Frontal white matter integrity as an endophenotype for schizophrenia: Diffusion tensor imaging in monozygotic twins and patients' nonpsychotic relatives

Frontiers in Human Neuroscience

Volumn 3, Issue OCT, 2009, Pages

  Camchong, Jazmin ^a   Lim, Kelvin O ^a,b   Sponheim, Scott R ^a,b   MacDonald III, Angus W ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Diffusion tensor imaging; Endophenotype; Fractional anisotropy; Medial frontal; Monozygotic twin pairs; Schizophrenia relatives; White matter

Indexed keywords

EID: 77954365001     PISSN: 16625161     EISSN: None     Source Type: Journal    
DOI: 10.3389/neuro.09.035.2009     Document Type: Article

References (33)

1. Basser, P. J., and Pierpaoli, C. (1996). Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI. J. Magn. Reson. B 111, 209-219.
2. Behrens, T. E., Woolrich, M. W., Jenkinson, M., Johansen-Berg, H., Nunes, R. G., Clare, S., Matthews, P. M., Brady, J. M. and Smith, S. M., (2003). Characterization and propagation of uncertainty in diffusion-weighted MR imaging. Magn. Reson. Med. 50, 1077-1088.
3. Camchong, J., MacDonald III, A., Bell, C., Mueller, B., and Lim, K. (2009). Altered functional and anatomical connectivity in schizophrenia. Schizophr. Bull. in press.
4. Cheung, V., Cheung, C., McAlonan, G. M., Deng, Y., Wong, J. G., Yip, L., Tai, K. S., Khong, P. L., Sham, P. and Chua, S. E., (2008). A diffusion tensor imaging study of structural dysconnectivity in never-medicated, firstepisode schizophrenia. Psychol. Med. 38, 877-885.
5. Ellison-Wright, I., and Bullmore, E. (2009). Meta-analysis of diffusion tensor imaging studies in schizophrenia. Schizophr. Res. 108, 3-10.
6. Fitzsimmons, J., Kubicki, M., Smith, K., Bushell, G., Estepar, R. S., Westin, C. F., Nestor, P. G., Niznikiewicz, M. A., Kikinis, R., McCarley, R. W., and Shenton, M. E. (2009). Diffusion tractography of the fornix in schizophrenia. Schizophr. Res. 107, 39-46.
7. Fujiwara, H., Namiki, C., Hirao, K., Miyata, J., Shimizu, M., Fukuyama, H., Sawamoto, N., Hayashi, T., and Murai, T. (2007). Anterior and posterior cingulum abnormalities and their association with psychopathology in schizophrenia: a diffusion tensor imaging study. Schizophr. Res. 95, 215-222.
8. Gottesman, I. I., and Gould, T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. Am. J. Psychiatry 160, 636-645.
9. Hoptman, M. J., Ardekani, B. A., Butler, P. D., Nierenberg, J., Javitt, D. C., and Lim, K. O. (2004). DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis. Neuroreport 15, 2467-2470.
10. Hoptman, M. J., Nierenberg, J., Bertisch, H. C., Catalano, D., Ardekani, B. A., Branch, C. A., and Delisi, L. E. (2008). A DTI study of white matter microstructure in individuals at high genetic risk for schizophrenia. Schizophr. Res. 106, 115-124.
11. Howell, D., (2001). Randomization Tests on Correlation Coefficients. available at: http://www.uvm.edu//dhowell/ StatPages/Resampling/RandomCorr/ randomization_Correlation.html.
12. Howell, D., (2007). Randomization Tests. available at: http://www.uvm.edu/ /dhowell/StatPages/Resampling/.
13. Kanaan, R. A., Kim, J. S., Kaufmann, W. E., Pearlson, G. D., Barker, G. J., and McGuire, P. K. (2005). Diffusion tensor imaging in schizophrenia. Biol. Psychiatry 58, 921-929.
14. Karlsgodt, K. H., Niendam, T. A., Bearden, C. E., and Cannon, T. D. (2009). White matter integrity and prediction of social and role functioning in subjects at ultra-high risk for psychosis. Biol Psychiatry 66, 562-569.
15. Kubicki, M., Park, H., Westin, C. F., Nestor, P. G., Mulkern, R. V., Maier, S. E., Niznikiewicz, M., Connor, E. E., Levitt, J. J., Frumin, M., Kikinis, R., Jolesz, F. A., McCarley, R. W., and Shenton, M. E. (2005). DTI and MTR abnormalities in schizophrenia: analysis of white matter integrity. Neuroimage 26, 1109-1118.
16. Kubicki, M., Styner, M., Bouix, S., Gerig, G., Markant, D., Smith, K., Kikinis, R., McCarley, R. W., and Shenton, M. E. (2008). Reduced interhemispheric connectivity in schizophrenia-tractography based segmentation of the corpus callosum. Schizophr. Res. 106, 125-131.
17. Kubicki, M., Westin, C. F., Nestor, P. G., Wible, C. G., Frumin, M., Maier, S. E., Kikinis, R., Jolesz, F. A., McCarley, R. W., and Shenton, M. E. (2003). Cingulate fasciculus integrity disruption in schizophrenia: a magnetic resonance diffusion tensor imaging study. Biol. Psychiatry 54, 1171-1180.
18. Kyriakopoulos, M., Bargiotas, T., Barker, G. J., and Frangou, S. (2008a). Diffusion tensor imaging in schizophrenia. Eur. Psychiatry 23, 255-273.
19. Kyriakopoulos, M., Vyas, N. S., Barker, G. J., Chitnis, X. A., and Frangou, S. (2008b). A diffusion tensor imaging study of white matter in early-onset schizophrenia. Biol. Psychiatry 63, 519-523.
20. Manoach, D. S., Ketwaroo, G. A., Polli, F. E., Thakkar, K. N., Barton, J. J., Goff, D. C., Fischl, B., Vangel, M., and Tuch, D. S. (2007). Reduced microstructural integrity of the white matter underlying anterior cingulate cortex is associated with increased saccadic latency in schizophrenia. Neuroimage 37, 599-610.
21. Mazziotta, J. C., Toga, A. W., Evans, A., Fox, P., and Lancaster, J. (1995). A probabilistic atlas of the human brain: theory and rationale for its development. The International Consortium for Brain Mapping (ICBM). Neuroimage 2, 89-101.
22. Munoz Maniega, S., Lymer, G. K., Bastin, M. E., Marjoram, D., Job, D. E., Moorhead, T. W., Owens, D. G., Johnstone, E. C., McIntosh, A. M., and Lawrie, S. M. (2008). A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia. Schizophr. Res. 106, 132-139.
23. Nichols, T. E., and Holmes, A. P. (2002). Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum. Brain Mapp. 15, 1-25.
24. Reese, T. G., Heid, O., Weisskoff, R. M. and Wedeen, V. J. (2003). Reduction of eddy-current-induced distortion in diffusion MRI using a twice-refocused spin echo. Magn. Reson. Med. 49, 177-182.
25. Rueckert, D., Sonoda, L. I., Hayes, C., Hill, D. L., Leach, M. O., and Hawkes, D. J. (1999). Nonrigid registration using free-form deformations: application to breast MR images. IEEE Trans. Med. Imaging 18, 712-721.
26. Schlosser, R. G., Nenadic, I., Wagner, G., Gullmar, D., von Consbruch, K., Kohler, S., Schultz, C. C., Koch, K., Fitzek, C., Matthews, P. M., Reichenbach, J. R., and Sauer, H. (2007). White matter abnormalities and brain activation in schizophrenia: a combined DTI and fMRI study. Schizophr. Res. 89, 1-11.
27. Skelly, L. R., Calhoun, V., Meda, S. A., Kim, J., Mathalon, D. H., and Pearlson, G. D. (2008). Diffusion tensor imaging in schizophrenia: relationship to symptoms. Schizophr. Res. 98, 157-162.
28. Smith, S. M., Jenkinson, M., Johansen-Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Ciccarelli, O., Cader, M. Z., Matthews, P. M., and Behrens, T. E. (2006). Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage 31, 1487-1505.
29. Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., Niazy, R. K., Saunders, J., Vickers, J., Zhang, Y., De Stefano, N., Brady, J. M., and Matthews, P. M. (2004). Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage 23(Suppl. 1), S208-S219.
30. Spoletini, I., Cherubini, A., Di Paola, M., Banfi, G., Rusch, N., Martinotti, G., Bria, P., Rubino, I. A., Siracusano, A., Caltagirone, C., and Spalletta, G. (2009). Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia. Schizophr. Res. 108, 57-68.
31. Sun, Z., Wang, F., Cui, L., Breeze, J., Du, X., Wang, X., Cong, Z., Zhang, H., Li, B., Hong, N., and Zhang, D. (2003). Abnormal anterior cingulum in patients with schizophrenia: a diffusion tensor imaging study. Neuroreport 14, 1833-1836.
32. Takei, K., Yamasue, H., Abe, O., Yamada, H., Inoue, H., Suga, M., Sekita, K., Sasaki, H., Rogers, M., Aoki, S., and Kasai, K. (2008). Disrupted integrity of the fornix is associated with impaired memory organization in schizophrenia. Schizophr. Res. 103, 52-61.
33. Whitfield-Gabrieli, S., Thermenos, H. W., Milanovic, S., Tsuang, M. T., Faraone, S. V., McCarley, R. W., Shenton, M. E., Green, A. I., Nieto-Castanon, A., LaViolette, P., Wojcik, J., Gabrieli, J. D., and Seidman, L. J. (2009). Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia. Proc. Natl. Acad. Sci. U.S.A. 106, 1279-1284.