Application of capillary gas chromatography to the study of hydrolysis of the nerve agent VX in rat plasma

Journal of Chromatography B: Biomedical Applications

Volumn 688, Issue 2, 1997, Pages 255-264

  Bonierbale, Eric ^a   Debordes, Lydia ^a   Coppet, Lucien ^a  

^a CENTRE D ETUDES DU BOUCHET   (France)

Author keywords

Diisopropylaminoethanethiol; Nerve agent; Nerve agents; O Ethyl S (2 diisopropylaminoethyl)methylphosphonothiolate; VX

Indexed keywords

CHEMICAL WARFARE AGENT; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER;

ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CALIBRATION; CAPILLARY GAS CHROMATOGRAPHY; CONTROLLED STUDY; DRUG DETERMINATION; DRUG HYDROLYSIS; IN VITRO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; TECHNIQUE;

ANIMALS; ARYLDIALKYLPHOSPHATASE; CHELATING AGENTS; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; CHROMATOGRAPHY, GAS; ESTERASES; ETHYLAMINES; HYDROLYSIS; MALE; MERCURY; ORGANOTHIOPHOSPHORUS COMPOUNDS; RATS; RATS, WISTAR; SENSITIVITY AND SPECIFICITY; SULFHYDRYL COMPOUNDS;

EID: 0031045409     PISSN: 15726495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(96)00310-6     Document Type: Article

References (25)

1. P. Taylor, A.G. Gilman and L.S. Goodman, The Pharmacological Basis of Therapeutics, Macmillan, New York, 1985, p. 10.
2. B. Holmstedt, Pharmacol. Review., 11 (1959) 567.
3. T. Namba, C.T. Nolte, J. Jackson and D. Grob, Am. J. Med., 50 (1971) 475.
4. C. Decandole, W.W. Douglas, C.L. Evans, R. Holmes, K.E.V. Spencer, R.W. Torrance and K.M. Wilson, Br. J. Pharmacol., 8 (1953) 466.
5. L.P.A. De Jong, C. Van Dijk and H.P. Benschop, Biochem. Pharmacol., 37 (1988) 2939.
6. G. Chettur, JJ. DeFrank, B.J. Gallo, F.C.G. Hoskin, S. Mainer, P.M. Robbins, K.E. Steinmann and J.E. Walker, Fundam. Appl. Toxicol., 11 (1988) 373.
7. H. De Bisschop, J.G. Mainil and J.L. Willems, Biochem. Pharmacol., 34 (1985) 1895.
8. J.S. Little, C.A. Broomfield, M.K. Fox-Talbot, L.J. Boucher, B. Maclver and D.E. Lenz, Biochem. Pharmacol., 38 (1989) 23.
9. D.A. Farquharson, F.C.G. Hoskin, K. Hubbard and R.D. Prusch, Bull. Environ. Contam. Toxicol., 24 (1980) 719.
10. M.D. Maxwell, Toxicol. Appl. Pharmacol., 114 (1992) 306.
11. Y.-C. Yang, L.L. Szafraniec, W.T. Beaudry and D.K. Rohrbaugh, J. Am. Chem. Soc., 112 (1990) 6621.
12. J.J. DeFrank, Applications of Enzyme Biotechnology, Plenum Press, New York, 1991, p. 165.
13. K.I. Dave, L. Phillips, V.A. Luckow and J.R. Wild, Biotechnol. Appl. Biochem., 19 (1994) 271.
14. F.C.G. Hoskin, J.E. Walker, W.-D. Dettbarn and J.R. Wild, Biochem. Pharmacol., 49 (1995) 711.
15. G.L. Ellman, K.D. Courtney, V.J. Andres and R.M. Featherstone, Biochem. Pharmacol., 7 (1961) 88.
16. S. Bezeau, PhD thesis, Faculté de Pharmacie de Montpellier I, 1995.
17. J. Epstein, J.J. Callahan and V.E. Bauer, Phosphorus, 4 (1974) 157.
18. E. Reiner, F.C.G. Hoskin and N.W. Aldridge, Enzymes hydrolysing organophosphorus compounds, Ellis Horwood, Chichester, 1989.
19. D.B. Coult and D.J. Marsh, Biochem. J., 98 (1966) 869.
20. W.K. Berry and D.R. Davies, Biochem. J., 100 (1966) 572.
21. G. Bucht and G. Puu, Biochem. Pharmacol., 33 (1984) 3573.
22. A. Bencsura, I. Enyedy and I.N. Kovach, Biochemistry, 34 (1995) 8989.
23. K.-B. Augustinsson, Handbuch der experimentellen pharmakologie: cholinesterases and anticholinesterases agents, Springer-Verlag, Berlin, 1963, p. 90.
24. Y.-C. Yang, J.A. Baker and J.R. Ward, Chem. Rev., 92 (1992) 1729.
25. F.C.G. Hoskin, Squid as Experimental Animals, Plenum Press, New York, 1990, p. 469.