Simultaneous quantification of VX and its toxic metabolite in blood and plasma samples and its application for in vivo and in vitro toxicological studies

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 26, 2011, Pages 2704-2713

  Reiter, Georg ^a   Mikler, John ^b   Hill, Ira ^b   Weatherby, Kendal ^b   Thiermann, Horst ^a   Worek, Franz ^a  

^a BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

^b DEFENCE RESEARCH AND DEVELOPMENT CANADA   (Canada)

Author keywords

Acetylcholinesterase inhibition; Large volume injection; Nerve agents; Organophosphorus; Toxicokinetics; VX

Indexed keywords

ACETYLCHOLINESTERASE INHIBITION; LARGE VOLUME INJECTION; NERVE AGENTS; ORGANOPHOSPHORUS; TOXICOKINETICS; VX;

BIOMOLECULES; BLOOD; METABOLISM; METABOLITES;

TOXIC MATERIALS;

CENTRAL NERVOUS SYSTEM AGENTS; EA 2192; O ETHYL S [2 (DIISOPROPYLAMINO)ETHYL]METHYLPHOSPHONOTHIOATE; TOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SWINE; TANDEM MASS SPECTROMETRY; TOXICOKINETICS;

ACUTE TOXICITY TESTS; ANIMALS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GUINEA PIGS; HUMANS; LINEAR MODELS; MALE; MICE; ORGANOTHIOPHOSPHORUS COMPOUNDS; RABBITS; RATS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SWINE; TANDEM MASS SPECTROMETRY;

SUIDAE;

EID: 80052369919     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.07.031     Document Type: Article

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