GLUT1-induced cFLIP expression promotes proliferation and prevents apoptosis in vascular smooth muscle cells

American Journal of Physiology - Cell Physiology

Volumn 297, Issue 3, 2009, Pages

  Vesely, Eileen D ^a   Heilig, Charles W ^b   Brosius III, Frank C ^a,c  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

c FLICE inhibitory protein; Glucose; Metabolism; Neointimal hyperplasia

Indexed keywords

BETA TUBULIN; CASPASE 3; CASPASE 8; CYCLINE; FLICE INHIBITORY PROTEIN; FLICE INHIBITORY PROTEIN L; FLICE INHIBITORY PROTEIN S; GLUCOSE TRANSPORTER 1; ISOPROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL COUNT; CELL GROWTH; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; INTIMA; LENTIVIRINAE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SMOOTH MUSCLE FIBER; TRANSCRIPTOMICS; TRANSGENIC MOUSE; VASCULAR SMOOTH MUSCLE;

ANIMALS; APOPTOSIS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CELL LINE; CELL PROLIFERATION; GENE EXPRESSION REGULATION; GLUCOSE TRANSPORTER TYPE 1; MICE; MICE, TRANSGENIC; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; RATS; RNA, MESSENGER;

MUS MUSCULUS;

EID: 70349229249     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00213.2009     Document Type: Article

References (25)

1. Bauriedel G, Schluckebier S, Hutter R, Welsch U, Kandolf R, Luderitz B, Prescott MF. Apoptosis in restenosis versus stable-angina atherosclerosis: implications for the pathogenesis of restenosis. Arterioscler Thromb Vasc Biol 18: 1132-1139, 1998. (Pubitemid 28323598)
2. Berthier CC, Zhang H, Schin M, Henger A, Nelson RG, Yee B, Boucherot A, Neusser MA, Cohen CD, Carter-Su C, Argetsinger LS, Rastaldi MP, Brosius FC, Kretzler M. Enhanced expression of Janus kinase-signal transducer and activator of transcription pathway members in human diabetic nephropathy. Diabetes 58: 469-477, 2009.
3. Budd RC, Yeh WC, Tschopp J. cFLIP regulation of lymphocyte activation and development. Nat Rev Immunol 6: 196-204, 2006. (Pubitemid 43290989)
4. Chen SHK, Brosius FC III, Heilig CW. Diabetes increases glomerular GLUT1 and antisense-GLUT1 protects against diabetic glomerulosclerosis (Abstract). J Am Soc Nephrol 14: 581A, 2003.
5. Hall JL, Chatham JC, Eldar-Finkelman H, Gibbons GH. Upregulation of glucose metabolism during intimal lesion formation is coupled to the inhibition of vascular smooth muscle cell apoptosis. Role of GSK3beta. Diabetes 50: 1171-1179, 2001. (Pubitemid 32374550)
6. Hall JL, Gibbons GH, Chatham JC. IGF-I promotes a shift in metabolic flux in vascular smooth muscle cells. Am J Physiol Endocrinol Metab 283: E465-E471, 2002.
7. Hammerman PS, Fox CJ, Thompson CB. Beginnings of a signaltransduction pathway for bioenergetic control of cell survival. Trends Biochem Sci 29: 586-592, 2004.
8. Heilig C, Brosius F, Siu B, Concepcion L, Mortensen R, Heilig K, Zhu M, Weldon R, Wu G, Conner D. Implications of glucose transporter protein type 1 (GLUT1)-haplodeficiency in embryonic stem cells for their survival in response to hypoxic stress. Am J Pathol 163: 1873-1885, 2003.
9. House SJ, Potier M, Bisaillon J, Singer HA, Trebak M. The nonexcitable smooth muscle: calcium signaling and phenotypic switching during vascular disease. Pflügers Arch 456: 769-785, 2008.
10. Kataoka T, Budd RC, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J. The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways. Curr Biol 10: 640-648, 2000. (Pubitemid 30354699)
11. Kearney M, Pieczek A, Haley L, Losordo DW, Andres V, Schainfeld R, Rosenfield K, Isner JM. Histopathology of in-stent restenosis in patients with peripheral artery disease. Circulation 95: 1998-2002, 1997.
12. Kirkpatrick JN, Collins KA, Heilig K, Wang YL, Lammertin G, Schlimme M, Hall J, Quigg R, Lang RM, Heilig C. Cardiac hypertrophy and renal disease in GLUT-1 overexpressing mice (Abstract). In: 55th Annual Scientific Session of the American College of Cardiology, Atlanta, GA. Elsevier Science, 2006, p. 38A-38A.
13. Lin Z, Weinberg JM, Malhotra R, Merritt SE, Holzman LB, Brosius FC 3rd. GLUT-1 reduces hypoxia-induced apoptosis and JNK pathway activation. Am J Physiol Endocrinol Metab 278: E958-E966, 2000. (Pubitemid 30366415)
14. Loberg RD, Vesely E, Brosius FC 3rd. Enhanced glycogen synthase kinase-3beta activity mediates hypoxia-induced apoptosis of vascular smooth muscle cells and is prevented by glucose transport and metabolism. J Biol Chem 277: 41667-41673, 2002. (Pubitemid 35257473)
15. Macheda ML, Rogers S, Best JD. Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J Cell Physiol 202: 654-662, 2005. (Pubitemid 40175840)
16. Maelfait J, Beyaert R. Non-apoptotic functions of caspase-8. Biochem Pharmacol 76: 1365-1373, 2008.
17. Malhotra R, Tyson DG, Sone H, Aoki K, Kumagai AK, Brosius FC 3rd. Glucose uptake and adenoviral mediated GLUT1 infection decrease hypoxia-induced HIF-1alpha levels in cardiac myocytes. J Mol Cell Cardiol 34: 1063-1073, 2002. (Pubitemid 35316153)
18. Moley KH, Mueckler MM. Glucose transport and apoptosis. Apoptosis 5: 99-105, 2000.
19. Okano H, Shiraki K, Inoue H, Kawakita T, Yamanaka T, Deguchi M, Sugimoto K, Sakai T, Ohmori S, Fujikawa K, Murata K, Nakano T. Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma. Lab Invest 83: 1033-1043, 2003. (Pubitemid 36899070)
20. Owens GK. Regulation of differentiation of vascular smooth muscle cells. Physiol Rev 75: 487-517, 1995.
21. Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol 23: 7315-7328, 2003.
22. Ray JL, Leach R, Herbert JM, Benson M. Isolation of vascular smooth muscle cells from a single murine aorta. Methods Cell Sci 23: 185-188, 2001. (Pubitemid 34863290)
23. Thyberg J. Phenotypic modulation of smooth muscle cells during formation of neointimal thickenings following vascular injury. Histol Histopathol 13: 871-891, 1998. (Pubitemid 28329189)
24. Thyberg J, Blomgren K, Hedin U, Dryjski M. Phenotypic modulation of smooth muscle cells during the formation of neointimal thickenings in the rat carotid artery after balloon injury: an electron-microscopic and stereological study. Cell Tissue Res 281: 421-433, 1995.
25. Vander Heiden MG, Plas DR, Rathmell JC, Fox CJ, Harris MH, Thompson CB. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol Cell Biol 21: 5899-5912, 2001.