The N1 auditory evoked potential component as an endophenotype for schizophrenia: High-density electrical mapping in clinically unaffected first-degree relatives, first-episode, and chronic schizophrenia patients

European Archives of Psychiatry and Clinical Neuroscience

Volumn 261, Issue 5, 2011, Pages 331-339

  Foxe, John J ^a,b,c,d   Yeap, Sherlyn ^c   Snyder, Adam C ^a,d   Kelly, Simon P ^a,c   Thakore, Jogin H ^c   Molholm, Sophie ^a,b,d  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c St Vincent's Hospital Ireland   (Ireland)

^d CITY COLLEGE OF NEW YORK   (United States)

Author keywords

Electrophysiology; Endophenotype; ERP; Event related potential; Genetic liability; N1 deficit; Schizophrenia

Indexed keywords

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRODE; EVOKED AUDITORY RESPONSE; FAMILY RELATION; FEMALE; GENETIC RISK; HUMAN; MALE; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA;

ACOUSTIC STIMULATION; ADULT; BRAIN MAPPING; CHRONIC DISEASE; ELECTROENCEPHALOGRAPHY; ENDOPHENOTYPES; EVOKED POTENTIALS, AUDITORY; FAMILY; FEMALE; HUMANS; MALE; MIDDLE AGED; PSYCHOACOUSTICS; SCHIZOPHRENIA;

EID: 80052350437     PISSN: 09401334     EISSN: 14338491     Source Type: Journal    
DOI: 10.1007/s00406-010-0176-0     Document Type: Article

References (70)

1. J Ahveninen IP Jaaskelainen D Osipova MO Huttunen RJ Ilmoniemi J Kaprio J Lonnqvist M Manninen S Pakarinen S Therman R Naatanen TD Cannon 2006 Inherited auditory-cortical dysfunction in twin pairs discordant for schizophrenia Biol Psychiatry 60 612 620 16876141 10.1016/j.biopsych.2006.04.015 (Pubitemid 44402379)
2. C Alain F Cortese LJ Bernstein Y He RB Zipursky 2001 Auditory feature conjunction in patients with schizophrenia Schizophr Res 49 179 191 11343876 10.1016/S0920-9964(00)00138-9 1:STN:280:DC%2BD3M3kt1eisw%3D%3D (Pubitemid 32434324)
3. Andreasen N (1984) Scale for the Assessment of Negative Symptoms (SANS). Department of Psychiatry, University of Iowa, Iowa City
4. AP Anokhin AB Vedeniapin AC Heath O Korzyukov NN Boutros 2007 Genetic and environmental influences on sensory gating of mid-latency auditory evoked responses: a twin study Schizophr Res 89 312 319 17014995 10.1016/j.schres.2006. 08.009 (Pubitemid 44881286)
5. PA A (1994) Diagnostic and statistical manual of mental disorders, 4th edn. American Psychiatric Association, Washington, DC
6. PE Bestelmeyer LH Phillips C Crombie P Benson D St Clair 2009 The P300 as a possible endophenotype for schizophrenia and bipolar disorder: evidence from twin and patient studies Psychiatry Res 169 3 212 219 19748132 10.1016/j.psychres.2008.06.035
7. DH Blackwood DM St Clair WJ Muir JC Duffy 1991 Auditory P300 and eye tracking dysfunction in schizophrenic pedigrees Arch Gen Psychiatry 48 899 909 1929759 1:STN:280:DyaK38%2FivVagtw%3D%3D
8. NN Boutros O Korzyukov B Jansen A Feingold M Bell 2004 Sensory gating deficits during the mid-latency phase of information processing in medicated schizophrenia patients Psychiatry Res 126 203 215 15157747 10.1016/j.psychres. 2004.01.007 (Pubitemid 38626182)
9. NN Boutros O Korzyuko G Oliwa A Feingold D Campbell D McClain-Furmanski F Struve BH Jansen 2004 Morphological and latency abnormalities of the mid-latency auditory evoked responses in schizophrenia: a preliminary report Schizophr Res 70 303 313 15329306 10.1016/j.schres.2003.12.009 (Pubitemid 39141108)
10. KJ Brown CJ Gonsalvez AW Harris LM Williams E Gordon 2002 Target and non-target ERP disturbances in first episode vs. chronic schizophrenia Clin Neurophysiol 113 1754 1763 12417228 10.1016/S1388-2457(02)00290-0 1:STN:280:DC%2BD38nlslChsQ%3D%3D (Pubitemid 35335464)
11. G Bruder J Kayser C Tenke X Amador M Friedman Z Sharif J Gorman 1999 Left temporal lobe dysfunction in schizophrenia: event-related potential and behavioural evidence from phonetic and tonal dichotic listening tasks Arch Gen Psychiatry 56 267 276 10078505 10.1001/archpsyc.56.3.267 1:STN:280: DyaK1M7ns1eqsw%3D%3D (Pubitemid 29125136)
12. J Camchong KO Lim SR Sponheim AW Macdonald 2009 Frontal white matter integrity as an endophenotype for schizophrenia: diffusion tensor imaging in monozygotic twins and patients' nonpsychotic relatives Front Hum Neurosci 3 35 19893757 10.3389/neuro.09.035.2009
13. GG Celesia 1976 Organization of auditory cortical areas in man Brain 99 403 414 1000279 10.1093/brain/99.3.403 1:STN:280:DyaE2s%2Fms1entg%3D%3D
14. NJ Clunas PB Ward 2005 Auditory recovery cycle dysfunction in schizophrenia: a study using event-related potentials Psychiatry Res 136 17 25 16023732 10.1016/j.psychres.2005.05.009 (Pubitemid 41032969)
15. Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Erlbaum Associates Publishers, Hillsdale
16. JJ de Jong PP Hodiamont J Van den Stock B de Gelder 2009 Audiovisual emotion recognition in schizophrenia: reduced integration of facial and vocal affect Schizophr Res 107 2-3 286 293 18986799 10.1016/j.schres.2008.10.001
17. OM de Wilde LJ Bour PM Dingemans JH Koelman DH Linszen 2007 Failure to find P50 suppression deficits in young first-episode patients with schizophrenia and clinically unaffected siblings Schizophr Bull 33 6 1319 1323 17289652 10.1093/schbul/sbm001 (Pubitemid 350022766)
18. OM de Wilde LJ Bour PM Dingemans JH Koelman T Boerée DH Linszen 2008 P300 deficits are present in young first-episode patients with schizophrenia and not in their healthy young siblings Clin Neurophysiol 119 12 2721 2726 18986832 10.1016/j.clinph.2008.08.024
19. G Donohoe DW Morris P De Sanctis E Magno JL Montesi HP Garavan IH Robertson DC Javitt M Gill AP Corvin JJ Foxe 2008 Early visual processing deficits in dysbindin-associated schizophrenia Biol Psychiatry 63 5 484 489 17945199 10.1016/j.biopsych.2007.07.022 (Pubitemid 351220791)
20. RB Force NC Venables SR Sponheim 2008 An auditory processing abnormality specific to liability for schizophrenia Schizophr Res 103 298 310 18571375 10.1016/j.schres.2008.04.038
21. JM Ford PM White JG Csernansky WO Faustman WT Roth A Pfefferbaum 1994 ERPs in schizophrenia: effects of antipsychotic medication Biol Psychiatry 36 153 170 7948453 10.1016/0006-3223(94)91221-1 1:STN:280:DyaK2M%2FjsFGnsA%3D%3D (Pubitemid 24269143)
22. JJ Foxe GM Doniger DC Javitt 2001 Early visual processing deficits in schizophrenia: impaired P1 generation revealed by high-density electrical mapping Neuroreport 12 17 3815 3820 11726801 10.1097/00001756-200112040-00043 1:STN:280:DC%2BD3MnovV2msQ%3D%3D (Pubitemid 33105178)
23. JJ Foxe MM Murray DC Javitt 2005 Filling-in in schizophrenia: a high-density electrical mapping and source-analysis investigation of illusory contour processing Cereb Cortex 15 12 1914 1927 15772373 10.1093/cercor/bhi069 (Pubitemid 41628332)
24. JJ Foxe S Molholm 2009 Ten years at the Multisensory Forum: musings on the evolution of a field Brain Topogr 21 3-4 149 154 19452270 10.1007/s10548-009-0102-9
25. S Frangou T Sharma G Alarcon T Sigmudsson N Takei C Binnie RM Murray 1997 The Maudsley family study, II: endogenous event-related potentials in familial schizophrenia Schizophr Res 23 45 53 9050127 10.1016/S0920-9964(96)00089-8 1:STN:280:DyaK2s3gt1Kjug%3D%3D (Pubitemid 27095190)
26. J Gallinat C Mulert M Bajbouj WM Herrmann J Schunter D Senkowski R Moukhtieva D Kronfeldt G Winterer 2002 Frontal and temporal dysfunction of auditory stimulus processing in schizophrenia Neuroimage 17 110 127 12482071 10.1006/nimg.2002.1213
27. MH Giard F Perrin JF Echallier M Thevenet JC Froment J Pernier 1994 Dissociation of temporal and frontal components in the human auditory N1 wave: a scalp current density and dipole model analysis Electroencephalogr Clin Neurophysiol 92 238 252 7514993 10.1016/0168-5597(94)90067-1 1:STN:280:DyaK2c3lt1ahtA%3D%3D (Pubitemid 24171903)
28. S Guerra A Ibáñez M Martín MA Bobes A Reyes R Mendoza T Bravo M Domínguez MV Sosa 2009 N400 deficits from semantic matching of pictures in probands and first-degree relatives from multiplex schizophrenia families Brain Cogn 70 2 221 230 19307049 10.1016/j.bandc.2009.02.004
29. MH Hall F Rijsdijk M Picchioni K Schulze U Ettinger T Toulopoulou E Bramon RM Murray P Sham 2007 Substantial shared genetic influences on schizophrenia and event-related potentials Am J Psychiatry 164 5 804 812 17475740 10.1176/appi.ajp.164.5.804 (Pubitemid 46808536)
30. Hall MH, Taylor G, Sham P, Schulze K, Rijsdijk F, Picchioni M, Toulopoulou T, Ettinger U, Bramon E, Murray RM, Salisbury DF The early auditory gamma-band response is heritable and a putative endophenotype of schizophrenia. Schizophr Bull (in press)
31. LE Hong A Summerfelt BD Mitchell RP McMahon I Wonodi RW Buchanan GK Thaker 2008 Sensory gating endophenotype based on its neural oscillatory pattern and heritability estimate Arch Gen Psychiatry 65 9 1008 1016 18762587 10.1001/archpsyc.65.9.1008
32. MX Huang RR Lee KM Gaa T Song DL Harrington C Loh RJ Theilmann JC Edgar GA Miller JM Canive E Granholm 2010 Somatosensory system deficits in schizophrenia revealed by MEG during a median-nerve oddball task Brain Topogr 23 1 82 104 19943100 10.1007/s10548-009-0122-5
33. B Karoumi A Laurent F Rosenfeld T Rochet AM Brunon J Dalery T d'Amato M Saoud 2000 Alteration of event related potentials in siblings discordant for schizophrenia Schizophr Res 41 325 334 10708341 10.1016/S0920-9964(99)00062-6 1:STN:280:DC%2BD3c7ntVKgtw%3D%3D (Pubitemid 30077474)
34. EC Lalor S Yeap RB Reilly BA Pearlmutter JJ Foxe 2008 Dissecting the cellular contributions to early visual sensory processing deficits in schizophrenia using the VESPA evoked response Schizophr Res 98 1-3 256 264 17996424 10.1016/j.schres.2007.09.037 (Pubitemid 350235895)
35. EC Lalor AJ Power RB Reilly JJ Foxe 2009 Resolving precise temporal processing properties of the auditory system using continuous stimuli J Neurophysiol 102 1 349 359 19439675 10.1152/jn.90896.2008
36. EC Lalor JJ Foxe 2010 Neural responses to uninterrupted natural speech can be extracted with precise temporal resolution Eur J Neurosci 31 1 189 193 20092565 10.1111/j.1460-9568.2009.07055.x
37. A Laurent L Garcia-Larrea T d'Amato JL Bosson M Saoud M Marie-Cardine F Maugiere J Dalery 1999 Auditory event-related potentials and clinical scores in unmedicated schizophrenic patients Psychiatry Res 86 229 238 10482342 10.1016/S0165-1781(99)00038-4 1:STN:280:DyaK1MvhtVSlug%3D%3D (Pubitemid 29393045)
38. VM Leavitt S Molholm W Ritter M Shpaner JJ Foxe 2007 Auditory processing in schizophrenia during the middle latency period (10-50 ms): high-density electrical mapping and source analysis reveal subcortical antecedents to early cortical deficits J Psychiatry Neurosci 32 339 353 17823650 (Pubitemid 47492759)
39. E Magno S Yeap JH Thakore H Garavan P De Sanctis JJ Foxe 2008 Are auditory-evoked frequency and duration mismatch negativity deficits endophenotypic for schizophrenia? High-density electrical mapping in clinically unaffected first-degree relatives and first-episode and chronic schizophrenia Biol Psychiatry 64 5 385 391 18472090 10.1016/j.biopsych.2008.03.019
40. DH Mathalon BJ Roach JM Ford 2010 Automatic semantic priming abnormalities in schizophrenia Int J Psychophysiol 75 2 157 166 19995582 10.1016/j.ijpsycho.2009.12.003
41. PT Michie AM Fox PB Ward SV Catts N McConaghy 1990 Event-related potential indices of selective attention and cortical lateralization in schizophrenia Psychophysiology 27 209 227 2247551 10.1111/j.1469-8986.1990. tb00372.x 1:STN:280:DyaK3M%2Fmt1GjtA%3D%3D (Pubitemid 20186731)
42. PT Michie H Innes-Brown J Todd AV Jablensky 2002 Duration mismatch negativity in biological relatives of patients with schizophrenia spectrum disorders Biol Psychiatry 52 7 749 758 12372666 10.1016/S0006-3223(02)01379-3
43. S Molholm P Sehatpour AD Mehta M Shpaner M Gomez-Ramirez S Ortigue JP Dyke TH Schwartz JJ Foxe 2006 Audio-visual multisensory integration in superior parietal lobule revealed by human intracranial recordings J Neurophysiol 96 721 729 16687619 10.1152/jn.00285.2006 (Pubitemid 44155212)
44. M Myles-Worsley 2002 P50 sensory gating in multiplex schizophrenia families from a Pacific island isolate Am J Psychiatry 159 12 2007 2012 12450949 10.1176/appi.ajp.159.12.2007 (Pubitemid 35428806)
45. M Myles-Worsley L Ord F Blailes H Ngiralmau R Freedman 2004 P50 sensory gating in adolescents from a pacific island isolate with elevated risk for schizophrenia Biol Psychiatry 55 7 663 667 15038993 10.1016/j.biopsych.2003.12. 006 (Pubitemid 38376176)
46. JM Nousak D Deacon W Ritter HG Vaughan Jr. 1996 Storage of information in transient auditory memory Brain Res Cogn Brain Res 4 305 317 8957572 10.1016/S0926-6410(96)00068-7 1:STN:280:DyaK2s7hs1Crtg%3D%3D (Pubitemid 26390790)
47. BF O'Donnell H Hokama RW McCarley RS Smith DF Salisbury E Mondrow PG Nestor ME Shenton 1994 Auditory ERPs to non-target stimuli in schizophrenia: relationship to probability, task-demands, and target ERPs Int J Psychophysiol 17 219 231 7806466 10.1016/0167-8760(94)90065-5 (Pubitemid 24289484)
48. C Ogura Y Nageishi M Matsubayashi F Omura A Kishimoto M Shimokochi 1991 Abnormalities in event-related potentials, N100, P200, P300 and slow wave in schizophrenia Jpn J Psychiatry Neurol 45 57 65 1753491 1:STN:280: DyaK38%2Fpt1eqtQ%3D%3D
49. RC Oldfield 1971 The assessment and analysis of handedness: the Edinburgh inventory Neuropsychologia 9 97 113 5146491 10.1016/0028-3932(71)90067-4 1:STN:280:DyaE387msVSqsQ%3D%3D
50. J Overall 1962 The Brief Psychiatric Rating Scale Psychol Rep 10 13
51. GF Potts Y Hirayasu BF O'Donnell ME Shenton RW McCarley 1998 High-density recording and topographic analysis of the auditory oddball event-related potential in patients with schizophrenia Biol Psychiatry 44 982 989 9821562 10.1016/S0006-3223(98)00223-6 1:STN:280:DyaK1M%2FjvFSjsQ%3D%3D (Pubitemid 28545226)
52. SJ Press S Wilson 1978 Choosing between logistic regression and discriminant analysis J Am Stat Assoc 73 699 705 10.2307/2286261
53. GW Price PT Michie J Johnston H Innes-Brown A Kent P Clissa AV Jablensky 2006 A multivariate electrophysiological endophenotype, from a unitary cohort, shows greater research utility than any single feature in the Western Australian family study of schizophrenia Biol Psychiatry 60 1 10 16368076 10.1016/j.biopsych.2005.09.010
54. LA Ross D Saint-Amour VM Leavitt S Molholm DC Javitt JJ Foxe 2007 Impaired multisensory processing in schizophrenia: deficits in the visual enhancement of speech comprehension under noisy environmental conditions Schizophr Res 97 1-3 173 183 17928202 10.1016/j.schres.2007.08.008 (Pubitemid 350088394)
55. PJ Rousseeuw K Van Driessen 1999 A fast algorithm for the minimum covariance determinant estimator Technometrics 41 212 223 10.2307/1270566
56. O Saitoh S Niwa K Hiramatsu T Kameyama K Rymar K Itoh 1984 Abnormalities in late positive components of event-related potentials may reflect a genetic predisposition to schizophrenia Biol Psychiatry 19 293 303 6722227 1:STN:280:DyaL2c3gtlyjsg%3D%3D (Pubitemid 14130667)
57. DF Salisbury KC Collins W McCarley 2010 Reductions in the N1 and P2 auditory event-related potentials in first-hospitalized and chronic schizophrenia Biol Psychiatry 36 991 1000
58. H Schreiber G Stolz-Born J Rothmeier A Kornhuber HH Kornhuber J Born 1991 Endogenous event-related brain potentials and psychometric performance in children at risk for schizophrenia Biol Psychiatry 30 177 189 1912108 10.1016/0006-3223(91)90172-I 1:STN:280:DyaK38%2Fgt1Ghuw%3D%3D
59. C Shagass RA Roemer JJ Straumanis M Amadeo 1979 Temporal variability of somatosensory, visual, and auditory evoked potentials in schizophrenia Arch Gen Psychiatry 36 12 1341 1351 40537 1:STN:280:DyaL3c%2FktFKgsg%3D%3D (Pubitemid 11145671)
60. AM Shelley G Silipo DC Javitt 1999 Diminished responsiveness of ERPs in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction Schizophr Res 37 65 79 10227109 10.1016/S0920-9964(98)00138-8 1:STN:280:DyaK1M3ktlKqtA%3D%3D (Pubitemid 29167027)
61. RL Spitzer JB Williams M Gibbon MB First 1992 The Structured Clinical Interview for DSM-III-R (SCID). I: history, rationale, and description Arch Gen Psychiatry 49 624 629 1637252 1:STN:280:DyaK38zksVGjuw%3D%3D
62. A Sumich A Harris G Flynn T Whitford N Tunstall V Kumari M Brammer E Gordon LM Williams 2006 Event-related potential correlates of depression, insight and negative symptoms in males with recent-onset psychosis Clin Neurophysiol 117 1715 1727 16807100 10.1016/j.clinph.2006.04.017 (Pubitemid 44109999)
63. I Szendi M Racsmány C Cimmer G Csifcsák ZA Kovács G Szekeres G Galsi F Tóth A Nagy EA Garab K Boda G Gulyás JG Kiss J Dombi C Pléh Z Janka 2010 Two subgroups of schizophrenia identified by systematic cognitive neuropsychiatric mapping Eur Arch Psychiatry Clin Neurosci 260 3 257 266 19842010 10.1007/s00406-009-0073-6
64. BI Turetsky ME Calkins GA Light A Olincy AD Radant NR Swerdlow 2007 Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measures Schizophr Bull 33 69 94 17135482 10.1093/schbul/sbl060 (Pubitemid 46026260)
65. BI Turetsky TA Greenwood A Olincy AD Radant DL Braff KS Cadenhead DJ Dobie R Freedman MF Green RE Gur RC Gur GA Light J Mintz KH Nuechterlein NJ Schork LJ Seidman LJ Siever JM Silverman WS Stone NR Swerdlow DW Tsuang MT Tsuang ME Calkins 2008 Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probands Biol Psychiatry 64 10 1051 1059 18701089 10.1016/j.biopsych.2008.06.018
66. M Valkonen-Korhonen M Purhonen IM Tarkka P Sipila J Partanen J Karhu J Lehtonen 2003 Altered auditory processing in acutely psychotic never-medicated first-episode patients Brain Res Cogn Brain Res 17 747 758 14561460 10.1016/S0926-6410(03)00199-X (Pubitemid 38373378)
67. G Winterer MF Egan T Radler R Coppola DR Weinberger 2001 Event-related potentials and genetic risk for Schizophrenia Biol Psychiatry 50 407 417 11566157 10.1016/S0006-3223(01)01072-1 1:STN:280:DC%2BD3MrhvFSkug%3D%3D (Pubitemid 32885590)
68. S Yeap SP Kelly P Sehatpour E Magno H Garavan JH Thakore JJ Foxe 2008 Visual sensory processing deficits in Schizophrenia and their relationship to disease state Eur Arch Psychiatry Clin Neurosci 258 305 316 18504634 10.1007/s00406-008-0802-2
69. S Yeap SP Kelly JH Thakore JJ Foxe 2008 Visual sensory processing deficits in first-episode patients with Schizophrenia Schizophr Res 102 1-3 340 343 18485671 10.1016/j.schres.2008.03.026
70. S Yeap SP Kelly P Sehatpour E Magno DC Javitt H Garavan JH Thakore JJ Foxe 2006 Early visual sensory deficits as endophenotypes for schizophrenia: high-density electrical mapping in clinically unaffected first-degree relatives Arch Gen Psychiatry 63 1180 1188 17088498 10.1001/archpsyc.63.11.1180 (Pubitemid 44708075)