Chemical synthesis of two series of nerve agent model compounds and their stereoselective interaction with human acetylcholinesterase and human butyrylcholinesterase

Chemical Research in Toxicology

Volumn 22, Issue 10, 2009, Pages 1669-1679

  Barakat, Nora H ^a   Zheng, Xueying ^a   Gilley, Cynthia B ^a   MacDonald, Mary ^a   Okolotowicz, Karl ^a   Cashman, John R ^a   Vyas, Shubham ^b   Beck, Jeremy M ^b   Hadad, Christopher M ^b   Zhang, Jun ^a  

^a HUMAN BIOMOLECULAR RESEARCH INSTITUTE   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(DIMETHYLAMINO)(ETHOXY)PHOSPHORYLTHIO] N,N,N TRIMETHYLETHANAMINIUM IODIDE; ACETYLCHOLINESTERASE; CHLORODIMETHYL 5 PHENYL 1, 3, 2 OXAZAPHOSPHOLIDINE 2 THIONE; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DIMETHYLAMINOETHYL METHYLPHOSPHONOTHIOATE DERIVATIVE; N,N DIMETHYLAMINODIMETHYL 5 PHENYL 1, 3, 2 OXAZAPHOSPHOLIDINE 2 THIONE; ORGANOPHOSPHATE; PHOSPHORUS; THIOCHOLINE; TRIMETHYL 5 PHENYL 1,3,2 OXAZAPHOSPHOLIDINE 2 THIONE; UNCLASSIFIED DRUG;

ARTICLE; DIASTEREOISOMER; ENANTIOMER; HUMAN; MOLECULAR DOCKING; STEREOCHEMISTRY; STEREOISOMERISM; SYNTHESIS;

ACETYLCHOLINESTERASE; BINDING SITES; BUTYRYLCHOLINESTERASE; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; HUMANS; KINETICS; ORGANOPHOSPHORUS COMPOUNDS; ORGANOTHIOPHOSPHORUS COMPOUNDS; PHOSPHORIC ACID ESTERS; PROTEIN BINDING; SARIN; SOMAN; STEREOISOMERISM;

EID: 70350221013     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx900096j     Document Type: Article

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