Neurophysiology of micturition

Female Urology, Urogynecology, and Voiding Dysfunction

Volumn , Issue , 2004, Pages 23-43

  Ghoniem, Gamal M ^a   Hairston, John C ^b  

^a DEPARTMENT OF COLORECTAL SURGERY   (United States)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80052431019     PISSN: None     EISSN: None     Source Type: Book    
DOI: None     Document Type: Chapter

References (95)

1. Zderic SA, Levin RM, Wein AJ. Voiding function and dysfunction. In: Gillenwater JY, Grayhack JT, Howards SS, Duckett JW, eds. Adult and Pediatric Urology. 4th ed. Baltimore: Lippincott Williams & Wilkins, 2002.
2. Keith LM. Anatomy of the pelvis and perineum. In: Clinically Oriented Anatomy. 2nd ed. Baltimore:Williams & Wilkins, 1985:359-403.
3. Clemente C, ed. Gray’s Anatomy of the Human Body. 30th American ed. Philadelphia: Lea & Febiger, 1985.
4. Romanes GJ. Muscles and fascia. In: Cunningham’s Textbook of Anatomy. Oxford: Oxford University Press, 1972:360-364.
5. Mitchell BS. Morphology and neurochemistry of the pelvic, and paracervical ganglia. Histol Histopathol 1993; 8(4):761-773.
6. Gilepsie L. Destruction of the vesicoureteric plexus for the treatment of hypersensitive bladder disorders. Br J Urol 1994; 74:40.
7. Elbadawi A. Neuromorphologic basis of vesicouretheral function. I. Histochemistry, ultastructure and function of intrinsic nerves of the bladder and urethra. Neurourol Urodyn 1982; 1:3.
8. Elbadawi A. Autonomic muscular innervation of the vesical outlet and its role in micturition. In: Hinman FJ, ed. Benign Prostatic Hypertrophy. Berlin: Springer-Verlag, 1983:330-348.
9. Elbadawi A. Ultrastructure of vesicourethral innervation. II. Postganglionic axoaxonal synapses in intrinsic innervation of the vesicourethral lissosphincter. A new structural and functional concept in micturition. J Urol 1984; 131:781.
10. Elbadawi A. Ultrastructure of vesicourethral innervation. III. Anoaxonal synapses between postganglionic cholinergic axons and probably SIF cell derived processes in the feline lissosphincter. J Urol 1985; 133:524.
11. Elbadawi A. Ultrastructure of vesicourethral innervation. IV. Evidence for somatomotor plus autonomic innervation of the male feline rhabdosphincter. Neurourol Urodyn 1985; 4:23.
12. Kakizaki H, Koyanagi T, Kato M. Sympathetic innervation of the male feline urethra rhabdosphincter. Neurosci Lett 1991; 129:165-167.
13. Hollabaugh RS, Steiner MS, Dmochowski RR. Neuroanatomy of the female continence complex:clinical implications. Urology 2001; 57(2):382-388.
14. Kakizaki H, Fraser MO, De Groat WC. Reflex pathways controlling urethral striated and smooth muscle function in the male rat. Am J Physiol 1997; 272(5 Pt 2):1647-1656.
15. Wang P, Luthin GR, Ruggieri MR. Muscarinic acetylcholine receptor subtypes mediating urinary bladder contractility and coupling to GTP binding proteins. J Pharmacol Exp Ther 1995; 273:959-956.
16. Hegde SS, Choppin A, Bonhaus D, Briaud S, Loeb M. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol 1997; 120:1409-1418.
17. Somogyi GT, De Groat WC. Functional, signal transduction mechanisms, and plasticity of presynaptic muscarinic receptors in the urinary bladder. Life Sci 1998; 64:411-418.
18. Tobin G, Sjogren C. Prejunctional facilitatory and inhibitory modulation of parasympathetic nerve transmission in the rabbit urinary bladder. J Auton Nerv Syst 1998; 68:153-156.
19. Hills CJ, Winter SA, Balfour JA. Tolterodine. Drugs 1998; 55:813-820.
20. 3H]darifenacin as a novel radioligand for the study of M3 receptors. J Recept Signal Transduct Res 1997; 17:177-184.
21. Dykstra DD, Sidi AA, Scott AB, Pagel JM, Goldish GD. Effects of botulinum A toxin on detrusorsphincter dyssnergia in spinal cord patients. J Urol 1988; 139:919-922.
22. Stohrer M, Schurch B, Kramer G, Schmid D, Daul D, Hauri D. Botulinum A-toxin detrusor injections in the treatment of detrusor hyperreflexia. J Urol 2000; 163:244A. Abstract.
23. 3H]acetylcholine release in the rat urinary bladder. J Pharm Exp Ther 1986; 239:522.
24. Mattiasson A, Andersson KE, Elbadawi A. Interaction between adrenergic and cholinergic nerve terminals in the urinary bladder of rabbit, cat and man. J Urol 1987; 137:1017.
25. 3H-acetylcholine secretion in the guinia pig urinary bladder in vitro. J Pharmacol Exp Ther 1995; 274:458-468.
26. Sogbein SK, Downie JW, Awad SA. Urethral response during bladder contraction induced by subcutaneous bethanechol chloride: elicitation of sympathetic reflex constriction. J Urol 1984; 131:791.
27. Testa R, Guarneri L, Ibba M. Characterization of the alpha-1 adrenoceptor subtypes in the prostate and prostatic urethra of rat, rabbit, dog and man. Eur J Pharmacol 1993; 249:307-315.
28. Chess-Williams R, Aston N, Couldwell C. Alpha-1A subtype mediates contraction of the rat urethra. J Auton Pharmacol 1994; 14:375-381.
29. Andersson KE. Pharmacology of lower urinary tract smooth muscle and penile erectile tissues. Pharmacol Rev 1993; 45:253-307.
30. Treatment of urinary incontinence. Urinary Incontinence in Adults. Clinical Practice Guideline. U.S. Department of Health and Human Services, Public Health Service, Agency for Health Care Policy and Research. March 1992:27-65.
31. 1 adrenoceptors. Eur Urol 1999; 36(suppl 1):68-73.
32. 1 adrenoceptors. Br J Pharmacol 2000; 130:1685-1691.
33. 1 adrenoceptors. Br J Pharmacol 1996; 117:962-966.
34. Castleden CM, Morgan B. The effect of beta-adrenoceptor agonists on urinary incontinence in the elderly. Br J Clin Pharmacol 1980; 10(6):619.
35. De Groat WC, Lalley PM. Reflex firing in lumbar sympathetic outflow to activation of vesical afferent fibers. J Physiol 1972; 226:289.
36. Blaivas JG, Labib KL, Bauer SB, Retik AB. A new approach to electromyography of the external urethral sphincter. J Urol 1977; 117:773.
37. Edvardsen P. Nervous control of urinary bladder in cats. I. The collecting phase. Acta Physiol Scand 1968; 72(1):157-171.
38. Edvardsen P. Sympathetic inhibition of the urinary bladder. Electroencephalogr Clin Neurophysiol 1968; 24(1):91.
39. Skehan AM, Downie JW, Awad SA. Control of detrusor stiffness in the chronic decentralized feline bladder. J Urol 1993; 149(5):1165-1173.
40. Skehan AM, Downie JW, Awad SA. The pathophysiology of contractile activity in the chronic decentralized feline bladder. J Urol 1993; 149(5):1156-1164.
41. Burnstock G. Dumsday B, Smythe A. Atropine-resistant excitation of the urinary bladder: possibility of transmission via nerves releasing a purine nucleotide. Br J Pharmacol 1972; 44:451.
42. Bolego C, Pinna C, Abbracchio MP, Catabeni F, Puglisi L. Br J Pharmacol 1995; 114:1557-1562.
43. Klarskov P, Gerstenberg T, Hald T. Vasoactive intestinal polypeptide influence on lower urinary tract smooth muscle from human and pig. J Urol 1984; 131:1000.
44. Cardozo LD, Stanton SL. A comparison between bromocriptine and indomethacin in the treatment of detrusor instability. J Urol 1980; 123:399-401.
45. Kinder RB, Mundy AR. Atropine blockade of nerve-mediated stimulation of the human detrusor. Br J Urol 1985; 57(4):418-421.
46. Bayliss M, Wu C, Newgreen D, Mundy AR, Fry CH. A quantitative study of atropine-resistant contractile responses in human detrusor smooth muscle, from stable, unstable and obstructed bladders. J Urol 1999; 162(5):1833-1839.
47. Ghoniem GM, Shoukry MS, Hassouna ME. Detrusor properties in myelomeningocele patients:in vitro study. J Urol 1998; 159:2193-2196.
48. Levin RM, Ruggieri MR, Wein AJ. Functional effects of the purinergic innervation of the rabbit urinary bladder. J Pharmacol Exp Ther 1986; 236:432.
49. Chancellor MB, Kaplan SA, Blaivas JG. The cholinergic and purinergic components of detrusor contractility in a whole rabbit bladder model. J Urol 1992; 148:906-909.
50. Sneddon P, McLees A. Purinergic and cholinergic contractions in adult and neonatal rabbit bladder. Eur J Pharmacol 1992; 214:7-12.
51. Theobald RJ. Purinergic and cholinergic components of bladder contractility and flow. Life Sci 1995; 56:445-454.
52. Igawa Y, Mattiasson A, Andersson KE. Functional importance of cholinergic and purinergic neurotransmission for micturition contraction in the normal unanesthetized rat. Br J Pharmacol 1993; 109:473-479.
53. De Groat WC, Yoshimura N. Pharmacology of the lower urinary tract. Annu Rev Pharmacol Toxicol 2001; 41:691-721.
54. Lee HY, Bardini M, Burnstock G. Distribution of P2X receptors in the urinary bladder and the ureter of the rat. J Urol 2000; 163:2002-2007.
55. O’Reilly MA, Kosaka AH, Knight GF, Chang TK, Ford A, Rymer JM, Popert R, Burnstock G, McMahon SB. P2X receptors and their role in female idiopathic detrusor instability. J Urol 2002; 167:157-164.
56. Ralevic V, Burnstock G. Receptors for purines and pyrimidines. Pharmacol Rev 1998; 50:413-492.
57. Namasivayam S, Eardley I, Morrison JFB. Purinergic sensory neurotransmission in the urinary bladder: an in vivo study in the rat. Br J Urol Int 1999; 84:854-860.
58. Dmitrieva N, Burnstock G, McMahon SB. ATP and 2-methyl thio ATP activate bladder reflexes and induce discharge of bladder sensory neurons. Soc Neurosci Abstr 1998; 24:2088.
59. Yoshimura N, Sasa M, Yoshida O, Takaori S. Dopamine D1 receptor-mediated inhibition of micturition reflex by central dopamine from the substantia nigra. Neurourol Urodyn 1992; 11:535-545.
60. Yoshimura N. Mizuta E, Kuno S, Sasa M, Yoshida O. The dopamine D1 receptor agonist SKF 38393 suppresses detrusor hyperreflexia in the monkey with Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Neuropharmacology 1993; 32:315-321.
61. Araki I, Kitahara M, Oida T, Kuno S. Voiding dysfunction and Parkinson’s disease: urodynamic abnormalities and urinary symptoms. J Urol 2000; 164:1640-1643.
62. De Groat WC, Booth AM, Yoshimura N. Neurophysiology of micturition and its modification in animal models of human disease. In: Maggi CA, ed. The Autonomic Nervous System. Vol 3. Nervous Control of the Urogenital System. London: Harwood, 1993:227-290.
63. Kuno S, De Groat WC, Yoshimura N. Dopaminergic mechanisms underlying bladder hyperactivity in rats with unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway. Soc Neurosci Abstr 1999; 25:1686.
64. McMahon SB, Spillane K. Brain stem influences on the parasympathetic supply to the urinary bladder of the cat. Brain Res 1982; 234:237-249.
65. Steers WD, De Groat WC. Effects of m-chlorophenylpiperazine on penile and bladder function in rats. Am J Physiol Regul Integr Comp Physiol 1989; 257:R1441-R1449.
66. Andersson KE. Changes in bladder tone during filling: pharmacological aspects. Scand J Urol Nephrol Suppl 1999; 201:67-72.
67. 4 receptors in the human isolated detrusor muscle: effects of indole, benzimidazolone and substituted benzamide agonists and antagonists. Br J Pharmacol 1996; 118:1965-1970.
68. Espey MJ, Du HJ, Downie JW. Serotonergic modulation of spinal ascending activity and sacral reflex activity evoked by pelvic nerve stimulation in cats. Brain Res 1998; 798:101-108.
69. 2 receptor-mediated facilitation of pudendal nerve reflexes in the anaesthetized cat. Br J Pharmacol 1996; 118:150-154.
70. Araki I, De Groat WC. Unitary excitatory synaptic currents in preganglionic neurons mediated by two distinct groups of interneurons in neonatal rat sacral parasympathetic nucleus. J Neurophysiol 1996; 76:215-226.
71. Matsumoto G, Hisamitsu T, De Groat WC. Non-NMDA glutaminergic excitatory transmission in the descending limb of the spinobulbospinal micturition reflex pathway in the rat. Brain Res 1995; 693:246-250.
72. Yoshiyama M, Roppolo JR, De Groat WC. Effects of LY215490, a competitive a-amino-3-hydoxy-5- methylisooxazole-4-propionic acid (AMPA) receptor antagonist, on the micturition reflex in the rat. J Pharmacol Exp Ther 1997; 280:894-904.
73. Kontani H, Kawabata Y, Koshiura R. In vivo effects of g-aminobutyric acid on the urinary bladder contraction accompanying micturition. Jpn J Pharmacol 1987; 45:45-53.
74. McMahon SB. Sensory-motor integration in urinary bladder function. In: Cervero F, Morrison JFB, eds. Visceral Sensation. Amsterdam: Elsevier Science, 1986:245-283.
75. Hulsebosch CE, Coggeshall RE. An analysis of the axon populations in the nerves to the pelvic viscera in the rat. J Comp Neurol 1982; 211:1.
76. Yoshimura N, De Groat WC. Patch clamp analysis of afferent and efferent neurons that innervated the urinary bladder of the rat. Soc Neurosci Abstr 1992; 18(59.7):127. Abstract.
77. Maggi CA, Meli A. The sensory-efferent function of capsaicin-sensitive sensory neurons. Gen Pharmacol 1988; 19:1.
78. Chen C, Ma C, De Groat WC. Effects of capsaicin on micturition and associated reflexes in rats. Am J Physiol 1993; 265: R132-R138.
79. Fagerli J, Fraser MO, De Groat WC, Chancellor MB, Flood HD, Smith D, Jordan ML. Intravesical capsaicin for the treatment of interstitial cystitis: a pilot study. Can J Urol 1999; 6(2):737-744.
80. Avenilo A, Cruz F, Coimbra A. Intravesical resiniferatoxin desensitizes rat bladder sensory fibres without causing intense noxious excitation: a c-fos study. Eur J Pharmacol 1999; 378:17-22.
81. Park WH, Kim HG, Park BJ, Kim DY, Oh DJ, Lim YS. Comparison of the effects of intravesical capsaicin and resiniferatoxin for treatment of detrusor hyperreflexia in patients with spinal cord injury. Neurourol Urodyn 1999; 18:402. Abstract.
82. Gosling JA, Dixon JS. The structure and innervation of smooth muscle in the wall of the bladder neck and proximal urethra. Br J Urol 1975; 47:549-554.
83. Gosling JA, Dixon JS, Critchley OD, Thompson SA. A comparative study of the human external sphincter and periurethral levator ani muscles. Br J Urol 1981; 53:35-41.
84. Bazeed MA, Thuroff JW, Schmidt R, Tanagho EA. Histochemical study of the urethral striated musculature in the dog. J Urol 1982; 128:406.
85. Stein M, Discippio W, David M, Taub H. Biofeedback for the treatment of stress and urge incontinence. J Urol 1995; 153:641-643.
86. De Groat WC, Steers WD. Autonomic regulation of the urinary bladder and sexual organs. In: Lowey AD, Spyer KM, eds. Central Regulation of the Autonomic Functions. 1st ed. Oxford:Oxford University Press, 1990:313.
87. De Groat WC. Nervous control of the urinary bladder in the cat. Brain Res 1975; 87:201.
88. Bradley WE, Scott FB. Physiology of the urinary bladder. In: Harrison JH, Gittes RF, Pearlmutter AD. eds. Campbell’s Urology, 4th ed. Philadelphia: W.B. Saunders, 1978:87-124.
89. Bradley WE, Rockswold GL, Timm GW, Scott FB. Neurology of micturition. J Urol 1976; 115:481-486.
90. Fowler CJ. Neurological disorders of micturition and their treatment. Brain 1999; 122(Pt 7):1213-1231.
91. Andrew J, Nathan PW. The cerebral control of micturition. Proc R Soc Med 1965; 58:553-555.
92. Bradley WE, Timm JW, Scott FB. Cystometry. V. Bladder sensation. Urology 1975; 6:654-658.
93. Bradley WE, Timm JW, Scott FB. Innervation of the detrusor muscle and urethra. Urol Clin North Am 1974; 1:3-27.
94. Bhatia NN. Neurophysiology of micturition. In: Ostergard DR, Bent AE, eds. Urogynecology and Urodynamics. Baltimore: Williams & Wilkins, 1991:31-54.
95. Mahoney DT, Laberte RO, Blais DJ. Integral storage and voiding reflexes: neurophysiological concept of continence and micturition. Urology 1977; 10:95-106.