Role of TGF-β/GLUT1 axis in susceptibility vs resistance to diabetic glomerulopathy in the Milan rat model

Nephrology Dialysis Transplantation

Volumn 21, Issue 6, 2006, Pages 1514-1524

  Ricci, Carlo ^a   Iacobini, Carla ^a,b   Oddi, Giovanna ^a,b   Amadio, Lorena ^a,b   Menini, Stefano ^a   Rastaldi, Maria Pia ^c   Frasheri, Aurora ^b   Pricci, Flavia ^a   Pugliese, Francesco ^a   Pugliese, Giuseppe ^a,d  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^c SAN CARLO BORROMEO HOSPITAL   (Italy)

^d FONDAZIONE POLICLINICO UNIVERSITARIO A GEMELLI IRCCS   (Italy)

Author keywords

Diabetic nephropathy; Extracellular matrix; Glucose transport; GLUT1; Renal haemodynamics; TGF

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER 1; MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; DISEASE MODEL; DISEASE PREDISPOSITION; DISEASE RESISTANCE; EXTRACELLULAR MATRIX; FOLLOW UP; GLUCOSE TRANSPORT; HYPERGLYCEMIA; KIDNEY BLOOD FLOW; MALE; MEDICAL ASSESSMENT; MESANGIUM CELL; METABOLIC PARAMETERS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; RAT; UPREGULATION;

ANIMALS; DIABETES COMPLICATIONS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE SUSCEPTIBILITY; EXTRACELLULAR MATRIX; GLOMERULONEPHRITIS; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; HYPERGLYCEMIA; HYPERTENSION; IMMUNITY, INNATE; IMMUNITY, NATURAL; RATS; RATS, MUTANT STRAINS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 33744828004     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfk089     Document Type: Article

References (30)

1. Di Mario U, Pugliese G. 15th Golgi lecture: From hyperglycaemia to the dysregulation of vascular remodelling in diabetes. Diabetologia 2001; 44: 674-692
2. Heilig CW, Liu Y, England RL et al. D-glucose stimulates mesangial cell GLUT1 expression and basal and IGF-I-sensitive glucose uptake in rat mesangial cells: Implications for diabetic nephropathy. Diabetes 1997; 46: 1030-1039
3. Heilig CW, Kreisberg JI, Freytag S et al. Antisense GLUT-1 protects mesangial cells from glucose induction of GLUT-1 and fibronectin expression. Am J Physiol 2001; 280: F657-F666
4. Heilig CW, Concepcion LA, Riser BL, Freytag SO, Zhu M, Cortes P. Overexpression of glucose transporters in rat mesangial cells cultured in a normal glucose milieu mimics the diabetic phenotype. J Clin Invest 1995; 96: 1802-1814
5. Henry DN, Busik JV, Brosius FC 3rd, Heilig CW. Glucose transporters control gene expression of aldose reductase, PKCalpha, and GLUT1in mesangial cells in vitro. Am J Physiol 1999; 277: F97-F104
6. Weigert C, Brodbeck K, Brosius FC III et al. Evidence for a novel TGF-β1-independent mechanism of fibrosis in mesangial cells overexpressing glucose transporters. Diabetes 2003; 52: 527-535
7. D'Agord Schaan B, Lacchini S, Bertoluci MC, Irigoyen MC, Machado UF, Schmid H. Increased renal GLUT1 abundance and urinary TGF-beta 1 in streptozotocin-induced diabetic rats: Implications for the development of nephropathy complicating diabetes. Horm Metab Res 2001; 33: 664-669
8. Chen S, Heilig K, Brosius F III, Heilig C. Diabetes increases glomerular GLUT1 and antisense-GLUT1 protects against diabetic glomerulosclerosis. J Am Soc Nephrol 2003; 14: 46A
9. Heilig KO, Chen S, Xiang M, Brosius FC, Heilig CW. Transgenic overexpression of GLUT1 in glomeruli produces features of diabetic nephropathy in mice. J Am Soc Nephrol 2004; 15: 263A
10. Pugliese G, Pricci F, Romeo G et al. Autocrine and paracrine mechanisms in the early stages of diabetic nephropathy. J Endocrinol Invest 1999; 22: 708-735
11. Inoki K, Haneda M, Maeda S, Koya D, Kikkawa R. TGF-beta 1 stimulates glucose uptake by enhancing GLUT1 expression in mesangial cells. Kidney Int 1999; 55: 1704-1712
12. Mogyorosi A, Ziyadeh FN. GLUT1 and TGF-beta: The link between hyperglycaemia and diabetic nephropathy. Nephrol Dial Transplant 1999; 14: 2827-2829
13. Brosius FC, Heilg CW. Glucose transporters in diabetic nephropathy. Pediatr Nephrol 2005; 20: 447-451
14. Gnudi L, Viberti GC, Raij L et al. GLUT-1 overexpression. Link between hemodynamic and metabolic factors in glomerular injury? Hypertension 2003; 42: 19-24
15. Zatz R, Dunn BR, Meyer TW, Anderson S, Rennke HG, Brenner BM. Prevention of diabetic glomerulopathy by pharmacological amelioration of glomerular capillary hypertension. J Clin Invest 1986; 77: 1925-1930
16. Cooper ME. Interaction of metabolic and haemodynamic factors in mediating experimental diabetic nephropathy. Diabetologia 2001; 44: 1957-1972
17. Brandis A, Bianchi G, Reale E, Helmchen U, Kuhn K. Age-dependent glomerulosclerosis and proteinuria occurring in rats of the Milan normotensive strain and not in rats of the Milan hypertensive strain. Lab Invest 1986; 55: 234-243
18. Salvati P, Ferti C, Ferrario GR et al. Enhanced glomerular synthesis of thromboxane A2 is a major determinant of the progressive kidney disease of normotensive rats of Milan strain. Kidney Int 1990; 38: 447-458
19. Bianchi G, Ferrari P, Barber BR. The Milan hypertensive strain. In: De Jong W, ed. Handbook of Hypertension, Vol. 4, Experimental and Genetic Models of Hypertension. Elsevier Science Publishers BV, Basel, Switzerland: 1984; 328-336
20. Bianchi G, Tripodi G, Casari G et al. Two point mutations within the adducin genes are involved in blood pressure variation. Proc Natl Acad Sci USA 1994; 91: 3999-4003
21. Ferrandi M, Tripodi G, Salardi S et al. Renal Na, K-ATPase in genetic hypertension. Hypertension 1996; 28: 1018-1025
22. Menini S, Ricci C, Iacobini C, Bianchi G, Pugliese G, Pesce C. Glomerular number and size in Milan hypertensive and normotensive rats: their relationship to susceptibility and resistance to hypertension and renal disease. J Hypertens 2004; 22: 2185-2192
23. Pugliese G, Pricci F, Barsotti P et al. Development of diabetic nephropathy in the Milan normotensive strain, but not in the Milan hypertensive strain: Possible permissive role of hemodynamics. Kidney Int 2005; 67: 1440-1452
24. Pugliese G, Pricci F, Menè P et al. High glucose level unmasks a genetic predisposition to enhanced extracellular matrix production in mesangial cells from rats of the Milan normotensive strain. J Am Soc Nephrol 1997; 8: 406-414
25. Pugliese F, Ferrario RG, Ciavolella A et al. Growth abnormalities in cultured mesangial cells from rats with spontaneous glomerulosclerosis. Kidney Int 1995; 47: 106-113
26. Pugliese G, Pricci F, Pesce CM et al. Early, but not advanced, experimental diabetic glomerulopathy is reversed by pancreatic islet transplants. Correlation with glomerular extracellular matrix mRNA levels. Diabetes 1997; 46: 1198-1206
27. Rastaldi MP, Armelloni S, Berra S et al. Glomerular podocytes possess the synaptic vesicle molecule Rab3A and its specific effector rabphilin-3a. Am J Pathol 2003; 163: 889-899
28. Pugliese G, Pricci F, Leto G et al. The diabetic milieu modulates the AGE-receptor complex in the mesangium by inducing or up-regulating galectin-3 expression. Diabetes 2000; 49: 1249-1257
29. Pugliese G, Pricci F, Iacobini C et al. Accelerated diabetic glomerulopathy in galectin-3/AGE-receptor-3 knockout mice. FASEB J 2001; 15: 2471-2479
30. Chen S, Heilig KO, Pravtcheva D et al. Rapidly progressive renal disease and renal failure with increased GLUT1 expression in the new line of mice fvb.ROS Os/+. J Am Soc Nephrol 2004; 15: 701A