Performance of automated drusen detection by polarization-sensitive optical coherence tomography

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 7, 2011, Pages 4571-4579

  Schlanitz, Ferdinand G ^a   Baumann, Bernhard ^a   Spalek, Tobias ^a   Schütze, Christopher ^a   Ahlers, Christian ^a   Pircher, Michael ^a   Götzinger, Erich ^a   Hitzenberger, Christoph K ^a   Schmidt Erfurth, Ursula ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALGORITHM; ARTICLE; AUTOFLUORESCENCE IMAGING; B SCAN; CLINICAL ARTICLE; CLINICAL TRIAL; DRUSEN; EYE PHOTOGRAPHY; FEMALE; HUMAN; MALE; OPTICAL COHERENCE TOMOGRAPHY; PIGMENT EPITHELIUM; POLARIZATION SENSITIVE OPTICAL COHERENCE TOMOGRAPHY; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPHY; AUTOMATION; COMPARATIVE STUDY; DIFFERENTIAL DIAGNOSIS; EARLY DIAGNOSIS; METHODOLOGY; MIDDLE AGED; OPTIC DISK ANOMALY; REPRODUCIBILITY; RETINA MACULA DEGENERATION; THREE DIMENSIONAL IMAGING;

AGED; AUTOMATION; DIAGNOSIS, DIFFERENTIAL; EARLY DIAGNOSIS; FEMALE; HUMANS; IMAGING, THREE-DIMENSIONAL; MACULAR DEGENERATION; MALE; MIDDLE AGED; OPTIC DISK DRUSEN; REPRODUCIBILITY OF RESULTS; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 80052370664     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6846     Document Type: Article

References (64)

1. Jager RD, Mieler WF, Miller JW. Age-related macular degeneration. N Engl J Med. 2008;358:2606-2617.
2. Klein R, Klein BEK, Knudtson MD, Meuer SM, Swift M, Gangnon RE. Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology. 2007;114:253-262.
3. Green WR. Histopathology of age-related macular degeneration (Abstract). Mol Vis. 1999;5:27.
4. Sarks SH, Arnold JJ, Killingsworth MC, Sarks JP. Early drusen formation in the normal and aging eye and their relation to age related maculopathy: a clinicopathological study. Br J Ophthalmol. 1999;83:358-368.
5. Ishibashi T, Patterson R, Ohnishi Y, Inomata H, Ryan SJ. Formation of drusen in the human eye. Am J Ophthalmol. 1986;101:342-353.
6. Sarks JP, Sarks SH, Killingsworth MC. Evolution of soft drusen in age-related macular degeneration. Eye. 1994;8:269-283.
7. Hageman GS, Mullins RF. Molecular composition of drusen as related to substructural phenotype (Abstract). Mol Vis. 1999;5:28.
8. Li C-M, Clark ME, Rudolf M, Curcio CA. Distribution and composition of esterified and unesterified cholesterol in extra-macular drusen. Exp Eye Res. 2007;85:192-201.
9. Abdelsalam A, Del Priore L, Zarbin M. Drusen in age-related macular degeneration: pathogenesis, natural course, and laser photocoagulation-induced regression. Surv Ophthalmol. 1999;44:1-29.
10. Hageman GS, Luthert PJ, Victor Chong NH, Johnson LV, Anderson DH, Mullins RF. An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration. Prog Retin Eye Res. 2001;20:705-732.
11. Al-Hussaini H, Schneiders M, Lundh P, Jeffery G. Drusen are associated with local and distant disruptions to human retinal pigment epithelium cells. Exp Eye Res. 2009;88:610-612.
12. Curcio CA, Medeiros NE, Millican CL. Photoreceptor loss in agerelated macular degeneration. Invest Ophthalmol Vis Sci. 1996;37:1236-1249.
13. Grossniklaus HE, Martinez JA, Brown VB, et al. Immunohistochemical and histochemical properties of surgically excised subretinal neovascular membranes in age-related macular degeneration. Am J Ophthalmol. 1992;114:464-472.
14. Pauleikhoff D, Barondes MJ, Minassian D, Chisholm IH, Bird AC. Drusen as risk factors in age-related macular disease. Am J Ophthalmol. 1990;109:38-43.
15. Bressler NM, Munoz B, Maguire MG, et al. Five-year incidence and disappearance of drusen and retinal pigment epithelial abnormalities. Waterman study. Arch Ophthalmol. 1995;113:301-308.
16. Holz F, Wolfensberger T, Piguet B, et al. Bilateral macular drusen in age-related macular degeneration. Prognosis and risk factors. Ophthalmology. 1994;101:1522-1528.
17. Freeman SR, Kozak I, Cheng L, et al. Optical coherence tomography-raster scanning and manual segmentation in determining drusen volume in age-related macular degeneration. Retina. 2010;30:431-435.
18. Rudolf M, Clark ME, Chimento MF, Li C-M, Medeiros NE, Curcio CA. Prevalence and morphology of druse types in the macula and periphery of eyes with age-related maculopathy. Invest Ophthalmol Vis Sci. 2008;49:1200-1209.
19. Klein R, Davis MD, Magli YL, Segal P, Klein BE, Hubbard L. The Wisconsin age-related maculopathy grading system. Ophthalmology. 1991;98:1128-1134.
20. Bird A, Bressler N, Bressler S, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration. Surv Ophthalmol. 1995;39:367-374.
21. The Age-Related Eye Disease Study Research Group. The Age-Related Eye Disease Study (AREDS): design implications. AREDS Report No. 1. Control Clin Trials. 1999;20:573-600.
22. The Age-Related Eye Disease Study Research Group. Risk factors associated with age-related macular degeneration. A case-control study in the age-related eye disease study: Age-Related Eye Disease Study Report Number 3. Ophthalmology. 2000;107:2224-2232.
23. Davis MD, Gangnon RE, Lee L-Y, et al. The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17. Arch Ophthalmol. 2005;123:1484-1498.
24. Ferris FL, Davis MD, Clemons TE, et al. A simplified severity scale for age-related macular degeneration: AREDS Report No. 18. Arch Ophthalmol. 2005;123:1570-1574.
25. The Age-Related Eye Disease Study Research Group. The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study Report No. 6. Am J Ophthalmol. 2001;132:668-681.
26. Rapantzikos K, Zervakis M, Balas K. Detection and segmentation of drusen deposits on human retina: potential in the diagnosis of agerelated macular degeneration. Med Image Anal. 2003;7:95-108.
27. Smith R, Chan J, Nagasaki T, et al. Automated detection of macular drusen using geometric background leveling and threshold selection. Arch Ophthalmol. 2005;123:200-206.
28. Spaide RF, Curcio CA. Drusen characterization with multimodal imaging. Retina. 2010;30:1441-1454.
29. Fercher A, Hitzenberger CK, Kamp G, El-Zaiat SY. Measurement of intraocular distances by backscattering spectral interferometry. Opt Commun. 1995;117:43-48.
30. Wojtkowski M, Leitgeb R, Kowalczyk A, Bajraszewski T, Fercher AF. In vivo human retinal imaging by Fourier domain optical coherence tomography. J Biomed Opt. 2002;7:457-463.
31. Leitgeb R, Hitzenberger C, Fercher A. Performance of fourier domain vs. time domain optical coherence tomography. Opt Express. 2003;11:889-894.
32. Drexler W, Fujimoto JG. State-of-the-art retinal optical coherence tomography. Prog Retin Eye Res. 2008;27:45-88.
33. Schmidt-Erfurth U, Leitgeb RA, Michels S, et al. Three-dimensional ultrahigh-resolution optical coherence tomography of macular diseases. Invest Ophthalmol Vis Sci. 2005;46:3393-3402.
34. Ahlers C, Schmidt-Erfurth U. Three-dimensional high resolution OCT imaging of macular pathology. Opt Express. 2009;17:4037-4045.
35. Stopa M, Bower BA, Davies E, Izatt JA, Toth CA. Correlation of pathologic features in spectral domain optical coherence tomography with conventional retinal studies. Retina. 2008;28:298-308.
36. Chen Y, Vuong LN, Liu J, et al. Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration. Opt Express. 2009;17:4046-4060.
37. Baroni M, Fortunato P, La Torre A. Towards quantitative analysis of retinal features in optical coherence tomography. Med Eng Phys. 2007;29:432-441.
38. Fabritius T, Makita S, Miura M, Myllylä R, Yasuno Y. Automated segmentation of the macula by optical coherence tomography. Opt Express. 2009;17:15659-15669.
39. Mishra A, Wong A, Bizheva K, Clausi DA. Intra-retinal layer segmentation in optical coherence tomography images. Opt Express. 2009;17:23719-23728.
40. Schlanitz F, Ahlers C, Sacu S, et al. Performance of drusen detection by spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2010;51:6715-6721.
41. Götzinger E, Pircher M, Hitzenberger CK. High speed spectral domain polarization sensitive optical coherence tomography of the human retina. Opt Express. 2005;13:10217-10229.
42. Pircher M, Götzinger E, Leitgeb R, Sattmann H, Findl O, Hitzenberger C. Imaging of polarization properties of human retina in vivo with phase resolved transversal PS-OCT. Opt Express. 2004;12:5940-5951.
43. Pircher M, Götzinger E, Findl O, et al. Human macula investigated in vivo with polarization-sensitive optical coherence tomography. Invest Ophthalmol Vis Sci. 2006;47:5487-5494.
44. Götzinger E, Pircher M, Baumann B, et al. Three-dimensional polarization sensitive OCT imaging and interactive display of the human retina. Opt Express. 2009;17:4151-4165.
45. Götzinger E, Pircher M, Geitzenauer W, et al. Retinal pigment epithelium segmentation by polarization sensitive optical coherence tomography. Opt Express. 2008;16:16410-16422.
46. Michels S, Pircher M, Geitzenauer W, et al. Value of polarisationsensitive optical coherence tomography in diseases affecting the retinal pigment epithelium. Br J Ophthalmol. 2008;92:204-209.
47. Ahlers C, Goetzinger E, Pircher M, et al. Imaging of the retinal pigment epithelium in age-related macular degeneration using polarization sensitive optical coherence tomography. Invest Ophthalmol Vis Sci. 2010;51:2149-2157.
48. Baumann B, Götzinger E, Pircher M, Hitzenberger CK. Measurements of depolarization distribution in the healthy human macula by polarization sensitive OCT. J Biophotonics. 2009;2:426-434.
49. American National Standards Institute (ANSI). ANSI Z136.1-2000: American National Standard for Safe Use of Lasers. Orlando, FL: Laser Institute of America; 2000.
50. International Electrotechnical Commission (IEC). IEC 60825-1: 2001: Safety of Laser Products-Part 1: Equipment Classification, Requirements, and User's Guide. Geneva: IEC; 2001.
51. Baumann B, Götzinger E, Pircher M, et al. Segmentation and quantification of retinal lesions in age-related macular degeneration using polarization-sensitive optical coherence tomography. J Biomed Opt. 2010;15:061704.
52. Khanifar AA, Koreishi AF, Izatt JA, Toth CA. Drusen ultrastructure imaging with spectral domain optical coherence tomography in age-related macular degeneration. Ophthalmology. 2008;115: 1883-1890.
53. Wojtkowski M, Sikorski BL, Gorczynska I, et al. Comparison of reflectivity maps and outer retinal topography in retinal disease by 3-D Fourier domain optical coherence tomography. Opt Express. 2009;17:4189-4207.
54. Bland JM, Altman DG. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet. 1986;1: 307-310.
55. Ho J, Sull AC, Vuong LN, et al. Assessment of artifacts and reproducibility across spectral-and time-domain optical coherence tomography devices. Ophthalmology. 2009;116:1960-1970.
56. Baumann B, Baumann S, Konegger T, et al. Polarization sensitive optical coherence tomography of melanin provides tissue inherent contrast based on depolarization. Proc SPIE. 2010;7554: 75541M-6.
57. Baumgartner A, Dichtl S, Hitzenberger CK, et al. Polarizationsensitive optical coherence tomography of dental structures. Caries Res. 2000;34:59-69.
58. Johnson P, Lewis G, Talaga K, et al. Drusen-associated degeneration in the retina. Invest Ophthalmol Vis Sci. 2003;44:4481-4488.
59. Keilhauer CN, Delori FC. Near-infrared autofluorescence imaging of the fundus: visualization of ocular melanin. Invest Ophthalmol Vis Sci. 2006;47:3556-3564.
60. Arnold JJ, Sarks SH, Killingsworth MC, Sarks JP. Reticular pseudodrusen. A risk factor in age-related maculopathy. Retina. 1995;15: 183-191.
61. Rudolf M, Malek G, Messinger JD, Clark ME, Wang L, Curcio CA. Sub-retinal drusenoid deposits in human retina: organization and composition. Exp Eye Res. 2008;87:402-408.
62. Schmitz-Valckenberg S, Steinberg JS, Fleckenstein M, Visvalingam S, Brinkmann CK, Holz FG. Combined confocal scanning laser ophthalmoscopy and spectral-domain optical coherence tomography imaging of reticular drusen associated with agerelated macular degeneration. Ophthalmology. 2010;117:1169-1176.
63. Bressler NM, Bressler SB, West SK, Fine SL, Taylor HR. The grading and prevalence of macular degeneration in Chesapeake Bay watermen. Arch Ophthalmol. 1989;107:847-852.
64. Klein R, Klein B, Linton K. Prevalence of age-related maculopathy. Ophthalmology. 1992;99:933-943.