High molecular weight isoforms of growth hormone in cells of the immune system

Cellular Immunology

Volumn 271, Issue 1, 2011, Pages 44-52

  Weigent, Douglas A ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Growth hormone; Lymphocytes; Molecular weight isoforms; Oxidative stress

Indexed keywords

GROWTH HORMONE; ISOPROTEIN; LUCIFERASE;

ADAPTATION; ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL NUCLEUS; CELL POPULATION; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOPLASM; HORMONE DETERMINATION; HUMAN; HUMAN CELL; LYMPHOID CELL; LYMPHOMA CELL; MASS SPECTROMETRY; MOLECULAR WEIGHT; MOUSE; NONHUMAN; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SPLEEN CELL; T LYMPHOCYTE; WESTERN BLOTTING;

ANIMALS; ANTIOXIDANTS; B-LYMPHOCYTES; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CELL LINE, TUMOR; CELLS, CULTURED; GROWTH HORMONE; HUMANS; IMMUNE SYSTEM; LUCIFERASES; LYMPHOCYTES; MALE; MALEATES; MASS SPECTROMETRY; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; OXIDATION-REDUCTION; PROTEIN ISOFORMS; PYRROLIDINES; RESPONSE ELEMENTS; SPLEEN; T-LYMPHOCYTES; THIOCARBAMATES;

EID: 80052372067     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2011.06.001     Document Type: Article

References (55)

1. Maggiano N., Piantelli M., Ricci R., Larocca L.M., Capelli A., Ranelletti O. Detection of growth hormone-producing cells in human thymus by immunohistochemistry and non-radioactive in situ hybridization. J. Histochem. Cytochem. 1994, 42:1349-1354.
2. Wu H., Devi R., Malarkey W.B. Localization of the growth hormone messenger ribonucleic acid in the human immune system-a clinical research center study. J. Clin. Endocrinol. Metab. 1996, 81:1278-1282.
3. Palmetshofer A., Zechner D., Luger T.A., Barta A. Splicing variants of the human growth hormone mRNA: detection in pituitary, mononuclear cells and dermal fibroblasts. Mol. Cell. Endocrinol. 1995, 113:225-234.
4. Mol J.A., VanGardesen E., Seman P.J., Wolswinkel J., Rijinberk A., Rutterman G.R. Growth hormone mRNA in mammary gland tumours of dogs and cats. J. Clin. Invest. 1995, 95:2028-2034.
5. Weigent D.A., Blalock J.E. The production of growth hormone by subpopulations of rat mononuclear leukocytes. Cell. Immunol. 1991, 135:55-65.
6. Weigent D.A., Blalock J.E., LeBoeuf R.D. An antisense oligodeoxynucleotide to growth hormone messenger ribonucleic acid inhibits lymphocyte proliferation. Endocrinology 1991, 128:2053-2057.
7. Baxter J.B., Blalock J.E., Weigent D.A. Characterization of immunoreactive insulin-like growth factor-I from leukocytes and its regulation by growth hormone. Endocrinology 1991, 129:1727-1734.
8. Arnold R.E., Weigent D.A. The inhibition of superoxide production in EL4 lymphoma cells overexpressing growth hormone. Immunopharmacol. Immunotoxicol. 2003, 25:159-177.
9. Arnold R.E., Weigent D.A. The production of nitric oxide in EL4 lymphoma cells overexpressing growth hormone. J. Neuroimmunol. 2003, 134:82-94.
10. Arnold R.E., Weigent D.A. The inhibition of apoptosis in EL4 lymphoma cells overexpressing growth hormone. NeuroImmunoModulation 2004, 11:149-159.
11. Weigent D.A., Arnold R.E. Expression of insulin-like growth factor-1 and insulin-like growth factor-1 receptors in EL4 lymphoma cells overexpressing growth hormone. Cell. Immunol. 2005, 234:54-66.
12. Farmer J.T., Weigent D.A. Expression of insulin-like growth factor-2 receptors on EL4 cells overexpressing growth hormone. Brain Behav. Immun. 2007, 21:79-85.
13. Farmer J.T., Weigent D.A. TGF-beta-1 expression in EL4 lymphoma cells overexpressing growth hormone. Cell. Immunol. 2006, 240:22-30.
14. Weigent D.A. Regulation of Id2 expression in EL4 T lymphoma cells overexpressing growth hormone. Cell. Immunol. 2009, 255:46-54.
15. Malarkey W.B., Wang J., Cheney C., Glaser R., Nagaraja H. Human lymphocyte growth hormone stimulates interferon gamma production and is inhibited by cortisol and norepinephrine. J. Neuroimmunol. 2002, 123:180-187.
16. Kao T.L., Harbour D.V., Meyer W.J. Immunoreactive growth hormone production by cultured lymphocytes. Ann. N.Y. Acad. Sci. 1992, 650:179-181.
17. Weigent D.A., Baxter J.B., Blalock J.E. The production of growth hormone and insulin-like growth factor-I by the same subpopulation of rat mononuclear leukocytes. Brain Behav. Immun. 1992, 6:365-376.
18. Re R.N., Cook J.L. Senescence, apoptosis, and stem cell biology: the rationale for an expanded view of intracrine action. Am. J. Physiol. Heart Circ. Physiol. 2009, 297:H893-H901.
19. Baumann G. Growth hormone heterogeneity: genes, isohormones, variants, and binding proteins. Endocr. Rev. 1991, 12:424-449.
20. Nindl B.C., Kramer W.J., Marx J.O., Tuckow A.P., Hymer W.C. Growth hormone molecular heterogeneity and exercise. Exerc. Sport Sci. Rev. 2003, 31:161-166.
21. Diaz M.J., Dominguez F., Haro L.S., Ling N., Devesa J. A 12-kDa N-glycosylated growth hormone-related peptide is present in human pituitary extracts. J. Clin. Endocrinol. Metab. 1993, 77:134-138.
22. Haro L.S., Lewis U.J., Garcia M., Bustamante J., Martinez A.O., Ling N.C. Glycosylated human growth hormone (hGH): a novel 24kDa hGH-N variant. Biochem. Biophys. Res. Commun. 1996, 228:549-556.
23. Baumman G. Growth hormone heterogeneity: genes, isohormones, variants, and binding proteins. Endocr. Rev. 1991, 12:424-449.
24. Lewis U.J., Sinha Y.N., Lewis G.P. Structure and properties of members of the hGH family: a review. Endocr. J. 2000, 47:S1-S8.
25. Grigorian A.L., Bustamante J.J., Hernandez P., Martinez A.O., Haro L.S. Extraordinarily stable disulfide-linked homodimer of human growth hormone. Protein Sci. 2005, 14:902-913.
26. A.L. Grigorian, J. Bustamante, R.M. Aguilar, J. Munoz, A.O. Maratinez, L.S. Haro, Characterization of 45 kDa mercaptoethanol-resistant human growth hormone by radioimmunoassay and bioassays, Program of the 85th Annual Meeting of The Endocrine Society, Philadelphia, PA, 2003, p. 381.
27. Pierce J.R., Tuckow A.P., Alemany J.A., Rarick K.R., Staab J.S., Harman E.A., Nindl B.C. Effects of acute and chronic exercise on disulfide-linked growth hormone variants. Med. Sci. Sports Exerc. 2009, 41:581-587.
28. Weigent D.A., Baxter J.B., Wear W.E., Smith L.R., Bost K.L., Blalock J.E. Production of immunoreactive growth hormone by mononuclear leukocytes. FASEB J. 1988, 2:2812-2818.
29. Costoya J.A., Vidal A., Garcia-Barros M., Arce V., Devesa J. Expression of the human growth hormone normal gene (hGH-N) in proliferating and differentiated HL-60 cells. Exp. Cell Res. 1996, 228:164-167.
30. Sabharwal P., Varma S. Growth hormone synthesized and secreted by human thymocytes acts via insulin-like growth factor I as an autocrine and paracrine growth factor. J. Clin. Endocrinol. Metab. 1996, 81:2663-2669.
31. Kooijman R., Gerlo S., Coppens A., Hooghe-Peters E.L. Growth hormone and prolactin expression in the immune system. Ann. N.Y. Acad. Sci. 2006, 917:534-540.
32. Lytras A., Quan N., Vrontakis M.E., Shaw J.E., Cattini P.A., Friesen H.G. Growth hormone expression in human Burkitt lymphoma serum-free Ramos cell line. Endocrinology 1993, 132:620-628.
33. Baglia L.A., Cruz D., Shaw J.E. Production of immunoreactive forms of growth hormone by the Burkitt tumor serum-free cell line sfRamos. Endocrinology 1992, 130:2446-2454.
34. Julius M.H., Simpson E., Herzenberg L.A. A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur. J. Immunol. 1973, 3:645-649.
35. Dignam J.D. Preparation of extracts from higher eukaryotes. Methods Enzymol. 1990, 182:194-203.
36. Leonardi E., Girlando S., Serio G., Mauri F.A., Perrone G., Scampini S., Dalla Palma P., Barbareschi M. PCNA and Ki 67 expression in breast carcinoma: correlations with clinical and biological variables. J. Clin. Pathol. 1992, 45:416-419.
37. Weigent D.A., Blalock J.E. Production of peptide hormones and neurotransmitters by the immune system. Neuroimmunoendocrinology 1997, 1-30. Karger, Basel. J.E. Blalock (Ed.).
38. Hansen J., Watson W., Jones O. Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1. Toxicol. Sci. 2007, 82:308-317.
39. Shearwin-Whyatt L.M., Harvey N.L., Kumar S. Subcellular localization and CARD-dependent oligomerization of the death adaptor RAIDD. Cell Death Differ. 2000, 7:155-165.
40. Wild A.C., Mulcahy R.T. Pyrrolidine dithiocarbamate up-regulates the expression of the genes encoding the catalytic and regulatory subunits of gamma-glutamycysteine synthetase and increases intracellular glutathione levels. Biochem. J. 1999, 338:659-665.
41. Casey W., Anderson S., Fox T., Dold K., Colton H., Morgan K. Transcriptional and physiological responses of HepG2 cells exposed to diethyl maleate: time course analysis. Physiol. Genom. 2002, 8:115-122.
42. Li J., Lee J.-M., Johnson D.A., Johnson J.A. Antioxidant responsive element activation by quinones: antioxidant responsive element target genes, role of PI3 kinase in activation. Methods Enzymol. 2001, 378:238-258.
43. Edens A., Talamantes F. Alternative processing of growth hormone receptor transcripts. Endocr. Rev. 1998, 19:559-582.
44. Lobie P.E., Mertani H., Morel G., Morales-Bustos O., Norstedt G., Waters M.J. Receptor-mediated nuclear translocation of growth hormone. J. Biol. Chem. 1994, 269:21330-21339.
45. Lobie P.E., Wood T.J.J., Chen C.M., Waters M.J., Norstedt G. Nuclear translocation and anchorage of the growth hormone receptor. J. Biol. Chem. 1994, 269:31735-31746.
46. Nguyen T., Sherratt P.J., Pickett C.B. Regulatory mechanisms controlling gene expression mediated by the antioxidant response element. Annu. Rev. Pharmacol. Toxicol. 2003, 43:233-260.
47. Berruyer C., Martin F.M., Castellano R., Macone A., Malergue F., Garrido-Urbani S., Millet V., Imbert J., Dupre S., Pitari G., Naquet P., Galland F. Vanin-1 -/- mice exhibit a glutathione-mediated tissue resistance to oxidative stress. Mol. Cell. Biol. 2004, 24:7214-7224.
48. Schafer G., Cramer T., Suske G., Kemmner W., Wiedenmann B., Hocker M. Oxidative stress regulates vascular endothelial growth factor-A gene transcription through Sp1- and Sp3-dependent activation of two proximal GC-rich promoter elements. J. Biol. Chem. 2003, 278:8190-8198.
49. Vines C.R., Weigent D.A. Identification of SP3 as a negative regulatory transcription factor in the monocyte expression of growth hormone. Endocrinology 2000, 141:938-946.
50. Polla B.S., Bachelet M., Elia G., Santoro M.G. Stress proteins in inflammation. Ann. N.Y. Acad. Sci. 1998, 851:75-85.
51. Re R.N., Cook J.L. The basis of an intracrine pharmacology. J. Clin. Pharmacol. 2008, 48:344-350.
52. Blalock J.E. The immune system as a sensory organ. J. Immunol. 1984, 132:1067-1070.
53. Weigent D.A., Blalock J.E. Associations between the neuroendocrine and immune systems. J. Leukoc. Biol. 1995, 58:137-150.
54. Miyamoto N., Izumi H., Miyamoto R., Bin H., Kondo H., Tawara A., Sasaguri Y., Kohno K. Transcriptional regulation of activating transcription factor 4 under oxidative stress in retinal pigment epithelial ARPE-19/HPV-16 cells. Invest. Ophthalmol. Vis. Sci. 2011, 52:1226-1234.
55. Burgoyne J.R., Madhani M., Cuello F., Charles R.L., Brennan J.P., Schroder E., Browning D.D., Eaton P. Cysteine redox sensor in PKG1a enables oxidant-induced activation. Science 2007, 317:1393-1397.