Combination treatment with low-dose Niaspan and tissue plasminogen activator provides neuroprotection after embolic stroke in rats

Journal of the Neurological Sciences

Volumn 309, Issue 1-2, 2011, Pages 96-101

  Shehadah, Amjad ^a   Chen, Jieli ^a   Cui, Yisheng ^a   Zhang, Li ^a   Roberts, Cynthia ^a   Lu, Mei ^a   Chopp, Michael ^a,b  

^a HENRY FORD HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

Author keywords

Apoptosis; Neuroprotection; Niaspan; TLR 4; TNF alpha; tPA

Indexed keywords

CASPASE 3; NICOTINIC ACID; TISSUE PLASMINOGEN ACTIVATOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL BEHAVIOR; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN EMBOLISM; BRAIN INFARCTION; BRAIN ISCHEMIA; COMMON CAROTID ARTERY; CONTROLLED STUDY; DRUG POTENTIATION; IMMUNOHISTOCHEMISTRY; LOW DRUG DOSE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MONOTHERAPY; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STROKE;

ANIMALS; DRUG THERAPY, COMBINATION; INTRACRANIAL EMBOLISM; MALE; NEUROPROTECTIVE AGENTS; NIACIN; RATS; RATS, WISTAR; RECOVERY OF FUNCTION; STROKE; TISSUE PLASMINOGEN ACTIVATOR;

EID: 80052382515     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2011.07.008     Document Type: Article

References (47)

1. M.J. Chapman, G. Assmann, J.C. Fruchart, J. Shepherd, and C. Sirtori Raising high-density lipoprotein cholesterol with reduction of cardiovascular risk: the role of nicotinic acid-a position paper developed by the European Consensus Panel on HDL-C Curr Med Res Opin 20 8 2004 1253 1268 (Pubitemid 39120790)
2. C.D. Meyers, V.S. Kamanna, and M.L. Kashyap Niacin therapy in atherosclerosis Curr Opin Lipidol 15 6 2004 659 665 (Pubitemid 39612984)
3. I.M. Singh, M.H. Shishehbor, and B.J. Ansell High-density lipoprotein as a therapeutic target: a systematic review JAMA 298 7 2007 786 798 (Pubitemid 47263161)
4. L.A. Carlson Niaspan, The prolonged release preparation of nicotinic acid (niacin), the broad-spectrum lipid drug Int J Clin Pract 58 7 2004 706 713 (Pubitemid 39144586)
5. A. Shehadah, J. Chen, A. Zacharek, Y. Cui, M. Ion, and C. Roberts Niaspan treatment induces neuroprotection after stroke Neurobiol Dis 40 1 2010 277 283
6. Z. Zhang, L. Zhang, M. Yepes, Q. Jiang, Q. Li, and P. Arniego Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke Circulation 106 6 2002 740 745 (Pubitemid 34851936)
7. L. Zhang, Z.G. Zhang, G.L. Ding, Q. Jiang, X. Liu, and H. Meng Multitargeted effects of statin-enhanced thrombolytic therapy for stroke with recombinant human tissue-type plasminogen activator in the rat Circulation 112 22 2005 3486 3494 (Pubitemid 43739565)
8. S.H. Graham, and J. Chen Programmed cell death in cerebral ischemia J Cereb Blood Flow Metab 21 2 2001 99 109 (Pubitemid 32143971)
9. K.J. Becker Inflammation and acute stroke Curr Opin Neurol 11 1 1998 45 49 (Pubitemid 28052494)
10. J.B. Schulz, M. Weller, and M.A. Moskowitz Caspases as treatment targets in stroke and neurodegenerative diseases Ann Neurol 45 4 1999 421 429 (Pubitemid 29165807)
11. S. Namura, J. Zhu, K. Fink, M. Endres, A. Srinivasan, and K.J. Tomaselli Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia J Neurosci 18 10 1998 3659 3668 (Pubitemid 28225674)
12. M. Rabuffetti, C. Sciorati, G. Tarozzo, E. Clementi, A.A. Manfredi, and M. Beltramo Inhibition of caspase-1-like activity by Ac-Tyr-Val-Ala-Asp- chloromethyl ketone induces long-lasting neuroprotection in cerebral ischemia through apoptosis reduction and decrease of proinflammatory cytokines J Neurosci 20 12 2000 4398 4404 (Pubitemid 30396604)
13. C. Manabat, B.H. Han, M. Wendland, N. Derugin, C.K. Fox, and J. Choi Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain Stroke 34 1 2003 207 213 (Pubitemid 36070825)
14. F.C. Barone, and G.Z. Feuerstein Inflammatory mediators and stroke: new opportunities for novel therapeutics J Cereb Blood Flow Metab 19 8 1999 819 834 (Pubitemid 30173383)
15. A. Chamorro, and J. Hallenbeck The harms and benefits of inflammatory and immune responses in vascular disease Stroke 37 2 2006 291 293 (Pubitemid 43731945)
16. Q. Wang, X.N. Tang, and M.A. Yenari The inflammatory response in stroke J Neuroimmunol 184 1-2 2007 53 68 (Pubitemid 46365991)
17. X. Wang, G.Z. Feuerstein, L. Xu, H. Wang, W.A. Schumacher, and M.L. Ogletree Inhibition of tumor necrosis factor-alpha-converting enzyme by a selective antagonist protects brain from focal ischemic injury in rats Mol Pharmacol 65 4 2004 890 896 (Pubitemid 38420494)
18. J.M. Hallenbeck The many faces of tumor necrosis factor in stroke Nat Med 8 12 2002 1363 1368 (Pubitemid 36019420)
19. E. Shohami, I. Ginis, and J.M. Hallenbeck Dual role of tumor necrosis factor alpha in brain injury Cytokine Growth Factor Rev 10 2 1999 119 130 (Pubitemid 29446376)
20. B.J. Marsh, R.L. Williams-Karnesky, and M.P. Stenzel-Poore Toll-like receptor signaling in endogenous neuroprotection and stroke Neuroscience 158 3 2009 1007 1020
21. A. Katsargyris, C. Klonaris, A. Alexandrou, A.E. Giakoustidis, I. Vasileiou, and S. Theocharis Toll-like receptors in liver ischemia reperfusion injury: a novel target for therapeutic modulation? Expert Opin Ther Targets 13 4 2009 427 442
22. S.C. Tang, T.V. Arumugam, X. Xu, A. Cheng, M.R. Mughal, and D.G. Jo Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits Proc Natl Acad Sci U S A 104 34 2007 13798 13803 (Pubitemid 350003400)
23. M.M. Buchanan, M. Hutchinson, L.R. Watkins, and H. Yin Toll-like receptor 4 in CNS pathologies J Neurochem 114 1 2010 13 27
24. C.X. Cao, Q.W. Yang, F.L. Lv, J. Cui, H.B. Fu, and J.Z. Wang Reduced cerebral ischemia-reperfusion injury in Toll-like receptor 4 deficient mice Biochem Biophys Res Commun 353 2 2007 509 514 (Pubitemid 46023466)
25. R.L. Zhang, M. Chopp, Z.G. Zhang, Q. Jiang, and J.R. Ewing A rat model of focal embolic cerebral ischemia Brain Res 766 1-2 1997 83 92 (Pubitemid 27431437)
26. F. Niessen, T. Hilger, M. Hoehn, and K.A. Hossmann Thrombolytic treatment of clot embolism in rat: comparison of intra-arterial and intravenous application of recombinant tissue plasminogen activator Stroke 33 12 2002 2999 3005 (Pubitemid 35462878)
27. J. Chen, Y. Li, L. Wang, M. Lu, X. Zhang, and M. Chopp Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats J Neurol Sci 189 1-2 2001 49 57 (Pubitemid 32776649)
28. T.M. Barth, M.L. Grant, and T. Schallert Effects of MK-801 on recovery from sensorimotor cortex lesions Stroke 21 11 Suppl. 1990 III153 III157
29. T. Schallert, S.M. Fleming, J.L. Leasure, J.L. Tillerson, and S.T. Bland CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury Neuropharmacology 39 5 2000 777 787 (Pubitemid 30103682)
30. R.A. Swanson, M.T. Morton, G. Tsao-Wu, R.A. Savalos, C. Davidson, and F.R. Sharp A semiautomated method for measuring brain infarct volume J Cereb Blood Flow Metab 10 2 1990 290 293 (Pubitemid 20096202)
31. L. Zhang, M. Chopp, L. Jia, Y. Cui, M. Lu, and Z.G. Zhang Atorvastatin extends the therapeutic window for tPA to 6 h after the onset of embolic stroke in rats J Cereb Blood Flow Metab 29 11 2009 1816 1824
32. Y. Li, N. Jiang, C. Powers, and M. Chopp Neuronal damage and plasticity identified by microtubule-associated protein 2, growth-associated protein 43, and cyclin D1 immunoreactivity after focal cerebral ischemia in rats Stroke 29 9 1998 1972 1980 [discussion 1980-1971] (Pubitemid 28400003)
33. J. Chen, Z.G. Zhang, Y. Li, L. Wang, Y.X. Xu, and S.C. Gautam Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats Circ Res 92 6 2003 692 699 (Pubitemid 36417705)
34. L. Calza, L. Giardino, A. Giuliani, L. Aloe, and R. Levi-Montalcini Nerve growth factor control of neuronal expression of angiogenetic and vasoactive factors Proc Natl Acad Sci U S A 98 7 2001 4160 4165 (Pubitemid 32249915)
35. J. Chen, Z.G. Zhang, Y. Li, Y. Wang, L. Wang, and H. Jiang Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke Ann Neurol 53 6 2003 743 751 (Pubitemid 36622511)
36. M. Lu, J. Chen, D. Lu, L. Yi, A. Mahmood, and M. Chopp Global test statistics for treatment effect of stroke and traumatic brain injury in rats with administration of bone marrow stromal cells J Neurosci Methods 128 1-2 2003 183 190 (Pubitemid 37013561)
37. S.I. Savitz, J.A. Erhardt, J.V. Anthony, G. Gupta, X. Li, and F.C. Barone The novel beta-blocker, carvedilol, provides neuroprotection in transient focal stroke J Cereb Blood Flow Metab 20 8 2000 1197 1204 (Pubitemid 30636755)
38. D.A. Le, Y. Wu, Z. Huang, K. Matsushita, N. Plesnila, and J.C. Augustinack Caspase activation and neuroprotection in caspase-3-deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation Proc Natl Acad Sci U S A 99 23 2002 15188 15193 (Pubitemid 35334631)
39. M. Sun, and C. Xu Neuroprotective mechanism of taurine due to up-regulating calpastatin and down-regulating calpain and caspase-3 during focal cerebral ischemia Cell Mol Neurobiol 28 4 2008 593 611 (Pubitemid 351624504)
40. J. Xu, J. Culman, A. Blume, S. Brecht, and P. Gohlke Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic death Stroke 34 5 2003 1287 1292 (Pubitemid 36547530)
41. Y. Luo, G. Cao, W. Pei, C. O'Horo, S.H. Graham, and J. Chen Induction of caspase-activated deoxyribonuclease activity after focal cerebral ischemia and reperfusion J Cereb Blood Flow Metab 22 1 2002 15 20 (Pubitemid 34038378)
42. F.C. Barone, B. Arvin, R.F. White, A. Miller, C.L. Webb, and R.N. Willette Tumor necrosis factor-alpha. A mediator of focal ischemic brain injury Stroke 28 6 1997 1233 1244 (Pubitemid 27248902)
43. N. Hosomi, C.R. Ban, T. Naya, T. Takahashi, P. Guo, and X.Y. Song Tumor necrosis factor-alpha neutralization reduced cerebral edema through inhibition of matrix metalloproteinase production after transient focal cerebral ischemia J Cereb Blood Flow Metab 25 8 2005 959 967 (Pubitemid 41061711)
44. H. Nawashiro, D. Martin, and J.M. Hallenbeck Inhibition of tumor necrosis factor and amelioration of brain infarction in mice J Cereb Blood Flow Metab 17 2 1997 229 232 (Pubitemid 27085847)
45. F. Hua, J. Ma, T. Ha, Y. Xia, J. Kelley, and D.L. Williams Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion J Neuroimmunol 190 1-2 2007 101 111 (Pubitemid 47625617)
46. J.R. Caso, J.M. Pradillo, O. Hurtado, P. Lorenzo, M.A. Moro, and I. Lizasoain Toll-like receptor 4 is involved in brain damage and inflammation after experimental stroke Circulation 115 12 2007 1599 1608 (Pubitemid 46648645)
47. U. Kilic, E. Kilic, C.M. Matter, C.L. Bassetti, and D.M. Hermann TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration Neurobiol Dis 31 1 2008 33 40