Effect of maternal folic acid supplementation on hepatic one-carbon unit associated gene expressions in newborn piglets

Molecular Biology Reports

Volumn 38, Issue 6, 2011, Pages 3849-3856

  Liu, Jing Bo ^a   Chen, Dai Wen ^a   Yu, Bing ^a   Mao, Xiang Bing ^a  

^a SICHUAN AGRICULTURAL UNIVERSITY   (China)

Author keywords

Folic acid; Gene expression; Intrauterine growth retardation; Maternal nutrition

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ACYL COENZYME A OXIDASE; CYSTATHIONINE BETA SYNTHASE; DNA METHYLTRANSFERASE 1; FOLIC ACID; GLUCOCORTICOID RECEPTOR; MESSENGER RNA; METHIONINE ADENOSYLTRANSFERASE; METHIONINE ADENOSYLTRANSFERASE 1A; METHIONINE ADENOSYLTRANSFERASE 2A; OBESITY RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIRTH WEIGHT; BLOOD SAMPLING; CONTROLLED STUDY; DIETARY INTAKE; GENE EXPRESSION; GILT (SWINE); INTRAUTERINE GROWTH RETARDATION; LIVER; MATERNAL CARE; MATERNAL NUTRITION; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTCOME ASSESSMENT; PIGLET; REAL TIME POLYMERASE CHAIN REACTION; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ANIMALS; ANIMALS, NEWBORN; CARBON; DIET; DIETARY SUPPLEMENTS; ENERGY METABOLISM; FEMALE; FETAL GROWTH RETARDATION; FOLIC ACID; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LIVER; METHYLTRANSFERASES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; REPRODUCTION; SUS SCROFA;

EID: 80052428942     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-010-0500-9     Document Type: Article

References (31)

1. Mcmillen I, Robinson J (2005) Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol Rev 85(2):571-633. (Pubitemid 40404637)
2. Wu G, Bazer F, Wallace J et al (2006) Board-invited review: intrauterine growth retardation: implications for the animal sciences. J Anim Sci 84(9):2316-2337. (Pubitemid 44367856)
3. Wu G, Bazer F, Cudd T et al (2004) Maternal nutrition and fetal development. J Nutr 134(9):2169-2172. (Pubitemid 39201580)
4. MacLennan N, James S, Melnyk S et al (2004) Uteroplacental insufficiency alters DNA methylation, one-carbon metabolism, and histone acetylation in IUGR rats. Physiol Genomics 18(1): 43-50. (Pubitemid 39319485)
5. Baserga M, Hale M, McKnight R et al (2005) Uteroplacental insufficiency alters hepatic expression, phosphorylation, and activity of the glucocorticoid receptor in fetal IUGR rats. Am J Physiol Regul Integr Comp Physiol 289(5):R1348-R1353. (Pubitemid 41507399)
6. Lillycrop K, Phillips E, Jackson A et al (2005) Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135(6):1382-1386. (Pubitemid 40799599)
7. Taylor P, Poston L (2007) Developmental programming of obesity in mammals. Exp Physiol 92(2):287-298. (Pubitemid 46376323)
8. Xu Y, Tang Y, Li Y (2007) Effect of folic acid on prenatal alcohol-induced modification of brain proteome in mice. Br J Nutr 99(03):455-461.
9. Bailey L, Gregory J (1999) III. Folate metabolism and requirements. J Nutr 129(4):779-782.
10. Benevenga N (2007) Consideration of betaine and one- carbon sources of N5-methyltetrahydrofolate for use in homo-cystinuria and neural tube defects. Am J Clin Nutr 85(4): 946-949. (Pubitemid 46557906)
11. Mason J (2003) Biomarkers of nutrient exposure and status in one-carbon (methyl) metabolism. J Nutr 133(3):941S-947S. (Pubitemid 36262802)
12. Perry J, Rowell J (1969) Variations in foetal weight and vascular supply along the uterine horn of the pig. Reproduction 19(3): 527-534.
13. Lindemann M, Kornegay E (1989) Folic acid supplementation to diets of gestating-lactating swine over multiple parities. J Anim Sci 7(2):459-464.
14. Storch KJ, Wagner DA, Burke JF et al (1988) Quantitative study in vivo of methionine cycle in humans using [methyl-2H3]-and [1-13C] methionine. Am J Physiol 255(3):E322-E331.
15. Jacobs R, House J, Brosnan M et al (1998) Effects of strepto-zotocin- induced diabetes and of insulin treatment on homocysteine metabolism in the rat. Diabetes 47(12):1967-1970. (Pubitemid 28549207)
16. Jacobs R, Stead L, Brosnan M et al (2001) Hyperglucagonemia in rats results in decreased plasma homocysteine and increased flux through the transsulfuration pathway in liver. J Biol Chem 276(47):43740-43747.
17. Jacques P, Bostom A, Williams R et al (1996) Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 93(1):7-9. (Pubitemid 26006560)
18. Bestor T, Hellewell S, Ingram V (1984) Differentiation of two mouse cell lines is associated with hypomethylation of their genomes. Mol Cell Biol 4(9):1800-1806. (Pubitemid 14008290)
19. Fatemi M, Hermann A, Gowher H et al (2002) Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA. Eur J Biochem 269(20):4981-4984. (Pubitemid 35279011)
20. Okano M, Bell DW, Haber DA et al (1999) DNA methyltrans-ferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99(3):247-258.
21. Slack A, Cervoni N, Pinard M et al (1999) DNA methyltrans- ferase is a downstream effector of cellular transformation triggered by simian virus 40 large T antigen. J Biol Chem 274(15): 10105-10112.
22. Takagi H, Tajima S, Asano A (2008) Overexpression of DNA methyltransferase in myoblast cells accelerates myotube formation. Eur J Biochem 231(2):282-291.
23. Kasperzyk J, Fall K, Mucci L et al (2009) One-carbon metabolism-related nutrients and prostate cancer survival. Am J Clin Nutr 90(3):561-569.
24. Anguera M, Field M, Perry C et al (2006) Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. J Biol Chem 281(27):18335-18342. (Pubitemid 44035490)
25. Seckl J (2001) Glucocorticoid programming of the fetus; adult phenotypes and molecular mechanisms. Mol Cell Endocrinol 185(1-2):61-71. (Pubitemid 33103954)
26. Bertram C, Trowern A, Copin N et al (2001) The maternal diet during pregnancy programs altered expression of the glucocorticoid receptor and type 2 11 {beta}-hydroxysteroid dehydrogenase: potential molecular mechanisms underlying the programming of hypertension in utero. Endocrinology 142(7):2841-2853. (Pubitemid 32575519)
27. Burdge G, Phillips E, Dunn R et al (2004) Effect of reduced maternal protein consumption during pregnancy in the rat on plasma lipid concentrations and expression of peroxisomal proliferator-activated receptors in the liver and adipose tissue of the offspring. Nutr Res 24(8):639-646. (Pubitemid 39094299)
28. Tugwood J, Issemann I, Anderson R et al (1992) The mouse peroxisome proliferator activated receptor recognizes a response element in the 5'flanking sequence of the rat acyl CoA oxidase gene. EMBO J 11(2):433-439.
29. Xu SY, Wu D, Guo HY et al. (2009) The level of feed intake affects embryo survival and gene expression during early pregnancy in gilts. Reprod Domest Anim. [Epub ahead of print].
30. Guay F, Palin M, Jacques Matte J et al (2001) Effects of breed, parity, and folic acid supplement on the expression of leptin and its receptors' genes in embryonic and endometrial tissues from pigs at day 25 of gestation. Biol Reprod 65(3):921-927. (Pubitemid 32777381)
31. Pogribny I, Basnakian A, Miller B, Lopatina N, Poirier L, James S (1995) Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats. Cancer Res 55(9):1894-1901.