Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia

Biological Psychiatry

Volumn 63, Issue 5, 2008, Pages 484-489

  Donohoe, Gary ^a,b   Morris, Derek W ^a   De Sanctis, Pierfilippo ^b,c   Magno, Elena ^a,b   Montesi, Jennifer L ^b,c   Garavan, Hugh P ^a,b   Robertson, Ian H ^a   Javitt, Daniel C ^c,d   Gill, Michael ^a   Corvin, Aiden P ^a   Foxe, John J ^a,b,c,d  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b St Vincent's Hospital Ireland   (Ireland)

^c NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^d CITY COLLEGE OF NEW YORK   (United States)

Author keywords

Dysbindin; EEG; ERP; P1; schizophrenia; sensory processing

Indexed keywords

DYSBINDIN;

ADULT; ARTICLE; BRAIN FUNCTION; CALCULATION; COGNITION; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; ELECTROENCEPHALOGRAM; ELECTROENCEPHALOGRAPHY; EVENT RELATED POTENTIAL; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HETEROZYGOTE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RELATIVE; SCALP; SCHIZOPHRENIA; SENSORY DYSFUNCTION; STATISTICAL SIGNIFICANCE; VISION; VISUAL STIMULATION;

ADOLESCENT; ADULT; AGNOSIA; CARRIER PROTEINS; ELECTROENCEPHALOGRAPHY; EVOKED POTENTIALS, VISUAL; FEMALE; FRONTAL LOBE; GENE EXPRESSION; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HETEROZYGOTE DETECTION; HIGHER NERVOUS ACTIVITY; HUMANS; MALE; MIDDLE AGED; OCCIPITAL LOBE; PARIETAL LOBE; PATTERN RECOGNITION, VISUAL; PHENOTYPE; REACTION TIME; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY; SCHIZOTYPAL PERSONALITY DISORDER; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 38949126972     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2007.07.022     Document Type: Article

References (29)

1. Norton N., Williams H.J., and Owen M.J. An update on the genetics of schizophrenia. Curr Opin Psychiatry 19 (2004) 158-164
2. Bray N.J., Preece A., Williams N.M., Moskvina V., Buckland P.R., Owen M.J., et al. Haplotypes at the dystrobrevin binding protein 1 (DTNBP1) gene locus mediate risk for schizophrenia through reduced DTNBP1 expression. Hum Mol Genet 14 (2005) 1947-1954
3. Talbot K., Eidem W.L., Tinsley C.L., Benson M.A., Thompson E.W., and Smith R.J. dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia. J Clin Invest 113 (2004) 1353-1363
4. Weickert C.S., Straub R.E., McClintock B.W., Matsumoto M., Hashimoto R., Hyde T.M., et al. Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry 61 (2004) 544-555
5. Numakawa T., Yagasaki Y., Ishimoto T., Okada T., Suzuki T., Iwata N., et al. Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet 13 (2004) 2699-2708
6. Burdick K.E., Lencz T., Funke B., Finn C.T., Szeszko P.R., Kane J.M., et al. Genetic variation in DTNBP1 influences general cognitive ability. Hum Mol Genet 15 (2006) 1563-1568
7. Fallgatter A.J., Herrmann M.J., Hohoff C., Ehlis A.C., Jarczok T.A., Freitag C.M., et al. DTNBP1 (dysbindin) gene variants modulate prefrontal brain function in healthy individuals. Neuropsychopharmacology 31 (2006) 2002-2010
8. Donohoe G., Morris D.W., Clarke S., McGhee K.A., Schwaiger S., Nangle J.M., et al. Variance in neurocognitive performance is associated with dysbindin-1 in schizophrenia: A preliminary study. Neuropsychologia 45 (2007) 454-458
9. Butler P.D., and Javitt D.C. Early-stage visual processing deficits in schizophrenia. Curr Opin Psychiatry 18 (2005) 151-157
10. Foxe J.J., Doniger G.M., and Javitt D.C. Early visual processing deficits in schizophrenia: Impaired P1 generation revealed by high-density electrical mapping. Neuroreport 12 (2001) 3815-3820
11. Foxe J.J., Murray M.M., and Javitt D.C. Filling-in in schizophrenia: a high-density electrical mapping and source-analysis investigation of illusory contour processing. Cereb Cortex 15 (2005) 1914-1927
12. Butler P.D., Schechter I., Zemon V., Schwartz S.G., Greenstein V.C., Gordon J., et al. Dysfunction of early-stage visual processing in schizophrenia. Am J Psychiatry 158 (2001) 1126-1133
13. Butler P.D., Zemon V., Schechter I., Saperstein A.M., Hoptman M.J., Lim K.O., et al. Early-stage visual processing and cortical amplification deficits in schizophrenia. Arch Gen Psychiatry 62 (2005) 495-504
14. Doniger G.M., Foxe J.J., Murray M.M., Higgins B.A., and Javitt D.C. Impaired visual object recognition and dorsal/ventral stream interaction in schizophrenia. Arch Gen Psychiatry 59 (2002) 1011-1020
15. Schechter I., Butler P.D., Zemon V.M., Revheim N., Saperstein A.M., Jalbrzikowski M., et al. Impairments in generation of early-stage transient visual evoked potentials to magno- and parvocellular-selective stimuli in schizophrenia. Clin Neurophysiol 116 (2005) 2204-2215
16. Yeap S., Kelly S.P., Sehatpour P., Magno E., Javitt D.C., Garavan H., et al. Early visual sensory deficits as endophenotypes for schizophrenia: High-density electrical mapping in clinically unaffected first-degree relatives. Arch Gen Psychiatry 63 (2006) 1180-1188
17. Liu 2004 Liu Z., Tam W.C., Xue Z., Yao S., and Wu D. Positive and negative symptom profile schizophrenia and abnormalities in the P300 component of the event-related potential: A longitudinal controlled study. Psychiatry Res 132 (2004) 131-139
18. Wood S.M., Potts G.F., Hall J.F., Ulanday J.B., and Netsiri C. Event-related potentials to auditory and visual selective attention in schizophrenia. Int J Psychophysiol 60 (2006) 67-75
19. Williams N.M., Preece A., Morris D.W., Spurlock G., Bray N.J., Stephens M., et al. Identification in 2 independent samples of a novel schizophrenia risk haplotype of the dystrobrevin binding protein gene (DTNBP1). Arch Gen Psychiatry 61 (2004) 336-344
20. Mutsuddi M., Morris D.W., Waggoner S.G., Daly M.J., Scolnick E.M., and Sklar P. Analysis of high-resolution HapMap of DTNBP1 (dysbindin) suggests no consistency between reported common variant associations and schizophrenia. Am J Hum Genet 79 (2006) 903-909
21. American Psychiatric Association. Structured Clinical Assessment for the DSM-III-R (1992), American Psychiatric Association, Washington, DC
22. Oldfield R.C. The assessment of handedness: The Edinburgh inventory. Neuropsychologia 9 (1971) 97-113
23. Stephens M., and Donnelly P. A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73 (2003) 1162-1169
24. Fanous A.H., van den Oord E.J., Riley B.P., Aggen S.H., Neale M.C., O'Neill F.A., et al. Relationship between a high-risk haplotype in the DTNBP1 (dysbindin) gene and clinical features of schizophrenia. Am J Psychiatry 162 (2005) 1824-1832
25. DeRosse P., Funke B., Burdick K.E., Lencz T., Ekholm J.M., Kane J.M., et al. dysbindin genotype and negative symptoms in schizophrenia. Am J Psychiatry 163 (2006) 532-534
26. Martinez A., Anllo-Vento L., Sereno M.I., Frank L.R., Buxton R.B., and Dubowitz D.J. Involvement of striate and extrastriate visual cortical areas in spatial attention. Nat Neurosci 2 (1999) 364-369
27. Handy T.C., and Khoe W. Attention and sensory gain control: A peripheral visual process?. J Cogn Neurosci 17 (2005) 1936-1949
28. Kwon Y.H., Nelson S.B., Toth L.J., and Sur M. Effect of stimulus contrast and size on NMDA receptor activity in cat lateral geniculate nucleus. J Neurophysiol 68 (1992) 182-196
29. Fox K., Daw N., Sato H., and Czepita D. The effect of visual experience on development of NMDA receptor synaptic transmission in kitten visual cortex. J Neurosci 12 (1992) 2672-2684