Simultaneous measurement of intracellular triphosphate metabolites of zidovudine, lamivudine and abacavir (carbovir) in human peripheral blood mononuclear cells by combined anion exchange solid phase extraction and LC-MS/MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 850, Issue 1-2, 2007, Pages 310-317

  Robbins, Brian L ^a   Poston, Philip A ^a   Neal, Erin F ^a   Slaughter, Clive ^a   Rodman, John H ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Antiviral drug metabolism; Carbovir triphosphate; Human immunodeficiency virus; Lamivudine triphosphate; Zidovudine triphosphate

Indexed keywords

ANTIVIRAL DRUG METABOLISM; CARBOVIR TRIPHOSPHATE; HUMAN IMMUNODEFICIENCY VIRUS; LAMIVUDINE TRIPHOSPHATE; ZIDOVUDINE TRIPHOSPHATE;

BLOOD; CELL CULTURE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PLASMA (HUMAN);

DRUG PRODUCTS;

ABACAVIR; ABACAVIR PLUS LAMIVUDINE PLUS ZIDOVUDINE; CARBOVIR; DRUG METABOLITE; LAMIVUDINE; PHOSPHATE; RNA DIRECTED DNA POLYMERASE INHIBITOR; TRIPHOSPHATE; UNCLASSIFIED DRUG; ZIDOVUDINE;

ANION EXCHANGE; ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SOLID PHASE EXTRACTION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIDEOXYNUCLEOSIDES; HIV INFECTIONS; HUMANS; LAMIVUDINE; PHOSPHATES; REFERENCE STANDARDS; REVERSE TRANSCRIPTASE INHIBITORS; TANDEM MASS SPECTROMETRY; ZIDOVUDINE;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 34247253856     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2006.12.015     Document Type: Article

References (17)

1. Rodman J.H., Robbins B., Flynn P.M., and Fridland A. J. Infect. Dis. 174 (1996) 490
2. Gao W.Y., Agbaria R., Driscoll J.S., and Mitsuya H. J. Biol. Chem. 269 (1994) 12633
3. Robbins B.L., Rodman J., McDonald C., Srinivas R.V., Flynn P.M., and Fridland A. Antimicrob. Agents Chemother. 38 (1994) 115
4. Wattanagoon Y., Bangchang K.N., Hoggard P.G., Khoo S.E., Gibbons S.E., Phiboonbhanakit D., Karbwang J., and Back D.J. Antimicrob. Agents Chemother. 44 (2000) 1986
5. Slusher J.T., Kuwahara S.K., Hamzeh F.M., Lewis L.D., Kornhauser D.M., and Lietman P.S. Antimicrob. Agents Chemother. 36 (1992) 2473
6. Robbins B.L., Waibel B.H., and Fridland A. Antimicrob. Agents Chemother. 40 (1996) 2651
7. Moore J.D., Valette G., Darque A., Zhou X.J., and Sommadossi J.P. Am. Soc. Mass Spectrom. 11 (2000) 1134
8. Compain S., Schlemmer D., Levi M., Pruvost A., Goujard C., Grassi J., and Benech H. J. Mass Spectrom. 40 (2005) 9
9. King T., Bushman L., Anderson P.L., Delahunty T., Ray M., and Fletcher C.V. J. Chromatogr. B 831 (2006) 248
10. Robbins B.L., Tran T.T., Pinkerton Jr. F.H., Akeb F., Guedj R., Grassi J., Lancaster D., and Fridland A. Antimicrob. Agents Chemother. 42 (1998) 2656
11. Kewn S., Hoggard P.G., Sales S.D., Jones K., Maher B., Khoo S.H., and Back D.J. Anitmicrob. Agents Chemother. 46 (2002) 135
12. Fung E.N., Cai Z., Burnette T.C., and Sinhababu A.K. J. Chrom. B Biomed. Sci. Appl. 754 2 (2001) 285
13. Hawkins T., Veikley W., St. Claire III R.L., Guyer B., Clarke N., and Kearney B.P. J. Acquir. Immune Defic. Syndr. 39 (2005) 406
14. Rodman J.H., Flynn P.M., Robbins B.L., Jimenez E., Bardeguez A.D., Rodriguez J.F., Blanchard S., and Fridland A. J. Infect. Dis. 180 (1999) 1844
15. Becher F., Pruvost A., Goujard C., Guerreiro C., Delfraissy J., Grassi J., and Benech H. Rapid Commun. Mass Spectrom. 16 (2002) 555
16. Becher F., Prouvost A., Gale J., Couerbe P., Goujard C., Boutet V., Ezan E., Grassi J., and Benech H. J. Mass Spectrom. 38 (2003) 879
17. Shah V.P., Midha K.K., Findlay J.W.A., Hill H.M., Hulse J.D., McGilveray I.J., McKay G., Miller K.J., Patnaik R.N., Powell M.L., Tonelli A., Viswanathan C.T., and Yacobi A. Pharm. Res. 17 (2000) 1551