Comprehensive analysis of the intracellular metabolism of antiretroviral nucleosides and nucleotides using liquid chromatography-tandem mass spectrometry and method improvement by using ultra performance liquid chromatography

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 26, 2011, Pages 2772-2782

  Coulier, Leon ^a   Gerritsen, Henk ^a   van Kampen, Jeroen J A ^b   Reedijk, Mariska L ^b   Luider, Theo M ^b   Osterhaus, Albert D M E ^b   Gruters, Rob A ^b   Brüll, Lars ^a  

^a TNO   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Antiretroviral drugs; HIV; Ion pair LC MS MS; NRTI; Phosphorylated metabolites; UPLC

Indexed keywords

ANTIRETROVIRAL DRUGS; HIV; ION PAIRS; NRTI; PHOSPHORYLATED METABOLITES; UPLC;

BIOMOLECULES; ELECTROSPRAY IONIZATION; ENZYME INHIBITION; LIQUIDS; MASS SPECTROMETRY; METABOLISM; METABOLITES; PHOSPHORYLATION;

LIQUID CHROMATOGRAPHY;

2',3' DIDEOXYADENOSINE; ABACAVIR; CARBOVIR; DEOXYRIBONUCLEOTIDE; DIDANOSINE; EMTRICITABINE; LAMIVUDINE; RNA DIRECTED DNA POLYMERASE INHIBITOR; STAVUDINE; TENOFOVIR; ZALCITABINE; ZIDOVUDINE;

ACCURACY; ARTICLE; CELL METABOLISM; ELECTROSPRAY; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HIV INFECTIONS; HUMANS; LEUKOCYTES, MONONUCLEAR; NUCLEOSIDES; NUCLEOTIDES; REPRODUCIBILITY OF RESULTS; REVERSE TRANSCRIPTASE INHIBITORS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; ZIDOVUDINE;

EID: 80052378499     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.07.045     Document Type: Article

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