Herpes simplex virus type 1-induced transcriptional networks of corneal endothelial cells indicate antigen presentation function

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 7, 2011, Pages 4282-4293

  Miyazaki, Dai ^a   Haruki, Tomoko ^a   Takeda, Sachiko ^a   Sasaki, Shin ichi ^a   Yakura, Keiko ^a   Terasaka, Yuki ^a   Komatsu, Naoki ^a   Yamagami, Satoru ^b   Touge, Hirokazu ^c   Touge, Chizu ^a   Inoue, Yoshitsugu ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c TOTTORI UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVITY REGULATED CYTOSKELETON ASSOCIATED PROTEIN; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN; B CELL ACTIVATING FACTOR; CD38 ANTIGEN; CXCL11 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HERPESVIRUS ENTRY MEDIATOR LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLEAMINE 2, 3 DIOXYGENASE; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; KALLIKREIN; MITOGEN ACTIVATED PROTEIN KINASE; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 2; PROLYLLEUCYLGLYCINAMIDE; PROTEIN RET; RANTES; RAS PROTEIN; STROMAL CELL DERIVED FACTOR 1; THYROXINE DEIODINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSCRIPTION FACTOR MAFA; TRANSCRIPTION FACTOR SOX17; TRANSCRIPTION FACTOR SOX3; TRANSCRIPTOME; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS RNA;

ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORNEA ENDOTHELIUM; DNA MICROARRAY; DOWN REGULATION; GENE REGULATORY NETWORK; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; UNINDEXED SEQUENCE; UPREGULATION; CELL CULTURE; COMPARATIVE STUDY; GENETICS; HERPES SIMPLEX KERATITIS; IMMUNOLOGY; PATHOLOGY; T LYMPHOCYTE; VIRAL EYE INFECTION; VIROLOGY;

ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; CELLS, CULTURED; ENDOTHELIUM, CORNEAL; EYE INFECTIONS, VIRAL; GENE REGULATORY NETWORKS; HERPESVIRUS 1, HUMAN; HUMANS; KERATITIS, HERPETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; T-LYMPHOCYTES;

EID: 80052327885     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.10-6911     Document Type: Article

References (34)

1. Zheng X, Yamaguchi M, Goto T, Okamoto S, Ohashi Y. Experimental corneal endotheliitis in rabbit. Invest Ophthalmol Vis Sci. 2000;41:377-385.
2. Kakimaru-Hasegawa A, Kuo CH, Komatsu N, Komatsu K, Miyazaki D, Inoue Y. Clinical application of real-time polymerase chain reaction for diagnosis of herpetic diseases of the anterior segment of the eye. Jpn J Ophthalmol. 2008;52:24-31.
3. Hillenaar T, Weenen C, Wubbels RJ, Remeijer L. Endothelial involvement in herpes simplex virus keratitis: an in vivo confocal microscopy study. Ophthalmology. 2009;116:2077-2086 e2071-2072.
4. Sugioka K, Drake JD, Fukuda M, Shimomura Y, Hwang DG. Susceptibility of human corneal endothelial cells to HSV-1 infection. Curr Eye Res. 2005;30:863-869.
5. Streilein JW. Ocular immune privilege: therapeutic opportunities from an experiment of nature. Nat Rev Immunol. 2003;3:879-889.
6. + T helper 1 cells by a contact-dependent mechanism. Invest Ophthalmol Vis Sci. 2009;50:263-272.
7. + T cells by human corneal endothelial cells via membrane-bound TGFbeta. Invest Ophthalmol Vis Sci. 2010;51:2548-2557.
8. Terasaka Y, Miyazaki D, Yakura K, Haruki T, Inoue Y. Induction of IL-6 in transcriptional networks in corneal epithelial cells after herpes simplex virus type 1 infection. Invest Ophthalmol Vis Sci. 2010;51:2441-2449.
9. Miyata K, Drake J, Osakabe Y, et al. Effect of donor age on morphologic variation of cultured human corneal endothelial cells. Cornea. 2001;20:59-63.
10. Kawano Y, Kobune M, Yamaguchi M, et al. Ex vivo expansion of human umbilical cord hematopoietic progenitor cells using a coculture system with human telomerase catalytic subunit (hTERT)-transfected human stromal cells. Blood. 2003;101:532-540.
11. Pasieka TJ, Baas T, Carter VS, Proll SC, Katze MG, Leib DA. Functional genomic analysis of herpes simplex virus type 1 counteraction of the host innate response. J Virol. 2006;80:7600-7612.
12. Khodarev NN, Advani SJ, Gupta N, Roizman B, Weichselbaum RR. Accumulation of specific RNAs encoding transcriptional factors and stress response proteins against a background of severe depletion of cellular RNAs in cells infected with herpes simplex virus1. Proc Natl Acad Sci U S A. 1999;96:12062-12067.
13. Stingley SW, Ramirez JJ, Aguilar SA, et al. Global analysis of herpes simplex virus type 1 transcription using an oligonucleotide-based DNA microarray. J Virol. 2000;74:9916-9927.
14. Mossman KL, Macgregor PF, Rozmus JJ, Goryachev AB, Edwards AM, Smiley JR. Herpes simplex virus triggers and then disarms a host antiviral response. J Virol. 2001;75:750-758.
15. He B, Gross M, Roizman B. The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells. J Biol Chem. 1998;273:20737-20743.
16. Daubeuf S, Singh D, Tan Y, et al. HSV ICP0 recruits USP7 to modulate TLR-mediated innate response. Blood. 2009;113:3264-3275.
17. Kamakura M, Nawa A, Ushijima Y, et al. Microarray analysis of transcriptional responses to infection by herpes simplex virus types 1 and 2 and their US3-deficient mutants. Microbes Infect. 2008;10:405-413.
18. Amici C, Belardo G, Rossi A, Santoro MG. Activation of I kappa b kinase by herpes simplex virus type 1. A novel target for antiherpetic therapy. J Biol Chem. 2001;276:28759-28766.
19. Amit I, Garber M, Chevrier N, et al. Unbiased reconstruction of a mammalian transcriptional network mediating pathogen responses. Science. 2009;326:257-263.
20. Lokensgard JR, Hu S, Sheng W, et al. Robust expression of TNFalpha, IL-1beta, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus. J Neurovirol. 2001;7:208-219.
21. He B, Gross M, Roizman B. The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase. Proc Natl Acad Sci U S A. 1997;94:843-848.
22. Glass CK, Saijo K. Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells. Nat Rev Immunol. 2010;10:365-376.
23. Zhu H, Cong JP, Shenk T. Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs. Proc Natl Acad Sci U S A. 1997;94:13985-13990.
24. Zhu H, Cong JP, Mamtora G, Gingeras T, Shenk T. Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays. Proc Natl Acad Sci U S A. 1998;95: 14470-14475.
25. Kodym R, Kodym E, Story MD. 2'-5'-Oligoadenylate synthetase is activated by a specific RNA sequence motif. Biochem Biophys Res Commun. 2009;388:317-322.
26. Haller O, Kochs G. Interferon-induced mx proteins: dynamin-like GTPases with antiviral activity. Traffic. 2002;3:710-717.
27. Li H, Zhang J, Kumar A, Zheng M, Atherton SS, Yu FS. Herpes simplex virus 1 infection induces the expression of proinflammatory cytokines, interferons and TLR7 in human corneal epithelial cells. Immunology. 2006;117:167-176.
28. Roberts ES, Burudi EM, Flynn C, et al. Acute SIV infection of the brain leads to upregulation of IL6 and interferon-regulated genes: expression patterns throughout disease progression and impact on neuroAIDS. J Neuroimmunol. 2004;157:81-92.
29. Unsal E, Aksaray S, Koksal D, Sipit T. Potential role of interleukin 6 in reactive thrombocytosis and acute phase response in pulmonary tuberculosis. Postgrad Med J. 2005;81:604-607.
30. Gao W, Thompson L, Zhou Q, et al. Treg versus Th17 lymphocyte lineages are cross-regulated by LIF versus IL-6. Cell Cycle. 2009;8: 1444-1450.
31. Fenton RR, Molesworth-Kenyon S, Oakes JE, Lausch RN. Linkage of IL-6 with neutrophil chemoattractant expression in virus-induced ocular inflammation. Invest Ophthalmol Vis Sci. 2002;43:737-743.
32. Biswas PS, Banerjee K, Kinchington PR, Rouse BT. Involvement of IL-6 in the paracrine production of VEGF in ocular HSV-1 infection. Exp Eye Res. 2006;82:46-54.
33. Hayashi K, Hooper LC, Chin MS, Nagineni CN, Detrick B, Hooks JJ. Herpes simplex virus 1 (HSV-1) DNA and immune complex (HSV-1-human IgG) elicit vigorous interleukin 6 release from infected corneal cells via Toll-like receptors. J Gen Virol. 2006;87: 2161-2169.
34. Hayashi K, Hooper LC, Detrick B, Hooks JJ. HSV immune complex (HSV-IgG: IC) and HSV-DNA elicit the production of angiogenic factor VEGF and MMP-9. Arch Virol. 2009;154:219-226.