Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 878, Issue 7-8, 2010, Pages 621-627

  Jansen, Robert S ^a   Rosing, Hilde ^a   Kromdijk, Wiete ^a   ter Heine, Rob ^a   Schellens, Jan HM ^a,b   Beijnen, Jos H ^a,b  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Emtricitabine; LC MS; Nucleotides; Tenofovir; Weak anion exchange

Indexed keywords

ANION EXCHANGE; ANION EXCHANGE CHROMATOGRAPHY; ANTIVIRAL AGENTS; CLINICAL SAMPLES; COEFFICIENTS OF VARIATIONS; DIPHOSPHATES; INTERNAL STANDARDS; LOWER LIMIT OF QUANTIFICATIONS; PERIPHERAL BLOOD MONONUCLEAR CELLS; REFERENCE COMPOUNDS; STABLE ISOTOPES; TANDEM MASS SPECTROMETRY; TENOFOVIR; THERMAL DEGRADATIONS; TRIPHOSPHATE;

ABERRATIONS; BLOOD; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; IONS; ISOTOPES; MASS SPECTROMETERS; MASS SPECTROMETRY; METHANOL; NUCLEOTIDES; PERCOLATION (SOLID STATE); PHOSPHORYLATION; PLASMAS;

DYNAMIC POSITIONING;

CYTOSINE; EMTRICITABINE; METHANOL; NUCLEOTIDE DERIVATIVE; PYROPHOSPHATE; TENOFOVIR; WATER;

ACCURACY; ANION EXCHANGE CHROMATOGRAPHY; ARTICLE; CONTROLLED STUDY; DRUG ERYTHROCYTE LEVEL; HUMAN; HUMAN CELL; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY;

ADENINE; ADENINE NUCLEOTIDES; ANIONS; CHROMATOGRAPHY, ION EXCHANGE; DEOXYCYTIDINE; DRUG STABILITY; HUMANS; LEUKOCYTES, MONONUCLEAR; LINEAR MODELS; NUCLEOTIDES; PHOSPHONIC ACIDS; PHOSPHORYLATION; PYRIMIDINE NUCLEOTIDES; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 76549105948     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2010.01.002     Document Type: Article

References (24)

1. Wang L.H., Begley J., St III C.R., Harris J., Wakeford C., and Rousseau F.S. AIDS Res. Hum. Retroviruses 20 (2004) 1173
2. Barditch-Crovo P., Deeks S.G., Collier A., Safrin S., Coakley D.F., Miller M., Kearney B.P., Coleman R.L., Lamy P.D., Kahn J.O., McGowan I., and Lietman P.S. Antimicrob. Agents Chemother. 45 (2001) 2733
3. Hawkins T., Veikley W., Claire III R.L., Guyer B., Clark N., and Kearney B.P. J. Acquir. Immune. Defic. Syndr. 39 (2005) 406
4. Borroto-Esoda K., Vela J.E., Myrick F., Ray A.S., and Miller M.D. Antivir. Ther. 11 (2006) 377
5. Back D.J., Burger D.M., Flexner C.W., and Gerber J.G. J. Acquir. Immune. Defic. Syndr. 39 Suppl. 1 (2005) S1
6. Darque A., Valette G., Rousseau F., Wang L.H., Sommadossi J.P., and Zhou X.J. Antimicrob. Agents Chemother. 43 (1999) 2245
7. King T., Bushman L., Kiser J., Anderson P.L., Ray M., Delahunty T., and Fletcher C.V. J. Chromatogr. B 843 (2006) 147
8. Claire III R.L. Rapid Commun. Mass Spectrom. 14 (2000) 1625
9. Bartley S., Begley J.A., and Clark T.N. Proceedings of the 55th ASMS Conference on Mass Spectrometry and Allied Topics (2007)
10. Delaney W.E., Ray A.S., Yang H., Qi X., Xiong S., Zhu Y., and Miller M.D. Antimicrob. Agents Chemother. 50 (2006) 2471
11. Ray A.S., Myrick F., Vela J.E., Olson L.Y., Eisenberg E.J., Borroto-Esodo K., Miller M.D., and Fridland A. Antivir. Ther. 10 (2005) 451
12. Lynch T., Eisenberg G., and Kernan M. Nucleosides Nucleotides Nucleic Acids 20 (2001) 1415
13. Kuklenyik Z., Martin A., Pau C., Garcia-Lerma G., Heneine W., Pirkle J., and Barr J. Proceedings of the 56th ASMS Conference on Mass Spectrometry and Allied Topics (2008)
14. Pruvost A., Theodoro F., Agrofoglio L., Negredo E., and Benech H. J. Mass Spectrom. 43 (2008) 224
15. Durand-Gasselin L., Da Silva D., Benech H., Pruvost A., and Grassi J. Antimicrob. Agents Chemother. 51 (2007) 2105
16. Pruvost A., Negredo E., Benech H., Theodoro F., Puig J., Grau E., Garcia E., Molto J., Grassi J., and Clotet B. Antimicrob. Agents Chemother. 49 (2005) 1907
17. Delinsky D., Hernandez-Santiago B., and Schinazi R. Proceedings of the 54th ASMS Conference on Mass Spectrometry and Allied Topics (2006)
18. Veltkamp S.A., Hillebrand M.J., Rosing H., Jansen R.S., Wickremsinhe E.R., Perkins E.J., Schellens J.H., and Beijnen J.H. J. Mass Spectrom. 41 (2006) 1633
19. Jansen R.S., Rosing H., de Wolf C.J., and Beijnen J.H. Rapid Commun. Mass Spectrom. 21 (2007) 4049
20. Shi G., Wu J.T., Li Y., Geleziunas R., Gallagher K., Emm T., Olah T., and Unger S. Rapid Commun. Mass Spectrom. 16 (2002) 1092
21. U.S Food and Drug Administration: Centre for Drug Evaluation and Research, Guidance for Industry: Bioanalytical Method Validation, 2001.
22. Becher F., Pruvost A., Gale J., Couerbe P., Goujard C., Boutet V., Ezan E., Grassi J., and Benech H. J. Mass Spectrom. 38 (2003) 879
23. Durand-Gasselin L., Van Rompay K.K., Vela J.E., Henne I.N., Lee W.A., Rhodes G.R., and Ray A.S. Mol. Pharm. 6 (2009) 1145
24. Vela J.E., Olson L.Y., Huang A., Fridland A., and Ray A.S. J. Chromatogr. B 848 (2007) 335