Genetic polymorphisms of GSTM1, GSTT1 and GSTP1 and susceptibility to DNA damage in workers occupationally exposed to organophosphate pesticides

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 725, Issue 1-2, 2011, Pages 36-42

  Singh, Satyender ^a   Kumar, Vivek ^b   Singh, Priyanka ^a   Thakur, Sachin ^a,c   Banerjee, Basu Dev ^b   Rautela, Rajender Singh ^a   Grover, Shyam Sunder ^a   Rawat, Devendra Singh ^a   Pasha, Syed Tazeen ^a,d   Jain, Sudhir Kumar ^a   Rai, Arvind ^a  

^a National Centre for Disease Control   (India)

^b UNIVERSITY COLLEGE OF MEDICAL SCIENCES   (India)

^c University of Texas Health Science Center   (United States)

^d GOVERNMENT OF INDIA   (India)

Author keywords

DNA damage; Genetic polymorphisms; Glutathione S transferase; Organophosphate pesticides

Indexed keywords

DNA; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; ORGANOPHOSPHATE PESTICIDE;

ADULT; ARTICLE; COMET ASSAY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DNA DAMAGE; DNA TAIL MOMENT; GENE DELETION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENOTOXICITY; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; OCCUPATIONAL EXPOSURE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; CASE-CONTROL STUDIES; COMET ASSAY; DNA DAMAGE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; MALE; MIDDLE AGED; OCCUPATIONAL EXPOSURE; ORGANOPHOSPHORUS COMPOUNDS; PESTICIDES; POLYMORPHISM, GENETIC; SMOKING;

EID: 80052419040     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2011.06.006     Document Type: Article

References (52)

1. Holstege C.P., Kirk M., Sidell F.R. Chemical warfare. Nerve agent poisoning. Crit. Care Clin. 1997, 13:923-942.
2. Mackenzie-Ross S.J., Brewin C.R., Curran H.V., Furlong C.E., Abraham-Smith K.M., Harrison V. Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides. Neurotoxicol. Teratol. 2010, 32:452-459.
3. Mansour S.A. Pesticide exposure - Egyptian scene. Toxicology 2004, 198:91-115.
4. Waddell B.L., Zahm S.H., Baris D., Weisenburger D.D., Holmes F., Burmeister L.F., Cantor K.P., Blair A. Agricultural use of organophosphate pesticides and the risk of non-Hodgkin's lymphoma among male farmers (United States). Cancer Causes Control 2001, 12:509-517.
5. Bonner M.R., Williams B.A., Rusiecki J.A., Blair A., Beane-Freeman L.E., Hoppin J.A., Dosemeci M., Lubin J., Sandler D.P., Alavanja M.C. Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study. Cancer Causes Control 2010, 21:871-877.
6. Tang J., Cao Y., Rose R.L., Brimfield A.A., Dai D., Goldstein J.A., Hodgson E. Metabolism of chlorpyrifos by human cytochrome P450 isoforms and human, mouse, and rat liver microsomes. Drug Metab. Dispos. 2001, 29:1201-1204.
7. Sams C., Cocker J., Lennard M.S. Biotransformation of chlorpyrifos and diazinon by human liver microsomes and recombinant human cytochrome p450s (CYP). Xenobiotica 2004, 34:861-873.
8. Mutch E., Williams F.M. Diazinon, chlorpyrifos and parathion are metabolised by multiple cytochromes P450 in human liver. Toxicology 2006, 224:22-32.
9. Mutch E., Blain P.G., Williams F.M. The role of metabolism in determining susceptibility to parathion toxicity in man. Toxicol. Lett. 1999, 107:177-187.
10. Costa L.G., Li W.F., Richter R.J., Shih D.M., Lusis A., Furlong C.E. The role of paraoxonase (PON1) in the detoxication of organophosphates and its human polymorphism. Chem. Biol. Interact. 1999, 119-120:429-438.
11. Di Ilio C., Sacchetta P., Iannarelli V.A., Aceto A. Binding of pesticides to alpha, mu and pi class glutathione transferase. Toxicol. Lett. 1995, 76:173-177.
12. Fujioka K., Casida J.E. Glutathione S-transferase conjugation of organophosphorus pesticides yields S-phospho-, S-aryl-, and S-alkylglutathione derivatives. Chem. Res. Toxicol. 2007, 20:1211-1217.
13. Baranova H., Perriot J., Albuisson E., Ivaschenko T., Baranov V.S., Hemery B., Mouraire P., Riol N., Malet P. Pecularities of the GSTM1 0/0 genotype in French heavy smokers with various types of chronic bronchitis. Hum. Genet. 1997, 99:822-826.
14. De Wart Kok F.J., Smilde T.J., Hijmans A., Wollersheim H., Stalenhoef A.F. Effect of glutathione S-transferase M1 genotype on progression of atherosclerosis in lifelong male smokers. Atherosclerosis 2001, 158:227-231.
15. Wahner A.D., Glatt C.E., Bronstein J.M., Ritz B. Glutathione S-transferase mu, omega, pi, and theta class variants and smoking in Parkinson's disease. Neurosci. Lett. 2007, 413:274-278.
16. Lin J.L., Han C.Y., Bernstein D.A., Hsiao W., Lin B.K., Hardy S. Ethnic distribution of the glutathione transferase Mu 1-1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer susceptibility. Carcinogenesis 1994, 15:1077-1081.
17. Timofeeva M., Kropp S., Sauter W., Beckmann L., Rosenberger A., Illig T., Jäger B., Mittelstrass K., Dienemann H., LUCY-Consortium, Bartsch H., Bickeböller H., Chang-Claude J., Risch A., Wichmann H.E. Genetic polymorphisms of MPO, GSTT1, GSTM1, GSTP1, EPHX1 and NQO1 as risk factors of early-onset lung cancer. Int. J. Cancer 2010, 127:1547-1561.
18. Strange R.C., Jones P.W., Fryer A.A. Glutathione S-transferase: genetics and role in toxicology. Toxicol. Lett. 2000, 112/113:357-363.
19. Wang J., Jiang J., Zhao Y., Gajalakshmi V., Kuriki K., Suzuki S., Nagaya T., Nakamura S., Akasaka S., Ishikawa H., Tokudome S. Genetic polymorphisms of glutathione S-transferase genes and susceptibility to colorectal cancer: a case-control study in an Indian population. Cancer Epidemiol. 2011, 35:66-72.
20. Elexpuru-Camiruaga J., Buxton N., Kandula V., Dias P.S., Campbell D., McIntosh J., Broome J., Jones P., Inskip A., Alldersea J., et al. Susceptibility to astrocytoma and meningioma: influence of allelism at glutathione S-transferase (GSTT1 and GSTM1) and cytochrome p-450 (CYP2D6) loci. Cancer Res. 1995, 55:4237-4239.
21. Deakin M., Elder J., Hendrickse C., Peckham D., Baldwin D., Pantin C., Wild N., Leopard P., Bell D.A., Jones P., Duncan H., Brannigan K., Alldersea J., Fryer A.A., Strange R.C. Glutathione S-transferase GSTT1 genotypes and susceptibility to cancer: studies of interaction with GSTM1 in lung, oral, gastric and colorectal cancers. Carcinogenesis 1996, 17:881-884.
22. Chen Y.L., Tseng H.S., Kuo W.H., Yang S.F., Chen D.R., Tsai H.T. Glutathione S-transferase P1 (GSTP1) gene polymorphism increases age-related susceptibility to hepatocellular carcinoma. BMC Med. Genet. 2010, 11:46.
23. Lavender N.A., Benford M.L., Van-Cleave T.T., Brock G.N., Kittles R.A., Moore J.H., Hein D.W., Kidd L.C. Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study. BMC Cancer 2009, 9:397.
24. Lu S., Wang Z., Cui D., Liu H., Hao X. Glutathione S-transferase P1 Ile105Val polymorphism and breast cancer risk: a meta-analysis involving 34,658 subjects. Breast Cancer Res. Treat. 2011, 125:253-259.
25. Bernstein C. DNA Damage and Cancer. SciTopics 2009, Available from: http://www.scitopics.com/DNA_Damage_and_Cancer.html (accessed 10.11.10).
26. Liu Y.J., Huang P.L., Chang Y.F., Chen Y.H., Chiou Y.H., Xu Z.L., Wong R.H. GSTP1 genetic polymorphism is associated with a higher risk of DNA damage in pesticide-exposed fruit growers. Cancer Epidemiol. Biomarkers Prev. 2006, 15:659-666.
27. Da Silva J., Moraes C.R., Heuser V.D., Andrade V.M., Silva F.R., Kvitko K., Emmel V., Rohr P., Bordin D.L., Andreazza A.C., Salvador M., Henriques J.A., Erdtmann B. Evaluation of genetic damage in a Brazilian population occupationally exposed to pesticides and its correlation with polymorphisms in metabolizing genes. Mutagenesis 2008, 23:415-422.
28. Wong R.H., Chang S.Y., Ho S.W., Huang P.L., Liu Y.J., Chen Y.C., Yeh Y.H., Lee H.S. Polymorphisms in metabolic GSTP1 and DNA-repair XRCC1 genes with an increased risk of DNA damage in pesticide-exposed fruit growers. Mutat. Res. 2008, 654:68-75.
29. Abhishek S., Kaur N., Kaur S., Lata M., Sharma J.K., Sharma A. Association of GSTM1 and GSTT1 gene deletions with susceptibility to DNA damage in the pesticide-exposed workers of Punjab. Rejuvenation Res. 2010, 13:281-284.
30. Singh S., Kumar V., Thakur S., Banerjee B.D., Chandna S., Rautela R.S., Grover S.S., Rawat D.S., Pasha S.T., Jain S.K., Ichhpujani R.L., Rai A. DNA damage and cholinesterase activity in occupational workers exposed to pesticides. Environ. Toxicol. Pharmacol. 2011, 31:278-285.
31. Farrow A., Jacobs A., West R.R. Myelodysplasia, chemical exposure and other environmental factors. Leukemia 1989, 3:33-35.
32. Dich J., Zahm S.H., Hanberg A., Adami H.O. Pesticides and cancer. Cancer Causes Control 1997, 8:420-443.
33. Potti A., Panwalkar A.W., Langness E. Prevalence of pesticide exposure in young males (
34. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
35. Grover P.K., Danadevi K., Mahboob M. Evaluation of genetic damage in workers employed in pesticide production utilizing comet assay. Mutagenesis 2003, 18:201-205.
36. Chandna S. Single cell gel electrophoresis assay monitors precise kinetics of DNA fragmentation induced during programmed cell death. Cytometry Part A 2004, 61A:127-133.
37. Lee E., Oh E., Lee J., Sul D., Lee J. Use of the tail moment of the lymphocytes to evaluate DNA damage in human biomonitoring studies. Toxicol. Sci. 2004, 81:121-132.
38. Singh S., Kumar V., Thakur S., Banerjee B.D., Grover S.S., Rawat D.S., Pasha S.T., Jain S.K., Lal S., Rai A. Genetic polymorphism of glutathione S-transferase M1 and T1 in Delhi population of Northern India. Environ. Toxicol. Pharmacol. 2009, 28:25-29.
39. Shadnia S., Azizi E., Hosseini R., Khoei S., Fouladdel S., Pajoumand A., Jalali N., Abdollahi M. Evaluation of oxidative stress and genotoxicity in organophosphorous insecticide formulators. Hum. Exp. Toxicol. 2005, 24:439-445.
40. Atherton K.M., Williams F.M., González F.J., Glass R., Rushton S., Blain P.G., Mutch E. DNA damage in horticultural farmers: a pilot study showing an association with organophosphate pesticide exposure. Biomarkers 2009, 14:443-451.
41. Moller P., Knudsen L.E., Loft S., Wallin H. The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors. Cancer Epidemiol. Biomarkers Prev. 2000, 9:1005-1015.
42. Jiang S., Yu L., Cheng J., Leng S., Dai Y., Zhang Y., Niu Y., Yan H., Qu W., Zhang C., Zhang K., Yang R., Zhou L., Zheng Y. Genomic damages in peripheral blood lymphocytes and association with polymorphisms of three glutathione S-transferases in workers exposed to formaldehyde. Mutat. Res. 2010, 695:9-15.
43. Lodovici M., Luceri C., Guglielmi F., Bacci C., Akpan V., Fonnesu M.L., Boddi V., Dolara P. Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH. Cancer Epidemiol. Biomarkers Prev. 2004, 13:1342-1348.
44. Hu X., Xia H., Srivastava S.K., Herzog C., Awasthi Y.C., Ji X., Zimniak P., Singh S.V. Activity of four allelic forms of glutathione S-transferase hGSTP1-1 for diol epoxides of polycyclic aromatic hydrocarbons. Biochem. Biophys. Res. Commun. 1997, 238:397-402.
45. Watson M.A., Stewart R.K., Smith G.B., Massey T.E., Bell D.A. Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution. Carcinogenesis 1998, 19:275-280.
46. Norppa H. Cytogenetic markers of susceptibility: influence of polymorphic carcinogen-metabolizing enzymes. Environ. Health Perspect. 1997, 105:829-835.
47. Petruzzelli S., Camus A.M., Carrozzi L., Ghelarducci L., Rindi M., Menconi G., Angeletti C.A., Ahotupa M., Hietanen E., Aitio A., et al. Long-lasting effects of tobacco smoking on pulmonary drug-metabolizing enzymes: a case-control study on lung cancer patients. Cancer Res. 1988, 48:4695-4700.
48. Autrup H. Genetic polymorphisms in human xenobiotica metabolizing enzymes as susceptibility factors in toxic response. Mutat. Res. 2000, 464:65-76.
49. Schoket B., Papp G., Lévay K., Mracková G., Kadlubar F.F., Vincze I. Impact of metabolic genotypes of levels of biomarkers of genotoxic exposure. Mutat. Res. 2001, 482:57-69.
50. Bolognesi C. Genotoxicity of pesticides: a review of human biomonitoring studies. Mutat. Res. 2003, 543:251-272.
51. Poirier M.C. Chemical-induced DNA damage and human cancer risk. Nat. Rev. Cancer 2004, 4:630-637.
52. Bernstein C., Bernstein H., Payne C.M., Dvorak K., Garewal H. Field defects in progression to gastrointestinal tract cancers. Cancer Lett. 2008, 260:1-10.