Enhancing transfection efficiency using polyethylene glycol grafted polyethylenimine and fusogenic peptide

Biotechnology and Bioprocess Engineering

Volumn 6, Issue 4, 2001, Pages 269-273

  Lee, Haeshin ^a   Jeong, Ji Hoon ^a   Lee, Je Hoon ^a   Park, Tae Gwan ^a  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

A DNA delivery system; KALA; Polyethylene glycol (PEG); Polyethylenimine (PEI)

Indexed keywords

EID: 14844303045     PISSN: 12268372     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02931988     Document Type: Article

References (26)

1. Feigner, P. L., Y. Barenholz, J.-P. Behr, S. H. Cheng, P. Cullis, L. Huang, J. A. Jessee, L. Seymour, F. C. Szoka, A. R. Thierry, E. Wagner, and G. Wu (1997) Nomenclature for synthetic gene delivery systems. Human Gene Ther. 8: 511-512.
2. Cotton, M. and E. Wagner (1993) Non-viral approaches to gene therapy. Current Op. Biotech. 4: 705-710.
3. Ledley, F. (1994) Non-viral gene therapy. Current Op. Biotech. 5: 626-636.
4. Wolfert, M. A. and L. W. Seymour (1998) Chlroroquine and amphipathic peptide helices show synergistic transfection in vitro. Human Gene Ther. 5: 409-414.
5. Wagner E. (1999) Application of membrane-active peptides for nonviral gene delivery. Adv. Drug Del. Rev. 38: 279-289.
6. Zaunter, W., M. Ogris, and E. Wagner (1998) Polylysine-based transfection systems utilizing receptor-mediated delivery. Adv. Drug Del. Rev. 30: 97-113.
7. Remy J. S., B. Adballah, M. A. Zanta, O. Boussif, J. P. Behr, and B. Demeneix, (1998) Gene transfer with lipospermines and polyethyleneimines. Adv. Drug Delivery Rev. 30: 85-95.
8. Zauner, J. and F. C. Szoka (1993) Polyamidoamine cascade polymers mediate efficient transfection of cells in culture. Bioconjugate Chem. 4: 372-379.
9. Cherng, J. Y., P. V. D. Wetering, H. Talsma, D. J. A. Crommelin, and W. E. Hennink (1996) Effect of size and serum proteins on transfection efficiency of poly-((2-dimethylamino)-ethyl methacrylate)-plasmid nanoparticles. Pharm. Res. 13: 1038-1042.
10. Cherng, J. Y., P. V. D. Wetering, H. Talsma, D. J. A. Crommelin, and W. E. Hennink (1997) Freeze-drying of poly-((2-dimethylamino)-ethyl methacrylate)-based gene delivery systems. Pharm. Res. 14: 1838-1841.
11. Wetering, P. V. D., J. Y. Cherng, H. Talsma, and W. E. Hennink (1997) Relation between transfection efficiency and cytotoxicity of poly poly-((2-dimethylamino)-ethyl methacrylate)-plasmid complex. J. Controlled Release 49: 59-69.
12. Boussif, O., F. Lezoualc'h, M. A. Zanta, M. D. Mergny D. Scherman, B. Demeneix, and J.-P. Behr (1995) A versatile vector for gene and oligonnucleotide transfer into cells in culture and in vivo: polyethylenimine. Proc. Natl. Acad. Sci. USA 92: 7297-7301.
13. Ogris, M., P. Steinlein, and M. Kursa (1998) The size of DNA/transferring-PEI complexes is an important factor for gene expression in cultured cells. Gene Ther. 5: 1425-1433.
14. Plank, C., B. Oberhauser, K. Mechtler, C. Koch, and E. Wagner (1994) The influence of endosome-distruptive peptides on gene transfer using synthetic virus-like gene transfer system. J. Biol. Chem. 269: 12918-12924.
15. Hart, S. L., L. Collins, K. Gustafsson, and J. W. Fabre (1997) Integrin-mediated transfection with peptides containing arginine-glycine- aspartic acid domains. Gene Ther. 4: 1225-1230.
16. Niidome, T., N. Ohmori, and A. Ichinose (1997) Binding of cationic a-helical peptides to plasmid DNA and their gene transfer abilities into cells. J. Biol. Chem. 272: 15307-15312.
17. Sorgi, F. L., S. Bhattacharya, and L. Huang (1997) Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther. 4: 961-968.
18. Wyman, T. B., F. Nicol, O. Zephalti, P. V. Scaria, C. Plank, and F. C. Szoka (1997) Design, Synthesis, and Characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers. Biochemistry 36: 3008-3017.
19. Fominaya, J., M. Gasset, R. Garcia, F. Roncal, J. P. Albar, and A. Bernad (2000) An optimized amphiphilic cationic peptide as an efficient non-viral gene delivery vector. J. Gene Med. 2: 455-464.
20. Lim, D. W., Y. I. Yeom, and T. G. Park (2000) Poly-(DMAEMA-NVP)-b-PEG- galactose as gene delivery vector for hepatocytes. Bioconjugate Chem. 11: 688-695.
21. Lee, H., J. H. Jeong, and T. G. Park (2001) A new gene delivery formulation of polyethylenimine/DNA complexes coated with PEG conjugated fusogenic peptides. J. Controlled Rel. in press.
22. Fischer, D., R. Zange, and T. Kissel (1997) Comparative in vitro cytotoxicity studies of polycations for gene therapy. Proceedings of 24th Intern. Symp. Control. Rel. Bioact. Mater. pp. 647-648.
23. Fischer, D., T. Bieber, Y. X. Li, H. P. Elsasser, and T. Kissel (1999) A novel non-viral vector for DNA delivery based on low molecular weight, branched polyethyleimine: Effect of molecular weight on transfection dfficiency and cytotoxicity. Pharm. Res. 16: 1273-1279.
24. Ferrari, S., E. Moro, A. Pettenazzo, J.-P. Behr, F. Zacchello, and M. Scarpa (1997) ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo. Gene Ther. 4: 1100-1106.
25. Fischer, D., Y. X. Li, A. von Harpe, T. Bieber, H. P. Elsasser, and T. Kissel (1999) Poly(ethyleimine-co-2-hydroxyethyl ethylenimine) polymers: Relation between polymer structure, biocompatibility and transfection efficiency. Proceeding of 26th Intern. Symp. Control. Rel. Bioact. Mater. pp. 104-105.
26. Jeong, J. H., S. H. Song, D. W. Lim, H. Lee, and T. G. Park (2001) DNA Transfection Using Linear Polyethylenemine) Prepared by Controlled Acid Hydrolysis of Poly(2-ethyl-2-oxazoline). J. Controlled Rel. 6: 391-399.