, Annet ^a   Karrupiah, Kanchana ^a   Tsuda, Shigeharu ^a   Caldwell Busby, Jennifer ^b   Cardounel, Arturo J ^a   Keseru, György M ^c   Sayeski, Peter P ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMICAL MECHANISMS; CELL VIABILITY; CELLULAR PROLIFERATIONS; DOSE-DEPENDENT; ELECTROSPRAY MASS SPECTROSCOPY; HUMAN DISEASE; IN-VIVO; INTACT CELLS; INTERMEDIATE FILAMENTS; INTRACELLULAR CALCIUM MOBILIZATION; KINASE ACTIVITY; MOUSE MODELS; PATHOGENIC CELLS; PATHOLOGICAL CELLS; PROTEIN EXPRESSION PROFILES; STRUCTURE-BASED; TWO-DIMENSIONAL GEL ELECTROPHORESIS; TYROSINE KINASE; VEHICLE CONTROL; VIMENTIN; VIRTUAL SCREENING;

AMINO ACIDS; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CONTROL SYSTEM SYNTHESIS; ELECTROPHORESIS; ENZYMES; GROWTH KINETICS; MAMMALS; MASS SPECTROMETRY;

PROTEINS;

CALPAIN; DIMETHYL SULFOXIDE; JANUS KINASE 2 INHIBITOR; VIMENTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM MOBILIZATION; CELL DEATH; CELL DISRUPTION; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOLYSIS; DRUG INHIBITION; ELECTROSPRAY MASS SPECTROMETRY; ERYTHROLEUKEMIA; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TREATMENT OUTCOME; TWO DIMENSIONAL GEL ELECTROPHORESIS; WESTERN BLOTTING;

ANIMALS; CALPAIN; CELL DEATH; CELL LINE, TUMOR; HUMANS; JANUS KINASE 2; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MICE; MICE, INBRED NOD; MICE, SCID; PROTEIN KINASE INHIBITORS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STILBENES; VIMENTIN;

EID: 80052433119     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200847n     Document Type: Article

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